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Maurice V.,CEA Saclay Nuclear Research Center | Rivolta I.,University of Milan Bicocca | Vincent J.,CEA Saclay Nuclear Research Center | Raccurt O.,NanoChemistry and NanoSafety Laboratory DRT LITEN DTNM LCSN | And 5 more authors.
Journal of Nanoparticle Research | Year: 2012

This article presents a process for surface coating and functionalization of luminescent silicon nanoparticles. The particles were coated with silica using a microemulsion process that was adapted to the fragile silicon nanoparticles. The as-produced core- shell particles have a mean diameter of 35 nm and exhibit the intrinsic photoluminescence of the silicon core. The silica layer protects the core from aqueous oxidation for several days, thus allowing the use of the nanoparticles for biological applications. The nanoparticles were further coated with amines and functionalized with polyethylene glycol chains and the toxicity of the particles has been evaluated at the different stages of the process. The core-shell nanoparticles exhibit no acute toxicity towards lung cells, which is promising for further development. © Springer Science+Business Media B.V. 2012. Source

Auger A.,NanoChemistry and NanoSafety Laboratory DRT LITEN DTNM LCSN | Samuel J.,NanoChemistry and NanoSafety Laboratory DRT LITEN DTNM LCSN | Poncelet O.,NanoChemistry and NanoSafety Laboratory DRT LITEN DTNM LCSN | Raccurt O.,NanoChemistry and NanoSafety Laboratory DRT LITEN DTNM LCSN
Nanoscale Research Letters | Year: 2011

Numerous luminophores may be encapsulated into silica nanoparticles (< 100 nm) using the reverse microemulsion process. Nevertheless, the behaviour and effect of such luminescent molecules appear to have been much less studied and may possibly prevent the encapsulation process from occurring. Such nanospheres represent attractive nanoplatforms for the development of biotargeted biocompatible luminescent tracers. Physical and chemical properties of the encapsulated molecules may be affected by the nanomatrix. This study examines the synthesis of different types of dispersed silica nanoparticles, the ability of the selected luminophores towards incorporation into the silica matrix of those nanoobjects as well as the photophysical properties of the produced dye-doped silica nanoparticles. The nanoparticles present mean diameters between 40 and 60 nm as shown by TEM analysis. Mainly, the photophysical characteristics of the dyes are retained upon their encapsulation into the silica matrix, leading to fluorescent silica nanoparticles. This feature article surveys recent research progress on the fabrication strategies of these dye-doped silica nanoparticles. © 2011 Auger et al. Source

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