Houston, TX, United States

Nano3D Biosciences, Inc.

www.n3dbio.com
Houston, TX, United States
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Grant
Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase I | Award Amount: 190.47K | Year: 2014

DESCRIPTION (provided by applicant): Several disorders in reproductive medicine are results of changes in smooth muscle contractile activity. Increased myometrial contraction can lead to preterm labor, which affects 12% of the US population. However, the mechanisms involved in the transition from uterine quiescence to contractility at the onset of labor are not well-known. As a result, the management of labor disorders such as preterm birth is poor, particularly tocolytic therapies, which could delay preterm labor, but have not been effectively proven and tested for this purpose. The slow progress in understanding myometrial contractility and tocolytic management of preterm labor can be attributed to the lack of faithful in vitro models of the myometrium, aswell as the ability to efficiently screen tocolytic compounds in a high-throughput fashion. While in vivo models are used in the uterine contractility research, pronounced differences in how animals and humans give labor mean that pathological change


Becker J.L.,Nano3D Biosciences, Inc. | Souza G.R.,Nano3D Biosciences, Inc.
Nature Reviews Cancer | Year: 2013

Experiments conducted in the microgravity environment of space are not typically at the forefront of the mind of a cancer biologist. However, space provides physical conditions that are not achievable on Earth, as well as conditions that can be exploited to study mechanisms and pathways that control cell growth and function. Over the past four decades, studies have shown how exposure to microgravity alters biological processes that may be relevant to cancer. In this Review, we explore the influence of microgravity on cell biology, focusing on tumour cells grown in space together with work carried out using models in ground-based investigations. © 2013 Macmillan Publishers Limited. All rights reserved.


Patent
Nano3D Biosciences, Inc. | Date: 2013-04-22

Camera phone accessories for using the camera phone to collect scientific data.


Patent
Nano3D Biosciences, Inc. | Date: 2013-06-11

Methods of making and using a magnetic ECM are disclosed. The ECM comprises positively and negatively charged nanoparticles, wherein one of said nanoparticles contains a magnetically responsive element. When the magnetic ECM is seeded with cells, the cells will be magnetized and can be levitated for 3-D cell culture.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2014

DESCRIPTION (provided by applicant): Currently available models for toxicity screening are not always accurate predictors of toxicity in humans. Animal models are commonly used, but they are costly, time-consuming, and ethically challenging, they vary between species, and they do not accurately predict toxicity in humans. In vitro toxicity tests have been explored for years as cheaper alternatives or as initial screens before in vivo testing, but there are still issues regarding accuracy, primarily becausethey are cultured on two-dimensional (2D) surfaces, while native tissues exist in three-dimensional environments (3D). As a result, while ethical and cost motivations drive toxicity screening towards in vitro models, the limitations of current in viro assays in mimicking native tissue have prevented their widespread acceptance and use. This proposal puts forward a 3D model that is rapid, quantitative, and representative for high-throughput toxicity testing. Recently, research has gravitated towards in


Patent
Nano3D Biosciences, Inc. | Date: 2013-02-07

Devices for magnetic 3d culture are described including magnetic lids/bases for single Petri plates, adjustable height cap for same, as well similar devices for multi-magnet culture plates. A pen-like device for sterilely lifting and moving cells is also described, and this magnetic pipettor can also exist in multi-well magnetic pipettor formats.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: STTR PHASE II | Award Amount: 1.27M | Year: 2011

This Small Business Innovation Research (SBIR) Phase II project will use in vitro three-dimensional (3D) cell culturing enabled by the magnetic levitation method (MLM) as an improved tool for toxicity testing. This work will probe the effects of common agents on the lung, liver and kidney, three organs that play a central role in drug metabolism and are predisposed to toxic injury. 2D cell culture, commonly utilized for testing the cytotoxic effects of drugs, displays limited accuracy in predicting toxicity in vivo due to fundamental differences in the cellular microenvironment. While better representations of the 3D architecture of in vivo tissue are provided by animal models, they fail to accurately reflect whether or not drugs will cause cellular damage in humans as a result of biological differences between species. Our preliminary data shows that magnetic levitation maintains cells in culture in an arrangement that allows the cells to develop and communicate in a manner that is much closer to the in vivo environment than other in vitro systems.

The broader impacts of this research are to improve assessment of drug toxicity and chemical hazards, reduce the use of animals, and advance the fields of in vitro toxicology testing and drug discovery. Commercial potential includes expansion of the device into high-throughput screening, generation of a prototype of a gas delivery system with capabilities to perform live cell microscopy, and development of a label-free viability assay for drug discovery and toxicity testing.


Patent
Nano3D Biosciences, Inc. | Date: 2013-02-07

Devices for magnetic 3d culture are described including magnetic lids/bases for single Petri plates, adjustable height cap for same, as well similar devices for multi-magnet culture plates. A pen-like device for sterilely lifting and moving cells is also described, and this magnetic pipettor can also exist in multi-well magnetic pipettor formats.


Patent
Nano3D Biosciences, Inc. | Date: 2014-11-07

A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.


Patent
Nano3D Biosciences, Inc. | Date: 2015-12-10

Devices for magnetic 3d culture are described including magnetic lids/bases for single Petri plates and adjustable height cap for same. Similar devices for multi-magnet culture plates wherein multiwell plates have all adjacent magnets orientated in the opposite polarity, and methods of making same.

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