Nanocell Institute

Divinópolis, Brazil

Nanocell Institute

Divinópolis, Brazil
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Procopio M.S.,Federal University of Minas Gerais | de Avelar G.F.,Federal University of Minas Gerais | Costa G.M.J.,Federal University of Minas Gerais | Lacerda S.M.S.N.,Federal University of Minas Gerais | And 4 more authors.
Cell and Tissue Research | Year: 2017

In recent decades, infertility has been considered a major widespread public health issue of very high concern. Currently, almost 50% of infertility cases are due to male factors, including semen disorders, obstructions, cryptorchidism, varicocele and testicular failures, which can occur due to malfunctions in both somatic and germ cells. In this context, besides other approaches, different miRNAs have been used as biomarkers for the diagnosis of male infertility, with different pathologic conditions such as Sertoli cell-only syndrome, mixed atrophy, and germ cell arrest. However, most studies related to male fertility do not point out the functions and cell targets of the described miRNAs. Initial investigations using experimental assays in murine and porcine models were performed, providing the first evidence of the influence of miRNAs on Sertoli cell function including, for instance, proliferation, maturation and hormone responses of these cells. The aim of this mini-review is therefore to summarize our present knowledge of this relevant subject and to highlight the importance of future investigations concerning the miRNA influence in the control of Sertoli cells, spermatogenesis and male fertility. © 2017 Springer-Verlag GmbH Germany


Tonelli F.M.P.,Federal University of Minas Gerais | Tonelli F.M.P.,Nanocell Institute | Lacerda S.M.S.N.,Federal University of Minas Gerais | Lacerda S.M.S.N.,National Institute of Amazonian Research | And 13 more authors.
RSC Advances | Year: 2016

Multiwalled carbon nanotubes (MWCNTs), nanographene oxide (NGO), and gold nanorods (NRs) can be functionalized and complexed to DNA to promote efficient gene delivery to Nile tilapia spermatogonial stem cells inducing less cell death than electroporation and the commercial reagents tested. Therefore, nanomaterials can contribute to achieve fish transgenesis. © The Royal Society of Chemistry.


Tonelli F.M.,Federal University of Minas Gerais | Tonelli F.M.,Nanocell Institute | Goulart V.A.,Federal University of Minas Gerais | Goulart V.A.,Nanocell Institute | And 7 more authors.
Nanomedicine | Year: 2015

Graphene and its derivatives, due to a wide range of unique properties that they possess, can be used as starting material for the synthesis of useful nanocomplexes for innovative therapeutic strategies and biodiagnostics. Here, we summarize the latest progress in graphene and its derivatives and their potential applications for drug delivery, gene delivery, biosensor and tissue engineering. A simple comparison with carbon nanotubes uses in biomedicine is also presented. We also discuss their in vitro and in vivo toxicity and biocompatibility in three different life kingdoms (bacterial, mammalian and plant cells). All aspects of how graphene is internalized after in vivo administration or in vitro cell exposure were brought about, and explain how blood-brain barrier can be overlapped by graphene nanomaterials. © 2015 Future Medicine Ltd.


Tonelli F.M.P.,Federal University of Minas Gerais | Tonelli F.M.P.,Nanocell Institute | Lacerda S.M.S.N.,Federal University of Minas Gerais | Paiva N.C.O.,Federal University of Minas Gerais | And 13 more authors.
Nanoscale | Year: 2015

Nanodiamonds (NDs), multiwalled carbon nanotubes (MWCNTs) and gold nanorods (NRs) can be functionalized to promote gene delivery to hard-to-transfect cells with higher transfection efficiency than cationic lipids, and inducing less cell death. © 2015 The Royal Society of Chemistry.

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