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NANOEGG Research Laboratories Inc. and INC Research | Date: 2009-08-11

Chemicals for use in industry and science; higher fatty acids for use in industry and science. Polishing preparations; soaps and detergents; dentifrices; cosmetics; perfumery. Pharmaceutical anti-allergic preparations and substances; pharmaceutical preparations for use in chemotherapy; pharmaceutical preparations for the treatment of infectious diseases; pharmaceutical preparations for the treatment of hormonal disorders and the prevention of osteoporosis; pharmaceutical preparations for wounds; pharmaceutical preparations for the prevention and treatment of disorders of the nervous system, the immune system, the cardio-vascular system, the metabolic system, the respiratory system, the musculoskeletal system, the genitourinary system; pharmaceutical preparations for the treatment of inflammatory disorders; pharmaceutical preparations for use in dermatology, oncology, hematology and in tissue and organ transplantation, in ophthalmology and for gastroenterological disorders; pharmaceutical preparations, namely, a transdermal drug delivery system comprising polymer-based skin creams or gel for the continuous release of a wide variety of therapeutic agents.


Patent
Japan Science, Technology Agency and NANOEGG Research Laboratories Inc. | Date: 2010-09-07

An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved.


Patent
Japan Science, Technology Agency and NANOEGG Research Laboratories Inc. | Date: 2010-06-18

An object of the present invention is to provide a novel dermal regeneration enhancer. In accordance with the present invention, there is provided a dermal regeneration enhancer as a novel pharmaceutical use of lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, and the dermal regeneration enhancer of the present invention achieves an excellent suppressive effect to aging of the skin, generation of spots, etc.


Nishiura H.,Ezaki Glico Co. | Sugimoto K.,Ezaki Glico Co. | Akiyama K.,NANOEGG Research Laboratories Inc. | Musashi M.,NANOEGG Research Laboratories Inc. | And 6 more authors.
Journal of Nanomedicine and Nanotechnology | Year: 2013

We developed a novel nano-capsule using the micellization ability of α-lipoic acid for the purpose of stabilizing α-lipoic acid. α-Lipoic acid is an optically active substance consisting of a carboxyl group and a five-membered ring with a disulfide bond, functioning as a cofactor in multi-enzyme complexes. The disulfide bond in the five-membered ring is unstable and easily degraded by light or heat stress, resulting in the sulfurous smell that has often interfered with formulations, especially for cosmetics. It was found that the present encapsulation technology could drastically improve α-lipoic acid stability, that is, stabilize the unstable disulfide bond in α-lipoic acid by orienting the hydrophobic moiety of α-lipoic acid inside of the nano-capsule with an inorganic shell. The surface of the nano-capsule was covered by polyethylene chains and inorganic ions, forming a core-shell structure. Besides the nano-capsule showed mono-dispersity of the size distribution around 10 nm in diameter. This article reports on the formulation and the physicochemical properties of the nano-capsule of α-lipoic acid. © 2013 Nishiura H, et al.


Yamashita Y.,Chiba Institute of Science | Sato T.,NANOEGG Research Laboratories Inc. | Nagasawa T.,NANOEGG Research Laboratories Inc. | Kubota Y.,NANOEGG Research Laboratories Inc. | And 6 more authors.
Chemistry Letters | Year: 2013

A novel emulsion and its preparation route were established in a quasi-ternary system with a nonionic surfactant, water, glycerol, and squalane. This emulsion is simply obtained by diluting a discontinuous cubic liquid crystal. It consists of giant floc in part, corresponding to the fraction of the discontinuous cubic liquid crystal. Contrary to common emulsification, our emulsion has an unique and abnormal shear-response: the semistable structure is breaking down gradually by applying a mechanical energy. © 2013 The Chemical Society of Japan.

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