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Nanyang, China

Sun Y.,Nanyang Medical College
Chinese Journal of Lung Cancer | Year: 2014

Background and objective Tumor-suppressor gene promoter DNA methylation in tumor cells is associated with its reduced expression. FHIT (fragile histindine triad) was one of the important tumor suppressor genes which was found hypermethylated in the promoter region in most of tumors. The aim of this study is to evaluate the relationship between FIHT gene promother methylation and lung cancer risk by meta-analysis. Methods By searching Pubmed, CNKI and Wan-fang, the open published articles related to FHIT gene promoter methylation and lung carcinoma risk were collected. The odds ratio (OR) and range of FHIT gene of cancer tissue of lung cancer patients compared with normal lung tissue, plasma and the bronchial lavage fluid were pooled by statistical software Stata 11.0. Results Eleven studies were finally included in this meta-analysis. The median methylation rate were Pmediin=40.096 (0-68.3%), Pmediin=8.796 (0-35.0%), Pmediin=33.396 (17.196-38.3%) and Pmedian=35.9% (31.196-50.8%) in cancer tissue, NLT, BALF and plasm respectively. The pooled results showed the methylation rate in tumor tissue was much higer than that of NLT OR=5.82 (95%CI: 3.74-9.06, P<0.05), but without statistical significance for BALF OR=l.SS (9596CI: 0.89-2.70, P>0.05) and plasma OR=1.41 (9596CI: 0.90-2.20, P>0.05). Conclusion Hypermeth-ylation of FHIT gene promoter region was found more frequent in cancer tissue than that of NLT which may demonstrated association between lung cancer risk and FHIT gene promoter methylation. Source

Feng R.,Nanyang Medical College
Advanced Materials Research | Year: 2014

An effective approach to synthesize methacrylate-based hybrid monoliths was carried out by photopolymerization and the properties of the obtained monoliths mixed with mult-wall carbon nanotube (MWNT) were studied in this paper. The prepared hybrid materials with MWNT in the range of 0-5% total weight of monomers were characterized by Fourier transform infrared spectra, thermo-gravimetric analysis (TGA), and mercury intrusion porosimetry, respectively. Moreover, their porosities were evaluated by the determination of flow rate for different prepared monolithic capillaries. The results showed that the monoliths with more MWNT (1-5%) possessed larger pore sizes between 1-10 μm. The hybrid monoliths have the potential advantages including stronger hydrophobic properties and less resistance for the application of reversed phase liquid chromatography in the micro-column separation. © (2014) Trans Tech Publications, Switzerland. Source

Yan Y.W.,Nanyang Medical College
Applied Mechanics and Materials | Year: 2014

This paper is about the term as used in calculus.The derivative of a function of a real variable measures the sensitivity to change of a quantity (a function or dependent variable) which is determined by another quantity (the independent variable). It is a fundamental tool of calculus. This paper is based on the application of derivative in the field of manufacturing and mathematical modeling. © (2014) Trans Tech Publications, Switzerland. Source

Huang C.-F.,Wuhan University | Huang C.-F.,Nanyang Medical College | Sun C.-C.,Wuhan University | Zhao F.,Wuhan University | And 2 more authors.
Journal of Gastroenterology | Year: 2015

Background: Chronic hepatitis B virus (HBV) infection, which can lead to hepatic disease, has become a critical national healthcare problem, and many people die each year as a result of HBV infection and its complications. Although microRNA-33a (miR-33a) is a novel modulator of lipid and cholesterol metabolism, the role of miR-33a in the hepatic fibrogenesis is still unknown. Here, we aimed to explore the roles and mechanisms of miR-33a in liver fibrosis. Methods: miR-33a expression in whole liver and serum samples was measured from chronic hepatitis B (CHB) patients by quantitative real-time PCR (qRT-PCR). In addition, different murine hepatic fibrosis models were produced to consolidate the results in human tissue. Human and murine primary liver fibrosis-associated cells were isolated and treated with transforming growth factor-β1 (TGF-β1). Results: miR-33a expression levels in liver tissue significantly increased with a fibrosis progression manner in the human liver. Furthermore, serum miR-33a levels associated positively with progressing process of hepatic fibrosis. miR-33a was in particular increased in hepatic stellate cells (HSC) than other liver fibrosis-associated cells. Stimulation of HSCs with TGF-β1 leads to a critical increase of miR-33a. Increasing miR-33a levels increased (whereas inhibiting miR-33a weakened) the activation role of TGF-β1 in LX-2 cells, which might be a potential mechanism through moderating Smad7 expression. Conclusions: miR-33a may be a novel marker for HSC activation and hepatic fibrosis progress, suggesting a new therapeutic target in liver fibrosis. © 2014, Springer Japan. Source

Feng R.,Nanyang Medical College
Advanced Materials Research | Year: 2014

An in-situ polymerization method was used for the preparation of a novel stir bar based on neodymium magnet (Nd2Fe14B) powders. The processes were carried out by several steps including the enwrapping of Nd2Fe14B, the modification of the enclosed Nd2Fe14B, and the form of organic polymers on the surface of the modified powders. It was successfully used to enrich the plasticizers in water sample by stir bar sorptive extraction (SBSE). The experimental conditions for SBSE, such as the choice of extraction sorvents, salt concentration, extraction and desorption time were optimized in detail. Coupled to high performance liquid chromatography (HPLC), the recoveries of dibutyl phthalate (DBP), dimethyl phthalate (DMP), diethyl phthalate (DEP) were 89.2%~92.1%, 91.9%~96.6% and 94.3%~96.7%, respectively; the linear relationships between the concentration 5 μg/L and 800 μg/L for DBP were obtained; the limits of detection ranged from 0.09 μg/L to 0.21 μg/L in the optimal conditions. © (2014) Trans Tech Publications, Switzerland. Source

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