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Chen J.-Z.,Nanjing Gulou Hospital Group | You C.-W.,Nanjing Gulou Hospital Group | Liu J.-P.,Nanjing Gulou Hospital Group
Journal of Practical Oncology | Year: 2011

Objective: To assess the efficacy and toxicity of concurrent chemoradiotherapy with decetaxel and cisplatin in treatment of patients with locally advanced nasopharyngeal carcinoma. Methods: Seventy patients with locally advanced nasopharyngeal carcinoma received vein chemotherapy of DP regimen (docetaxel 75 mg/m2 at d1 and d8; cisplatin 25 mg/m 2 d1-3 for 21 d). All patients underwent concurrent radiotherapy by 6 MV X-ray and 15 MV X-ray with DT 70-78 Gy for 7-8 W. Results: Among 70 patients, 20 achieved CR and 37 PR with the effective rate of 81.4%; the 1.3 years survival rates were 98.4% and 83.9%, respectively. The main adverse effects were bone marrow depression, acute oral mucositis, nausea and vomiting, skin reactions. Conclusion: Concurrent chemoradiotherapy with docetaxel and cisplatin is effective with less toxicities in treatment of patients with locally advanced nasopharyngeal carcinoma. Source

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