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Hanzhong, China

Nanjing Medical University is a university in Nanjing, Jiangsu Province, China. It was established in 1934 in Zhenjiang, but subsequently relocated to Nanjing in 1957. The university has two main campuses: Wutai and Jiangning, both of which have international student apartments.In 2014, Academic Ranking of World Universities ranked it between 401-500 in the world and 26-32 in China. It was one of the first universities to offer an English taught Bachelor of Medicine, Bachelor of Surgery program, as approved by the Ministry of Education of the People's Republic of China . Wikipedia.


Triggering receptor expressed on myeloid cells 2 (TREM2) gene is a recently identified susceptibility gene for Alzheimer's disease (AD), as its low-frequency variants increase the risk of this disease with an odds ratio similar to that of an APOE e{open}4 allele. To date, the expression and biologic functions of TREM2 under AD context remain largely unknown. Using APPswe/PS1dE9 mice, a transgenic model of AD, we showed that TREM2 was upregulated in microglia during disease progression. For the first time, we provided in vitro and in vivo evidence that this upregulation was attributed to the increased amyloid-β (Aβ)1-42 levels in the brain. By knockdown and overexpression of TREM2 in cultured primary microglia, we revealed that TREM2 modulated microglial functions under AD context, as it facilitated Aβ1-42 phagocytosis and inhibited Aβ1-42-triggered proinflammatory responses. Meanwhile, this modulation was dependent on DAP12, the adapter protein of TREM2. More importantly, overexpression of TREM2 in the brain of APPswe/PS1dE9 mice markedly ameliorated AD-related neuropathology including Aβ deposition, neuroinflammation, and neuronal and synaptic losses, which was accompanied by an improvement in spatial cognitive functions. Taken together, our data suggest that the upregulation of TREM2 serves as a compensatory response to Aβ1-42 and subsequently protects against AD progression by modulation of microglia functions. These findings provide insights into the role of TREM2 in AD pathogenesis, and highlight TREM2 as a potential therapeutic target for this disease.Neuropsychopharmacology advance online publication, 20 August 2014; doi:10.1038/npp.2014.164. Source


What is the profile of miRNAs in seminal plasma of patients with non-obstructive azoospermia (NOA)? miR-141, miR-429 and miR-7-1-3p are significantly increased in seminal plasma of patients with NOA compared with fertile controls. There is currently an urgent need to develop a noninvasive diagnostic test for NOA. Altered microRNA (miRNA) profiles have been proposed as potential biomarkers for the diagnosis of disease states. A total of 200 subjects (n = 100 for NOA, n = 100 for fertile control) were recruited to participate in this study. Recruitment took place from May 2008 to June 2010. We employed a strategy consisting of initial screening by TaqMan Low Density Array then further validation with a TaqMan quantitative RT-PCR assay. Validation of the profiling results was conducted in two independent phases. In addition, the expression of the three validated seminal plasma miRNAs (sp-miRNAs) was examined in testicular tissues of patients with NOA and of fertile controls. Methylation status and functional analyses were also performed for the identified sp-miRNAs. miR-141, miR-429 and miR-7-1-3p were significantly increased in seminal plasma of patients with NOA compared with fertile controls. As sensitive and specific biomarkers, the profiling of these three identified sp-miRNAs provides a novel noninvasive, semen-based test for NOA diagnosis. The methylation status of these sp-miRNAs was inversely associated with their expression patterns. Additionally, we found that Cbl and Tgfβ2 were down-regulated by miR-141, while Rb1 and Pik3r3 were down-regulated by miR-7-1-3p. miRNA expression profile was investigated in seminal plasma samples from only a small number of NOA patients. In future investigations, a larger sample size should be adopted and the functional role of the three sp-miRNAs should be further characterized in animal models. Given that sp-miRNAs show reproducible and stable expression levels, they are potentially novel noninvasive biomarkers for the diagnosis of NOA. We propose that the three sp-miRNAs described above may participate in a methylation-miRNA-gene network related to NOA development. This work provides a foundation for interpretation of miRNA changes associated with pathogenesis of NOA and extends the current understanding of human NOA pathogenesis. Source


Patent
Nanjing Medical University | Date: 2013-11-13

A guiding apparatus for x-ray-free screw placement by a spinal posterior approach, comprising an interspinous spacer, a slide scale (


An exposure apparatus for a paraspinal muscle clearance approach with a posterior spinal small incision includes a spinous process side vertebral plate retractor and a cooperating vertebral arch outer side retractor is provided. The apparatus can be used to separate a clearance between a multifidus muscle and a longissimus muscle under direct view, easily and atraumatically reach a screw fixation position on a vertebral arch pedicle, expose a facet joint, bluntly separate the multifidus muscle from the vertebral arch, accurately place the retractors, and thereafter locally form a surgical operation tunnel space that externally extends 10 degrees to 15 degrees. A design of angles and structures of retractors effectively protects local soft tissues and prevents a tissue damage while executing traction on local muscles and ensuring an adequate surgical space.


Patent
Nanjing Medical University | Date: 2012-10-24

A recyclable and adjustable interventional stent for intravascular constriction. The stent main body is divided into three parts and shaped like a waist drum with expansion parts (

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