Entity

Time filter

Source Type


Xu C.,Nanjing Chest Hospital | Hao K.,Nanjing Chest Hospital | Yu L.,Nanjing Chest Hospital | Zhang X.,Nanjing Jiangning Hospital
Biomarkers | Year: 2014

Objective: The aim of this study was to explore the clinical role of serum interleukin (IL)-17 in patients with non-small-cell lung cancer (NSCLC). Materials and method: Serum specimens from 128 patients with NSCLC and 60 healthy controls were collected. The concentrations of IL-17 were measured using enzyme-linked immunosorbent assay. Results: Serum IL-17 levels were higher in the NSCLC group in comparison with the control group (p < 0.01). With a cut-off value of 16 pg/ml, IL-17 showed a good diagnostic performance for NSCLC. Multivariate survival analysis indicated that IL-17 was an independent prognostic factor in NSCLC. Conclusion: Measurement of IL-17 might be a useful diagnostic and prognostic value for patients with NSCLC. © 2014 Informa UK Ltd. Source


Xu C.-H.,Nanjing Chest Hospital | Zhang X.-W.,Nanjing Jiangning Hospital | Yan J.,Nanjing University | Yu L.-K.,Nanjing Chest Hospital
Tumor Biology | Year: 2015

B7-H4, a member of the inhibitory B7 family, can restrain T cell proliferation, activation, and cytokine secretion and may be involved in immune evasion in cancer patients. This study aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of soluble B7-H4 (sB7-H4) in lung cancer patients with malignant pleural effusion (MPE). Pleural effusion samples were collected from 98 lung cancer patients with malignant effusion and from 60 patients with nonmalignant pleural effusion. Pleural effusion concentrations of sB7-H4 were measured using sandwich enzyme-linked immunosorbent assay. Malignant effusion exhibited higher sB7-H4 levels than those in nonmalignant effusion (P < 0.01). Lung cancer patients with pleural effusion sB7-H4 levels below 35.8 ng/ml had a longer overall survival than those with higher levels (P < 0.05). By multivariate analysis, pleural effusion sB7-H4 was an independent prognostic factor in patients with MPE. In conclusion, measurement of sB7-H4 might be a useful diagnostic and prognostic value for MPE patients. © 2015, International Society of Oncology and BioMarkers (ISOBM). Source


Xu C.,Nanjing Chest Hospital | Yu L.-K.,Nanjing Chest Hospital | Zhang X.,Nanjing Jiangning Hospital
Tumori | Year: 2014

Background: Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that induces cell-cycle arrest and apoptosis in cells bearing the RCAS1 receptor. The aim of the study was to elucidate the diagnostic and prognostic value of RCAS1 levels in patients with non-small cell lung cancer.Methods: Sera collected from 30 healthy volunteers, 40 patients with benign lung diseases and 97 non-small cell lung cancer cases were subjected to RCAS1 ELISA, and relationships between serum RCAS1 and clinical characteristics were evaluated.Results: Serum RCAS1 levels were higher in the non-small cell lung cancer group than in the healthy volunteers and benign lung disease groups (P <0.001). With a cutoff level 19.8 U/ml, RCAS1 had a sensitivity of 87.6%, a specificity of 82.5% and an accuracy of 86.1% for non-small cell lung cancer. Univariate analysis revealed that non-small cell lung cancer patients with elevated RCAS1 levels had significantly shorter overall survival (P = 0.042) than the other two groups. By multivariate analysis, serum RCAS1 was identified as an independent prognostic factor (P = 0.003).Conclusions: Assessment of serum RCAS1 levels could be considered as a diagnostic and prognostic marker in non-small cell lung cancer. Source


Xu C.-H.,Nanjing Chest Hospital | Zhan P.,Nanjing Chest Hospital | Yu L.-K.,Nanjing Chest Hospital | Zhang X.-W.,Nanjing Jiangning Hospital
Tumor Biology | Year: 2014

Interleukin 17 (IL-17) has been found to be increased in some human cancers; however, the possible implication of IL-17 in regulating antitumor responses in lung cancer patients with malignant pleural effusions (MPE) remains to be elucidated. This study aimed to investigate the diagnostic value of pleural IL-17 and carcinoembryonic antigen (CEA) in MPE and benign pleural effusions (BPE). Pleural effusion samples from 108 patients were classified on the basis of diagnosis as MPE (n=56) and BPE (n=52). The concentration of IL-17 was determined by enzyme-linked immunosorbent assay (ELISA). The CEA levels were also determined in all patients. A significant difference was observed in the levels of CEA (P<0.01) between MPE and BPE. The concentration of IL-17 in MPE was significantly higher compared to that in BPE (P<0.01). With a cutoff point of 15.7 pg/ml, IL-17 had a sensitivity of 76.8% and a specificity of 80.8% for differential diagnosis. The combined detection of IL-17 and CEA had a sensitivity of 96.4% and a specificity of 92.3% to distinguish MPE from BPE. The combined detection of IL-17 and CEA may be more valuable in the differential diagnosis between MPE and BPE. © International Society of Oncology and BioMarkers (ISOBM) 2013. Source


Xu C.-H.,Nanjing Chest Hospital | Hao K.-K.,Nanjing Chest Hospital | Yu L.-K.,Nanjing Chest Hospital | Zhang X.-W.,Nanjing Jiangning Hospital
Asia-Pacific Journal of Clinical Oncology | Year: 2015

Aim: The aim of this study was to evaluate the diagnostic value of soluble receptor-binding cancer antigen expressed on SiSo cells (sRCAS1) and carcinoembryonic antigen (CEA) in lung cancer patients with malignant pleural effusion (MPE) and benign pleural effusion (BPE). Methods: Pleural effusion samples from 118 patients were classified on the basis of diagnosis as MPE (n=60) and BPE (n=58). The concentration of sRCAS1 was determined by enzyme-linked immunosorbent assay. The CEA levels were also determined in all patients. Results: Of 60 MPE patients, 50 had sRCAS1>9.7U/mL and 54 had CEA>5.5ng/mL. The concentration of both sRCAS1 and CEA in MPE was significantly higher compared with that in BPE (P<0.01 in both cases). With a cutoff point of 9.7U/mL, sRCAS1 had a sensitivity of 83.3% and a specificity of 91.4% for differential diagnosis. The combined detection of sRCAS1 and CEA had a sensitivity of 98.3% and a specificity of 96.6% to distinguish MPE from BPE. Conclusion: The combined detection of sRCAS1 and CEA may be more valuable in the differential diagnosis between MPE and BPE. © 2014 Wiley Publishing Asia Pty Ltd. Source

Discover hidden collaborations