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Godnjavec J.,Helios Domzale d.d. | Znoj B.,Helios Domzale d.d. | Venturini P.,Helios Domzale d.d. | Znidarsic A.,Nanotesla Institute
Informacije MIDEM

Nano - crystalline titanium dioxide (TiO 2) in rutile crystal form, generally used to indicate particles less than 100 nm in diameter, is mainly applied as pigment, adsorbent and UV absorber. The incorporation of a nano-sized titanium dioxide powder into a liquid media is made by dispersion process, that the final product consists of fine particles distribution throught the medium. So it is regarded as necessary for us to investigate in detail the factors which may have important effect upon the homogenious distribution of TiO 2 nanoparticles in clearcoat as liquid media. In this work, titanium dioxide nano-powders were prepared by the co-precipitation method. Using various techniques, including transmission electron microscopy (TEM) and X-ray diffraction (XRD), obtained powders were studied in order to find the possible elements of affecting the microstructures and grain size. The aim of this study is to determine the photostabilisation efficiency of TiO 2 in a clear coat as UV absorber considering the preparation of stable dispersions by using different surfactants and percentage of TiO 2. titanium dioxide, rutile, co-precipitation method, UV absorber, surfactant Helios Domžale, d.d., Količevo 2, p.p. 127, 1230 Domžale, Slovenia. Source

Sedlar A.,Institute of Oncology Ljubljana | Dolinsek T.,Institute of Oncology Ljubljana | Markelc B.,Institute of Oncology Ljubljana | Prosen L.,Nanotesla Institute | And 6 more authors.
Radiology and Oncology

Background. Electrochemotherapy provides good local tumor control but requires adjuvant treatment for increased local response and action on distant metastasis. In relation to this, intramuscular interleukin-12 (IL-12) gene electrotransfer, which provides systemic shedding of IL-12, was combined with local electrochemotherapy with cisplatin. Furthermore, the dependence on tumor immunogenicity and immunocompetence of the host on combined treatment response was evaluated. Materials and methods. Sensitivity of SA-1 sarcoma and TS/A carcinoma cells to electrochemotherapy with cisplatin was tested in vitro. In vivo, intratumoral electrochemotherapy with cisplatin (day 1) was combined with a single (day 0) or multiple (days 0, 2, 4) intramuscular murine IL-12 (mIL-12) gene electrotransfer. The antitumor effectiveness of combined treatment was evaluated on immunogenic murine SA-1 sarcoma in A/J mice and moderately immunogenic murine TS/A carcinoma, in immunocompetent BALB/c and immunodeficient SCID mice. Results. Electrochemotherapy in vitro resulted in a similar IC 50 values for both sarcoma and carcinoma cell lines. However, in vivo electrochemotherapy was more effective in the treatment of sarcoma, the more immunogenic of the tumors, resulting in a higher log cell kill, longer specific tumor growth delay, and also 17% tumor cures compared to carcinoma where no tumor cures were observed. Adjuvant intramuscular mIL-12 gene electrotransfer increased the log cell kill in both tumor models, potentiating the specific tumor growth delay by a factor of 1.8-2 and increasing tumor cure rate by approximately 20%. In sarcoma tumors, the potentiation of the response by intramuscular mIL- 12 gene electrotransfer was dose-dependent and also resulted in a faster onset of tumor cures. Comparison of the carcinoma response to the combined treatment modality in immunocompetent and immunodeficient mice demonstrated that the immune system is needed both for increased cell kill and for attaining tumor cures. Conclusions. Based on the comparison of the antitumor effectiveness of electrochemotherapy to intratumoral cisplatin administration, we can conclude that the fraction of cells killed and the tumor cure rate are higher in immunogenic sarcoma tumor compared to moderately immunogenic carcinoma tumor. The tumor cell kill and cure rate depend on the immune response elicited by the destroyed tumor cells, which might depend on the tumor immunogenicity. The effect of adjuvant intramuscular mIL-12 gene electrotransfer is dependent on the amount of IL-12 in the system and the immune competence of the host, as demonstrated by the dose-dependent increase in the cure rate of SA-1 tumors after multiple intramuscular mIL-12 gene electrotransfer and in the differential cure rate of TS/A tumors growing in immunocompetent and immunodeficient mice. Source

Music B.,Helios Domzale d.d. | Znidarsic A.,Nanotesla Institute | Venturini P.,Helios Domzale d.d.
Informacije MIDEM

Around 15 years have passed since the wireless technologies started with rapid development. During that time, different fields of electromagnetic waves have become more active. As a result of rapid advances in technology the use of wireless communication and radar systems is expanding quickly, which leads to a significant increase in the levels of background electromagnetic (EM) radiation/1/. To avoid potential health effects from high exposure to electromagnetic waves, unnecessary EM waves should be eliminated to protect human bodies, especially expectant mothers and children/2/. In European Pre-standard ENV 50166-2:1995 - Human exposure to electromagnetic fields - High frequency, is stated that electromagnetic fields interact with the human body and other systems through a number of physical mechanisms. Therefore, it is necessary to protect all of these systems. As mentioned in ENV standard, it is recognized that additional considerations have been made by some countries, regarding the reference levels as minimum requirements in certain frequency ranges. Those considerations resulted in additional reference margins/3/. This is the reason why is nowhere a background of electromagnetic waves including many reviews of diverse articles on topics of electromagnetic materials. We decided to bring out that summery to deliver this diversified information to all types of readers, both technical and non-technical. Source

Prijic S.,Nanotesla Institute | Sersa G.,Institute of Oncology Ljubljana
Radiology and Oncology

Background. Many different types of nanoparticles, magnetic nanoparticles being just a category among them, offer exciting opportunities for technologies at the interfaces between chemistry, physics and biology. Some magnetic nanoparticles have already been utilized in clinical practice as contrast enhancing agents for magnetic resonance imaging (MRI). However, their physicochemical properties are constantly being improved upon also for other biological applications, such as magnetically-guided delivery systems for different therapeutics. By exposure of magnetic nanoparticles with attached therapeutics to an external magnetic field with appropriate characteristics, they are concentrated and retained at the preferred site which enables the targeted delivery of therapeutics to the desired spot. Conclusions. The idea of binding chemotherapeutics to magnetic nanoparticles has been around for 30 years, however, no magnetic nanoparticles as delivery systems have yet been approved for clinical practice. Recently, binding of nucleic acids to magnetic nanoparticles has been demonstrated as a successful non-viral transfection method of different cell lines in vitro. With the optimization of this method called magnetofection, it will hopefully become another form of gene delivery for the treatment of cancer. Source

Music B.,Helios Domzale d.d. | Venturini P.,Helios Domzale d.d. | Znidarsic A.,Nanotesla Institute
Ceramics International

We have investigated an organic resin solution designed for EM wave absorption based on a magnetic filler, composed of phases within the Mn 0.66Zn0.27Fe2.07O4 system, embedded in an absorber composite with concentration ratios of 50:50, 75:25 and 90:10 by weight. The formation of the manganese zinc ferrite particles, as the principal magnetic phases, was achieved via the conventional ceramic method. The electromagnetic parameters of the composites were measured with a vector network analyser at 100 MHz to 10 GHz. The subject of the paper was a study of the electromagnetic absorber properties and the rheological properties of the resin composite based on ferrite particles with respect to using the materials in architectural coatings. © 2011 Elsevier Ltd and Techna Group S.r.l. Source

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