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Murviel-lès-Montpellier, France

Theron C.,Charles Gerhardt Institute | Theron C.,University of California at Los Angeles | Gallud A.,Montpellier University | Giret S.,Charles Gerhardt Institute | And 13 more authors.
RSC Advances | Year: 2015

The transport of anticancer molecules by nanoparticles has shown great promise in terms of bioavailability, concentrating drugs in the tumor area and minimizing drug side effects. Here, we report the high efficiency of pH-operated hybrid silica nanocarriers for colon cancer therapy. These silica nanoparticles carry the drugs which are tightly held by cyanuric acid as a new type of stopper. The latter can be autonomously removed upon acidic medium allowing a direct drug release inside the cancer cells. Importantly, the proof of concept was established by ex vivo experiments using primary cell cultures from patient biopsies. This journal is © The Royal Society of Chemistry 2015.

Chaix A.,National Graduate School of Chemistry, Montpellier | El Cheikh K.,French National Center for Scientific Research | Bouffard E.,French National Center for Scientific Research | Maynadier M.,NanoMedSyn | And 11 more authors.
Journal of Materials Chemistry B | Year: 2016

A novel non-toxic porous silicon nanoparticle grafted with a mannose-6-phosphate analogue and applicable in 2-photon imaging and photodynamic therapy was specifically designed for targeting prostate cancer cells. © 2016 The Royal Society of Chemistry.

Nyalosaso J.L.,Charles Gerhardt Institute | Rascol E.,Charles Gerhardt Institute | Pisani C.,Charles Gerhardt Institute | Pisani C.,CEA Marcoule Nuclear Site | And 13 more authors.
RSC Advances | Year: 2016

Mesoporous Silica Nanoparticles (MSN) are now considered as multifunctional platforms for pharmaceutical development. The goal of this study was to optimize a synthesis procedure to obtain reproducible monodisperse magnetic core@shell Fe3O4@MSN with different coatings and study their uptake by cells. 100 nm core@shell nanoparticles with a unique 18 nm magnetic core were synthesized and covered with PEG groups or coated with a lipid bilayer in a controlled manner and their cellular fate was investigated. Both PEG and lipidic coated nanoparticles exhibit a low toxicity when incubated with Hep-G2 cells compared to pristine ones. Furthermore, the different real-time impedance cellular profiles that were observed and the particles uptake by the cells investigated by TEM suggest different internalization mechanisms or uptake kinetics depending on MSN coverage. This study is a first essential step to ensuring the preparation of well-defined nanomaterials for medical applications; it is considered as a crucial step to be able to perform detailed research about cellular trafficking and signaling pathways. This journal is © The Royal Society of Chemistry 2016.

Perrier M.,Charles Gerhardt Institute | Gallud A.,Montpellier University | Ayadi A.,Montpellier University | Kennouche S.,Montpellier University | And 11 more authors.
Nanoscale | Year: 2015

Cyano-bridged Gd3+/[Fe(CN)6]3- coordination polymer nanoparticles of 3-4 nm stabilized with d-mannitol presenting a high r1 relaxivity value of 11.4 mM-1 s-1 were investigated in vivo as contrast agents (CA) for Magnetic Resonance Imaging (MRI). They allow an increase of the MR image contrast and can act as an efficient intravascular T1 CA with a relatively long blood-circulation lifetime (60 min) without specific toxicity. This journal is © The Royal Society of Chemistry.

Croissant J.G.,Charles Gerhardt Institute | Mauriello-Jimenez C.,Charles Gerhardt Institute | Maynadier M.,NanoMedSyn | Cattoe n X.,CNRS Neel Institute | And 8 more authors.
Chemical Communications | Year: 2015

Biodegradable bridged silsesquioxane (BS) nanomaterials for two-photon-excited (TPE) imaging and therapy of breast cancer cells were described. A versatile synthesis was developed to design monodisperse tetra-alkoxysilylated diamino-diphenylbutadiene or Zn-porphyrin-based nanospheres of 30 to 50 nm. © The Royal Society of Chemistry 2015.

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