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Kiev, Ukraine

Riabtseva A.,Lviv Polytechnic | Mitina N.,Lviv Polytechnic | Boiko N.,Ukrainian Academy of Sciences | Garasevich S.,Taras Shevchenko National University | And 4 more authors.
Chemistry and Chemical Technology | Year: 2012

Novel comb-like polymeric and oligomeric drug carriers combining backbone - copolymers of 5-tertbutylperoxy-5-methyl-1-hexene-3-yne (VEP) and glycidyl methacrylate (GMA) - and side PEG chains of various lengths were synthesized. Nanosized delivery systems containing conjugates of water soluble anticancer drug Doxorubicin were developed. The structures of copolymers and their conjugates with drugs were confirmed by IR-spectroscopy. Structural and colloidalchemical properties of water drug delivery systems were studied using photoluminescent (PL), UV-spectroscopy techniques, surface tension measurements and dynamic light scattering. The scheme of the immobilization of water soluble doxorubicin on developed PEGylated polymeric carriers was assumed. © Riabtseva A., Mitina N., Boiko N., Garasevich S., Yanchuk I., Stoika R., Slobodyanyuk O., Zaichenko A., 2012.

Lebyedyeva T.,Ukrainian Academy of Sciences | Kryvyi S.,Ukrainian Academy of Sciences | Lytvyn P.,Ukrainian Academy of Sciences | Skoryk M.,NanoMedTech LLC | Shpylovyy P.,Ukrainian Academy of Sciences
Nanoscale Research Letters | Year: 2016

Our research was aimed at the study of aluminum films and porous anodic alumina (PAA) films in thin-film РАА/Al structures for optical sensors, based on metal-clad waveguides (MCWG). The results of the scanning electron microscopy (SEM) and atomic force microscopy (AFM) studies of the structure of Al films, deposited by DC magnetron sputtering, and of PAA films, formed on them, are presented in this work. The study showed that the structure of the Al films is defined by the deposition rate of aluminum and the thickness of the film. We saw that under anodization in 0.3 M aqueous oxalic acid solution at a voltage of 40 V, the PAA film with a disordered array of pores was formed on aluminum films 200–600 nm thick, which were deposited on glass substrates with an ultra-thin adhesive Nb layer. The research revealed the formation of two differently sized types of pores. The first type of pores is formed on the grain boundaries of aluminum film, and the pores are directed perpendicularly to the surface of aluminum. The second type of pores is formed directly on the grains of aluminum. They are directed perpendicularly to the grain plains. There is a clear tendency to self-ordering in this type of pores. © 2016, Lebyedyeva et al.

Ovcharov M.,Ukrainian Academy of Sciences | Shcherban N.,Ukrainian Academy of Sciences | Filonenko S.,Ukrainian Academy of Sciences | Mishura A.,Ukrainian Academy of Sciences | And 3 more authors.
Materials Science and Engineering B: Solid-State Materials for Advanced Technology | Year: 2015

Porous carbon nitrides of different morphology were obtained via bulk and hard template (SBA-15 and MCF) pyrolysis of melamine. Matrix method allowed obtaining ordered porous C3N4 with higher bandgap (2.87 eV) in the contrary to the bulk sample (2.45 eV). Obtained carbon nitrides were found to be p-type semiconductors with catalytic activity towards photoreduction of carbon dioxide with water vapour. Carbon nitride obtained in MCF has the higher bandgap, developed surface, sponge-like morphology, spatially ordering and it's characterized by the highest photocatalytic activity. © 2015 Elsevier B.V. All rights reserved.

Heffeter P.,Medical University of Vienna | Riabtseva A.,Lviv Polytechnic | Senkiv Y.,Medical University of Vienna | Senkiv Y.,Ukrainian Academy of Sciences | And 10 more authors.
Journal of Biomedical Nanotechnology | Year: 2014

Ruthenium anticancer drugs belong to the most promising non-platinum anticancer metal compounds in clinical evaluation. However, although the clinical results are promising regarding both activity and very low adverse effects, the clinical application is currently hampered by the limited solubility and stability of the drug in aqueous solution. Here, we present a new nanoparticle formulation based on polymer-based micelles loaded with the anticancer lead ruthenium compound KP1019. Nanoprepared KP1019 was characterised by enhanced stability in aqueous solutions. Moreover, the nanoparticle formulation facilitated cellular accumulation of KP1019 (determined by ICP-MS measurements) resulting in significantly lowered IC50 values. With regard to the mode of action, increased cell cycle arrest in G2/M phase (PI-staining), DNA damage (Comet assay) as well as enhanced levels of apoptotic cell death (caspase 7 and PARP cleavage) were found in HCT116 cells treated with the new nanoformulation of KP1019. Summarizing, we present for the first time evidence that nanoformulation is a feasible strategy for improving the stability as well as activity of experimental anticancer ruthenium compounds. Copyright © 2014 American Scientific Publishers All rights reserved.

Kozytskiy A.V.,Ukrainian Academy of Sciences | Stroyuk O.L.,Ukrainian Academy of Sciences | Skoryk M.A.,NanoMedTech LLC | Skoryk M.A.,NASU G.V. Kurdyumov Institute For Metal Physics | And 4 more authors.
Journal of Photochemistry and Photobiology A: Chemistry | Year: 2015

The photocatalytic deposition of antimony(III) sulfide on the surface of TiO2 films on the conductive FTO glass was investigated. The photoprocess yields particles of amorphous and almost stoichiometric Sb2S3 with a size of 150-300 nm and spherical micrometer particles enriched with Sb with a Sb:S ratio that decreases gradually from 13:1 in the particle center to 5:1 at the surface. Thermal treatment of the FTO/TiO2/Sb2S3 films at 350°C results in the transformation of amorphous antimony(III) sulfide into crystalline stibnite without extensive changes in the film morphology. The crystalline FTO/TiO2/Sb2S3 films exhibit photoelectrochemical activity when illuminated in the spectral range of λ > 350 nm in aqueous solutions of ascorbic acid as a sacrificial electron donor. The maximal photocurrent density generated by the TiO2/Sb2S3 heterostructure is higher than the photoresponse of the starting FTO/TiO2 film by a factor of 3.6. Deposition of an intermediary layer of Inx(OH)ySz on the interface between TiO2 and Sb2S3 results in a further 3-fold increase in the photoelectrochemical activity of the FTO/TiO2/Sb2S3 heterostructure. © 2015 Elsevier B.V. All rights reserved.

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