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Nanyang, China

Zhao L.L.,Nanyang Central Hospital
Zhonghua er ke za zhi. Chinese journal of pediatrics | Year: 2011

Coronary artery lesion (CAL) is a serious complication of Kawasaki disease (KD). Whether there is CAL and the severity are the most critical factors of the prognosis of KD. The incidence of KD is currently increasing year by year. KD has replaced rheumatic fever as the main entity of acquired heart disease of children. This study aimed to identify risk factors of CAL secondary to KD and take early interventions to prevent CAL or reduce its incidence. Literature search was performed at Chinese Academic Literature Main Database, Chinese Science and Technology Periodical Database, Wanfang Periodicals and Dissertation Database, and the Chinese Biomedical Literature Database comprehensively, besides, retrospective retrieval and manual retrieval were also performed from the domestic public actions and the dissertations dating from January, 2000 to December, 2009. RavMan 4.2 provided by Cochrane was used for meta analysis. Fixed or random model was selected according to the results of heterogeneity test. Sensitivity analysis was done according to the different results. The publication bias was evaluated by funnel plots. Odds ratio (OR) and 95% confidence interval (CI) were estimated in the dissertation. Twenty studies were confirmed to be eligible. All the 20 studies were retrospective. OR and 95%CI of the risk factors were as follows: age ≤ 1 year, OR = 1.58, and 95%CI (1.23, 2.04), P = 0.0004; male gender, OR = 1.48, 95%CI (1.29, 1.71), P < 0.000 01; WBC > 20 × 10(9)/L, OR = 1.73, 95%CI (1.32, 2.26), P < 0.0001; C-reactive protein (CRP) > 100 mg/L, OR = 2.37, 95%CI (1.49, 3.77), P = 0.0003; fever duration > 10 d, OR = 3.23, 95%CI (2.08, 5.02), P < 0.000 01; use of intravenous gamma globulin (IVIG) > 10 d, OR = 2.50, 95%CI (1.98, 3.16), P < 0.000 01. The high risk factors for coronary artery lesion secondary to Kawasaki disease are age ≤ 1 year, male, WBC > 20 × 10(9)/L, CRP > 100 mg/L, fever duration>10 d, and use of intravenous gamma globulin (IVIG) > 10 d. Source


Liu Y.,Zhengzhou University | Li K.,Zhengzhou University | Ren Z.,Nanyang Central Hospital | Li S.,Zhengzhou University | And 2 more authors.
Journal of Histochemistry and Cytochemistry | Year: 2012

The human cervical cancer oncogene 1 (HCCR-1), a novel human oncoprotein, has been shown to be upregulated in various human tumors and plays a critical role in tumorigenesis and tumor progression. Here, the authors investigated HCCR-1 level in esophageal squamous cell carcinoma (ESCC) tissues and assessed the correlation between HCCR-1 level and prognosis of the patients with ESCC. HCCR-1 levels were investigated by immunohistochemistry, in situ hybridization, real-time quantitative RT-PCR and Western blotting methods; Kaplan-Meier curve was used to evaluate the prognostic value of HCCR-1 level in patients with ESCC using log-rank test. HCCR-1 displayed high levels in ESCC tissues compared to squamous dysplasia tissues and normal esophageal epithelial tissues. No significant correlation was observed between the levels of HCCR-1 mRNA and protein and gender and age (all p>0.05) but obviously related to histological grade, clinical stage, and lymph node metastasis (all p<0.001). Moreover, the survival rate of the patients with low HCCR-1 levels was higher than that of the patients with high HCCR-1 levels (both p<0.05). These data demonstrate that HCCR-1 may be used as a novel predictor for the prognosis of the patients with ESCC. © The Author(s) 2012. Source


Ren X.-S.,Nanyang Central Hospital | Wan Y.-C.,Zhengzhou Shuqing Medical College
World Chinese Journal of Digestology | Year: 2015

AIM: To assess the therapeutic effect of enteral nutrition liquid on digestive dysfunction after surgery for orthopedics trauma. METHODS: One hundred and sixty-seven patients with digestive dysfunction after surgery for orthopedics trauma treated at our hospital from December 2012 to November 2013 were randomly divided into either an observation group (n = 85) or a control group (n = 82). The observation group was given enteral nutrition liquid for adjuvant therapy on the basis of conventional treatment, while the control group was only given postoperative care and symptomatic treatment without enteral nutrition liquid. Indexes such as time to ambulation, hospitalization time and time to anal exhaust were compared for the two groups. The total effective rate and complication rate were also compared. RESULTS: The time to ambulation, hospitalization time and time to anal exhaust in the observation group were significantly shorter than those in the control group. The total effective rate was significantly higher in the observation group than in the control group [95.29% (81/85) vs 84.15% (69/82), P < 0.05]. The rate of complications was significantly lower in the observation group than in the control group [10.59% (9/85) vs 12.20% (10/82), P > 0.05]. CONCLUSION: Enteral nutrition liquid use in patients with digestive dysfunction after surgery for orthopedics trauma can effectively shorten hospitalization time and improve therapeutic effect and safety. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source


Ren L.,Nanyang Central Hospital | Zhu R.,Nanyang Medical College | Li X.,Nanyang Central Hospital
Genetics and Molecular Research | Year: 2016

Epilepsy is one of the most frequent neurological disorders. Recently, the regulation of microRNAs was found to be associated with epilepsy, but the molecular mechanism by which microRNA influences epilepsy process remains to be unveiled and the development of microRNA-based therapy requires more intensive research. In this study, five microRNAs with potential relevance to epilepsy were initially chosen: miR-132, miR-146a, miR-181a, miR-34a, and miR-124. Twenty-five children who were patients with epilepsy were selected as subjects to obtain tissue samples for the study. The miRNA-181a, which represented the most increased fold-changes in clinical samples, were then selected for further function study in mouse model. The temporal lobe epilepsy (TLE) model, along with lithium-pilocarpine-induced status epilepticus (SE), was established in Sprague-Dawley rats. The antagomir of miR-181a was used to determine the role of miR-181a in cell apoptosis. Analyses were conducted to determine the expression levels of miR-181a, neuronal apoptosis in post-SE, and activated caspase-3. We found evidence of significant time dependent up-regulation of miR-181a amongst post-SE rats and TLE on 24 h (4.47 ± 0.35), 7 days (4.85 ± 0.53), and 2 weeks (5.66 ± 0.64). Experiments with the miR-181a antagomir showed that this particular miRNA led to the inhibition of the protein expression of caspase-3, and was up-regulated in the course of seizure-induced neuronal apoptosis. This study provided evidence that targeting miR-181a leads to a neuroprotective response and is linked to an increase in the activation of the caspase-3 protein. These findings suggest that miR-181a may serve as a promising therapeutic target for epilepsy. © FUNPEC-RP. Source


Su P.-F.,Nanyang Central Hospital
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2015

OBJECTIVE: This study was to investigate the clinical efficacy of radiotherapy and chemotherapy combined with surgical treatment for treatment of patients with primay mediastinal B-cell lymphoma.METHODS: A total of 62 patients with primay mediastinal B-cell lymphoma was selected, out of them 26 patients received radiotherapy and che-motherapy were selected as A group, other 36 patients received radiotherapy and chemotherapy combined with surgical treatment and were selected as B group. Clinical efficacy were observed and compared after treatment.RESULTS: In A group 5 patients achieved complete remission (CR), 5 patients achieved partial remission (PR), the total remission rate of A group was 27.8%; in B grouop, 13 patients achieved complete remission (CR), 10 patients achieved PR, the total remission rate of B group was 63.9%. The average survival time of patients in B group was 57.244 months, and the average survival time of patients in A group was 55.541 months, the former was higher than latter. The 5 years survical rate of patients in A group was 57.7%, and the 5 years survival rate of patients in B group was 80.6%, the latter was significantly higher than former.CONCLUSIONS: Radiotherapy and chemotherapy combined with surgical treatment for patients with primay media-stinal B-cell lymphoma has been confirmed to be effective, and may be used in clinic. Source

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