Agency: National Aeronautics and Space Administration | Branch: | Program: STTR | Phase: Phase II | Award Amount: 600.00K | Year: 2011
This Small Business Technology Transfer Phase 2 effort focuses on development of a supercapacitor energy storage device based on novel metal oxide-carbon nanocomposites. In the Phase 1 project, NanoScale discovered a group of cathode nanocomposites with an exceptionally high capacitance of 270 F/g and a large potential window of 3.8 V versus metallic lithium in inorganic electrolytes. The combination of a large capacitance and a high achievable device voltage, allows for construction of hybrid supercapacitors with high energy and power densities and a very long lifetime. Importantly, the materials developed by NanoScale are easy to produce on a large industrial scale since no costly raw materials or manufacturing methods are required.In Phase 2, a complete supercapacitor system, including nanocomposite cathode and anode electrodes and nonaqueous low temperature electrolytes, will be tested and optimized. The proposed project will be a joint effort between NanoScale Corporation, Battelle Memorial Institute, the STTR partner, and Rayovac, a well known battery manufacturer. This team is uniquely qualified to carry out the proposed research due to its rich experience in manufacturing of nanoscale materials, supercapacitor development and large scale battery manufacturing. NanoScale and Battelle will jointly develop the proposed supercapacitor system. Rayovac will fabricate and evaluate prototype supercapacitors.
Agency: Department of Defense | Branch: Army | Program: STTR | Phase: Phase II | Award Amount: 492.71K | Year: 2011
High efficiency, low pollution, and long lifetime make hydrogen-powered fuel cells desirable for portable power generation by the Army. However, it is impractical to transport hydrogen to where it is needed. Instead, reforming a transportable liquid fuel such as JP-8 or diesel fuel can produce the hydrogen for the fuel cell. Noble metal catalysts can speed this reforming, but they are expensive and easily deactivated by formation of carbon deposits, and by fuel contaminants such as sulfur. In Phase I, NanoScale Corporation and Kansas State University demonstrated the feasibility of Ni and Pt nanoparticles supported on nanocrystalline alumina, for reforming dodecane with high activity and selectivity. In Phase II, NanoScale and KSU will optimize the catalytic system, scale up the catalyst synthesis, and confirm its activity in the presence of sulfur, aromatics, naphthalenes, and JP-8. We will construct a prototype reactor, for delivery to the Army for their validation. NanoScale has great experience in synthesis, characterization, and manufacture of metal nanoparticles and nanocrystalline metal oxides, while Prof. Keith Hohn is an expert in catalytic systems for reforming hydrocarbons into hydrogen."
Nanoscale Corporation Inc and Kansas State University | Date: 2010-08-31
The present invention provides multifunctional nanoplatforms for assessing the activity of a protease in vivo or in vitro, along with methods of imaging and detecting the presence of cancerous or precancerous tissues, and the therapeutic treatment thereof, including monitoring of treatment. The diagnostic nanoplatforms comprise nanoparticles and are linked to each other or other particles via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected using various sensors, and the diagnostic results can be correlated with cancer prognosis. Individual unlinked nanoplatforms are also adaptable for therapeutic hyperthermia treatment of the cancerous tissue.
Nanoscale Corporation Inc and Scott Technologies Inc. | Date: 2013-07-18
To achieve the removal of a broad spectrum of chemical hazards, multiple layers of impregnated activated carbon and nanocrystalline materials are incorporated into the adsorbent bed. For optimum performance using the least amount of material, a two-layer configuration is used. The top layer consists of a homogeneous mixture of an MgO/CaO based nanocrystalline material (e.g., Mg/Ca) and Kureha or other petroleum pitch-based bead shaped activated carbon impregnated treated with phosphoric acid. The bottom layer is comprised of a single layer of Calgon URC carbon. The volume ratios of the components are 9:5:11 Mg/Ca, phosphoric acid treated Kureha carbon, and URC, respectively. The new configuration leads to a 30% reduction in size of the existing NIOSH CBRN CAP 1 cartridge. Other embodiments are disclosed and claimed.
Nanoscale Corporation Inc and Scott Technologies Inc. | Date: 2013-07-18
An improved air purification adsorbent is disclosed. The air purification adsorbent comprises titanium dioxide (TiO_(2)) impregnated with zinc chloride (ZnCl2). The adsorbent may be used in air purification systems for removing ammonia from air streams. The nanocrystalline (amorphous) structure of the adsorbent results in a higher density of surface defects, higher surface area, and higher reactivity which, when combined with the synergistic effect of ZnCl_(2 )and the nanocrystalline TiO_(2), provides a significantly longer breakthrough time of ammonia as compared with breakthrough time from unimpregnated nanocrystalline TiO_(2), the commercial (crystalline) TiO_(2 )impregnated with ZnCl_(2), pure ZnCL_(2), and other commercially available adsorbents of ammonia. Other embodiments are described and claimed.
Nanoscale Corporation Inc | Date: 2012-10-17
Apparatus and methods for reducing or eliminating undesirable air-borne substances, such as odors, bacteria, viruses, fungi, and toxins, are provided. A filter containing nanocrystalline metal oxide or metal hydroxide particles may be installed within an air handling apparatus such as an existing HVAC unit located within a building, and particularly within a home, or a portable air processor or purifier. The air handling apparatus comprises a blower which pulls air containing various undesirable substances from within the enclosed environment and directs it through a filtering device containing the nanocrystalline particles. The undesirable substances are sorbed by the nanocrystalline particles thereby creating a deodorized stream of air that may then be directed back into various portions of the enclosed environment or vented to the atmosphere.
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 200.00K | Year: 2011
The goal of the project is to develop a rapid in vitro screening assay for detection of cancer biomarkers in urine and blood. The aim is testing and optimization of nanoparticle sensors, based on cyanine dyes that are chemically linked to Fe/Fe3O4 nanoparticles via protease-selective consensus (cleavage) sequences. The focus is on the quantitative determination of active cancer-specific proteases in urine and blood via simple fluorescence measurements. The severing from the nanoparticle stops the efficientfluorescence quenching of the organic luminophore by the nanoparticle, thus allowing the detection of the protease activity. The matrix metalloproteinases, urokinase-type plasminogen activator, and cathepsins, are up-regulated in the vast majority of progressing cancers and can, therefore, serve as markers for cell survival/tumor progression, angiogenesis, and tissue remodeling/ invasion. The focus will be on pancreatic cancer, and the studies will be done on urine and blood from 30 patients and 12 healthy individuals. Measuring twelve proteases in total that are linked to pancreatic cancer progression will allow us to obtain statistically significant measurements within 1 hour.
Agency: National Aeronautics and Space Administration | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 100.00K | Year: 2010
Spacecraft and lunar bases generate a variety of wastes containing water, including food wastes, feces, and brines. Disposal of these wastes, as well as recovery of water, is necessary. However, evaporation of water also evaporates compounds with foul odors, some of which are much more volatile than water. Even apart from a water recovery system, foul odors sap crew morale, and must be eliminated. NanoScaleREG Corporation has developed a formulation of its proprietary sorbents, termed OdorKlenzTM, that has been shown to effectively remove odorous compounds from air by destructive adsorption. NanoScale proposes development of a similar formulation, built around nanocrystalline metal oxides manufactured by NanoScale's proprietary procedures, such as NanoActive TiO2, NanoActive MgO, and NanoActive ZnO, to remove foul odors in a system that can recover water from wastes. The odor control system will function during waste storage, and also during water recovery . In Phase I, NanoScale will demonstrate feasibility by developing a formulation of metal oxides capable of removing odorous compounds from food and sanitary wastes, and compatible with a water recovery system. Specific test compounds include skatole (3-methylindole, found in feces), putrescine (1,4-diaminobutane, in rotten protein), ammonia (urine), ethanethiol, hydrogen sulfide (rotten eggs, flatus), butyric acid (rancid butter), and butyraldehyde. Gas streams containing these compounds will be passed through beds of the metal oxide formulation, with concentrations measured by GC, before and after passing through the bed. In Phase II, the odor control system will be integrated into the specific details of spacecraft and envisioned lunar stations. Then, brassboard hardware will be developed and evaluated. NanoScale, having pioneered the synthesis and manufacture of nanocrystalline metal oxides for destructive adsorption of hazardous compounds, is uniquely qualified to perform the proposed work.
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 1.00M | Year: 2010
Early diagnosis and treatment of cancer greatly improve the likelihood of long-term survival and health. In Phase I, NanoScale Corporation and its partners at Kansas State University developed functionalized cancer-seeking "stealth" Fe/Fe3O4 core/shell nanoparticles, and demonstrated their feasibility for diagnosis of cancer by optical imaging. In Phase II, the NanoScale/KSU team will optimize the nanoparticles for diagnosis of breast cancer by fluorescence optical imaging, giving the surgeon an immediate technique for identifying the tumor margin. A maximum Tolerated Dose study, including a Repeat Dose phase, will evaluate toxicity in rats. An Ames test will evaluate mutagenic potential. Ex vivo studies with excised breast tumor specimens will determine the ability of the functionalized nanoparticles to improve margin identification. A Clinical Study Report will be prepared, and discussed with FDA personnel in a pre-IND meeting. Strategic alliances with recognized diagnostic/imaging companies will be established. NanoScale has extensive experience in synthesis, manufacture, and characterization of metal and metal oxide nanoparticles. Professors Stefan Bossmann and Deryl Troyer are internationally recognized for their accomplishments in synthesizing and evaluating anti-cancer compounds. Dr. Mark Cohen, surgical oncologist, is an expert in evaluating novel targeted therapies. Dr. Scott Weir has great experience in drug development and registration.
Agency: Department of Defense | Branch: Army | Program: STTR | Phase: Phase II | Award Amount: 340.84K | Year: 2012
The proposed research incorporates several inventions to produce structural components that are assembled into a highly enhanced Toxic Material Forensic Container (TMFC) for transport and storage of contaminated articles. Bio-hazardous materials are frequently encountered in investigations, and the current evidence containers are designed to handle the issues associated with those materials. However, incident scenes resulting from military or terrorist activity increase the challenges for forensic evidence handling. New TMFC provided with unique features will be produced via a collaboration between NanoScale Corporation and Clemson University. The key feature of the produced system is integration of NanoScale"s reactive nano materials with Clemson's selected fabrics for enhanced CB-protection. In Phase I, we identified two promising formulations for CB-containment, designed the optimum system configuration, and are testing the baseline system. Key areas that will be refined during the Phase II project are: Sorbent composition and capacity, decontamination kinetics, final down selection of external fabric and internal fabric lining, and particle loading optimization. The project will conclude with actual CWA and BWA testing, using GB and HD chemical agents and Bacillus anthracis (anthrax) spores. The proposed work through Phase II will help develop a product that will be useful in DoD and commercial applications.