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Divinópolis, Brazil

Tonelli F.M.,Federal University of Minas Gerais | Tonelli F.M.,Nanocell Institute | Goulart V.A.,Federal University of Minas Gerais | Goulart V.A.,Nanocell Institute | And 7 more authors.
Nanomedicine | Year: 2015

Graphene and its derivatives, due to a wide range of unique properties that they possess, can be used as starting material for the synthesis of useful nanocomplexes for innovative therapeutic strategies and biodiagnostics. Here, we summarize the latest progress in graphene and its derivatives and their potential applications for drug delivery, gene delivery, biosensor and tissue engineering. A simple comparison with carbon nanotubes uses in biomedicine is also presented. We also discuss their in vitro and in vivo toxicity and biocompatibility in three different life kingdoms (bacterial, mammalian and plant cells). All aspects of how graphene is internalized after in vivo administration or in vitro cell exposure were brought about, and explain how blood-brain barrier can be overlapped by graphene nanomaterials. © 2015 Future Medicine Ltd. Source


Tonelli F.M.P.,Federal University of Minas Gerais | Tonelli F.M.P.,Nanocell Institute | Lacerda S.M.S.N.,Federal University of Minas Gerais | Lacerda S.M.S.N.,National Institute of Amazonian Research | And 13 more authors.
RSC Advances | Year: 2016

Multiwalled carbon nanotubes (MWCNTs), nanographene oxide (NGO), and gold nanorods (NRs) can be functionalized and complexed to DNA to promote efficient gene delivery to Nile tilapia spermatogonial stem cells inducing less cell death than electroporation and the commercial reagents tested. Therefore, nanomaterials can contribute to achieve fish transgenesis. © The Royal Society of Chemistry. Source


Tonelli F.M.P.,Federal University of Minas Gerais | Tonelli F.M.P.,Nanocell Institute | Lacerda S.M.S.N.,Federal University of Minas Gerais | Paiva N.C.O.,Federal University of Minas Gerais | And 13 more authors.
Nanoscale | Year: 2015

Nanodiamonds (NDs), multiwalled carbon nanotubes (MWCNTs) and gold nanorods (NRs) can be functionalized to promote gene delivery to hard-to-transfect cells with higher transfection efficiency than cationic lipids, and inducing less cell death. © 2015 The Royal Society of Chemistry. Source

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