Nanjing General Hospital in Nanjing Military Area Command

Nanjing, China

Nanjing General Hospital in Nanjing Military Area Command

Nanjing, China

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Wang Y.-L.,Xinxiang Medical University | Yuan Y.,Xinxiang Medical University | Yang J.,Xinxiang Medical University | Wang C.-H.,Xinxiang Medical University | And 18 more authors.
Neuropeptides | Year: 2013

Oxytocin (OXT), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of OXT to the brain directly, exploiting the olfactory pathway. Our previous study has demonstrated that OXT in the central nervous system rather than the blood circulation plays an important role in rat pain modulation. The communication tried to investigate the interaction between the OXT and pain modulation in Chinese patients with headache to understand the OXT effect on human pain modulation. The results showed that (1) intranasal OXT could relieve the human headache in a dose-dependent manner; (2) OXT concentration in both plasma and cerebrospinal fluid (CSF) increased significantly in headache patients in relation with the pain level; and (3) there was a positive relationship between plasma and CSF OXT concentration in headache patients. The data suggested that intranasal OXT, which was delivered to the central nervous system through olfactory region, could treat human headache and OXT might be a potential drug of headache relief by intranasal administration. © 2013 Elsevier Ltd.


Yang J.,Xinxiang Medical University | Lu L.,Xinxiang Medical University | Wang H.-C.,Xinxiang Medical University | Zhan H.-Q.,Xinxiang Medical University | And 18 more authors.
Peptides | Year: 2012

Arginine vasopressin (AVP), a nonapeptide hormone of posterior pituitary, reaches the central nervous system from systemic blood circulation with a difficulty because of the blood-brain barrier (BBB). The interest has been expressed in the use of the nasal route for delivery of AVP to the brain directly, exploiting the olfactory pathway. Our previous study has demonstrated that AVP in the brain rather than the spinal cord and blood circulation plays an important role in rat pain modulation. For understanding the role of AVP on pain modulation in human, the communication tried to investigate the effect of intranasal AVP on human headache. The results showed that (1) AVP concentration in both plasma and cerebrospinal fluid (CSF) increased significantly in headache patients, who related with the headache level; (2) there was a positive relationship between plasma and CSF AVP concentration in headache patients; and (3) intranasal AVP could relieve the human headache in a dose-dependent manner. The data suggested that intranasal AVP, which was delivered to the brain through olfactory region, could treat human headache and AVP might be a potential drug of pain relief by intranasal administration. © 2012 Elsevier Inc.


Shi X.,Nanjing General Hospital in Nanjing Military Area Command | Wu S.,Nanjing General Hospital in Nanjing Military Area Command | Jin J.,Nanjing Southeast University | Zhou Z.,Nanjing General Hospital in Nanjing Military Area Command
Chinese Journal of Clinical Oncology | Year: 2010

Objective: To explore the application of 64-slice spiral computed tomography perfusion imaging (CTPI) in evaluating angiogenesis in human osteosarcoma. Methods: Twenty-six patients (18 males and 8 females ranging from 9 to 56 years old, with an average of 19 years) with osteosarcoma underwent 64-slice spiral CTPI. We analyzed the correlations of CTPI parameters including blood flow (BF), blood volume (BV), time to peak (TTP), and permeability surface (PS) with the expression of markers of angiogenesis. Statistical analysis was performed with paired-samples t test, and Pearson correlation analysis was employed to investigate the correlations of CTPI parameterts with MVD. Results: Mean BF, BV, TTP, and PS values of osteosarcoma group were 46.6mL/100g/min ± 25.1 (standard deviation), 61.8 mL/100g ± 29.5, 122.9 seconds±26.2, and 44.5 mL/100g/min ± 14.6, respectively. Those in the normal muscle group were 5.2±6.6mL/ 100g/min, 9.6±7.3mL/100g, 115.5±33.1 and 17.0±29.3mL/100g/min, respectively. Osteosarcoma group showed higher BF, BV and PS compared with the normal muscle group (P=0.000, P=0.000, and P=0.000). However, no significant difference was found in TTP between osteosarcoma tissue and normal adjacent muscle tissue (P=0.273). BF, BV, and PS were positively correlated with MVD (r=0.83, P=0.000; r=0.87, P=0.000; and r=0.63, P=0.001). No correlation was found between TTP and MVD (r=-0.02, P=0.93). Conclusion: CTPI is useful for assessing tumor vascularity of osteosarcoma and CTPI parameters are positively correlated with MVD.

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