Nanyang Medical College

Henan’an, China

Nanyang Medical College

Henan’an, China
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Chen G.,Nanyang Medical College | Gong R.,Nanyang Medical College
Saudi Pharmaceutical Journal | Year: 2016

To successfully prepare fluorouracil-chitosan nanoparticles, and further analyze its anti-tumor activity mechanism, this paper makes a comprehensive study of existing preparation prescription and makes a detailed analysis of fluorouracil-chitosan in vitro release and pharmacodynamic behavior of animals. Two-step synthesis method is adopted to prepare 5-FU-CS-mPEG prodrugs, and infrared, 1H NMR and differential thermal analysis are adopted to analyze characterization synthetic products of prepared drugs. To ensure clinical efficacy of prepared drugs, UV spectrophotometry is adopted for determination of drug loading capacity of prepared drugs, transmission electron microscopy is adopted to observe the appearance, dynamic dialysis method is used to observe in vitro drug release of prepared drugs and fitting of various release models is done. Anti-tumor effect is studied via level of animal pharmacodynamics. After the end of the experiment, tumor inhibition rate, spleen index and thymus index of drugs are calculated. Experimental results show that the prepared drugs are qualified in terms of regular shape, dispersion, drug content, etc. Animal pharmacodynamics experiments have shown that concentration level of drug loading capacity of prepared drugs has a direct impact on anti-tumor rate. The higher the concentration, the higher the anti-tumor rate. Results of pathological tissue sections of mice show that the prepared drugs cause varying degrees of damage to receptor cells, resulting in cell necrosis or apoptosis problem. It can thus be concluded that ion gel method is an effective method to prepare drug-loading nanoparticles, with prepared nanoparticles evenly distributed in regular shape which demonstrate good slow-release characteristics in receptor vitro and vivo. At the same time, after completion of drug preparation, relatively strong anti-tumor activity can be generated for the receptor, so this mode of preparation enjoys broad prospects for development. © 2016.


Lei Z.,Nanyang Medical College
Chinese Journal of Tissue Engineering Research | Year: 2016

BACKGROUND: To date little is reported clinically on bone marrow mesenchymal stem cells (BMSCs) for acute respiratory distress syndrome (ARDS). OBJECTIVE: To study the effect of BMSCs in ARDS rats. METHODS: Sixty-three Sprague-Dawley rats were randomly assigned into normal control group, model and BMSCs groups (n=21 per group), followed by establishment of ARDS models. After awakening, rats in the model group were given no treatment, while those in the BMSCs group given tail vein injection of fluorouracil-labeled BMSCs. Then, pathological observation of the lung tissue was conducted using hematoxylin-eosin staining, and ELISA method was employed to detect interleukin-1 β level in the rat lung tissue homogenates. Repair effects on lung injury were compared between two groups. RESULTS AND CONCLUSION: Hematoxylin-eosin staining showed that inflammation, edema and congestion in the rat lung tissue were vanished gradually, but no consolidation was found in the BMSCs group, while there was visible edema and congestion in the lung tissue of rats in the model group. Compared with the model group, pulmonary edema and interleukin-1β level in the lung tissue were significantly reduced in the BMSCs group (P < 0.05). Therefore, the whole bone marrow culture method is suitable to obtain BMSCs that have desired effects on ARDS in rats. In ARDS rats, due to inhalation of lipopolysaccharide, BMSCs can be directly involved in lung epithelial repair by reducing the release of inflammatory factors. © 2016, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Huang C.-F.,Wuhan University | Huang C.-F.,Nanyang Medical College | Sun C.-C.,Wuhan University | Zhao F.,Wuhan University | And 2 more authors.
Journal of Gastroenterology | Year: 2015

Background: Chronic hepatitis B virus (HBV) infection, which can lead to hepatic disease, has become a critical national healthcare problem, and many people die each year as a result of HBV infection and its complications. Although microRNA-33a (miR-33a) is a novel modulator of lipid and cholesterol metabolism, the role of miR-33a in the hepatic fibrogenesis is still unknown. Here, we aimed to explore the roles and mechanisms of miR-33a in liver fibrosis. Methods: miR-33a expression in whole liver and serum samples was measured from chronic hepatitis B (CHB) patients by quantitative real-time PCR (qRT-PCR). In addition, different murine hepatic fibrosis models were produced to consolidate the results in human tissue. Human and murine primary liver fibrosis-associated cells were isolated and treated with transforming growth factor-β1 (TGF-β1). Results: miR-33a expression levels in liver tissue significantly increased with a fibrosis progression manner in the human liver. Furthermore, serum miR-33a levels associated positively with progressing process of hepatic fibrosis. miR-33a was in particular increased in hepatic stellate cells (HSC) than other liver fibrosis-associated cells. Stimulation of HSCs with TGF-β1 leads to a critical increase of miR-33a. Increasing miR-33a levels increased (whereas inhibiting miR-33a weakened) the activation role of TGF-β1 in LX-2 cells, which might be a potential mechanism through moderating Smad7 expression. Conclusions: miR-33a may be a novel marker for HSC activation and hepatic fibrosis progress, suggesting a new therapeutic target in liver fibrosis. © 2014, Springer Japan.


Yao Y.X.,Nanyang Medical College
Applied Mechanics and Materials | Year: 2014

This paper first introduces the types and characteristics of HWSN, expounds its typical architecture, through comparing with homogeneous wireless sensor network, the performance of HWSN is quantitative calculated, analysis results show that HWSN can improve the reliability of data transmission, reduce the energy consumption of data transmission, reduce the delay of data transmission, and with the increase of network scale, highlight the advantages of heterogeneous networks. HWSN covering algorithm performance evaluation indexes are given finally. © (2014) Trans Tech Publications, Switzerland.


Feng R.,Nanyang Medical College
Advanced Materials Research | Year: 2014

An effective approach to synthesize methacrylate-based hybrid monoliths was carried out by photopolymerization and the properties of the obtained monoliths mixed with mult-wall carbon nanotube (MWNT) were studied in this paper. The prepared hybrid materials with MWNT in the range of 0-5% total weight of monomers were characterized by Fourier transform infrared spectra, thermo-gravimetric analysis (TGA), and mercury intrusion porosimetry, respectively. Moreover, their porosities were evaluated by the determination of flow rate for different prepared monolithic capillaries. The results showed that the monoliths with more MWNT (1-5%) possessed larger pore sizes between 1-10 μm. The hybrid monoliths have the potential advantages including stronger hydrophobic properties and less resistance for the application of reversed phase liquid chromatography in the micro-column separation. © (2014) Trans Tech Publications, Switzerland.


Zhao Y.B.,Nanyang medical college
Advanced Materials Research | Year: 2013

A combination process of cellulosic ethanol wastewater treatment was described. This process includes iron-carbon micro-electrolysis-Fenton, UASB and MBR. Through the process, we'll get an exploration of engineering design operation parameters and pollutant removal mechanism. Test results show that if the wastewater have 5 hours' micro response, 36 hours to stay on the USAB and 25 hours to stay in the membrane bioreactor, after the flocculation decollating, the COD and ammonia nitrogen indexes of the wastewater have all reached the discharge standard of the Discharge Standard of Water Pollutants for Fermentation Alcohol and Distilled Spirits Industry (GB 27631-2011), and the effect of the operation is stable, cost is low. © (2013) Trans Tech Publications, Switzerland.


Yan Y.W.,Nanyang Medical College
Applied Mechanics and Materials | Year: 2014

This paper is about the term as used in calculus.The derivative of a function of a real variable measures the sensitivity to change of a quantity (a function or dependent variable) which is determined by another quantity (the independent variable). It is a fundamental tool of calculus. This paper is based on the application of derivative in the field of manufacturing and mathematical modeling. © (2014) Trans Tech Publications, Switzerland.


Feng R.,Nanyang Medical College
Advanced Materials Research | Year: 2014

An in-situ polymerization method was used for the preparation of a novel stir bar based on neodymium magnet (Nd2Fe14B) powders. The processes were carried out by several steps including the enwrapping of Nd2Fe14B, the modification of the enclosed Nd2Fe14B, and the form of organic polymers on the surface of the modified powders. It was successfully used to enrich the plasticizers in water sample by stir bar sorptive extraction (SBSE). The experimental conditions for SBSE, such as the choice of extraction sorvents, salt concentration, extraction and desorption time were optimized in detail. Coupled to high performance liquid chromatography (HPLC), the recoveries of dibutyl phthalate (DBP), dimethyl phthalate (DMP), diethyl phthalate (DEP) were 89.2%~92.1%, 91.9%~96.6% and 94.3%~96.7%, respectively; the linear relationships between the concentration 5 μg/L and 800 μg/L for DBP were obtained; the limits of detection ranged from 0.09 μg/L to 0.21 μg/L in the optimal conditions. © (2014) Trans Tech Publications, Switzerland.


Mei M.,Nanyang Medical College
Proceedings - 2016 8th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2016 | Year: 2016

We take university library as an example to mine association rules from circulation records in university libraries. To satisfy the requirement of information service in libraries, a mining algorithm is presented. This paper using association rule mining techniques to find law from the library borrowed document, and recommendation service is found by these rules. Furthermore, a recommendation service model which is applied to offer recommendation service is introduced. © 2016 IEEE.


Huang Y.Y.,Nanyang Medical College
Advanced Materials Research | Year: 2014

The rise of wavelet analysis in applied mathematics is due to its applications and the flexibility. We introduce vector-valued wave wraps with multi-scale dilation factor for space L2 (R2 C2), which is the generalization of univariate wavelet packets. A method for constructing a sort of orthogo- nal vector-valued wavelet wraps in three-dimensional space is presented and their orthogonality traits are characterized by virtue of iteration method and time-frequency analysis method. The orthog- onality formulas concerning these wave packets are established. Moreover, it is shown how to obtain new Riesz bases of space L2 (R3,Cs) from these wave wraps. The notion of multiple pseudo fames for subspaces with integer translation is proposed. The construction of a generalized multiresolution structure of Paley-Wiener subspaces of L2 (R2) is investigated. The pyramid decomposition scheme is derived based on a generalized multiresolution structure. © (2014) Trans Tech Publications, Switzerland.

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