Nantong, China
Nantong, China

Nantong University , colloquially known in Chinese as Tong da , was established in 1912. The university is located in Nantong, Jiangsu province, China. It occupies 4000 acres and have 800 thousand square meters used for school buildings. Nantong is comprehensive university constructed by Jiangsu Provincial Government and the state Ministry of Transport. It is composed of three parts, Nantong Medical College, Nantong Engineering College and Nantong Normal College and has four campuses: the new campus, Qixiu campus, Zhongxiu campus and Qidong campus. The enrollment is nearly 34 thousand full-time students, among whom 1550 are graduates and 300 are oversea students. The university has 84 undergraduate programs based on nine major disciplines, which are literature, science, engineering, medical science, education, economics, law, history and management. Wikipedia.

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A major challenge in tendon injury is the weak intrinsic healing capacity of tendon that may cause rupture of the repair after surgery. Growth factors are believed to be critical during tendon healing. This study aimed to investigate the effects of vascular endothelial growth factor (VEGF) genes delivered by adeno-associated virus (AAV) vectors on tendon healing and molecular events involved in a chicken model. A total of 128 deep flexor tendons in the long toes of chickens were completely transected and injected with 2 × 109 particles of AAV2-VEGF or saline before surgically repaired. At postoperative 4, 6 and 8 weeks, the gliding excursions of tendon were recorded and adhesions around the repair site scored. At 2, 4, 6 and 8 weeks, the ultimate strengths of the healing tendons were tested. Terminal deoxynucleotide transferase dUTP nick end labeling assay were performed to detect cellular apoptosis and immunofluorescence staining to detect type III collagen and matrix metalloprotease-2 (MMP2) expression in tendon tissues. The gliding excursion and adhesion score were similar between AAV2-VEGF-treated tendons and the control tendons. Delivery of AAV2-VEGF significantly increased ultimate strength of the healing tendons at postoperative 4, 6 and 8 weeks (P<0.05). Apoptotic reaction was inhibited from postoperative 2 to 8 weeks in tendon core area or surface area. Type III collagen expression was enhanced at 2, 4, 6 and 8 weeks and MMP2 expression enhanced at 2 and 4 weeks after AAV2-VEGF transfection. The current study confirms the therapeutic efficacy of AAV2-VEGF in improving healing strength of tendon without aggravating adhesion formation after tendon injury, shedding light on the application of molecular therapy in modulating tendon healing.Gene Therapy advance online publication, 23 March 2017; doi:10.1038/gt.2017.12. © 2017 Macmillan Publishers Limited, part of Springer Nature.

Yang W.-C.,CAS Institute of Genetics and Developmental Biology | Shi D.-Q.,CAS Institute of Genetics and Developmental Biology | Chen Y.-H.,Nantong University
Annual Review of Plant Biology | Year: 2010

The multicellular female gametophyte, a unique feature of higher plants, provides us with an excellent experimental system to address fundamental questions in biology. During the past few years, we have gained significant insight into the mechanisms that control embryo sac polarity, gametophytic cell specification, and recognition between male and female gametophytic cells. An auxin gradient has been shown for the first time to function in the female gametophyte to regulate gametic cell fate, and key genes that control gametic cell fate have also been identified. This review provides an overview of these exciting discoveries with a focus on molecular and genetic data. Copyright © 2010 by Annual Reviews. All rights reserved.

Wu Y.F.,Nantong University | Tang J.B.,Nantong University
Journal of Hand Surgery: European Volume | Year: 2014

Over the last decade, both basic researchers and surgeons have sought to identify the most appropriate techniques to be applied in flexor tendon repairs. Recent developments in experimental tendon repairs and clinical outcomes of newer repair techniques have been reviewed in an attempt to comprehensively summarize the most critical mechanical factors affecting the performance of tendon repairs and the surgical factors influencing clinical outcomes. Among them, attention to annular pulleys, the purchase and tension of the core suture, and the direction and curvature of the path of tendon motion have been found to be determining factors in the results of tendon repair. © The Author(s) 2013.

Tang J.B.,Nantong University
Hand Clinics | Year: 2013

This article reviews recent reports of outcomes of flexor tendon repair and discusses the problems associated with such surgeries. Reports of no repair rupture in individual case series have emerged recently. Their results move toward the clinical goal of primary repair without repair rupture. The Strickland method remains the most common to record the outcomes. Outcomes should be provided by subzones of the tendon injuries, and the level of expertise of the surgeons expertise should be reported to allow comparisons of the results. © 2013.

Tang J.B.,Nantong University
Journal of Hand Surgery | Year: 2014

During primary or delayed primary repair of the flexor digitorum profundus tendon, surgeons often face difficulty in passing the retracted tendon or repaired tendon under the dense, fibrous A4 pulley. The A4 pulley is the narrowest part of the flexor sheath, proximal to the terminal tendon. Disrupted tendon ends (or surgically repaired tendons) are usually swelling, making passage of the tendons under this pulley difficult or even impossible. During tendon repair in the A4 pulley area, when the trauma is in the middle part of the middle phalanx and the A3 pulley is intact, the A4 pulley can be vented entirely to accommodate surgical repair and facilitate gliding of the repaired tendon after surgery. Venting the pulley does not disturb tendon function when the other major pulleys are intact and when the venting of the A4 pulley and adjacent sheath is limited to the middle half of the middle phalanx. Such venting is easily achieved through a palmar midline or lateral incision of the A4 pulley and its adjacent distal or/and proximal sheath, which helps ensure a more predictable recovery of digital flexion and extension. © 2014 ASSH Published by Elsevier, Inc. All rights reserved.

Tang M.,Nantong University
Computer Vision and Image Understanding | Year: 2011

The scope of this research is to propose a novel method for automatic registration and fast volume reconstruction of serial tissue sections based on common-configured computer, on the premise that the algorithm can achieve accurate result with fast speed and little interaction as much as possible. The whole flowchart comprises the four main parts, of which image registration and image reconstruction are of great significance, materialized the following innovative ideas. Firstly, mutual information measure is combined with morphological gradient information to contain fewer erroneous maxima and lead to the global maximum when registration. Secondly, the hybrid optimizer combined Particle Swarm Optimization (PSO) with Powell algorithm is proposed to restrain local maxima of mutual information function and to improve the registration accuracy. Thirdly, the multiresolution data structure based on Mallat decomposition not only improves the behavior of registration function, but also accelerates the algorithm speed. Finally, an improved Shear-Warp algorithm is proposed based on the sorted volumetric dataset for registered image stack, which can skip all of the transparent voxels and achieve faster speed. Experimental results demonstrate that the novel registration and reconstruction algorithms are effective and efficient to achieve the virtual three-dimensional gekko's cervical spinal cord successfully and the reconstruction result can be rotated, scaled, incised and measured arbitrarily, which is valuable to be applied to the other kinds of serial histology sections. © 2011 Elsevier Inc. All rights reserved.

Cao H.,Nantong University
International Journal of Biological Macromolecules | Year: 2013

Tea (Camellia sinensis) has a long history of medicinal use in Asian countries such as China, Japan, India and Thailand as ancient as 500,000 years ago. Tea is globally one of the most popular and lowest cost beverages, next only to water. Tea leaves are popularly consumed with unfermented (green tea), semi-fermented (oolong tea), and fermented (black and puerh) forms. The chemical composition of tea mainly includes polyphenols (TPP), proteins, polysaccharides (TPS), chlorophyll, and alkaloids. Great advances have been made in chemical and bioactive studies of catechins and polyphenols from tea in recent decades. However, polysaccharides from tea materials have received much less consideration than TPP. Recently, TPS from tea leaves and flowers have attracted great interest. The number of relevant publications has increased rapidly in recent years. Herein, the bioactivities and function aspects of TPS from Chinese tea were reviewed. © 2013 Elsevier B.V.

Yao H.,Nantong University
Ocean and Coastal Management | Year: 2013

Coastal zones have the characteristics of rich biodiversity and high biological productivity. Based on TM images of 1990 and ETM images of 2000 and 2010, landuse in the coastal zone of Nantong (China) was classified as tidal salt marshes, silty beaches, shoals, aquaculture farms, construction land and other landuse types. Changes of landuse area and pattern were analyzed by landuse mapping and the corresponding statistical data. In 1990-2010, the terrestrial area increased notably and the land-sea demarcation line moved evidently in the direction of the ocean. Terrestrial expansion brought by natural silting was considerable and the overall trends of landuse pattern evolutions in the region were consistent with the guidance and strength of coastal development schemes in 1990-2010. Despite the fact that reclaiming along the coastal region can increase land resources, it may also cause serious damages to environmental quality and ecological health. In Jiangsu's coastal development, we should be cautious about the scope, speed, strength and mode of the schemes so as to avoid irreversible damages to coastal ecosystem. © 2012 Elsevier Ltd.

A tissue engineered nerve graft for repairing peripheral nerve injury consists of a nerve conduit and a extracellular matrix (ECM) that is secreted by autologous or allogeneic support cells and obtained by decellularization. A preparation method of the ECM-modified tissue engineered nerve grafts containing support cells, nerve conduit and constructing a ECM-modified tissue engineered nerve graft.

A tissue engineered nerve graft for repairing peripheral nerve injury consists of a nerve conduit and a extracellular matrix (ECM) that is secreted by autologous or allogeneic support cells and obtained by decellularization. A preparation method of the ECM-modified tissue engineered nerve grafts containing support cells, nerve conduit and constructing a ECM-modified tissue engineered nerve graft.

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