Jangseong, South Korea
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Cho Y.-I.,Korea Photonics Technology Institute | Kim B.H.,Chosun University | Kim S.-J.,Sejong University | Yun J.-J.,Nano Bio Research Center | And 3 more authors.
Advanced Powder Technology | Year: 2013

In this study, zero valent iron (ZVI) powders were generated by reducing iron oxide powders obtained from a pickling line in a transfer type reductor. The physical and chemical characteristic of the produced ZVI powders were analyzed by using instruments. Reaction activities of ZVI powders for decomposition of a methylene blue were evaluated. The mean size of ZVI powders increased and the specific surface area decreased with increasing reduction temperature due to sintering. The methylene blue decomposition rate increased with dose of ZVI powders. The ZVI powders generated by reducing iron oxide showed higher decomposition efficiencies than the commercial ZVI powders at all pH values tested in this study. Both non-commercial ZVIs showed a higher decomposition rate at a lower pH. © 2013 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.


Jeong S.-J.,Youngsan University | Choi B.-D.,Chosun University | Lee H.-Y.,Chosun University | Hwang Y.-H.,Chosun University | And 5 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2015

SLPI acts as a modulator of the innate immune responses of macrophages, neutrophils and odontoblasts, and LPS-inducible anti-inflammatory cytokine to suppress the production of pro-inflammatory products by macrophages. Many studies have revealed the effects of light emitting diodes (LEDs) on the tissue repair and inflammatory responses. Although the anti-inflammatory mechanisms of irradiation with LEDs in gingival fibroblasts are known, the effects of 660 nm red LEDs on the inflammation remain unclear. Moreover, there is no report regarding the molecular mechanism for the relationship between SLPI and biological effects of LEDs. The is effects of 660 nm red LEDs on inflammation with SLPI were investigated by examining the effects of 660 nm LED on the SLPI expression of RAW264.7 cells after LPS stimulation. This paper reports that the 660 nm red LED induced SLPI expression or reduced the LPS response, and inhibited NF-κB activation directly leading to the suppression of pro-inflammatory cytokines, such as TNF-α and IL-1β, suggesting that it might be a useful wavelength LED for inflammation therapy. Copyright © 2015 American Scientific Publishers All rights reserved.


Yun J.-J.,Nano Bio Research Center | Hong C.K.,Chonnam National University | Park K.H.,Chosun University
Transactions on Electrical and Electronic Materials | Year: 2015

A manganese dioxide (MnO2) layer and zinc (Zn) layer are used as the cathode and the anode to develop filmtype manganese battery, in which a stack of a MnO2 layer, gel electrolyte, and Zn layer are sandwiched between two plastic layers. This paper describes the chemical equation of swelling control upon the film-type manganese battery. We examined the reduction of hydrogen formation, by using calcium hydroxide Ca(OH)2 as an additive in the electrolyte of film-type manganese battery. The phenomena or an effect of reduced hydrogen gas was proven by cyclic voltammogram, X-ray photoelectron spectra (XPS), and volume of hydrogen formation. The amount of H2 gas generation in the presence of Ca2+ ion was reduced from 4.81 to 4.15 cc/g-zinc (14%), and the corrosion of zinc electrode in the electrolyte was strongly inhibited as time passed. © 2015 KIEEME. All rights reserved.


Kang S.N.,Korea Institute of Science and Technology | Kang S.N.,Korea University | Kim S.-E.,Korea Institute of Science and Technology | Choi J.,Korea Institute of Science and Technology | And 12 more authors.
Biomaterials | Year: 2015

A drug-eluting stent (DES) is one of the commonly used treatment techniques in percutaneous coronary intervention (PCI). Sirolimus (SRL) has been widely used for DES as a drug for suppressing neointimal hyperplasia causing restenosis. Phytoncides (PTC) are compounds released from trees and plants, and their solutions contain monoterpenoids such as α-pinene, careen, and myrceen. Some studies have reported that these components exhibit antioxidant, antimicrobial, and anti-inflammatory activities. We hypothesized that PTC may become an alternative drug to SRL for DES, exhibiting alleviated side effects as compared to SRL. A PTC-incorporated stent was compared with an SRL-incorporated stent in terms of physicochemical, pharmacokinetic, and biological properties. In invitro studies, the effects of each drug on cells were investigated. The results showed that both drugs exhibited similar cytotoxicity, anti-inflammation, and antiproliferation effects. However, these effects resulted from different mechanisms associated with cells, as seen in the immunofluorescence result. An invivo assay showed that the lumen area was significantly larger and the neointimal area was significantly smaller in SRL- and PTC-loaded stents compared to a drug-unloaded stent. These results suggest that phytoncide can be a feasible alternative drug to SRL for advanced DES although more studies are needed. © 2014 Elsevier Ltd.


Lee H.,Sunchon National University | Park S.H.,Sunchon National University | Jung S.-C.,Sunchon National University | Yun J.-J.,Nano Bio Research Center | And 2 more authors.
Journal of Materials Research | Year: 2013

The liquid phase plasma reduction method has been applied to prepare silver nanoparticles from a solution of silver nitrate (AgNO3) using a bipolar pulsed electrical discharge system. The excited states of atomic silver, hydrogen and oxygen as well as the molecular bands of hydroxyl radicals were detected in the emission spectra. As the discharge duration increased up to 10 min, silver particle peaks produced by surface plasmon absorption were observed around 430 nm. Both the particle size and the particle numbers were observed to increase with the length of the plasma treatment time and with the initial AgNO3 concentration. Spherical nanoparticles of about 5-20 nm in size were obtained with the discharging time of 5 min, whereas aggregates of nanoparticles of about 10-50 nm in size were mainly produced with the discharging time of 20 min. The cationic surfactant of cetyltrimethylammonium bromide (CTAB) added with the CTAB/AgNO3 molar ratio of 30% was shown to inhibit nanoparticle aggregation. Copyright © Materials Research Society 2013.


Park J.-Y.,Chosun University | Park J.-Y.,Seoul National University | Yun J.-J.,Nano Bio Research Center | Hwang C.-H.,Chosun University | Lee I.-H.,Chosun University
Materials Letters | Year: 2010

Ag doped TiO2 nanofibers were fabricated by electrospinning technique using polyvinyl pyrrolidone (PVP) and titanium isopropoxide (TiP) as precursor. The effects of silver and calcination temperature on the preparation of electrospun TiO2 nanofibers were investigated. The calcination temperature determines the TiO2 phases as ether anatase or rutile. When the calcination temperature increased, crystallite size of TiO2 nanofiber increased. The crystallite size of Ag doped TiO2 nanofiber is smaller than that of the pure TiO2 nanofiber because silver is retrained in this phase transformation. Silver controlled the phase transformation as well as had an inhibition effect on the growth of anatase crystallite. © 2010 Elsevier B.V.


Lim L.,Chosun University | Jang Y.-S.,Nano Bio Research Center | Yun J.-J.,Nano Bio Research Center | Song H.,Chosun University
Journal of Nanoscience and Nanotechnology | Year: 2015

Phytoncide, nanochemicals extracted from Chamaecyparis obtusa (C. obtusa), is reported to possess many pharmacological activities including immunological stimulating, anti-cancer, antioxidant, and antiinflammatory activities. However, the effect of phytoncide in vascuar diseases, especially on the behavior of vascular smooth muscle cells, has not yet been clearly elucidated. Therefore, in the present study, we investigated the effects of 15 kinds of phytoncide by various extraction conditions from C. obtusa on the proliferation and migration in rat aortic smooth muscle cells (RAoSMCs). First of all, we determined the concentration of each extracts not having cytotoxicity by MTT assay. We observed that the proliferation rate measured using BrdU assay was significantly reduced by supercritical fluid, steam distillation, Me-OH, and hexane extraction fraction in order with higher extent, respectively. Moreover, the treatment of above nanofractions inhibit the migration of RAoSMCs by 40%, 60%, and 30%, respectively, both in 2-D wound healing assay and 3-D boyden chamber assay. Immunoblot revealed that the phosphorylated levels of Akt and ERK were significantly reduced in nanofractions treated RAoSMCs. Taken together, these data suggest that phytoncide extracted from C. obtusa inhibits proliferation and migration in RAoSMCs via the modulation of phosphorylated levels of Akt and ERK. Therefore, phytoncide nanomolecules might be a potential therapeutic approach to prevent or treat atheroscrelosis and restenosis. Copyright © 2015 American Scientific Publishers All rights reserved.


Heon L.,Sunchon National University | Kim H.-G.,Sunchon National University | Kim B.H.,Chosun University | Yun J.-J.,Nano Bio Research Center | And 4 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2015

The liquid-phase plasma reduction method has been applied to prepare iron nanoparticles from iron chloride solution using a bipolar pulsed electrical discharge system. The excited states of atomic iron, hydrogen, and oxygen as well as the molecular bands of hydroxyl radicals were detected in the emission spectra. The iron nanoclusters formed at the initial stage convert to dispersion of small iron nanoparticles, which then grows slowly to form anisotropic, tetragonal shape. The cationic surfactant of CTAB was shown to exhibit a large influence on the particle generation procedure. Copyright © 2015 American Scientific Publishers All rights reserved.


Lim L.,Chosun University | Yun J.-J.,Nano Bio Research Center | Jeong J.-E.,Korea forest Research Institute | Wi A.-J.,Korea forest Research Institute | Song H.,Chosun University
Journal of Nanoscience and Nanotechnology | Year: 2015

The plant Dendropanax morbifera Léveille (D. morbifera), a subtropical broad-leaved evergreen tree, have been used in folk medicine for the treatment of infectious diseases, skin diseases, and other maladies. However, the effect of extracts from D. morbifera in vascuar diseases has not yet been reported. In this study, BrdU assay revealed that extracts from D. morbifera inhibit significantly the proliferation rate of Rat Aortic Smooth Muscle Cells (RAoSMCs) by ∼40% in treated samples compared to controls. Notably, 2-D wound healing assay and 3-D boyden chamber assay showed the significant reduction of RAoSMCs migration induced by serum in nano extracts treated groups by ∼50%. We further observed that the phosphorylated levels of Akt and ERK were significantly reduced by 70% in extracts treated RAoSMCs. Moreover, the expression levels of matrix metalloproteinase (MMP) 2 and 9 were significantly reduced by extracts from D. morbifera. Our results suggest that extracts from D. morbifera inhibit proliferation and migration in RAoSMCs via the modulation of phosphorylated levels of Akt and ERK. Subsequently, the reduced MMP2 and 9 expression might result to reduced migration of RAoSMCs. Copyright © 2015 American Scientific Publishers All rights reserved.


Choi J.-H.,Chungnam National University | Cho S.-H.,Korea Research Institute of Chemical Technology | Yun J.-J.,Nano Bio Research Center | Yu Y.-B.,Nambu University | Cho C.-W.,Chungnam National University
Journal of Nanoscience and Nanotechnology | Year: 2015

Red ginseng (the steamed root of Panax ginseng C. A. Mayer), which contains ginsenosides as its main constituents, is frequently used to treat tumor, inflammation, diabetes, stress and acquired immunodeficiency syndrome in Asian countries. Ginsenoside Rh1, a bacterial metabolite of ginsenoside Rg1, is a protopanaxatriol type of ginsenosides. Liposomes do not deeply penetrate the skin and remain confined to the stratum corneum. Thus, new vesicular colloidal carriers such as ethosomes and transfersomes have been developed as an enhanced type of liposomes, recently. The aim of this study was to improve the topical delivery of ginsenoside Rh1 isolated from red ginseng employing new vesicular system of ethosomes and transfersomes compared to conventional liposome. Characterization of ginsenoside Rh1-loaded vesicles were prepared and evaluated for particle size, zeta potential, entrapment efficiency (%EE), and transmission electron microscopy (TEM) studies. In addition, skin permeation profile was obtained using frantz diffusion cells and rat dorsal skin treated with ethosome and transfersome compared with conventional liposome. The size of vesicles range from 108.5 to 322.9 nm, and negatively charged from -20.95 to -31.37 mV. The % EE of ginsenoside Rh1 was obtained between 45.0 to 65.0%. Transfersomes provided a significantly higher skin permeation of ginsenoside Rh1 compared to ethosome and conventional liposome. Therefore, based on the current study, ginsenoside Rh1-loaded transfersomes can act as a topical therapeutic effects potential. Copyright © 2015 American Scientific Publishers All rights reserved.

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