Puerto Caimito, Panama
Puerto Caimito, Panama

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Marin E.,HIGH-TECH | Marin E.,Nano Dispersions Technology Inc. | Marin E.,Acharya Nagarjuna University | Marin E.,University of Panamá | And 12 more authors.
Planta Medica | Year: 2017

The medicinal applications of curcumin, the major component of Curcuma longa, are limited by its poor solubility and low oral bioavailability. In order to overcome this limitation, a method to produce nanocapsules of chitosan loaded with curcumin was developed. Three different molecular weight and deacetylation degree chitosan polymers were used in the formulation in order to prepare curcumin-loaded nanocapsules (mass ratio 1?:?1.4). The best results were achieved using chitosan-Bi with a molecular weight of 710?000 Da. A bimodal distribution was observed in samples; moreover, chitosan-Bi produced the lowest particle size (197 nm). The entrapment efficacy of all chitosan nanocapsules produced reached values between 75 and 92?%. Their rate of drug release at different pH levels (2.0 and 7.4) showed a fast onset of curcumin release. Swiss mice were used to determine oral and total bioavailability of the new curcumin-loaded nanocapsules. Remarkably, the bioavailability of curcumin nanoformulated increased 9-fold compared with no formulated curcumin. These nanocapsules have the ability to cross the blood-brain barrier, and its production is an easy to scale-up procedure using nontoxic materials. Copyright © 2017, Georg Thieme Verlag KG. All rights reserved.


Nunez G.A.,Nano Dispersions Technology Inc. | Briceno M.I.,Nano Dispersions Technology Inc. | Joseph D.D.,Nano Dispersions Technology Inc. | Joseph D.D.,University of Minnesota | And 2 more authors.
Energy and Environmental Science | Year: 2010

We discuss the possible clean coal applications of colloidal suspensions of coal in water (CCW) manufactured with a proprietary wet-comminution device. These suspensions are a new material with new properties. First, the colloidal fraction plus water is a pseudo fluid good for transport, handling and suspension of large particles. Second, the surface area per unit volume of coal available for chemical reaction and burning is greatly increased and finally, CCW may be milled with a third fluid, seeding the mixture with submicron coal.The colloidal nature of the majority of particles provides for very good features such as outstanding long-term stability, in contrast to regular coal water slurries (CWS) which rapidly sediment under storage. Moreover, the very small particles create an increased reactivity to combustion because small particles with large surface area react faster than large particles with the same volume. © 2010 The Royal Society of Chemistry.


Marin E.,HIGH-TECH | Marin E.,Nano Dispersions Technology Inc. | Marin E.,Archaria Nagarjuna University | Briceno M.I.,Nano Dispersions Technology Inc. | Caballero-George C.,HIGH-TECH
International Journal of Nanomedicine | Year: 2013

Use of biodegradable polymers for biomedical applications has increased in recent decades due to their biocompatibility, biodegradability, flexibility, and minimal side effects. Applications of these materials include creation of skin, blood vessels, cartilage scaffolds, and nanosystems for drug delivery. These biodegradable polymeric nanoparticles enhance properties such as bioavailability and stability, and provide controlled release of bioactive compounds. This review evaluates the classification, synthesis, degradation mechanisms, and biological applications of the biodegradable polymers currently being studied as drug delivery carriers. In addition, the use of nanosystems to solve current drug delivery problems are reviewed. © 2013 Marin et al.


Alvarado A.,Nano Dispersions Technology Inc. | Briceno M.I.,Nano Dispersions Technology Inc. | Dietel C.,DTE Energy | Gomez C.,Nano Dispersions Technology Inc. | And 3 more authors.
2012 TAPPI PEERS Conference: Building a Sustainable Future | Year: 2012

Kraft paper mill energy costs can be better managed with diversity in the types of fuels available, to take advantage of fluctuating prices. However, fuel delivery systems are often designed for only one fuel type (solid, liquid, or gas), which limits the ability to use some of the most economical fuels, without multiple delivery systems. New mixing technologies have led to the development of colloidal fuel dispersions using coal, petroleum coke, and asphaltite. These non-settling liquid fuels have the handling characteristics of fuel oil, and have been demonstrated in conventional oil-fired boilers. This paper discusses the technology, trial results, and implications for the use of colloidal fuel dispersions derived from less expensive solid fuels.


Olmedo H.,Nano Dispersions Technology Inc. | Rojas N.,Nano Dispersions Technology Inc. | Torres S.,Nano Dispersions Technology Inc. | Azocar A.,Nano Dispersions Technology Inc. | And 2 more authors.
Journal of Non-Newtonian Fluid Mechanics | Year: 2015

A new fuel is being developed to substitute fuel oil in power plant boilers. This fuel is a mostly colloidal suspension of petcoke in water. In this work, the flow behaviour of this fuel is evaluated by means of a rotational rheometer and a pipe viscometer. The flow characteristics of the material are complex, showing viscoelastic, and viscoplastic behaviour. There is also strong evidence of lubricated flow or slip at the wall. The results are used to obtain relevant data for engineering purposes. © 2014 Elsevier B.V.


Colloidal carbonaceous material-in-water slurries having nano-particles of carbonaceous material creating a pseudo-fluid. The colloidal carbonaceous material-in-water slurry generally includes from about fifty to about seventy two weight percent of carbonaceous material, with about 20 to about 80 percent of the carbonaceous material having a particle size of about one micron or less with a mode particle size of about 250 nanometers. The carbonaceous material-in-water slurry can also include a surfactant system containing one surfactant or mixtures of two or more surfactants, or mixtures of one or more surfactants and an inorganic or organic salt. The carbonaceous material-in-water slurry can be used in low NOx burner applications as the main fuel and/or the reburn fuel, in gasification processes as the input fuel either alone, or in combination with organic materials, in gas turbine applications, and in diesel engine applications.


Colloidal coal-in-water slurries having nano-particles of coal creating a pseudo-fluid. The colloidal coal-in-water slurry generally includes from about fifty to about seventy two weight percent of coal, with about 20 to about 80 percent of the coal having a particle size of about one micron or less with a mode particle size of about 250 nanometers. The coal-in-water slurry can also include a surfactant system containing one surfactant or mixtures of two or more surfactants, or mixtures of one or more surfactants and an inorganic or organic salt. The coal-in-water slurry can be used in low NOx burner applications as the main fuel and/or the reburn fuel, in gasification processes as the input fuel either alone, or in combination with organic materials, in gas turbine applications, and in diesel engine applications.


A process and system for reducing the viscosity of heavy and extra heavy crude oils, and more particularly to a process for reducing the viscosity of heavy and extra heavy crude oils by means of total or partial oil deasphalting using a precipitating agent in order to obtain an upgraded crude oil of lower viscosity that can be pumped without the use of diluents. The upgrading also includes a reduction in metals and sulfur associated with asphaltene removal. The process consists of relatively simple equipment such as static mixers and stirred tanks and operation temperature is low and pressure is moderate.

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