Nanomedicine Research Laboratory

Delhi, India

Nanomedicine Research Laboratory

Delhi, India
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Kumar P.,Nanomedicine Research Laboratory
International Journal of Pharmaceutical Sciences Review and Research | Year: 2012

Dried blood spot (DBS) has long been the preferred technique for the screening of newborn metabolic defects. The use of blood spot collection cards is a simple way to obtain specimens for analysis of drugs for the purpose of therapeutic drug monitoring, assessing adherence to medications and preventing toxicity. DBS sampling is a promising and patient friendly alternative for venous sampling. However, its benefits must be weighed against the degree of potential errors introduced via the sampling method; there is evidently a need for more standardization, quality assurance, basic research, and assay development. The collection of dried blood spots on filter paper offers a powerful tool in screening programs and in large population based surveys. DBS is ideal for pediatric studies and with more recent development of sensitive mass spectrometers, has gained significant interest as a potentially powerful tool for quantitative analysis of small molecules for pharmaceutical drug development and toxicology. Small sample volumes and the drying of the collected samples provide DBS several advantages over the traditional plasma method. Small sample volume translates into reduced number of animals per study, ability to collect serial time points from a single animal, and ultimately, a reduction in the cost of a given animal study. For clinical studies, small sample volume and simple non-invasive sample collection techniques, like the finger prick, can potentially improve subject recruitment and retention. Once dried, the collected samples can also be stored and shipped at ambient atmospheric conditions.


Kumar S.,Nanomedicine Research Laboratory | Arora S.,Nanomedicine Research Laboratory
Critical Reviews in Therapeutic Drug Carrier Systems | Year: 2013

Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor dissolution rate of BCS class II and IV drugs. In this literature review, novel formulation options, particularly for class II drugs designed for applications such as micronization, selfemulsification, cyclodextrin complexation, co-crystallisation, super critical fluid technology, solubilisation by change in pH, salt formation, co-solvents, melt granulation, and solid dispersion, liposomal/niosomal formulations, are discussed in detail to introduce biopharmaceutical challenges and recent approaches to facilitate more efficient drug formulation and development. © 2013 Begell House, Inc.


Ahmad M.Z.,Najran University | Alkahtani S.A.,Najran University | Akhter S.,Nanomedicine Research Laboratory | Ahmad F.J.,Nanomedicine Research Laboratory | And 4 more authors.
Journal of Drug Targeting | Year: 2016

Comprehensive pharmacological screening of curcumin (CUR) has given the evidence that it is an excellent naturally occurring therapeutic moiety for cancer. It is very well tolerated with insignificant toxicity even after high doses of oral administration. Irrespective of its better quality as an anticancer agent, therapeutic application of CUR is hampered by its extremely low-aqueous solubility and poor bioavailability, rapid clearance and low-cellular uptake. A simple means of breaking up the restrictive factor of CUR is to perk-up its aqueous solubility, improve its bioavailability, protect it from degradation, and metabolism and potentiate its targeting capacity towards the cancer cell. The development in the field of nanomedicine has made excellent progresses toward enhancing the bioavailability of lipophilic drugs like CUR. Nanoparticles (NPs) are capable to deliver the CUR at specific area and thereby prevent it from physiological degradation and systemic clearance. In recent year, an assortment of nanomedicine-based novel drug delivery system has been designed to potentiate the bioavailability of CUR towards anticancer therapy. In this review, we discuss the recent development in the field of nanoCUR (NanoCur), including polymeric micelles, liposome, polymeric NPs, nanoemulsion, nanosuspension, solid lipid NPs (SLNPs), polymer conjugates, nanogel, etc. in anticancer application. © 2015 Informa UK Ltd.


Ahmad M.Z.,Najran University | Akhter S.,Najran University | Mohsin N.,Najran University | Abdel-Wahab B.A.,Najran University | And 5 more authors.
Current Drug Discovery Technologies | Year: 2014

Curcumin (CUR) is a yellow-coloured polyphenolic compound obtained from the rhizomes of Curcuma longa. In-depth pharmacological screening of curcumin has given the evidence that CUR persuades shielding and curative effects against various cancers, cardiovascular, wound healing effect and neuro disorders etc owning to anti-oxidant, antiproliferative, anti-inflammatory, anti-angiogenic and antimicrobial activities. However, miserable bioavailability due to poor aqueous solubility limits the application of CUR in various ailments. Different methodologies including the nanoparticle technology have been reported for the bioavailability enhancement of CUR. Nanoparticles exhibit not only the improvement in the solubility of CUR and alike lipophilic molecules (resulted in improved bioavailability) but also giving the opportunity for the disease specific cellular and organ targeting. Improved bioavailability and disease based site specific delivery of CUR is more likely to bring it as a safe multifunctional medicine. © 2014 Bentham Science Publishers.


Paramjot,Nanomedicine Research Laboratory | Khan N.M.,Nanomedicine Research Laboratory | Kapahi H.,Nanomedicine Research Laboratory | Kumar S.,Polymer Chemistry and Technology Research Laboratory | And 3 more authors.
Journal of Drug Targeting | Year: 2015

Polymers have been utilized to deliver the drug to targeted site in controlled manner, achieving the high-therapeutic efficacy. Polymeric drug conjugates having variable ligands as attachments have been proved to be biodegradable, stimuli sensitive and targeted systems. Numerous polymeric drug conjugates having linkers degraded by acidity or intracellular enzymes or sensitive to over expressed groups of diseased organ/tissue have been synthesized during last decade to develop targeted delivery systems. Most of these organs have number of receptors attached with different cells such as Kupffer cells of liver have mannose-binding receptors while hepatocytes have asialoglycoprotein receptors on their surface which mainly bind with the galactose derivatives. Such ligands can be used for achieving high targeting and intracellular delivery of the drug. This review presents detailed aspects of receptors found in different cells of specific organ and ligands with binding efficiency to these specific receptors. This review highlights the need of further studies on organ-specific polymer-drug conjugates by providing detailed account of polymeric conjugates synthesized till date having organ-specific targeting. © 2015 Informa UK Ltd.


PubMed | Nanomedicine Research Laboratory
Type: Journal Article | Journal: Critical reviews in therapeutic drug carrier systems | Year: 2013

Poor aqueous solubility impedes a drugs bioavailability and challenges its pharmaceutical development. Pharmaceutical development of drugs with poor water solubility requires the establishment of a suitable formulation layout among various techniques. Various approaches have been investigated extensively to improve the aqueous solubility and poor dissolution rate of BCS class II and IV drugs. In this literature review, novel formulation options, particularly for class II drugs designed for applications such as micronization, self-emulsification, cyclodextrin complexation, co-crystallisation, super critical fluid technology, solubilisation by change in pH, salt formation, co-solvents, melt granulation, and solid dispersion, liposomal/niosomal formulations, are discussed in detail to introduce biopharmaceutical challenges and recent approaches to facilitate more efficient drug formulation and development.


PubMed | Nanomedicine Research Laboratory
Type: Journal Article | Journal: Journal of drug targeting | Year: 2015

Polymers have been utilized to deliver the drug to targeted site in controlled manner, achieving the high-therapeutic efficacy. Polymeric drug conjugates having variable ligands as attachments have been proved to be biodegradable, stimuli sensitive and targeted systems. Numerous polymeric drug conjugates having linkers degraded by acidity or intracellular enzymes or sensitive to over expressed groups of diseased organ/tissue have been synthesized during last decade to develop targeted delivery systems. Most of these organs have number of receptors attached with different cells such as Kupffer cells of liver have mannose-binding receptors while hepatocytes have asialoglycoprotein receptors on their surface which mainly bind with the galactose derivatives. Such ligands can be used for achieving high targeting and intracellular delivery of the drug. This review presents detailed aspects of receptors found in different cells of specific organ and ligands with binding efficiency to these specific receptors. This review highlights the need of further studies on organ-specific polymer-drug conjugates by providing detailed account of polymeric conjugates synthesized till date having organ-specific targeting.

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