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Nanjing, China

Sun L.,Changzhou No. 3 Peoples Hospital | Zhu X.,Changzhou No. 3 Peoples Hospital | Xu L.,Changzhou NO. 2 Peoples Hospital | Wang Z.,Nanjing No. 1 Hospital | And 2 more authors.
Oncology Letters | Year: 2013

The aim of the present study was to investigate the antitumor effects and tissue distribution of 32P-chromic-poly (L-lactide) (32P-CP-PLLA) in nude mice with human prostate cancer. Tumor models were obtained by transplantation of PC-3M tumor cells into male BALB/c nude mice. Animals were randomly divided into control, 32P-chromic phosphate (32P-CP) colloid and 32P-CP-PLLA groups (all n=20). A series of indices were investigated, including apoptosis of tumor cells, rate of apoptosis, expression of caspase 3 and 8, biodistribution and intratumoral concentration of 32P-CP-PLLA, intensity of radioactivity, tumor volume and microvessel density (MVD). Highly concentrated radioactivity of 32P-CP-PLLA in the tumor mass was detected by single photon emission computed tomography (SPECT) scanning. The residual activities of the 32P-CP-PLLA and 32P-CP colloid groups were 3.02±0.32 and 1.76±0.31 MBq, respectively, on day 14 following treatment. The tumor inhibition rates were 67.24±3.55 and 55.92±7.65%, respectively (P<0.01). Necrotic changes, in conjunction with apoptosis, were observed in the treatment group. MVD values for the 32P-CP-PLLA and 32P-CP colloid groups were 28.24±10.07 and 36.15±11.06, respectively. 32P-CP-PLLA showed an excellent capacity for killing tumor cells, inducing apoptosis and inhibiting angiogenesis.

Zhao J.,Changzhou NO. 2 Peoples Hospital | Du G.,Changzhou NO. 2 Peoples Hospital | Su Y.,Changzhou NO. 2 Peoples Hospital | Shao G.,Nanjing No. 1 Hospital | And 2 more authors.
Cancer Biotherapy and Radiopharmaceuticals | Year: 2013

Objective: To investigate the drug release kinetic of 32P- chromic phosphate-poly(L-lactide) (32P-CP-PLLA). Methods: 32P-CP-PLLA were placed into physiological saline and H22 solid tumor mass, respectively. The weight loss rate and radioactivity release rate were evaluated. The release of the microparticles was evaluated using fitting curves. The correlation of the release of the microparticles between physiological saline and H22 solid tumor mass was analyzed. Results: Close correlation was noted in the release of the microparticles between physiological saline and H22 solid tumor mass. The Weibull equation showed the best fitting of 32P-CP-PLLA in physiological saline. Conclusions: The Weibull equation could be used for the predictive release of microparticles in vitro. The parameters obtained from the drug release kinetics could be used to estimate the dose of radiopharmaceuticals within the tumors and the surrounding tissues. © Copyright 2013, Mary Ann Liebert, Inc. 2013.

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