Daresbury, United Kingdom
Daresbury, United Kingdom
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Patent
Nanoflex | Date: 2017-09-27

The present invention relates to an electrode assembly (eg a nanoelectrode assembly), to an electrochemical glucose biosensor comprising the electrode assembly and to an apparatus for combatting (eg management of) diabetes mellitus which comprises the electrochemical glucose biosensor.


Freeman N.J.,University of Manchester | Freeman N.J.,Nanoflex | Sultana R.,Nanoflex | Reza N.,Nanoflex | And 6 more authors.
Physical Chemistry Chemical Physics | Year: 2013

The performance of two electrode architectures with broadly similar overall active electrode areas are examined. The first is an electrode comprising a single contiguous area (a disc) and the second is an electrode in which the cumulative electrode area is dispersed over a wide area as a 50 nm thickness platinum nanoband. A direct comparison of the electrochemical performance of these two electrodes has been made. The relatively simple nanoband electrode architecture is shown to have benefits, including two orders of magnitude greater mass transport limited currents, the ability to measure faster electrode kinetics (by a similar factor), a three orders of magnitude lowering of the Limit of Detection and a significantly reduced susceptibility to hydrodynamic perturbations. The consequences and implications of these performance characteristics on the uses of such a nanoband electrode have been considered. © 2013 the Owner Societies.


Schmueser I.,University of Edinburgh | Walton A.J.,University of Edinburgh | Terry J.G.,University of Edinburgh | Woodvine H.L.,University of Edinburgh | And 3 more authors.
Faraday Discussions | Year: 2014

Micron resolution photolithography has been employed to make microsquare nanoband edge electrode (MNEE) arrays with reproducible and systematic control of the crucial dimensional parameters, including array element size and spacing and nanoelectrode thickness. The response of these arrays, which can be reproducibly fabricated on a commercial scale, is first established. The resulting characteristics (including high signal and signal-to-noise, low limit of detection, insensitivity to external convection and fast, steady-state, reproducible and quantitative response) make such nanoband electrode arrays of real interest as enhanced electroanalytical devices. In particular, the nanoelectrode response is presented and analysed as a function of nanometre scale electrode dimension, to assess the impact and relative contributions of previously postulated nanodimensional effects on the resulting response. This work suggests a significant contribution of migration at the band edges to mass transfer, which affects the resulting electroanalytical response even at ionic strengths as large as 0.7 mol dm-3 and for electrodes as wide as 50 nm. For 5 nm nanobands, additional nanoeffects, which are thought to arise from the fact that the size of the redox species is comparable to the band width, are also observed to attenuate the observed current. The fundamental insight this gives into electrode performance is discussed along with the consequent impact on using such electrodes of nanometre dimension. © 2013 The Royal Society of Chemistry.


Terry J.G.,University of Edinburgh | Schmuser I.,University of Edinburgh | Underwood I.,University of Edinburgh | Corrigan D.K.,University of Edinburgh | And 4 more authors.
IET Nanobiotechnology | Year: 2013

A novel technique for the production of nanoscale electrode arrays that uses standard microfabrication processes and micron-scale photolithography is reported here in detail. These microsquare nanoband edge electrode (MNEE) arrays have been fabricated with highly reproducible control of the key array dimensions, including the size and pitch of the individual elements and, most importantly, the width of the nanoband electrodes. The definition of lateral features to nanoscale dimensions typically requires expensive patterning techniques that are complex and low-throughput. However, the fabrication methodology used here relies on the fact that vertical dimensions (i.e. layer thicknesses) have long been manufacturable at the nanoscale using thin film deposition techniques that are well established in mainstream microelectronics. The authors report for the first time two aspects that highlight the particular suitability of these MNEE array systems for probe monolayer biosensing. The first is simulation, which shows the enhanced sensitivity to the redox reaction of the solution redox couple. The second is the enhancement of probe film functionalisation observed for the probe film model molecule, 6-mercapto-1-hexanol compared with microsquare electrodes. Such surface modification for specific probe layer biosensing and detection is of significance for a wide range of biomedical and other sensing and analytical applications. © The Institution of Engineering and Technology 2013.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.92M | Year: 2013

The proposed ITN BIOENERGY deals with the understanding of experimental limits and fundamental principles for exploiting and developing electro-conducting nanoarchitectures to assemble highly efficient bioelectrocatalytic structures as a basis for efficient and stable biofuel cells. Based on that fundamental understanding, the main technological objective of BIOENERGY is to develop efficient and stable biofuel cells including potentially implantable biodevices. Individual elements like electrodes, enzymes and mediators will be developed, integrated into each other and finally assembled to bio fuel cells. ESR and ER will be work on the all tasks of this scientific chain being therefore trained in the fundamentals of bioelectrochemistry, modern experimental methods in bioelectrochemistry and applications of bioelectrochemistry. Training of the fellows will take place at the host institute, via secondments, workshops, summer schools and joint measurement campaigns. The scientific training will be completed by training of complementary skill with respect management, fund raising and scientific communication. The consortium consists of the leading scientists in bioelectrochemistry in Europe and is supported by several private partners working in the field. It is expected that BIOENERGY will improve the availability of a highly skilled workforce for European industries and research, and will be the seed of innovative long-term research and education in bioelectrochemistry.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Innovation Voucher | Award Amount: 5.00K | Year: 2015

Medilink are vastly experienced in the area of wound care, wound healing and models of wound healing. Medilink are also experts in competitor and technology landscaping and are best placed to do a review of the key analytes that might be of value for monitoring wound healing progression and directing targeted treatments in the long term. This information would guide the development and testing of sensors for these applications and the basis of any business case for sensor development.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Launchpad | Award Amount: 100.00K | Year: 2013

This project seeks to address the cost effective and reproducible manufacture of high performance electrochemical sensor devices. NanoFlex have brought to market the first commercial nanoelectrode for academic and blue-chip researchers. Through this project NanoFlex seek to develop their current nanoelectrode technology up the value chain, integrating it into high-value sensor system solutions, for health-care diagnostics, environmental monitoring, nuclear decommissioning and energy storage. An integrated sensor system will offer a enhancements in performance characteristics and hence enable electrochemical applications solutions that are not currently addressable using existing electrodes or sensor systems. Our approach to sensor systems is innovative in that it offers a relatively simple and highly scalable method of manufacture utilising established thin film techniques in a radical and efficient manner. Our enabling technology is patent protected. TSB investment in this project will ensure that this innovative technology and approach to manufacture continues to be developed within the UK to maximise its value and enable it to provide high value manufacturing opportunities.


Nanoflex | Entity website

NanoFlexTM and CAVIARETM are trademarks of NanoFlex Limited 2016 Nanoflex Limited


Nanoflex | Entity website

NanoFlexTM and CAVIARETM are trademarks of NanoFlex Limited 2016 Nanoflex Limited

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