Chiba, Japan
Chiba, Japan

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Patent
NanoCarrier Co | Date: 2017-04-05

The present invention provides a polymeric micelle comprising: block copolymer units being arranged radially with hydrophobic polymer-chain segments radially inside and hydrophilic polymer-chain segments radially outside; and a charged lipid which carries a charge opposite to the charge of a drug to be encapsulated, the charged lipid being attracted to the hydrophobic polymer-chain segment. In this polymeric micelle, the drug is retained within the micelle via electrostatic binding with the charged lipid, whereby the outer surface of the micelle is prevented from being charged to attract a substance which has a charge opposite to that of the charged lipid.


Patent
National Cancer Center, University of Tokyo, Riken and NanoCarrier Co | Date: 2015-02-03

Monoclonal antibodies against human and mouse tissue factor, and fragments thereof, are disclosed, as well as pharmaceutical compositions and compositions for drug delivery containing the same. Therapeutic methods using the same are also disclosed.


Patent
National Cancer Center, University of Tokyo, Riken and NanoCarrier Co | Date: 2016-12-14

The present invention provides novel antibodies against tissue factor. The present invention also provides pharmaceutical compositions in which an antibody is used as a target-binding factor. Antibodies according to the present invention can exhibit an ability to be internalized into cells expressing tissue factor.


Patent
University of Tokyo, Tokyo Medical, Dental University and NanoCarrier Co | Date: 2014-09-24

The present invention provides a block copolymer as a carrier that simultaneously achieves stability of a biotechnology-based drug in blood and drug-releasing property of the drug at an affected area. The block copolymer of the present invention is a block copolymer, including: a polyamino acid chain segment; and a hydrophilic polymer chain segment, wherein the polyamino acid chain segment includes an amino acid residue having a cationic group in a side chain and an amino acid residue having a substituted phenylboronic acid group in a side chain, the substituted phenylboronic acid group having a phenyl ring in which at least one hydrogen atom is substituted to have a pKa around a physiological pH.


Patent
University of Tokyo and NanoCarrier Co | Date: 2015-03-04

According to the present invention, it is possible to improve the blood retention capability by a carrier for delivering a nucleic acid such as siRNA. A unit structure-type pharmaceutical composition of the present invention contains a block copolymer having a cationic polyamino acid segment and a hydrophilic polymer chain segment and a nucleic acid; the composition is electrically neutral by counterbalancing negative charge (s) of the nucleic acid with positive charge(s) of the cationic polyamino acid segment, and the nucleic acid is covered with the hydrophilic polymer chain segment.


Patent
NanoCarrier Co | Date: 2014-05-16

A polymer micelle pharmaceutical composition is provided and includes: a block copolymer unit having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; and a block copolymer unit having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment, wherein: the block copolymer unit and the block copolymer unit are radially arranged in the state in which the hydrophilic polymer chain segments are directed outward and the hydrophobic polymer chain segments are directed inward; and the hydrophobic polymer chain segment of the block copolymer unit is constituted of repeating units having side chains, at least one of the side chains having a hydrophilic group.


Patent
NanoCarrier Co | Date: 2015-11-02

The present invention provides a particulate pharmaceutical composition which has improved drug encapsulation stability and is suitable for a drug delivery system. The particulate pharmaceutical composition 1 contains: a plurality of block copolymer unit 2 arranged radially, each of which has a hydrophobic polymer-chain segment 2b, which is arranged radially inside, and a hydrophilic polymer-chain segment 2a, which is arranged radially outside; a drug 4, which includes a biomacromolecule; and a charged lipid 3, which has an electrical charge opposite to that of the drug 4; wherein the charged lipid 3 is being attracted to the hydrophobic polymer-chain segment 2b, and the drug 3 is positioned radially inside the hydrophobic polymer-chain segment 2b. The pharmaceutical composition 1 can effectively prevent the drug 4 from disengaging from the particle.


The present invention provides a pharmaceutical composition. The pharmaceutical composition includes a block copolymer includng: a hydrophilic segment; a hydrophobic segment; and a boronic acid compound bonded to a side chain of the hydrophobic segment via a linker moiety including a heterocyclic structure, wherein: a cyclic skeleton of the heterocyclic structure has a boron atom derived from the boronic acid compound, atoms Xs bonded to the boron atom and each selected from an oxygen atom and a nitrogen atom, and carbon atoms bonded to the atoms Xs; and the block copolymer further comprises an organic group bonded to the carbon atoms, the organic group containing an aromatic group or cyclic alkyl group as a structure for protecting a boronic acid ester bond and/or a boron amide bond resulting from bonding between the boron atom and the atoms Xs.


Patent
NanoCarrier Co | Date: 2016-03-23

A polymer micelle pharmaceutical composition is provided and includes: a block copolymer unit having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment; and a block copolymer unit having a hydrophilic polymer chain segment and a hydrophobic polymer chain segment, wherein: the block copolymer unit and the block copolymer unit are radially arranged in the state in which the hydrophilic polymer chain segments are directed outward and the hydrophobic polymer chain segments are directed inward; and the hydrophobic polymer chain segment of the block copolymer unit is constituted of repeating units having side chains , at least one of the side chains having a hydrophilic group.


Patent
NanoCarrier Co | Date: 2015-09-16

The present invention provides a particulate pharmaceutical composition which has improved drug encapsulation stability and is suitable for a drug delivery system. The particulate pharmaceutical composition 1 contains: a plurality of block copolymer unit 2 arranged radially, each of which has a hydrophobic polymer-chain segment 2b, which is arranged radially inside, and a hydrophilic polymer-chain segment 2a, which is arranged radially outside; a drug 4, which includes a biomacromolecule; and a charged lipid 3, which has an electrical charge opposite to that of the drug 4; wherein the charged lipid 3 is being attracted to the hydrophobic polymer-chain segment 2b, and the drug 3 is positioned radially inside the hydrophobic polymer-chain segment 2b. The pharmaceutical composition 1 can effectively prevent the drug 4 from disengaging from the particle.

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