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Jangseong, South Korea

Park J.-Y.,Chosun University | Park J.-Y.,Seoul National University | Yun J.-J.,Nano Bio Research Center | Hwang C.-H.,Chosun University | Lee I.-H.,Chosun University
Materials Letters | Year: 2010

Ag doped TiO2 nanofibers were fabricated by electrospinning technique using polyvinyl pyrrolidone (PVP) and titanium isopropoxide (TiP) as precursor. The effects of silver and calcination temperature on the preparation of electrospun TiO2 nanofibers were investigated. The calcination temperature determines the TiO2 phases as ether anatase or rutile. When the calcination temperature increased, crystallite size of TiO2 nanofiber increased. The crystallite size of Ag doped TiO2 nanofiber is smaller than that of the pure TiO2 nanofiber because silver is retrained in this phase transformation. Silver controlled the phase transformation as well as had an inhibition effect on the growth of anatase crystallite. © 2010 Elsevier B.V.

Jeong S.-J.,Youngsan University | Choi B.-D.,Chosun University | Lee H.-Y.,Chosun University | Hwang Y.-H.,Chosun University | And 5 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2015

SLPI acts as a modulator of the innate immune responses of macrophages, neutrophils and odontoblasts, and LPS-inducible anti-inflammatory cytokine to suppress the production of pro-inflammatory products by macrophages. Many studies have revealed the effects of light emitting diodes (LEDs) on the tissue repair and inflammatory responses. Although the anti-inflammatory mechanisms of irradiation with LEDs in gingival fibroblasts are known, the effects of 660 nm red LEDs on the inflammation remain unclear. Moreover, there is no report regarding the molecular mechanism for the relationship between SLPI and biological effects of LEDs. The is effects of 660 nm red LEDs on inflammation with SLPI were investigated by examining the effects of 660 nm LED on the SLPI expression of RAW264.7 cells after LPS stimulation. This paper reports that the 660 nm red LED induced SLPI expression or reduced the LPS response, and inhibited NF-κB activation directly leading to the suppression of pro-inflammatory cytokines, such as TNF-α and IL-1β, suggesting that it might be a useful wavelength LED for inflammation therapy. Copyright © 2015 American Scientific Publishers All rights reserved.

Heon L.,Sunchon National University | Kim H.-G.,Sunchon National University | Kim B.H.,Chosun University | Yun J.-J.,Nano Bio Research Center | And 4 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2015

The liquid-phase plasma reduction method has been applied to prepare iron nanoparticles from iron chloride solution using a bipolar pulsed electrical discharge system. The excited states of atomic iron, hydrogen, and oxygen as well as the molecular bands of hydroxyl radicals were detected in the emission spectra. The iron nanoclusters formed at the initial stage convert to dispersion of small iron nanoparticles, which then grows slowly to form anisotropic, tetragonal shape. The cationic surfactant of CTAB was shown to exhibit a large influence on the particle generation procedure. Copyright © 2015 American Scientific Publishers All rights reserved.

Lim L.,Chosun University | Yun J.-J.,Nano Bio Research Center | Jeong J.-E.,Korea forest Research Institute | Wi A.-J.,Korea forest Research Institute | Song H.,Chosun University
Journal of Nanoscience and Nanotechnology | Year: 2015

The plant Dendropanax morbifera Léveille (D. morbifera), a subtropical broad-leaved evergreen tree, have been used in folk medicine for the treatment of infectious diseases, skin diseases, and other maladies. However, the effect of extracts from D. morbifera in vascuar diseases has not yet been reported. In this study, BrdU assay revealed that extracts from D. morbifera inhibit significantly the proliferation rate of Rat Aortic Smooth Muscle Cells (RAoSMCs) by ∼40% in treated samples compared to controls. Notably, 2-D wound healing assay and 3-D boyden chamber assay showed the significant reduction of RAoSMCs migration induced by serum in nano extracts treated groups by ∼50%. We further observed that the phosphorylated levels of Akt and ERK were significantly reduced by 70% in extracts treated RAoSMCs. Moreover, the expression levels of matrix metalloproteinase (MMP) 2 and 9 were significantly reduced by extracts from D. morbifera. Our results suggest that extracts from D. morbifera inhibit proliferation and migration in RAoSMCs via the modulation of phosphorylated levels of Akt and ERK. Subsequently, the reduced MMP2 and 9 expression might result to reduced migration of RAoSMCs. Copyright © 2015 American Scientific Publishers All rights reserved.

Choi J.-H.,Chungnam National University | Cho S.-H.,Korea Research Institute of Chemical Technology | Yun J.-J.,Nano Bio Research Center | Yu Y.-B.,Nambu University | Cho C.-W.,Chungnam National University
Journal of Nanoscience and Nanotechnology | Year: 2015

Red ginseng (the steamed root of Panax ginseng C. A. Mayer), which contains ginsenosides as its main constituents, is frequently used to treat tumor, inflammation, diabetes, stress and acquired immunodeficiency syndrome in Asian countries. Ginsenoside Rh1, a bacterial metabolite of ginsenoside Rg1, is a protopanaxatriol type of ginsenosides. Liposomes do not deeply penetrate the skin and remain confined to the stratum corneum. Thus, new vesicular colloidal carriers such as ethosomes and transfersomes have been developed as an enhanced type of liposomes, recently. The aim of this study was to improve the topical delivery of ginsenoside Rh1 isolated from red ginseng employing new vesicular system of ethosomes and transfersomes compared to conventional liposome. Characterization of ginsenoside Rh1-loaded vesicles were prepared and evaluated for particle size, zeta potential, entrapment efficiency (%EE), and transmission electron microscopy (TEM) studies. In addition, skin permeation profile was obtained using frantz diffusion cells and rat dorsal skin treated with ethosome and transfersome compared with conventional liposome. The size of vesicles range from 108.5 to 322.9 nm, and negatively charged from -20.95 to -31.37 mV. The % EE of ginsenoside Rh1 was obtained between 45.0 to 65.0%. Transfersomes provided a significantly higher skin permeation of ginsenoside Rh1 compared to ethosome and conventional liposome. Therefore, based on the current study, ginsenoside Rh1-loaded transfersomes can act as a topical therapeutic effects potential. Copyright © 2015 American Scientific Publishers All rights reserved.

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