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Patent
Nanocomposix, Inc. and Sienna Biopharmaceuticals Inc. | Date: 2016-12-09

Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.


Grant
Agency: Department of Defense | Branch: Defense Health Program | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2015

Lyme disease is the most common tick-borne disease in North America and one of the fast-growing infectious diseases in the United States. An inexpensive, portable and accurate diagnostic device for the detection of Borrelia bacteria in the deer tick will be developed. The diagnostic device will consist of an efficient extractor for disrupting the hard exoskeleton on the tick, an ultra-sensitive lateral flow based detection assay and a cell phone reader attachment for quantifying and geotagging the test strip results. The detection kit will have a small form factor, will be simple to use and will require minimal power.


Grant
Agency: Department of Defense | Branch: Navy | Program: SBIR | Phase: Phase II | Award Amount: 1.50M | Year: 2014

Pyrotechnic and pyrophoric IR decoy flares protect military aircraft from IR seeking surface-to-air missiles by closely mimicking the electromagnetic signature of the aircraft in order to divert the missile from its target. Pyrophoric based decoys have advantages over pyrotechnic technology in that they are more covert, are less likely to start fires, and produce a spectral signature that is more effective against dual spectral seeking MANPADs. During Phase II we demonstrated a nanoparticle based IR decoy that rapidly generated relevant apparent temperatures when exposed to air. During the Phase II.5 we will scale the production of devices and perform environmental, ground and flight tests to compare performance with current Raney metal foil technology.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2013

We propose a lateral flow assay which will ultimately be able to detect loiasis, lymphatic filariasis, and onchocerciasis on a single strip. The test combines: Latest antigens discovered at the NIH upon sequencing of the L. loa genome, proprietary ultra-bright and color-tunable reporter particles, and data capture via a smart phone for mapping and monitoring filariases. In the Phase I, the assay will be configured for loiasis. There is a critical need for a commercial assay for loiasis, not just for individual case management, but also to aid the elimination programs aimed at lymphatic filariasis and onchocerciasis. Mass drugs administrations for these two diseases are not possible in areas coincident with Loa loa, due to potentially severe adverse events. The assay is designed to detect antigens, rather than circulating antibodies. In the Phase II, the assay will be configured to also detect lymphatic filariasis and onchocerciasis. An "app" will be provided to capture data quantitatively via smart phone, alongside with GPS coordinates, so as to map the status of all filariases in a global database. This proposal is endorsed by the Head of the Helminth Parasitology Section of the NIH.


Patent
Nanocomposix, Inc. and Sienna Labs Inc. | Date: 2015-04-08

Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.


Patent
Nanocomposix, Inc. and Sienna Labs Inc. | Date: 2015-11-20

Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoparticle, such as nanoplates, silver nanoplates or silver platelet nanoparticles, and to the solutions and substrates prepared by the methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.


Patent
Nanocomposix, Inc. | Date: 2015-12-18

Embodiments of the present invention relate to methods for preparing high optical density solutions of nanoplates, such as silver nanoplates or silver platelet nanoparticles, and to nanoparticles, solutions and substrates prepared by said methods. The process can include the addition of stabilizing agents (e.g., chemical or biological agents bound or otherwise linked to the nanoparticle surface) that stabilize the nanoparticle before, during, and/or after concentration, thereby allowing for the production of a stable, high optical density solution of silver nanoplates. The process can also include increasing the concentration of silver nanoplates within the solution, and thus increasing the solution optical density.


Patent
Nanocomposix, Inc. | Date: 2014-10-09

The disclosed technology relates generally to material systems which include a plurality of particles and methods of making the same. The particles have a core and a shell which encapsulates the core and has at least one atomic element not included in the core. The cores of the particles have a median maximum dimension that is less than 10 microns and a median of at least one axial dimension that is between 10 nm and 500 nm. The shells of the particles have a median thickness that is less than 100 nm, a silicon concentration that is between 10% and 50% on the basis of the weight of the shells, and an aluminum concentration that is between 0.01% and 5% on the basis of the weight of the shells.


Patent
Nanocomposix, Inc. | Date: 2013-10-25

Embodiments of the present invention relate to a metastable silver nanoparticle composite, a process for its manufacture, and its use as a source for silver ions. In various embodiments, the composite comprises, consists essentially of, or consists of metastable silver nanoparticles that change shape when exposed to moisture, a stability modulant that controls the rate of the shape change, and a substrate to support the silver nanoparticles and the modulant.


Patent
Sienna Labs Inc. and Nanocomposix, Inc. | Date: 2014-11-18

Embodiments of the present invention relate to a metastable silver nanoparticle composite, a process for its manufacture, and its use as a source for silver ions and/or colorimetric signaling In various embodiments, the composite comprises, consists essentially of or consists of metastable silver nanoparticles that change shape when exposed to moisture, a stability modulant that controls the rate of the shape change, and a substrate to support the silver nanoparticles and the modulant.

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