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NanoSight Ltd is a company that designs and manufactures instruments for the scientific analysis of nanoparticles that are between approximately ten nanometers and one micron in diameter. The company was founded in 2003 by Bob Carr and John Knowles to further develop a technique Bob Carr had invented to visualize nanoparticles suspended in liquid. The company has since developed the technique of Nanoparticle Tracking Analysis , and they produce a series of instruments to count, size and visualize nanoparticles in liquid suspension using this patented technology.The company’s current headquarters is in Amesbury, Wiltshire, UK . NanoSight has 25 employees in the UK and has received several awards and recognitions. More than 450 instruments had been sold as of 2012. The technology has been cited in over 1300 scientific publications, presentations and reports.NanoSight was acquired by Malvern Instruments on the 30th September 2013. Wikipedia.

Nanoparticle Tracking Analysis (NTA) provides direct and real time visualization, sizing, and counting of particulate materials between 10 nm and 1 μm in liquid suspension. The technique works on a particle-by-particle basis, relating the degree of movement under Brownian motion to the sphere equivalent hydrodynamic diameter particle size, allowing high resolution particle size distributions to be obtained within minutes. Here we describe application of NTA to the analysis of 100 nm polystyrene nanospheres in liquid suspension. The technique can be adapted for use with nearly all particulate materials with sizes between 10 nm and 1 μm. © 2012 Springer Science+Business Media, LLC. Source

Malloy A.,NanoSight
Materials Today | Year: 2011

Nanoscale materials including nanotubes, nanowires, ceramics, quantum dots etc. can be produced from a huge variety of substances. Responsible development of new materials requires that risks to health and the environment associated with the development, production, use and disposal of these materials are fully addressed. Characterization of particles at the nanoscale thus becomes extremely important and new tools are being made available including the nanoparticle characterization systems from NanoSight and their technology, Nanoparticle Tracking Analysis. © 2011 Elsevier Ltd. Source

Vincent P.D.,NanoSight
Chimica Oggi/Chemistry Today | Year: 2012

The growing use of nanomaterials in a range of applications highlights the need for a clear understanding of their potential toxicity. Knowledge gaps currently exist regarding nanomaterials environmental fate, uptake, behaviour within biological systems and direct mechanisms of toxicity. Many physiochemical properties will influence the toxicity of nanomaterials including size, size distribution, agglomeration state, surface chemistry, surface area and electrostatic properties. Given the range of characteristics influencing the toxicity of nanomaterials, clear characterisation for toxicological and environmental studies is imperative. Currently, no single technique can meet the full range of these requirements. However, Nanoparticle Tracking Analysis (NTA) forms an important contribution to this area through the multi-parameter analysis of particle size, size distribution, concentration and zeta potential of nanomaterials in liquid suspensions. Source

Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: NMP-2010-1.2-1 | Award Amount: 4.21M | Year: 2011

In-Sight is a SME-driven project on the in-line characterisation of nanoparticles during nanomaterial manufacturing. This in-line characterisation is the ultimate goal. Within the time-span of the project (3 years) it is our objective to show that a combination of analytical techniques that are capable of real time measurements will provide valuable information for the nanoparticle user. It is our objective to enable monitoring real-time (unexpected) changes in particle count and dimensions during particle processing. The outcome of the project will contribute to minimised batch failure, improved yield, troubleshooting scale-up. In addition, the in-line measurements will enable quality by design throughout development of new products. Finally the result of the project will be reflected in a reduction of development time, as well as easy scale-up from the lab to manufacturing.

NanoSight | Date: 2012-08-06

The present invention provides a method of analysing a sample comprising sub-micron particles, comprising determining first information about the size of particles and number of particles in the sample by nanoparticle tracking analysis; determining second information about average particle size of particles in the sample by dynamic light scattering; determining from the first information third information representing the theoretical effect of the detected particles on results obtainable by dynamic light scattering; and adjusting the second information using the third information to produce fourth information representing adjusted information on average particle size.

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