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Nishiura H.,Ezaki Glico Co. | Sugimoto K.,Ezaki Glico Co. | Akiyama K.,NANOEGG Research Laboratories Inc. | Musashi M.,NANOEGG Research Laboratories Inc. | And 6 more authors.
Journal of Nanomedicine and Nanotechnology | Year: 2013

We developed a novel nano-capsule using the micellization ability of α-lipoic acid for the purpose of stabilizing α-lipoic acid. α-Lipoic acid is an optically active substance consisting of a carboxyl group and a five-membered ring with a disulfide bond, functioning as a cofactor in multi-enzyme complexes. The disulfide bond in the five-membered ring is unstable and easily degraded by light or heat stress, resulting in the sulfurous smell that has often interfered with formulations, especially for cosmetics. It was found that the present encapsulation technology could drastically improve α-lipoic acid stability, that is, stabilize the unstable disulfide bond in α-lipoic acid by orienting the hydrophobic moiety of α-lipoic acid inside of the nano-capsule with an inorganic shell. The surface of the nano-capsule was covered by polyethylene chains and inorganic ions, forming a core-shell structure. Besides the nano-capsule showed mono-dispersity of the size distribution around 10 nm in diameter. This article reports on the formulation and the physicochemical properties of the nano-capsule of α-lipoic acid. © 2013 Nishiura H, et al.


Yokomichi N.,St. Marianna University School of Medicine | Nagasawa T.,NANOEGG Research Laboratories Inc. | Coler-Reilly A.,St. Marianna University School of Medicine | Suzuki H.,NANOEGG Research Laboratories Inc. | And 6 more authors.
Human Cell | Year: 2013

PEGL-DOX is an excellent treatment for recurrent ovarian cancer that rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in Hand-Foot Syndrome (HFS). In severe cases, it can become necessary to reduce the PEGL-DOX concentration or the duration of the drug therapy, sometimes making it difficult to continue treatment. In this study, we prepared an animal model to compare the effects of DOX versus PEGL-DOX, and we noticed that only treatment with PEGL-DOX resulted in HFS, which led us to conclude that extravasation due to long-term circulation was one of the causes of HFS. In addition, we were able to show that the primary factor leading to the skin-specific outbreaks in the extremities was the appearance of reactive oxygen species (ROS) due to interactions between DOX and the metallic Cu(II) ions abundant in skin tissue. ROS directly disturb the surrounding tissue and simultaneously induce keratinocyte-specific apoptosis. Keratinocytes express the thermoreceptor TRPM2, which is thought to be able to detect ROS and stimulate the release of chemokines (IL-8, GRO, Fractalkine), which induce directed chemotaxis in neutrophils and other blood cells. Those cells and the keratinocytes then undergo apoptosis and simultaneously release IL-1β, IL-1α, and IL-6, which brings about an inflammatory state. In the future, we plan to develop preventative as well as therapeutic treatments by trapping the ROS. © 2013 The Author(s).


Patent
Japan Science, Technology Agency and NANOEGG Research Laboratories Inc. | Date: 2010-09-07

An object of the present invention is to provide a transdermal absorption enhancer by which various active ingredients are transdermally absorbed. In accordance with a transdermal absorption enhancer of the present invention which effective ingredient is lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, transdermal absorption of a macromolecular substance and a water-soluble substance was able to be improved.


Patent
NANOEGG Research Laboratories Inc. and St. Marianna University School of Medicine | Date: 2012-07-11

The present invention relates to a liquid crystal composition containing liquid crystals containing silicone compounds. The liquid crystal composition of the present invention contains liquid crystals containing one kind of or two or more kinds of silicone surfactants, a phenyl-modified silicone oil and water. The liquid crystal composition of the present invention contains 5 to 95% by weight in total of one kind of or two or more kinds of silicone surfactants, 0.1 to 90% by weight of a phenyl-modified silicone oil and 0.1 to 90% by weight of water. The liquid crystal composition of the present invention can solubilize hydrophobic compounds having poor solubility (for example, hydrocarbon oils such as squalane, fatty acids such as oleic acid and lipoic acid and ester oils such as cetyl isooctanoate) and is thus useful, for example, as toiletry materials and cosmetic materials.


Patent
Ezaki Glico Co. and NANOEGG Research Laboratories Inc. | Date: 2010-10-20

Provision of a stable -lipoic acid. A method for producing -lipoic acid nanoparticles, the method comprising the steps of: preparing an aqueous dispersion liquid containing -lipoic acid and a nonionic surfactant; adding a divalent metal salt into the aqueous dispersion liquid, wherein the divalent metal salt is a divalent metal halide, a divalent metal acetate or a divalent metal gluconate; and adding an alkali metal carbonate or an alkali metal phosphate into the aqueous dispersion liquid which has been added with the divalent metal salt, thereby forming -lipoic acid nanoparticles.


Patent
Japan Science, Technology Agency and NANOEGG Research Laboratories Inc. | Date: 2010-06-18

An object of the present invention is to provide a novel dermal regeneration enhancer. In accordance with the present invention, there is provided a dermal regeneration enhancer as a novel pharmaceutical use of lyotropic liquid crystal which has been utilized as a basic material for pharmaceutical preparations for external application and for cosmetics, and the dermal regeneration enhancer of the present invention achieves an excellent suppressive effect to aging of the skin, generation of spots, etc.


Yamashita Y.,Chiba Institute of Science | Sato T.,NANOEGG Research Laboratories Inc. | Nagasawa T.,NANOEGG Research Laboratories Inc. | Kubota Y.,NANOEGG Research Laboratories Inc. | And 6 more authors.
Chemistry Letters | Year: 2013

A novel emulsion and its preparation route were established in a quasi-ternary system with a nonionic surfactant, water, glycerol, and squalane. This emulsion is simply obtained by diluting a discontinuous cubic liquid crystal. It consists of giant floc in part, corresponding to the fraction of the discontinuous cubic liquid crystal. Contrary to common emulsification, our emulsion has an unique and abnormal shear-response: the semistable structure is breaking down gradually by applying a mechanical energy. © 2013 The Chemical Society of Japan.

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