Filipcsei G.,Nangenex Inc. |
Sumaru K.,Japan National Institute of Advanced Industrial Science and Technology |
Takagi T.,Japan National Institute of Advanced Industrial Science and Technology |
Kanamori T.,Japan National Institute of Advanced Industrial Science and Technology |
Zrinyi M.,Semmelweis University
Journal of Molecular Liquids | Year: 2014
Novel hydrogels that shrink in response to light irradiation and temperature change have been developed. Since any technical application of polymer gels critically depends on the response rate, therefore porous hydrogels have been prepared in order to accelerate the response reaction. Poly(N-isopropylacrylamide) gels were functionalized with photo-responsive spirobenzopyran and solvent/nonsolvent mixtures were used as swelling agent to introduce network heterogeneities during the gelation process. Both photo- and thermo-responsive properties of gels have been investigated and compared. The time dependence of bending deformation due to the asymmetric light irradiation as well as kinetics of shrinking has been measured. It was found that the fastest photo- and thermo-responsive shrinking was observed for loosely crosslinked porous hydrogels. Furthermore, it was confirmed that the highly cross-linked cylindrical gel rod with macroporous structure showed rapid bending deformation due to the asymmetric light irradiation. © 2013 Elsevier B.V.
Nangenex Inc. | Date: 2014-04-15
Medicines for humans; chemical preparations for medical purposes; food substances adapted for medical use; nutritional supplements; nutritive substances for microorganisms; diagnostic preparations for medical purposes. Medical research and development; scientific laboratory services; research and development of new product for others.
Nangenex Inc. | Date: 2013-12-02
Medicines, chemical preparations for medical purposes; dietetic supplements for medical purposes; nutritional supplements, foodstuffs for microorganisms; diagnostic preparations. Diagnostic instruments, observation instruments, measuring instruments, precision measuring apparatus, electronic measuring devices, electronic monitoring apparatus, signalling instruments, regulating instruments; laboratory instruments. Pharmaceutical research-development; scientific laboratory services; research and development of new products for others.
Solymosi T.,Nangenex Inc. |
Angi R.,Nangenex Inc. |
Basa-Denes O.,Nangenex Inc. |
Ranky S.,Nangenex Inc. |
And 4 more authors.
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2015
Abstract The oral bioavailability of Sirolimus is limited by poor dissolution of the compound in the gastrointestinal tract resulting in a low bioavailability and large inter-individual differences in blood levels. Several different formulation approaches were applied to overcome these disadvantageous pharmacokinetic properties including the marketed oral solution and a tablet form containing wet milled nanocrystals. These approaches deliver improved pharmacokinetics, yet, they share the characteristics of complex production method and composition. We have developed a nanostructured Sirolimus formulation prepared by the controlled continuous flow precipitation of the compound from its solution in the presence of stabilizers. We have shown that contrary to the batch production the process could be easily intensified and scaled up; apparently the uniformity of the precipitation is heavily dependent on the production parameters, most likely the mixing of the solvent and antisolvent. We compared the physicochemical and pharmacokinetic properties of the nanostructured formula with the marketed nanoformula. We found that our method produces particles in the size range of less than 100 nm. The solid form redispersed instantaneously in water and in biorelevant media. Both the solid form and the redispersed colloid solution showed excellent stability even in accelerated test conditions. The oral administration of the nanostructured formula resulted in faster absorption, higher exposure and higher trough concentrations when compared to the marked form. These advantageous properties could allow the development of solid oral Sirolimus formulae with lower strength and gel based topical delivery systems. © 2015 Elsevier B.V.
Heltovics G.,Nangenex Inc. |
Otvos Zs.,Nangenex Inc. |
Filipcsei G.,Nangenex Inc. |
Darvas F.,Nangenex Inc.
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 | Year: 2010
Nanotechnology provides new innovative solutions for original as well as generic applications in a wide variety of industries including pharmaceuticals, cosmetics, foods, nutraceuticals and home care. Nanoformulation is the reduction of particles size down to below 200 nm. This size reduction below 200 nm by using continuous flow nano precipitation technology led to 100s fold higher solubility and 103-4 fold increased drug concentration in a stable colloid solution. In the paper we will discuss the perspectives and pharmacokinetic benefits of the nanostructured active molecules over the parent active molecules. The bioavailability of reference and nanostructured drug was determined after oral administration (30 mg/kg) in fasted state at Sprague-Dawley rats. Nanosized drug had an AUC15-360min value of 6412 μg·min/ml while this value after reference treatment was 940.1 μg-min/ml. The ratio of the two AUC values (AUC 15-360min(nanosized)/AUC15-360min(reference)) was 6.82.