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Nanjing, China

Nanjing University , or Nanking University, is one of the oldest and most prestigious institutions of higher learning in China. Following many changes through dynasties since CE 258, it was established as a modern school in 1902 in late Qing dynasty, and became a modern university in the early 1920s, the early years of Republic of China, being the first Chinese modern university with the combination of education and research, and also as a pioneer laying the foundations for the establishment of the modern educational system in China. Before the eve of establishment of People's Republic of China in 1949, the name was changed from National Central University to Nanjing University.Nanjing University is a comprehensive research university. It is a member of the C9 League and Yangtze Delta Universities Alliance. NJU is a national university directly under the Ministry of Education of China, largely financed by the national and the Jiangsu provincial governments. Nanjing University has two campuses: Gulou campus, located in the centre of Nanjing, and Xianlin campus, located in northeast of Nanjing south of the Yangtze River, which is the home to most undergraduate students and graduate students of several departments. Wikipedia.

Wen H.-H.,Nanjing University
Reports on Progress in Physics | Year: 2012

Since the discovery of high temperature superconductivity in iron pnictides in early 2008, many iron-based superconductors with different structures have been discovered, with the highest transition temperature to date being 57K. By the end of 2010, another kind of new superconductor, the Fe-based chalcogenide K 1-xFe 2-ySe 2 was discovered. A naive counting of the electrons in the system would lead to the conclusion that the system is heavily electron overdoped (0.4 e/Fe). Band structure calculations further support this speculation and predict that the hole pockets which are found in the iron pnictides may be missing. This greatly challenges the widely perceived picture that the superconducting pairing is established by exchanging antiferromagnetic (AF) spin fluctuations and that the electrons are scattered between the electron and hole pockets. Later, it was found that both potassium and iron might be deficient in K 1-xFe 2-ySe 2, yielding to a picture of phase separation. In this picture the superconducting phase and the AF phase may separate spatially into different regions. This generates further curiosity about what the real superconducting phase is, what the relationship is between the superconducting phase and the AF phase, and what the parent state is for the superconducting phase. We propose a spider web model for the phase separation, which can explain both the transport and magnetic data. In this paper, we review the status of research in this rapidly growing field and list the important and unresolved issues as perspectives for future research. © 2012 IOP Publishing Ltd.

Deng S.,Nanjing University
The Analyst | Year: 2013

Since the electrogenerated chemiluminescence (ECL) of silicon nanoparticles (NPs) was reported in 2002, miscellaneous nanomaterials with various sizes and shapes have been employed as ECL nanoemitters for bioanalysis. Elucidation of the ECL derivation from these nanoemitters and pertinent biofunctionalization with multitudinous biomolecules can offer excellent ECL signal-transduction platforms for fabricating novel biosensing devices. In this review, we comprehensively describe retrospective and recent advances in NPs-based ECL and related biosensing methodologies, and review their analytical applications in the detection of small biological molecules, enzymatic sensing, immunoassay, DNA analysis and cytosensing.

Chen P.F.,Nanjing University
Living Reviews in Solar Physics | Year: 2011

Coronal mass ejections (CMEs) are the largest-scale eruptive phenomenon in the solar system, expanding from active region-sized nonpotential magnetic structure to a much larger size. The bulk of plasma with a mass of ~ 1011 - 1013 kg is hauled up all the way out to the interplanetary space with a typical velocity of several hundred or even more than 1000 km s-1, with a chance to impact our Earth, resulting in hazardous space weather conditions. They involve many other much smaller-sized solar eruptive phenomena, such as X-ray sigmoids, filament/prominence eruptions, solar flares, plasma heating and radiation, particle acceleration, EIT waves, EUV dimmings, Moreton waves, solar radio bursts, and so on. It is believed that, by shedding the accumulating magnetic energy and helicity, they complete the last link in the chain of the cycling of the solar magnetic field. In this review, I try to explicate our understanding on each stage of the fantastic phenomenon, including their pre-eruption structure, their triggering mechanisms and the precursors indicating the initiation process, their acceleration and propagation. Particular attention is paid to clarify some hot debates, e.g., whether magnetic reconnection is necessary for the eruption, whether there are two types of CMEs, how the CME frontal loop is formed, and whether halo CMEs are special.

Liu Z.-H.,Nanjing University
Nature Reviews Nephrology | Year: 2013

China has a large population and a high prevalence of chronic kidney disease (CKD). The increasing incidence of obesity and type 2 diabetes mellitus, coupled with an ageing population, will exacerbate the burden of CKD unless effective control and prevention strategies are implemented. The unmet challenges of managing the growing number of patients with end-stage renal disease (ESRD) in China are reflected by the lower rate of patients receiving dialysis relative to many Western countries, owing to a lack of financial and clinical resources, and inequalities in access to health care across regions and populations. The feasibility of expanding peritoneal dialysis is being examined, and ongoing health-care reforms provide an invaluable opportunity to improve the status and quality of dialysis for patients with ESRD in China. The Chinese Society of Nephrology (CSN) advocates for efforts focused on preventing CKD coupled with early detection, treatment, and adequate follow-up to reduce mortality and the long-term burden of CKD. In addition, rapid advances in nephrology research, from basic science to clinical epidemiology, as well as broad communication and collaboration between the CSN and other international nephrology societies, will promote the development of nephrology in China. © 2013 Macmillan Publishers Limited. All rights reserved.

Tang Z.,Nanjing University
Nature communications | Year: 2013

Pirt is a membrane protein that is specifically expressed in the peripheral nervous system, where it has been shown to increase the sensitivity of the transient receptor potential vanilloid 1 channel and modulate its role in heat pain. The broad expression of Pirt among dorsal root ganglion neurons suggests it may modulate other transient receptor potentials, such as the menthol and cooling sensor TRPM8. The discrepancies in the channel properties of TRPM8 in native neurons versus heterologous cells indicate the existence of endogenous modulators of the channel. Here we show that Pirt regulates the function of TRPM8 and its role in detecting cold. Pirt(-/-) mice exhibit decreased behavioural responses to cold and cool temperatures, and Pirt increases the sensitivity of TRPM8 to menthol and cool temperature. Our data suggest Pirt is an endogenous regulator of TRPM8.

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