Seattle, WA, United States
Seattle, WA, United States

NanoString Technologies, Inc. is a publicly held provider of life science tools for translational research and molecular diagnostics. The company's technology enables a wide variety of basic research, translational medicine and in vitro diagnostics applications. The company was founded by Krassen Dimitrov, Amber Ratcliffe, and Dwayne Dunaway in 2003, and is based in Seattle, Washington. NanoString's "nCounter Analysis System" is based on a digital molecular barcoding technology invented by Dimitrov and Dunaway in Leroy Hood's lab at the Institute for Systems Biology , and became commercially available in 2008. NanoString received a CE-mark designation for selling the Prosigna™ Breast Cancer Prognostic Gene Signature Assay in Israel and EU in September 2012, and in September 2013, NanoString received FDA 510 clearance for Prosigna. Wikipedia.


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Patent
NanoString Technologies | Date: 2016-09-06

The present invention relates to, among other things, polymer strands, probes, compositions, methods, and kits for enabling accurate and robust enzyme- and amplification-free detection of DNA and RNA with single base resolution (e.g., detection of a single nucleotide polymorphism (SNP), an insertion, and a deletion). The compositions, methods, and kits may further provide simultaneous detection of DNA and/or RNA and protein targets.


Patent
The Broad Institute Inc., Massachusetts General Hospital and NanoString Technologies | Date: 2016-10-14

The present disclosure relates to method of distinguishing between two or more species of one or more organisms in a sample, by contacting a biological sample comprising ribosomal ribonucleic acid (rRNA) with a set of antisense probes, wherein the set of probes contains at least one detectable probe that is specific for a target rRNA sequence of each species to be tested, and wherein the individual probes specific for each species comprises less than about 85% sequence identity; and, detecting hybridization between one or more of the probes and the rRNA, thereby distinguishing between two or more species in a sample.


Patent
NanoString Technologies | Date: 2015-08-04

Body fluid identification by mRNA profiling may allow extraction of contextual activity level information from forensic samples. Accordingly, a prototype multiplex digital gene expression method for forensic body fluid/tissue identification is provided, based upon solution hybridization of color-coded (e.g., NanoString) probes. For example, a model for gene expression in a sample from a single body fluid is provided and extended to mixtures of body fluids. A calculation of maximum likelihood estimates of body fluid quantities in a sample is performed, and use of likelihood ratios to test for the presence of each body fluid in a sample is described. A process/algorithm is described and, unlike conventional algorithms for detecting tissues and cells, may allow for zero false-positive fluid identifications across a plurality of samples. Such a protocol may facilitate routine use of mRNA profiling in casework (e.g., forensic) laboratories that previously has not been as reliable.


Patent
NanoString Technologies and The Institute For Systems Biology | Date: 2016-05-20

The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to coded, labeled probes that are capable of binding to and identifying target molecules based on the probes label codes. Methods of making and using such probes are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.


The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneously detecting nucleic acids or proteins in a plurality of samples.


Patent
NanoString Technologies | Date: 2015-11-23

The present disclosure is directed to systems, devices and methods for nucleic acid or protein purification and imaging. A system is provided including a cartridge comprising a sample input area configured to hold a sample, comprising a plurality of hybridized complexes comprising a plurality of target molecules each hybridized with probes and a plurality of non-hybridized probes. The cartridge may also include a first binding chamber configured with first magnetic beads to receive and bind the sample, a first elution channel configured to receive the first magnetic beads and elute the sample from the first magnetic beads, a second binding chamber configured with second magnetic beads to receive and bind the sample, a second elution channel configured to receive the second magnetic beads and elute the sample from the second magnetic beads, and a binding area configured to receive the eluted sample and hold molecules for imaging.


Patent
NanoString Technologies and The University Of Texas System | Date: 2016-07-15

The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.


The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.


Patent
NanoString Technologies | Date: 2016-03-28

The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to improved, stable nanoreporter probes that are capable of binding to and identifying target molecules based on the probes uniquely detectable signal. Methods for identifying target-specific sequences for inclusion in the probes are also provided, as are methods of making and using such probes. Polynucleotide sequences of certain nanoreporter components are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.


Patent
NanoString Technologies | Date: 2016-03-28

The present invention relates to compositions and methods for detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to improved, stable nanoreporter probes that are capable of binding to and identifying target molecules based on the probes uniquely detectable signal. Methods for identifying target-specific sequences for inclusion in the probes are also provided, as are methods of making and using such probes. Polynucleotide sequences of certain nanoreporter components are also provided. The probes can be used in diagnostic, prognostic, quality control and screening applications.

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