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Zhu Y.,Nanjing Research Institute for Comprehensive Utilization of Wild Plants | Zhao B.,Nanjing Research Institute for Comprehensive Utilization of Wild Plants | Huang X.,Nanjing Research Institute for Comprehensive Utilization of Wild Plants | Chen B.,Nanjing Research Institute for Comprehensive Utilization of Wild Plants | Qian H.,Nanjing Research Institute for Comprehensive Utilization of Wild Plants
Journal of Microbiology and Biotechnology | Year: 2014

The natural crosslinking agent genipin has been applied widely in biomedicines and foods nowadays. Because of the special hemiacetal ring structure in its molecule, it can only be prepared by hydrolysis of geniposide according to biocatalysis. In this research, strategies including aqueous-organic biphasic catalysis and substrate fed-batch mode were adopted to improve the biocatalysis process of genipin. A 10 L ethyl acetate-aqueous biphasic system with geniposide fed-batch led to a satisfying genipin yield. With Fusarium solani ACCC 36223, 15.7 g/l genipin in the ethyl acetate phase was obtained, corresponding to space-time yields of 0.654 g l-1 h-1. © 2015 by The Korean Society for Microbiology and Biotechnology. Source

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