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Columbus, OH, United States

Wang Y.,University of California at Los Angeles | Tran H.D.,Nanofiber Solutions | Kaner R.B.,University of California at Los Angeles
Macromolecular Rapid Communications | Year: 2011

This Feature Article provides an overview of the distinctive nanostructures that aniline oligomers form and the applications of these oligomers for shaping the nanoscale morphologies and chirality of conducting polymers. We focus on the synthetic methods for achieving such goals and highlight the underlying mechanisms. The clear advantages of each method and their possible drawbacks are discussed. Assembly and applications of these novel organic (semi)conducting nanomaterials are also outlined. We conclude this article with our perspective on the main challenges, new opportunities, and future directions for this nascent yet vibrant field of research. Oligomers of aniline have recently emerged as flexible building blocks for various nanostructures and as an important mediator in orchestrating nanostructure formation for conducting polymers. In this Feature Article, the role of oligomeric species in the synthesis, assembly, and applications of such nanomaterials are highlighted. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Wang Y.,University of California at Los Angeles | Tran H.D.,Nanofiber Solutions | Liao L.,University of California at Los Angeles | Duan X.,University of California at Los Angeles | Kaner R.B.,University of California at Los Angeles
Journal of the American Chemical Society | Year: 2010

While nanostructures of organic conductors have generated great interest in recent years, their nanoscale size and shape control remains a significant challenge. Here, we report a general method for producing a variety of oligoaniline nanostructures with well-defined morphologies and dimensionalities. 1-D nanowires, 2-D nanoribbons, and 3-D rectangular nanoplates and nanoflowers of tetraaniline are produced by a solvent exchange process in which the dopant acid can be used to tune the oligomer morphology. The process appears to be a general route for producing nanostructures for a variety of other aniline oligomers such as the phenyl-capped tetramer. X-ray diffraction of the tetraniline nanostructures reveals that they possess different packing arrangements, which results in different nanoscale morphologies with different electrical properties for the structures. The conductivity of a single tetraaniline nanostructure is up to 2 orders of magnitude higher than the highest previously reported value and rivals that of pressed pellets of conventional polyaniline doped with acid. Furthermore, these oligomer nanostructures can be easily processed by a number of methods in order to create thin films composed of aligned nanostructures over a macroscopic area. © 2010 American Chemical Society. Source

Research Institute At Nationwide Childrens Hospital Inc. and Nanofiber Solutions | Date: 2014-03-14

The invention provides for engineered intestinal construct and methods of making these constructs. The invention also provides for methods of treating short bowel syndrome or methods of repairing an intestine after resection comprising inserting an engineered intestinal construct into the intestine of a subject in need.

Nanofiber Solutions | Date: 2014-03-17

A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.

Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 250.00K | Year: 2015

DESCRIPTION provided by applicant Short bowel syndrome SBS a major clinical problem affecting patients of all ages results from the functional or anatomic loss of extensive segments of small intestine SBS has an overall year survival of and in newborn infants with less than of expected intestinal length year survival is only Current treatment options are inadequate and associated with severe complications and death Patients with SBS require total parenteral nutrition TPN to survive Currently over SBS patients per year are on home TPN in the US alone Annual costs of home TPN exceed $ per year per patient $ billion year In addition the use of TPN is associated with numerous central venous catheter associated infectious and thrombotic complications resulting in additional high costs Thus SBS represents an extremely costly and deadly burden to society At present the treatment for SBS is mainly supportive Although small bowel transplantation is an option the results are suboptimal with year and year survival rates of and respectively and the required life long immunosuppression causes substantial secondary complications Novel approaches for the treatment of patients with SBS are critically needed Our approach to this unsolved medical problem is the production of tissue engineered intestine TEI using the patientandapos s own intestinal cells combined with a synthetic nanofiber based scaffold resulting in a novel solution to this unmet clinical need In this project we will accomplish three specific aims necessary to move towards commercialization Aim Determine the optimal cell isolation and cell seeding methodology for structural formation of TEI Aim Optimize enteric nervous system ENS development in TEI Aim Develop an in vivo culture standard operating procedure SOP for development of TEI This Phase I SBIR project will allow us to collect the pivotal data needed to scale up to a large animal model in Phase II and to license the technology to a commercial partner in Phase III for commercialization PUBLIC HEALTH RELEVANCE In this work we will develop robust and healthy tissue engineered intestine using nanofiber scaffolds combined with intestinal stem cells for patients suffering from short bowel syndrome SBS Our initial clinical indication is necrotizing enterocolitis NEC which affects premature babies and has a mortality rate of nearly

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