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Berkeley, CA, United States

Labno A.,Nano scale Science and Engineering Center | Labno A.,University of California at Berkeley | Warrier A.,Nano scale Science and Engineering Center | Wang S.,Nano scale Science and Engineering Center | Zhang X.,Nano scale Science and Engineering Center

While plasticity is typically associated with persistent modifications of synaptic strengths, recent studies indicated that modulations of dendritic excitability may form the other part of the engram and dynamically affect computational processing and output of neuronal circuits. However it remains unknown whether modulation of dendritic excitability is controlled by synaptic changes or whether it can be distinct from them. Here we report the first observation of the induction of a persistent plastic decrease in dendritic excitability decoupled from synaptic stimulation, which is localized and purely activity-based. In rats this local plasticity decrease is conferred by CamKII mediated phosphorylation of A-type potassium channels upon interaction of a back propagating action potential (bAP) with dendritic depolarization. © 2014 Labno et al. Source

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