Nanchang, China
Nanchang, China

Nanchang University is a national university located in Nanchang, Jiangxi, China which was established in 1940 as National Chung-cheng University . Nanchang University is listed among the National Key Universities of China. Wikipedia.


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Jiang H.,Jiangxi Science and Technology Normal University | Xu X.,Nanchang University
Proceedings of 2016 IEEE Advanced Information Management, Communicates, Electronic and Automation Control Conference, IMCEC 2016 | Year: 2016

with the expanding of large-scale computing and the undate of computer equirments, energy utiliztion of computer has increasingly exposed the problem of high energy waste. Saving energy in using computer service has become a significant topic. There are lots of factors that can affect energy consumption of computers. Now, people have done much reasearch on how to evalute energy consumption of computer system. In this paper, we investigate some existing popular methods of energy consumpation analysis on computer system, and generalize them into three kinds of types, which consist of energy evaluation method by measurment, by analog simulation, and by analytic formula respectively. It may be advantage to green computing research and its related application. © 2016 IEEE.


Xiao S.,Nanchang University | Chena H.,Nanchang University
Journal of Mathematical Physics | Year: 2017

In this paper, the existence and uniqueness, the exponential stability, and the almost sure exponential stability of mild solution for impulsive stochastic partial functional differential equations with finite delay are considered. Some sufficient conditions are established for our concerned problems, and some existing results are generalized and improved. Finally, an illustrative example is provided to show the feasibility and effectiveness of the obtained results.


Li S.-S.,Nanchang University
International Journal of Theoretical Physics | Year: 2017

We investigate quantum entanglement in two mutually non-interacting and spatially non-overlapping Bose-Einstein condensates in two harmonic potentials with one-body losses. One-body losses play an important role in the dynamical process of generating quantum entanglement. The stronger one-body losses induce more entanglement and maintain in a longer time interval. © 2017 Springer Science+Business Media New York


Li J.-F.,Nanchang University | Huang P.-C.,Nanchang University | Wu F.-Y.,Nanchang University
Sensors and Actuators, B: Chemical | Year: 2017

Glutathione (GSH) plays a key role in biological systems and serves many cellular functions. Since biothiols all incorporate thiol, carboxylic and amino groups, discriminative detection of GSH over cysteine (Cys) and homocysteine (Hcy) is still challenging. Both Cys and Hcy can induce aggregation of AuNPs via the formation of zwitterionic networks, which is different from GSH. GSH induced aggregation of AuNPs by the hydrogen bonding between the carboxylic groups when pH <4.5, so pH plays a crucial part in our present work. By regulating the pH to 5.8, our proposed sensing system exhibits high selectivity and sensitivity towards GSH even in the presence of other biothiols, realizing the discriminative detection of GSH over Cys/Hcy based on anti-aggregation of AuNPs. In our work, 2-mercapto-1-methylimidazole (MMI) and GSH took the role of aggregation and anti-aggregation agent, respectively. A linear relationship between the intensity ratio A650 nm/A520 nm and the GSH concentration is obtained (R2 = 0.998) with a detection limit of 12.0 nM. © 2016 Elsevier B.V.


Ao M.,Nanchang University | Ao M.,Jiangxi University of Traditional Chinese Medicine | Chen Y.,Nanchang University
Chemical and Pharmaceutical Bulletin | Year: 2017

Beta-cyclodextrin (β-CD) has been applied as drug/food carriers or potential drugs for treating some diseases. Most recently, some evidence indicated that methyl-β-cyclodextrin (MβCD) and 2-hydroxypropyl-β-cyclodextrin (2-HPβCD), two major derivatives of β-CD, may inhibit atherogenesis, implying that cyclodextrins also can be potential drugs for treating atherosclerosis. It is well known that modification (e.g. oxidation) of low-density lipoprotein (LDL) is one of the most critical steps of atherogenesis. Lipoxygenase, an enzyme able to be expressed by atherosclerosis-related vascular cells, is generally regarded as a possible in vivo agent of LDL oxidation. In this study, the effects of MβCD on LDL oxidation induced by lipoxygenase were investigated by measuring the electrophoretic mobility, conjugated diene formation, malondialdehyde (MDA) production, and amino group blockage of LDL. We found that the lipids depleted from LDL by MβCD could be oxygenated more readily by lipoxygenase whereas the lipoxygenase-induced oxidation of the remaining lipid-depleted LDL decreased. The data imply that MβCD has an inhibitory effect on lipoxygenase-induced LDL oxidation and probably helps to inhibit atherogenesis. © 2017 The Pharmaceutical Society of Japan.


Liu W.,Henan University of Technology | Xu L.,Henan University of Technology | Lu G.,Henan University of Technology | Zhang H.,Nanchang University
ACS Sustainable Chemistry and Engineering | Year: 2017

Partial hydrogenation of carbon-carbon double bonds is among one of the approaches to improve the low oxidative stability of vegetable biodiesel, which is an important drawback in biodiesel technology. In the current work, we developed an efficient two-phase catalytic system utilizing Pd(OAc)2 dissolved in polyethylene glycol (PEG) that in situ generates palladium nanoparticles in order to promote a selective partial hydrogenation reaction of methyl linoleate into mono-hydrogenated compounds while avoiding the generation of saturated compounds. High yield of methyl oleate was also obtained by hydrogenation of sunflower oil biodiesel using the same catalytic system. Through evaluating the palladium nanoparticles by TEM analysis, it is observed that 4 nm palladium nanoparticles generated in situ in PEG4000 showed high selectivity both for the partial hydrogenation of methyl linoleate and sunflower oil biodiesel. © 2017 American Chemical Society.


Xi W.,Nanchang University | Song W.,Nanchang University
Journal of Central South University (Medical Sciences) | Year: 2016

Objective: To systematically review the prognostic value regarding the expression of long non-coding RNA (IncRNA) Hox transcript antisense intergenic RNA (HOTAIR) in patients with cancer. Methods: Databases including The Cochrane Library, EMBASE, MEDLINE, and PubMed were searched to collect English literature on the correlation between IncRNA HOTAIR expression and overall survival in tumors. The retrieval time was from inception to September 2015. After data were extracted, a Meta-analysis was performed using RevMan 5.3 software. Results: A total of 17 studies were included, which was involved in 1 639 patients. The Meta-analysis showed that high expression of HOTAIR could predict poor overall survival in cancer (HR: 2.39, 95% CI 2.01-2.86, P<0.001). High expression of HOTAIR could also predict poor overall survival both in digestive tumor (HR: 2.51, 95% CI 2.02-3.11, P<0.00l) and non-digestive tumor (HR: 2, 17, 95% CI 1.59-2.98, P<0.00l). Moreover, overexpression of HOTAIR was found to be significantly associated with recurrence-free survival. Conclusion: The overexpression of IncRNA HOTAIR might be associated with poor prognosis in patients with cancer.


Zhou Y.-L.,Nanchang University | Li F.,Nanchang University
Chinese Journal of Cancer Prevention and Treatment | Year: 2016

OBJECTIVE: Diffuse large B cell lymphoma (DLBCL) is the most common type of non Hodgkin's lymphoma and is highly heterogeneous according to clinical manifestations, immunophenotypes, molecular genetic abnormalities and prognosis. The introduction of rituximab to the conventional CHOP chemotherapy for DLBCL led to an unequivocal improvement in survival in the recently years. We review the updated understanding of prognostic factors of DLBCL in the rituximab era. METHODS: Searching for the literature in the recent ten years using the keyword “Diffuse large B cell lymphoma, rituximab, prognostic factors” from 2007 to 2016 in the Pubmed and Wanfang database. A total of 322 English articles and 38 Chinese articles were obtained. The inclusion criteria are as follows: all of documents associated with the Diffuse large B cell lymphoma and the prognostic factors of Diffuse large B cell lymphoma in the rituximab era. The exclusion criteria include, 1) Review without original data, 2) Case reports, 3) Repeated literatures. Finally 37 papers met the inclusion and exclusion criteria were analyzed. RESULTS: In the era of pre-rituximab, only approximately 40% of the DLBCL patients achieved long-term remission. Rituximab combined with conventional chemotherapy had dramatically improved the long-term outcomes for patients with DLBCL, and led to the significant alterations of previous prognostic factors. CONCLUSIONS: In the rituximab era, reevaluating the current prognostic factors, and establishing a more perfect prognostic evaluation system can provide more precise prognostic indicators for patients with DLBCL, and further improve the treatment effect and survival of DLBCL patients. © 2016, Editorial Board of Chinese Journal of Cancer Prevention and Treatment. All right reserved.


Pan Y.,Hubei University of Medicine | Yuan Y.,Anyang Tumor Hospital | Liu G.,Nanchang University | Wei Y.,Hubei University
PLoS ONE | Year: 2017

Triple-negative breast cancer (TNBC) is an aggressive subgroup of breast cancer lack of effective target therapy. This study was to investigate the prognostic role of p53 and Ki-67 in 156 cases of TNBC patients. Logistic regression analysis was used to examine the association between clinical parameters and recurrence. Univariate and multivariate analyses were used to examine the association between clinical characteristics and disease-free survival (DFS) or overall survival (OS). Survival analyses using the Kaplan-Meier method were performed to examine the association between p53/Ki-67 and DFS and OS. Our data showed that p53 was positive in 71.3% and the Ki-67 high index was in 82.8% of TNBC. Elevated p53 and Ki-67 were associated with histological grade. The tumor size, lymph node involvement, and p53 expression are associated with risk of recurrence. Tumor size, lymph node involvement, family history, Ki-67 and p53 are independent variables associated with either DFS or OS. TNBC patients with positive p53 or Ki-67 high index or family history of cancer have a significant association with worse prognosis. This study suggests that p53, Ki-67 and family history are useful prognostic markers in TNBC. © 2017 Pan et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Xiong Y.,Nanchang University | Pei K.,Nanchang University | Wu Y.,Nanchang University
Food Control | Year: 2017

This study described a sensitive direct competitive enzyme-linked immunosorbent assay (ELISA) for naked-eye detection of aflatoxin B1 (AFB1) by using glucose oxidase (GOx)-regulated bromocresol purple (BCP) color change. GOx was used as an alternative to horseradish peroxidase (HRP) for oxidization of glucose into hydrogen peroxide and gluconic acid. BCP, whose color is significantly sensitive to pH variation, was used as a signal output. Under optimal conditions, the developed method exhibited a considerably high sensitivity for AFB1 detection with a cutoff limit of 100 pg/mL by the naked eye. The reliability of the developed colorimetric ELISA using naked-eye detection showed no false negative and false positive results among 70 AFB1 spiked tests. Furthermore, the developed method showed a good linear range of 25–200 pg/mL for AFB1 quantitative detection with a half-maximal inhibitory concentration at 66.72 pg/mL, which was approximately 10-fold lower than that of conventional HRP-based ELISA (IC50 = 707 pg/mL). The recoveries from four kinds of AFB1-spiked concentrations in corn extract solutions ranged within 80.56%–108.53%, with a coefficient of variation range of 1.69%–11.86%. These results exhibited good agreement with those of LC–MS/MS method indicating an acceptable accuracy and precision for AFB1 quantitative detection in actual corn samples. In brief, this study was the first to use a GOx-mediated color change of BCP in immunoassay for naked-eye detection of AFB1. This study also provided a new method for high-throughput screening detection of other small molecular chemicals using naked eye in resource-constrained countries. © 2017 Elsevier Ltd


Xiong S.,Nanchang University | Jiang H.Q.,Nanchang University
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2016

Olfactory dysfunction is one of the common diseases in the Department of Otorhinolaryngology. Although the olfactory nerve has ability to regenerate in human central nervous system, if the damage involves nerve, only a few patients can restore the olfactory function. At present, there is no satisfactory treatment for sensorineural olfactory dysfunction. Therefore, it is urgent to explore new and effective method for treating sensorineural olfactory dysfunction. The progress of stem cells in the treatment of olfactory dysfunction is reviewed in this article.


Li J.-F.,Nanchang University | Huang P.-C.,Nanchang University | Wu F.-Y.,Nanchang University
RSC Advances | Year: 2017

An operationally simple colorimetric method for measuring glutathione (GSH) concentration was developed using anti-aggregation of gold nanoparticles (AuNPs) in this work. At a pH of 5.8, cysteine (Cys) could rapidly induce the aggregation of AuNPs, thereby resulting in color change and AuNPs absorbance ratio (A650 nm/A520 nm) change. However, the added glutathione (GSH) can cause the anti-aggregation process to occur. This method was based on the regulation of pH, which on one hand can selectively detect GSH over Cys by the process of anti-aggregation of AuNPs and on the other hand can distinguish GSH from homocysteine (Hcys), and cystine (Cye) through specific selectivity. Under optical conditions, the detection of GSH can be finished within 5 min. The concentration range of the probe is 0.1-1.0 μM and the limit of detection (LOD) can be reached to 20.3 nM. © The Royal Society of Chemistry.


Xia G.,Nanchang University | Wang H.,Nanchang University
Journal of Photochemistry and Photobiology C: Photochemistry Reviews | Year: 2017

Squaraine dyes, a four-membered ring system with structural rigidity, possess unique photoelectrical properties and are marked by their exceptionally sharp and intense absorption associated with a strong fluorescent emission in solution. These favorable characteristics have prompted their exploitation in a number of state of the art applications including photoconductivity, data storage, light-emitting field-effect transistors, solar cells and fluorescent histological probes. In this review, we first summarize the recently proposed novel methods in the synthesis of these versatile derivatives. Subsequently, their extensive applications in the prevalent optical detection of the surrounding medium such as ions, pH, thiol-based compounds, biomolecules and cell over the past decades are covered and discussed. In addition, different categories for the synthesis and sensing mechanisms for various squaric acid-based chemo-/bio- sensors are illustrated. Finally, the challenges and opportunities in the synthesis and application of these derivatives are also briefly discussed. © 2017 Elsevier B.V.


Wang J.,Nanchang University | Chen L.,Nanchang University
Chinese Journal of Medical Imaging Technology | Year: 2016

Sjögren's syndrome (SS) is a kind of autoimmune disease, which has the feature of damaging salivary and lachrymal glands. The major clinical manifestations are dry mouth and eyes. The diagnostic procedure of SS is relatively complex and has no golden stardard. Ultrasonography has the advantages of non-invasive, no radiation, easy to operate and so on. It is mainly used in the diagnosis of SS with conventional ultrasound, CDFI, CEUS and sonoelastography. The diagnostic value were reviewed in this paper. Copyright © 2016 by the Press of Chinese Journal of Medical Imaging and Technology.


Teaching informatization is an important part of talent cultivation in colleges and universities. There have a lot of problems for further research in the process of system development. This paper determines level-rate system including 9 level-rate variables based on 8 major problems to be solved in the process of system development and level ascension, establishes feedback simulation flow diagram model using stepwise setting up and recovering parameter combination simulation testing technology of rate fundamental in-tree method, builds 9 rate variable fundamental in-trees, 86 simulation equations and 14 regulation interval control parameter equations, confirms the reliability of each tree combination model using a certain value of each control parameter range, establishes complex flow graph model. Then, based on the control parameter range, designs fixed assets and software resources increasing input at the same time under the condition of the most satisfied and the most unsatisfied control parameter combination plan, fixed assets and software resources focus on input in stages under the condition of the most satisfied and the most unsatisfied control parameter combination plan, analysis of results of improving simulation experiments. Finally, close ties to the actual, this paper proposes seven pieces of countermeasures, in order to provide references for developing and implementing management measures of teaching information level ascension. © 2016, Editorial Board of Journal of Systems Engineering Society of China. All right reserved.


Fu Z.,Nanchang University | BeMiller J.N.,Purdue University
Food Hydrocolloids | Year: 2017

Retrogradation of native and hydroxypropylated normal maize starch heated in water in the presence or absence of hydrocolloids or the water-soluble polymer poly (ethylene glycol) was investigated. Results were compared both with the effects of no added hydrocolloid and with the effects of added salts known to be retrogradation promoters or inhibitors. Development of solution turbidity was used as the indicator of retrogradation. Chaotropic ions were the most effective in reducing retrogradation. Kosmotropic ions were the most effective in promoting retrogradation. Granule swelling and disintegration and dissolution of starch polymer molecules was inhibited by sulfate and citrate ions, xanthan, and guar gum. The hydrophilicity or hydrophobicity of hydrocolloid molecules may influence their effect on retrogradation. Dissolved substances may have an effect on hydration and solubility of hydroxypropylated starch molecules. © 2017


Zou W.-N.,Nanchang University | Zou W.-N.,University Paris Est Creteil | He Q.-C.,University Paris Est Creteil
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2017

Resorting to the superposition principle, the solution of Eshelby's problem of a spherical inclusion located eccentrically inside a finite spherical domain is obtained in two steps: (i) the solution to the problem of a spherical inclusion in an infinite space; (ii) the solution to the auxiliary problem of the corresponding finite spherical domain subjected to appropriate boundary conditions. Moreover, a set of functions called the sectional and harmonic deviators are proposed and developed to work out the auxiliary solution in a series form, including the displacement and Eshelby tensor fields. The analytical solutions are explicitly obtained and illustrated when the geometric and physical parameters and the boundary condition are specified. © 2017 The Author(s) Published by the Royal Society. All rights reserved.


Chen X.-H.,Nanchang University | Chen X.-H.,Xinyu University | Yan H.,Nanchang University
Journal of Alloys and Compounds | Year: 2017

The thixotropic compression tests of nano-Al2O3 (Al2O3np)/Al7075 composites with different particle sizes and contents and containing a high fraction of solid, were conducted under conditions of 560–590 °C and 0.01–5 s−1, and the microstructures were observed. A visco-plastic constitutive model of nanoparticle reinforced composites for thixoforming was proposed, considering the coupling effects of strain, strain rate, deformation temperature and liquid fraction and presence of nanoparticles, to describe constitutive behavior of the composites under various deformation conditions. Furthermore, the influence of deformation parameters on thixoforming was investigated. It could be shown that the predictions by the developed model were consistent with experimental results. Fracture analysis of the thixotropic compression samples revealed that high deformation temperature or/and high strain rate could prompt continuous uniform distribution of the liquid phase along the grain boundary, causing the formation of a thin liquid film around an approximately spherical grain, accordingly improving thixoformability of the composites with a high solid fraction. Moreover, deformation mechanisms of the composites during thixotropic compression process were discussed. © 2017 Elsevier B.V.


Gui W.,Nanchang University | Gui W.,Nanchang Institute of Technology | Liu S.,Nanchang University
Journal of Alloys and Compounds | Year: 2017

A collection of β-NaGdF4 core-shell structured (CSS) phosphors were synthesized by Hydrothermal method, both the core and shell regions of which are hexagonal phase. The as-prepared core particles have the microrods shape, and the shell was formed upon them via epitaxial growth. After thermal annealing treatment of the core phosphors at 600 °C, the corresponding core-shell structure can still be effectively constructed. The photoluminescence (PL) spectra reveal that the CSS phosphors grown upon the as-prepared core particles own superior luminescent properties; for the annealed CSS phosphor β-NaGdF4:Eu3+@β-NaGdF4, a large amount of defects existed on the interfaces between the core and shell regions severely quenched the emission intensity of the core region; on co-doped Ce3+ and Dy3+ ions into the null shell layer of the annealed CSS phosphor, the obtained phosphor shows excellent multicolor luminescence performance due to quenching phenomenon effectively suppressed by dual-channel excitation and energy migration procedure of Gd3+ ions. The prepared CSS phosphors in this work are excellent candidates for applications in solid-state lighting. © 2017 Elsevier B.V.


Wang X.,Nanchang University | Zhai S.,Nanchang University | Xie T.,Nanchang University
Construction and Building Materials | Year: 2017

Resin light conductive cementitious materials (RLCCM) is a kind of advanced composite materials with good prospects for development, but there is the most vulnerable area on the interface of RLCCM. To find out the effect of coupling agent on interface bonding mechanism of organic-inorganic composite, the micro-hardness, micro-topography, surface morphology structure and chemical reaction of organic transparent resin and inorganic cement matrix interface were evaluated by the micro-hardness tester, environmental scanning electron microscopy (ESEM), atomic force microscope (AFM) and Fourier transform infrared spectroscopy (FTIR) tests. The results show that the silane coupling agent A-151 and aluminate coupling agent not only reduced the transparent resin performance weakened region thickness up to 100 μm and the micro-hardness in the transition region was increased by 19.6% and 39.9%, respectively, but also improved the micro-hardness of the surface of the cement matrix in the range of 30 μm, 20 μm to 22.2 and 21.9 MPa, respectively. The interface treated with silane coupling agent A-151, the interfacial micro cracks caused by the sampling process have narrowed and discontinuous in the direction of length. The interface treated with aluminate coupling agent, although the boundary between transparent resin and cement matrix still exists, but the micro cracks caused by the sampling process is almost disappeared, and two substances are closely combined together to present a natural transition state. Silane coupling agent A-151 and cement hydration products formed flat spherical particle diameter of about 78 nm, and these particles mosaiced and fused in the surface of hydrate as a whole, therefore the surface become more denser and smoother. Hydrolyzing silane coupling agent A-151 to produce silanol (–SiOH), which could react with hydroxy (–OH) function groups of CSH to form Si–O–Si bond. Hydrophilic inorganic groups of aluminate coupling agent reacted with hydroxyl (–OH) function groups of CSH to form Al–O–Si bond, and hydrophilic organic groups and resin make crosslinking, twisting reaction happened. © 2017 Elsevier Ltd


Wei Q.,Nanchang University | Gong H.,Nanchang University | Lu Z.,Nanchang University
Electronics Letters | Year: 2017

A novel paradigm for building code modulated visual evoked potential (cVEP) brain-computer interfaces (BCIs) is proposed. The paradigm is based on grouping modulation of stimuli with different codes in order to increase the number of stimuli and resulting information transfer rate (ITR). In a single group, an original code and its circularly shifting codes are used for modulating 16 stimuli. To achieve good separability of stimuli, the original codes for different groups should have good autocorrelation and cross-correlation properties. A pair of Golay complementary series and an almost perfect autocorrelation sequence are used as the original codes to implement a three-group cVEP BCI with 48 targets. Four subjects participated in a simulated online experiment and a high ITR of 129.58 bits/min was achieved due to the sharp increase of the number of targets. © 2017 The Institution of Engineering and Technology.


OBJECTIVE: To investigate the difference in severity and clinical outcomes between hypertriglyceridemic pancreatitis (HTGP) and acute pancreatitis (AP) of other causes, and to analyze the correlation between the serum triglyceride (TG) level <24 h after onset and the disease severity.METHODS: Patients were selected from the AP database of the First Affiliated Hospital of Nanchang University, who were admitted between January 2005 and December 2013, aged ≥18 and ≤85 years, excluding pregnant or lactating women. Severity and etiology of AP were classified according to the latest relevant guidelines. The severity and clinical outcomes of HTGP patients (HTGP group) were compared with those of patients with AP of other causes (non-HTGP group). Among the HTGP patients, those admitted within 24 hours of onset were selected for comparison of serum TG levels on the first day of hospitalization day among patients with mild, moderate, and severe HTGP, and the correlation between the serum TG level and the severity was analyzed.RESULTS: Altogether 3 558 AP patients were selected, of which 623 (17.5%) were HTGP, and 2 935 (82.5%)were non-HTGP patients. Compared with the non-HTGP group, the HTGP group had higher incidence of pancreatic necrosis (28.3% vs 18.1%), infected pancreatic necrosis (6.1% vs 3.7%), organ failure(35.8% vs 29.1%), and persistent organ failure(24.4% vs 16.5%), with all the differences being statistically significant (all P<0.01). The mortality and average stay in intensive care unit were also higher in the HTGP group than in the non-HTGP group (all P<0.05). There were 291 patients with HTGP who were admitted to hospital within 24 hours of onset. The serum TG levels <24 h after onset were (9.38±9.00) mmol/L, (11.90±9.02) mmol/L, and (16.47±11.75) mmol/L in patients with mild, moderate, and severe HTGP, respectively (P<0.01). Spearman's correlation analysis showed a positive correlation between TG level <24 h after onset and disease severity (r=0.26, P<0.01).CONCLUSIONS: Compared with AP of other causes, HTGP patients have more severe clinical course and worse clinical outcomes. The serum TG level within 24 hours of onset may be positively correlated with the severity of HTGP.


Guo S.,Nanchang University
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology | Year: 2016

OBJECTIVE: To investigate the role of Th17/Treg balance in immune mechanism in severe exacerbation of hepatitis B.METHODS: The clinical data of 41 patients with chronic hepatitis B were collected, and according to the conditions during hospitalization, these patients were divided into exacerbation group (19 patients) and improvement group (22 patients). On admission, at weeks 1 and 2 of treatment, and at the end of treatment, flow cytometry was used to measure the frequencies of Th17 and Treg cells in peripheral blood, and enzyme-linked immunosorbent assay was used to determine the serum levels of interleukin-17 (IL-17), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β). The dynamic changes in the frequencies of Th17 and Treg cells were compared between the two groups, and the correlation between clinical indices for hepatitis and cytokines was analyzed. The t-test was used for comparison between groups, a one-way analysis of variance was used for comparison within one group across different time points, and Pearson correlation analysis was performed.RESULTS: With disease progression, the exacerbation group showed an increase in the frequency of Th17 cells and a relatively low frequency of Treg cells; compared with the improvement group, the exacerbation group had a higher frequency of Th17 cells and a lower frequency of Treg cells. Th17/Treg ratio gradually increased with exacerbation and decreased with improvement in conditions; in the exacerbation group and the improvement group, Th17/Treg ratio was positively correlated with total bilirubin and negatively correlated with prothrombin activity. In the exacerbation group and the improvement group, Th17 cells were positively correlated with IL-17, and Treg cells were positively correlated with IL-10 and TGF-β.CONCLUSION: Th17 and Treg cells play important roles in severe exacerbation of hepatitis B, and Th17/Treg ratio may be used as an immunobiological marker for the judgment of severity during severe exacerbation of hepatitis B.


Chen F.,Nanchang University | Chen L.,Nanchang University
Chinese Journal of Medical Imaging Technology | Year: 2016

Raynaud's phenomenon is the clinical manifestation which is with insufficient blood supply caused by microcirculation disorders. Raynaud's phenomenon is the concomitant symptom of many diseases and has close relationship with the progress of diseases and complications. It is an important indicator for the diseases prognosis and curative effect evaluation. With the development of science and techniques, more and more methods and techniques have been applied in diagnosis and differental diagnosis of Raynaud's phenomenon. The application progresses of the imaging techniques in Raynaud's phenomenon were reviewed in this article. Copyright © 2016 by the Press of Chinese Journal of Medical Imaging and Technology.


Wu H.,Nanchang University | Xin Y.,Nanchang University
Plastics, Rubber and Composites | Year: 2017

The miscibility of polyvinyl alcohol (PVA)/polyvinyl pyrrolidone (PVP) blends is investigated by atomistic molecular dynamics (MD). Specific volumes of five PVA/PVP blends (with mass ratio (ω, ω = mPVA /mPVP) at 25%, 50%, 100%, 200% and 400%) as well as pure PVA and PVP are reviewed at the temperature of 298 K. The Flory–Huggins parameter (Formula presented.) determined from the cohesive energy densities and the radial distribution functions of the inter-molecular atoms suggest that PVA/PVP blends can be miscible at all sample. This is further supported by the morphologies of PVA/PVP blends. Then the phase separation kinetics of PVA/PVP blends was examined using density profiles calculated from the MesoDyn approach to examine mesoscopic morphology of the blends, and the result strengthening the view that the blends can be miscible with any sample mass fraction by the enthalpy contributions of H-bonds. © 2017 Institute of Materials, Minerals and Mining Published by Taylor & Francis on behalf of the Institute.


Jiang G.,Nanchang University | Huang J.,Nanchang University | Liu M.,Nanchang University | Cao M.,Nanchang University
Applied Thermal Engineering | Year: 2017

A novel tube-shell Li-ion battery pack with a passive thermal management system (TMS) using composite phase change material (PCM) was designed to control cells temperature rising and improve battery module heat transfer. The battery pack consisted of expanded graphite (EG)/paraffin composite, aluminum tubes, baffles and a shell. EG/paraffin was applied to control cells temperature rising and create a thermal balance from one cell to another. The TMS was coupled with a forced air cooling to initialize PCM temperature (PCM solidification). In order to evaluate the effect of the baffles on improving air fluid heat transfer, a three dimensional numerical model of the tube-shell battery module with forced air cooling was performed using ANYSYS FLUENT. The thermal characteristics of the tube-shell battery pack were investigated both experimentally and numerically. The results show that(1) EG/paraffin composite significantly reduces cells temperature rising and keeps the maximum temperature difference across the battery module within a low value of 1–2 °C. The tube-shell battery module with EG/PCM exhibits high heat dissipation efficiency. (2) The baffles change the air fluid flow direction, improving the interaction of fluid and its heat transfer efficiency. © 2017 Elsevier Ltd


Luo H.,Nanchang University | Feng Y.,Nanchang University
Hecheng Shuzhi Ji Suliao/China Synthetic Resin and Plastics | Year: 2017

The causes of warpage on the cover of a MP4 were analyzed by Moldflow2012 software based on characteristics of rapid heat cycling. The orthogonal table of Taguchi experiment and Moldflow2012 were used to reduce the warping deformation and volume shrinkage, the impact of five research variables on warping deformation and volume shrinkage rate were analyzed via range. The property of smaller-the-better in Taguchi methods was studied to conclude that the optimal technological parameters combination of the comprehensive evaluation on parts quality are: melt temperature is 235℃, die temperature is 75℃, packing pressure is 85 MPa, injection pressure is 75 MPa, and injection time is 6 s, which have been verified. © 2017, Beijing Yanshan Branch, Assets Management Corporation, SINOPEC. All right reserved.


Wu H.,Nanchang University | Xin Y.,Nanchang University
Composite Interfaces | Year: 2017

Molecular dynamics (MD) simulations were performed to estimate the diffusion coefficients of O2 and H2O molecules in polyethylene terephthalate/aluminum/polyethylene interface at the temperature of 298 K. It came out that the diffusion coefficient of gasses in the interface is smaller than that of a single polymer, and the diffusion coefficients compare well with experimental data as well as previously published work. Furthermore, the diffusion coefficients of H2O molecules in the interface are preferable to that of O2 molecules. Interestingly, the largest diffusion coefficient was detected in the polyethylene terephthalate/aluminum(1 0 0)/polyethylene interface, while the smallest value of the diffusion coefficients was found in the polyethylene terephthalate/aluminum(1 1 1)/polyethylene interface. Calculation and analysis of the interaction between aluminum and polymers indicated that the interaction of polymer/aluminum(1 1 0) has the most interface strength, and crystal density of the metal surface has a definite effect on the planar interface energy. What’s more, the figure of gas molecule concentration is further resulted that the interface make contribution to adsorption of gas molecules. Moreover, the diffusion is belonging to the Einstein diffusion in the multilayer materials, and this work provides some key clues to improve the performance of polymer materials. © 2017 Informa UK Limited, trading as Taylor & Francis Group


Xu S.,Nanchang University | Yang X.,Nanchang University | Jiang S.,Nanchang University
Signal Processing | Year: 2017

The sparsity from self-similarity properties of natural images, which has received significant attention in the image processing community of researchers, is widely applied for image denoising. The recently proposed nonlocally centralized sparse representation (NCSR) algorithm that takes advantage of the sparse representations (SRs) and the nonlocal estimate of sparse coefficients (NESCs) has shown promising results with respect to noise reduction. Despite successful combination of the above two techniques, the iterative dictionary learning and the nonlocal estimate of unknown sparse coefficients make this algorithm computationally demanding, which largely limits its applicability in many applications. To address this problem, a fast version of the NCSR algorithm called FNCSR algorithm, which is based on pre-learned dictionary and adaptive parameter setting approaches, was proposed in this paper. Specifically, we adopted the same dictionary learning approach, i.e, the K-means and principal component analysis (PCA), with the NCSR algorithm to obtain a dictionary for each image in a selected image dataset including high-quality natural and texture images. Then we applied PNSR index to objectively assess the image quality of the reconstructed images using these dictionaries throughout the image dataset. The dictionary providing the best average reconstructed quality was selected as fixed dictionary, i.e., the pre-learned dictionary, for sparse coding throughout the iterative denoising process, which implies that it no longer requires dictionary learning procedure within the framework of the proposed FNCSR algorithm, resulting in greatly decreased execution time. In order to further improve computational efficiency, we employed quality-aware features and support vector regression (SVR) technique to build a fast noise level estimator (NLE) to estimate the noise level from a single noisy image. The parameters related to the NESC, i.e., the search window and the search step, which influences the computational performance of the NCSR algorithm strongly, were chosen automatically according to the estimated noise level. Compared to the original NCSR algorithm, these modifications lead to substantial benefits in computational efficiency (a performance gain of about 90% can be achieved) without sacrificing image quality too much (the largest decline is less than 0.55 dB and 0.014 in terms of PSNR and SSIM indices). Compared with other state-of-the-art denoising algorithms, experimental results show that the proposed FNCNR algorithm also achieves comparable performance in terms of both quantitative measures and visual quality. © 2016 Elsevier B.V.


Ren Z.,Jiangxi Science and Technology Normal University | Ren Z.,Nanchang University | Huang X.Y.,Nanchang University
IOP Conference Series: Materials Science and Engineering | Year: 2017

To determine the optimal gas length for the gas-assisted etrusion forming of melt, numerical investigations about the gas length on the extrudate swell of melt were performed by using the finite element method. Meanwhile, the geometric model of gas-assistd extrusion forming was established. The full slip boundary condition was used as the gas-assisted condition. Numerical results show that the gas length should be shortened with increasing of the inlet volumme flow rate of melt. In addition, under the given inlet volume flow rate of melt, the extrudate swell ratio, X velocity and shear stress of melt greatly decreases with increasing the gas length. Accroding to the numerical results and experiences reported past time, under the inlet volume flow rate of 0.5cm3/s, the optimal gas lenth of gas-assisted extrusion forming is about 10mm. © Published under licence by IOP Publishing Ltd.


Zou Y.,Nanchang University | Liu P.X.,Nanchang University | Liu P.X.,Carleton University
Computers in Biology and Medicine | Year: 2017

To achieve high computational efficiency and realistic visual effects, a new simulation algorithm for soft tissue deformation, which is based on a shape-matching scheme using splat primitives, is presented for interactive real-time applications, such as surgery simulation and video games. The most important novelty of the proposed approach lies in the fact that surface splats instead of points are employed in the computation of the deformation and fracturing of an elastic-plastic object. By controlling the sampling density and automatically adjusting the size of the circular splats, the surface of the simulated object can be seamlessly covered with a much small number of splats than points. Splats are then divided into clusters using the K-Means clustering algorithm. As a result, the elastic-plastic deformation of these clusters can be simulated using a shape-matching strategy, allowing more degrees of freedom (DOFs) in the simulation. Experimental results demonstrate that the proposed algorithm enormously reduces memory space and greatly improves computational efficiency (approximately twice in simulating plastic deformations compared with classical shape-matching methods), making it more suitable for interactive and real-time applications. © 2017 Elsevier Ltd


Wei J.,Nanchang University | Huang Y.,Jiangxi University of Finance and Economics
Multimedia Tools and Applications | Year: 2017

Adaptivity is important in remote sensing image fusion because of the data-intensive and mass-driven processing platforms that call for reliable evaluation metrics to assess the runtime fusion procedure. Spatial distortion, including poor detail, visual disorder, or over-injection, has not been measured as effectively as in the spectral domain. A new metric, namely normalized mean potential energy (NMPE), is proposed in this paper to check the generalized spatial distortion of fused images by calculating the potential energy of marginal filtering distributions using information of high-order Markov random fields. NMPE is defined based on the GFoE model, which is a new high-order model that we built for remote sensing image applications. To incorporate the evaluation experience of human vision system into the GFoE model, the real zero-mean Gabor filters with multiple directions and scales are used as feature extractors, and the Gaussian scale mixture model as the expert function. The model parameters are trained from 200 images of the Berkeley segmentation dataset. Poor detail in a fused image tends to result in small NMPE evaluation with respect to small Gabor scales. Our observation shows that scale invariance exists only for “good” details, so we use large scales of Gabor functions to detect visual disorder. Over-injection is checked when the fused NMPE is much higher than 1. In the experimental procedure, satellite images from Quickbird, LandSat-7, and SPOT-5 were put to fusion with five popular methods to produce different images for visual and digital comparison. It can be concluded from the experiment that NMPE is in line with our subjective judgment to measure the pansharpening quality in terms of enhanced detail, visual distortion, and over-injection. © 2017 Springer Science+Business Media New York


Li S.,Nanchang University | Huang P.,Nanchang University | Wu F.,Nanchang University
New Journal of Chemistry | Year: 2017

We report a facile yet effective strategy for the fluorescence assay of heparin based on assembly and disassembly of the glutathione-protected gold nanoclusters (GSH-Au NCs) modulated via the competitive interaction of cetyltrimethyl ammonium bromide (CTAB) with heparin and GSH. Firstly, CTAB can increase the fluorescence of Au NCs by forming a nanocomposite via electrostatic and hydrophobic self-assembly. By adding heparin to the assay, CTAB is removed from the nanocomposites because of its higher affinity for heparin, quenching the fluorescence signal. Such a fluorescence feature induced via assembly and disassembly of the NCs enables our assay to possess high selectivity and sensitivity. The linear response toward heparin was obtained over the range 0.1-1.6 μg mL-1 with a low detection limit of 0.075 μg mL-1. Furthermore, satisfactory sensing perfomance for heparin in human serum makes this method hold great promise in heparin-related biomedical applications. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.


Liu L.,Nanchang University | Miao S.,Nanchang Institute of Technology
Information Sciences | Year: 2017

In this paper, a new delay-introducing method is proposed to improve the dynamical degradation of a digital chaotic map. The delayed state is introduced to construct a function that is used to replace the control parameter of an original chaotic map. The numerical experimental results indicate that the delayed digital chaotic maps are more complex, have larger periods, and do not completely disrupt the phase space of an original chaotic map, indicating that our method is effective and can be competitive with other proposed methods. The most significant advantage of this method is that external systems are no longer required, making it easier to implement than the other popular methods. We also propose a type of pseudorandom bit generator (PRBG) based on the delay-introducing method as a simple application. © 2017 Elsevier Inc.


Chen Z.,Nanchang University | Wang J.-S.,Key Laboratory of Space Weather National Center for Space Weather | Deng Y.,University of Texas at Arlington | Huang C.-M.,Hubei University
Journal of Geophysical Research: Space Physics | Year: 2017

The spectral whitening method (SWM) has been previously proved to be very effective at identifying ionospheric disturbances on foF2 (the critical frequency of ionospheric F2 layer). To continuously investigate the strength of the new method, in this paper SWM has been used to extract the effect of geomagnetic activity on total electron content (TEC) and has been compared with the traditional 28day running median centered (RMC) method. First, ionospheric variations during quiet and disturbed conditions are analyzed by both SWM and RMC. The results from RMC, compared with those from SWM, overestimate the disturbance occurrence by about 5-20% during the geomagnetic storms and up to 35% during the quiet time. The possible reason is that the results can be contaminated by the residuals of periodic components in the RMC identified disturbances. Meanwhile, the power spectral analysis of the disturbance field shows that the annual and diurnal variations are still significant in RMC results but very weak in SWM results, which indicates that SWM has some advantage to clean up the background variation. Finally, the analysis of the spatial correlation of the disturbance field with F10.7 and Ap illustrates that the effects of solar and geomagnetic activities from SWM are significantly reduced and enhanced, respectively. It suggests that the SWM is more effective in extracting the effect of geomagnetic activity from TEC than RMC. The relative deviation of TEC derived by SWM is more sensitive to geomagnetic activity than solar activity. © 2017. American Geophysical Union. All Rights Reserved.


Huang G.-D.,Nanchang University | Xiong J.,Nanchang University
Tropical Journal of Pharmaceutical Research | Year: 2017

Purpose: To investigate the expression matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in ulcerative colitis (UC) patients admitted to The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Methods: The expression of MMPs and TIMPs) was evaluated in 50 patients (36 males, 14 females) with UC who were admitted to The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, China. Tissue samples obtained from core needle biopsies were evaluated using immunochemistry techniques. Results: MMP-9 and TIMP-1 were strongly expressed in the glandular epithelium and inflammatory cells. In addition, the expression was coupled with changes in the tissue architecture and inflammation in the lamina propria. The expression of MMPs and weak activation of their inhibitors was related to UC progression. There were significant correlations between MMP expression and histopathological parameters (p = 0.051, R = 0.392). MMP expression correlated with weaker expression of TIMPs (p = 0.032, R = 0.0581) Conclusion: MMP-2, MMP-7, and MMP-9 are potential targets for therapeutic control of UC. © Pharmacotherapy Group, Faculty of Pharmacy, 2017. All rights reserved.


Li N.,Nanchang University | Xie C.,Nanchang University | Lu N.,Nanchang University
FEBS Journal | Year: 2016

The Hippo signalling pathway co-ordinately modulates cell regeneration and organ size, and its deregulation contributes to tumorigenesis through many cellular processes, including overproliferation, apoptosis resistance and cell migration. Recent discoveries have shed new light on how microRNAs (miRNAs) are closely linked to the Hippo pathway in tumour progression. Hippo signalling has been reported to affect widespread miRNA biogenesis. In turn, several miRNAs regulate Hippo signalling, which contributes to carcinogenesis. This article will provide an overview of the crosstalk between Hippo signalling and miRNAs in the development of cancer and further appraise potential targets for therapeutic intervention. © 2017 Federation of European Biochemical Societies.


Gan C.,Nanchang University | Wang Z.,Nanchang University | Chen Y.,Nanchang University
Atherosclerosis | Year: 2017

Background and aims The major apolipoproteins of plasma lipoproteins play vital roles in the structural integrity and physiological functions of lipoproteins. More than ten structural models of apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoprotein (HDL), have been developed successively. In these models, apoA-I was supposed to organize in a ring-shaped form. To date, however, there is no direct evidence under physiological condition. Methods Here, atomic force microscopy (AFM) was used to in situ visualize the organization of apoA-I, which was exposed via depletion of the lipid component of plasma HDL pre-immobilized on functionalized mica sheets. Results For the first time, the ring-shaped coarse structure and three detailed structures (crescent-shaped, gapped “O”-shaped, and parentheses-shaped structures, respectively) of apoA-I in plasma HDL, which have the ability of binding scavenger receptors, were directly observed and quantitatively measured by AFM. The three detailed structures probably represent the different extents to which the lipid component of HDL was depleted. Data on lipid depletion of HDL may provide clues to understand lipid insertion of HDL. Conclusions These data provide important information for the understanding of the structure/maturation of plasma HDL. Moreover, they suggest a powerful method for directly visualizing the major apolipoproteins of plasma lipoproteins or the protein component of lipoprotein-like lipid-protein complexes. © 2017 Elsevier B.V.


Ma J.,Nanchang University | Ma J.,University of Cincinnati | Hong K.,Nanchang University | Wang H.-S.,University of Cincinnati
Endocrinology | Year: 2017

Bisphenol A (BPA) is an estrogenic endocrine-disrupting chemical (EDC) that has a range of potential adverse health effects. Previously we showed that acute exposure to BPA promoted arrhythmias in female rat hearts through estrogen receptor rapid signaling. Progesterone (P4) and estrogen have antagonistic or complementary actions in a number of tissues and systems. In the current study, we examined the influence and possible protective effect of P4 on the rapid cardiac actions of BPA in female rat cardiac myocytes. Preincubation with physiological concentration (1 nM) of P4 abolished BPA-induced triggered activities in female cardiac myocytes. Further, P4 abrogated BPA-induced alterations in Ca2+ handling, including elevated sarcoplasmic reticulum Ca2+ leak and Ca2+ load. Key to the inhibitory effect of P4 is its blockade of BPA-induced increase in the phosphorylation of phospholamban. At myocyte and protein levels, these inhibitory actions of P4 were blocked by pretreatment with the nuclear P4 receptor (nPR) antagonist RU486. Analysis using membraneimpermeable bovine serum albumin-conjugated P4 suggested that the actions of P4 were mediated by membrane-initiated signaling. Inhibitory G (Gi) protein and phophoinositide-3 kinase (PI3K), but not tyrosine protein kinase activation, were involved in the observed effects of P4. In conclusion, P4 exerts an acute protective effect against BPA-induced arrhythmogenesis in female cardiac myocytes through nPR and the Gi/PI3K signaling pathway. Our findings highlight the importance of considering the impact of EDCs in the context of native hormonals andmay provide potential therapeutic strategies for protection against the cardiac toxicities associated with BPA exposure. © 2017 Endocrine Society.


Zhao H.-X.,Nanchang University | Xu X.-X.,Jiangxi Normal University | Yuan H.-C.,Changzhou Institute of Technology
Optics Communications | Year: 2017

A non-Gaussian state being a mixture of the vacuum and single-photon states can be generated by truncating a thermal state in a quantum-scissors device of Pegg et al. (1998) [12]. In contrast to the thermal state, the generated state shows nonclassical property including the negativity of Wigner function. Besides, signal amplification and signal-to-noise ratio enhancement can be achieved. © 2016 Elsevier B.V.


Li F.,Jiangxi University of Traditional Chinese Medicine | Li T.,Nanchang University
Proceedings - 9th International Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2017 | Year: 2017

Based on the fuzzy comprehensive evaluation model, an artistic creation model is provided in this paper and evaluation result is a vector, not a point value, which contains abundant information, which can describe the evaluated object more accurately, and can be further processed to obtain the reference information. © 2017 IEEE.


Fu S.,Nanchang University | Zhang X.,Nanchang University
Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology | Year: 2017

The main pathological feature of glaucoma is progressive loss of retinal ganglion cells (RGCs), and the damage mechanisms have not been elucidated. Autophagy is a lysosomal degradative process that eliminates damaged cellular constituents, including organelles and long-life proteins. And autophagy plays an important role in cellular homeostasis. Recent studies have shown that autophagy is involved in the pathophysiological process of glaucoma. This article summarized the relationship between autophagy and RGCs in different animal models of glaucoma, such as optic nerve damage model, ischemia-reperfusion model and ocular hypertension model. In various animal models of glaucoma, autophagy can not only promote RGCs survival but also their death. And in the same animal model of glaucoma, autophagy also plays a double-edged sword effect on RGCs. Meanwhile, we elaborated the interaction between autophagy and Sirt1, which can protect the neurons. Copyright © 2017 by the Chinese Medical Association.


Hu H.,Nanchang University | Zou C.,Nanchang University
Current Stem Cell Research and Therapy | Year: 2017

Acute renal failure (ARF) is a syndrome of abrupt decline in renal function induced by a number of different insults. In clinic, the common etiology for ARF is ischemia-reperfusion injury (IRI). The pathophysiological process of renal IRI is complex, there is no good treatment. Stem cell therapy is a new and promising treatment for renal IRI. Mesenchymal stem cells (MSCs) have the ability to differentiate into tissues of mesodermal lineages. MSCs are under intensive study as potential therapeutic strategy for renal IRI. MSCs have been investigated with immunomodulatory, anti-inflammatory and tissue repair properties which could attenuate ischemic injury and accelerate the regeneration process in the condition of renal IRI. Moreover, the MSCs have the ability to migrate to the injury sites and to stimulate repair by paracrine mechanisms rather by differentiating into the injured cells. Here we review the latest information on MSCs, their biological characteristics, including their therapeutic perspectives, and envisage their putative role in renal ischaemic conditioning. © 2017 Bentham Science Publishers.


Hu Y.,Nanchang University | Zhu Y.,Nanchang University | Lu N.-H.,Nanchang University
Digestive Diseases and Sciences | Year: 2017

Background and Aims: Antibiotic resistance is the most important factor leading to the failure of eradication regimens; thus, it is important to obtain regional antibiotic resistance information. This review focuses on the prevalence of Helicobacter pylori primary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and furazolidone in China. Methods: We searched the PubMed, EMBASE, the China National Knowledge Infrastructure, and Chinese Biomedical databases from the earliest date of each database to October 2016. The search terms included the following: H. pylori, antibiotic (including clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and furazolidone) resistance with or without China or different regions of China. The data analysis was performed using MedCalc 15.2.2. Each article was weighted according to the number of isolated H. pylori strains. A pooled proportion analysis was performed. Results: Twenty-three studies (14 studies in English and 9 in Chinese) were included in this review. A total of 6274, 6418, 3921, 5468, 2802, and 275 H. pylori strains were included in this review to evaluate the prevalence of H. pylori primary resistance to clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline, and furazolidone, respectively. Overall, the primary resistance rates of clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline, and furazolidone were 28.9, 63.8, 28.0, 3.1, 3.9, and 1.7%, respectively. Conclusions: In China, the prevalence of H. pylori primary resistance to clarithromycin, metronidazole, and levofloxacin was high and increased over time, whereas the resistance rates to amoxicillin, tetracycline, and furazolidone were low and stable over time. © 2017 Springer Science+Business Media New York


Yao L.-Y.,Nanchang University | Xie Q.-L.,Nanchang University
Journal of Computers (Taiwan) | Year: 2017

The interaction between nodes to achieve service in Cloud computing is allowed. In the complex and dynamic network environment, access control and security communications are the main ways to protect the security. It provides a trust dynamic level access control method by simulating social trust, which can help users select a trustworthy node in internet. The comprehensive trust model is composed of direct trust and indirect trust. The direct trust value is deduced from user's satisfaction with interaction, amount of interactions, time decay, and punishment factor. The indirect trust is computed by direct trust in other nodes for the feature of trust transference. The trust dynamic access method will help users to select more secure service and provide reliable candidate nodes. The experiments show that trust mechanism can improve the credibility of the system in a certain extent and reduce deception task execution. The method can improve the efficiency of interaction, and is suitable for cloud computing environments. © 2017, Computer Society of the Republic of China. All rights reserved.


Qiu J.,Nanchang University | Zhou W.,Nanchang University | Xiong J.,Nanchang University
Annals of Vascular Surgery | Year: 2017

We report a 42-year-old male patient with bilateral persistent sciatic arteries (PSAs), diagnosed by computer tomography angiography for right thigh trauma and follow-up for more than 5 years. A review of 61 bilateral PSA patients reported in the international literature was performed. There was no gender predilection (male versus female: 46% vs. 54%). The same type of PSA in both sides was 74%. The complete PSA type was 77% in the right side and 75% in the left side. Symptomatic bilateral PSA was 72%, including aneurysm in 57% (combined with ischemia or embolism 39%), and the mean age was 61 ± 12 years. The asymptomatic bilateral PSA was 13%, and the mean age was 27 ± 8 years. Most asymptomatic PSAs were diagnosed by arteriography with demonstration of the proximal vessels, such as during embolization of the uterine arteries. One case experienced the loss of a limb to inadvertent embolization of PSA. The presented patient was treated with debridement and lifestyle modification to avoid repetitive PSA compression, and was followed up for more than 5 years without complications. The characteristics are no different between bilateral and unilateral PSAs. PSA complications may be avoided if we can prevent the acquired factors. We should pay attention to PSA in our clinical work to avoid severe complications. © 2017 Elsevier Inc.


The cDNA sequences of Corbicula fluminea HSP70/90 (designated as CfHSP70 and CfHSP90, respectively) were cloned in this study. The complete cDNA sequence of CfHSP70 was 2251 bp, including a 1959 bp ORF encoding a 652-amino-acid polypeptide with three HSP70 family signatures. The complete cDNA sequence of CfHSP90 was 2782 bp, including a 2184 bp ORF encoding a 727-amino-acid polypeptide with five HSP90 family signatures. BLAST analysis revealed that the CfHSP70/90 genes were highly homologous to members of HSP70/90 families. Basal mRNA expression of CfHSP70/90 was found in adductor muscle, foot, gill, digestive gland, gonad, and mantle tissues from C. fluminea. The highest expression levels of CfHSP70/90 were observed in the digestive gland. Real-time RT-PCR was used to analyze the mRNA expression of CfHSP70/90 in the digestive gland of C. fluminea exposed to heavy metals Cd2 +, Cu2 +, and Pb2 + for 5, 10, 15, and 20 days. The expression levels of CfHSP70/90 induced by heavy metal gradually, peaked at different times, and then decreased. These results indicate that the CfHSP70/90 genes can be used as sensitive molecular biomarkers of heavy metal pollution in water. © 2017 Elsevier Inc.


To investigate the clinical significance of hepatic parenchyma incision by lithotomy near the second hepatic portal area for the treatment of complex hepatolithiasis.A retrospective study was conducted with 35 patients who had complicated hepatolithiasis in our hospital from January 2008 to December 2013, who underwent hepatic parenchyma incision by lithotomy near the second hepatic portal area. The perioperative and long-term outcomes included the stone clearance rate, operative morbidity and mortality, and the stone recurrence rate. Patients with a preoperative diagnosis of cholangiocarcinoma were excluded from the study.All patients with hepatic duct stones were mainly located at S2, S4, and S8 regions. Surgical methods included were hepatic parenchyma incision by lithotomy near the second hepatic portal area, or by combined partial hepatectomy. The mean follow-up period was 51 months. One patient died during hospitalization. The surgical morbidity was 17.6%, stone clearance rate was 88.2%, and final clearance rate was 94.1% followed by postoperative choledochoscopic lithotripsy. The stone recurrence rate was 15.6% and the occurrence of postoperative cholangitis was 11.8% during the follow-up period.Hepatic parenchyma incision by lithotomy near the second hepatic portal area is safe with satisfactory short and long-term outcome results for complicated hepatolithiasis.


Luo C.-J.,Nanchang University | Kuang X.-M.,Pontifical Catholic University of Valparaíso | Shu F.-W.,Nanchang University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2017

We analytically obtain a new charged Lifshitz solution by adding a non-relativistic Maxwell field in Hořava–Lifshitz gravity. The black hole exhibits an anisotropic scaling between space and time (Lifshitz scaling) in the UV limit, while in the IR limit, the Lorentz invariance is approximately recovered. We introduce the probed Lorentz-violation fermions into the background and holographically investigate the spectral properties of the dual fermionic operator. The Lorentz-violation of the fermions will enhance the peak and correspond larger fermi momentum, which compensates the non-relativistic bulk effect of the dynamical exponent (z). For a fixed z, when the Lorentz-violation of fermions increases to a critical value, the behavior of the low energy excitation goes from a non-Fermi liquid type to a Fermi liquid type, which implies a kind of phase transition. © 2017 The Authors


In previous work, we presented experimental and theoretical evidence that podophyllum derivatives substituted by chlorine atom in the 3-posititon of 2-aminopyridine exhibited significantly elevated potency. In this study, a series of podophyllum derivatives substituted in the 3-position of 2-aminopyridine, including methyl and fluorine groups, were synthesized. Their chemical structures were confirmed by the spectral (1H-nuclear magnetic resonance, 13C-nuclear magnetic resonance, electrospray ionization mass spectrometry) and elemental analyses. These derivatives were tested for their respective cytotoxicities in HeLa, BGC-823, A549, Huh7, and MCF-7 cells by MTT assay and the pharmacological results showed that most of them displayed potent cytotoxicities against at least one of the tested cancer cell lines. Structure–activity relationship study suggested that the introduction of the fluorine atom into the 3-posititon of 2-aminopyridine had enhanced the cytotoxicity against numerous tumor cells compared to the chlorine atom, while the methyl group did not. Furthermore, other biological experiments were consistent with the beneficial effect of fluorine atom substituent in the 3-position of 2-aminopyridine, which then inhibited the microtubule polymerization and activity of topoisomerase II when 2-amino-3-fluoropyridine substituted in podophyllotoxin and 4′-O-demethylepipodophyllotoxin, and that they work by effecting the target proteins which induce P53-dependent apoptosis. © 2017 Springer Science+Business Media New York


Luo R.-Z.,Nanchang University | He L.-M.,Shanghai University
Chinese Physics B | Year: 2014

The PC synchronization of a class of chaotic systems is investigated in this paper. The drive system is assumed to have only one state variable available. By constructing proper observers, some novel criteria for PC synchronization are proposed via event-triggered control scheme. The Lü system and Chen system are taken as examples to demonstrate the efficiency of the proposed approach. © 2014 Chinese Physical Society and IOP Publishing Ltd.


Liu Z.,Tsinghua University | Liu J.Z.,Monash University | Cheng Y.,Tsinghua University | Li Z.,Peking University | And 3 more authors.
Physical Review B - Condensed Matter and Materials Physics | Year: 2012

Despite the interlayer binding energy being one of the most important material properties of graphite, direct experimental determination of this property is yet to be reported. In this paper, we present an experimental method to directly measure the interlayer binding energy of highly oriented pyrolytic graphite (HOPG). The obtained value of the binding energy is 0.19 (±0.01) J/m2, which can serve as a benchmark for other theoretical and experimental works related to graphite/graphene systems. © 2012 American Physical Society.


Yin X.,Nanchang University | Yue D.,Nanjing University of Posts and Telecommunications | Hu S.,Nanjing University of Posts and Telecommunications
International Journal of Robust and Nonlinear Control | Year: 2015

Summary This paper addresses the model-based event-triggered predictive control problem for networked control systems (NCSs). Firstly, we propose a discrete event-triggered transmission scheme on the sensor node by introducing a quadratic event-triggering function. Then, on the basis of the aforementioned scheme, a novel class of model-based event-triggered predictive control algorithms on the controller node is designed for compensating for the communication delays actively and achieving the desired control performance while using less network resources. Two cases, that is, the value of the communication delay of the first event-triggered state is less or bigger than the sampling period, are considered separately for certain NCSs, regardless of the communication delays of the subsequent event-triggered states. The codesign problems of the controller and event-triggering parameter for the two cases are discussed by using the linear matrix inequality approach and the (switching) Lyapunov functional method. Furthermore, we extended our results to the NCSs with systems uncertainties. Finally, a practical ball and beam system is studied numerically to demonstrate the compensation effect for the communication delays with the proposed novel model-based event-triggered predictive control scheme. Copyright © 2014 John Wiley & Sons, Ltd.


This paper focuses on the control and modified projective synchronization of a class of chaotic systems. Some robust criteria are proposed based on the adaptive control scheme to ensure perfect tracking and modified projective synchronization in the presence of parameter and model uncertainties and external disturbances. Two numerical simulations are given to demonstrate the robustness and efficiency of the proposed approach. © 2014 The physical society of the republic of China.


Chen F.-S.,Jiangxi Agricultural University | Yavitt J.,Cornell University | Hu X.-F.,Nanchang University
Applied Soil Ecology | Year: 2014

We used four vegetation types located along an urban-suburban-rural gradient in Nanchang, China to study how the deposition of nitrogen (N) and phosphorus (P) in the urban area affected soil carbon (C) cycling. We found that total P, nitrate (NO3 --N), available P, and the abundances of culturable bacteria, actinobacteria, and nitrifying bacteria in soils, collected to 15cm depth in August of 2008, decreased along the urban-to-rural gradient (P<0.05); the C/P and N/P ratios, ammonium (NH4 +-N), and culturable fungi abundance showed the reverse trends; whereas soil organic C, total N, C/N, mineral N, and the activities of sucrase and neutraland acid phosphatase showed no pattern with gradient and vegetation type. Compared to suburban and rural sites, total and available P in soil increased 168% and 131%, 47% and 139%, respectively in urban sites. The cumulative amount of CO2 emission per gram of soil (Cmin, incubated from 2 to 43 days) varied little along the urban-to-rural gradient, but showed positive correlations with organic C, total N, total P, nitrate, mineral N concentrations, C/N, bacteria and actinobacteria abundances, sucrase and acid phosphatase activities. In contrast, the cumulative amount of CO2 produced per gram organic C (Cmin/OC) within the incubation period was influenced by gradient, vegetation type, and their interaction, and values were about 35% greater in the urban than in suburban and rural sites. The relationship between elevated Cmin/OC in urban vegetations and the enrichment of P in organic matter (P/C ratio) suggests that P coming from urban household waste can degrade the stability of organic C in urban soils. © 2013 Elsevier B.V.


Liu A.-W.,Shanghai University of Traditional Chinese Medicine | Liu A.-W.,Nanchang University | Cai J.,Nanchang University | Zhao X.-L.,Shanghai University of Traditional Chinese Medicine | And 5 more authors.
Clinical Cancer Research | Year: 2011

Purpose: Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is overexpressed in many types of cancer. Herein, we aimed to investigate its expression pattern, clinical significance, and biological function in hepatocellular carcinoma (HCC). Experimental Design: MAP4K4 expression was examined in 20 fresh HCCs and corresponding nontumor liver tissues. Immunohistochemistry for MAP4K4 was performed on additional 400 HCCs, of which 305 (76%) were positive for hepatitis B surface antigens. The clinical significance of MAP4K4 expression was analyzed. MAP4K4 downregulation was performed in HCC cell lines HepG2 and Hep3B with high abundance of MAP4K4, and the effects of MAP4K4 silencing on cell proliferation in vitro and tumor growth in vivo were evaluated. Quantitative real-time PCR arrays were employed to identify the MAP4K4-regulated signaling pathways. Results: MAP4K4 was aberrantly overexpressed in HCCs relative to adjacent nontumor liver tissues. This overexpression was significantly associated with larger tumor size, increased histologic grade, advanced tumor stage, and intrahepatic metastasis, as well as worse overall survival and higher early recurrence rate. Knockdown of the MAP4K4 expression reduced cell proliferation, blocked cell cycle at S phase, and increased apoptosis. The antitumor effects of MAP4K4 silencing were also observed in vivo, manifested as retarded tumor xenograft growth. Furthermore, multiple tumor progression-related signaling pathways including JNK, NFkB, and toll-like receptors were repressed by MAP4K4 downregulation. Conclusions: MAP4K4overexpressionis an independent predictor ofpoor prognosis ofHCCpatients,and inhibition of its expression might be of therapeutic significance. ©2010 AACR.


Guo L.,Peking University | Xie B.,Nanchang University | Mao Z.,Peking University
International Journal of Molecular Sciences | Year: 2012

Autophagy is a highly regulated intracellular process involved in the turnover of most cellular constituents and in the maintenance of cellular homeostasis. In this study, we show that the activity of autophagy increases in H 2O 2 or RasV12-induced senescent fibroblasts. Inhibiting autophagy promotes cell apoptosis in senescent cells, suggesting that autophagy activation plays a cytoprotective role. Furthermore, our data indicate that the increase of autophagy in senescent cells is linked to the activation of transcription factor FoxO3A, which blocks ATP generation by transcriptionally up-regulating the expression of PDK4, an inhibitor of pyruvate dehydrogenase complex, thus leading to AMPK activation and mTOR inhibition. These findings suggest a novel mechanism by which FoxO3A factors can activate autophagy via metabolic alteration. © 2012 by the authors; licensee MDPI, Basel, Switzerland.


Wu J.-P.,Beijing Normal University | Cao Y.,Beijing Normal University | Kuang X.-M.,Nanchang University | Li W.-J.,Beijing Normal University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2011

In this Letter we study 3+1 holographic superconductors with Weyl corrections. We find that the critical temperature of a superconductor with Weyl corrections increases as we amplify the Weyl coupling parameter γ, indicating the condensation will be harder when the parameter γ decreases. We also calculate the conductivity and the ratio of gap frequency over critical temperature ωg/Tc numerically for various coupling parameters. We find that the ratio ωg/Tc becomes larger when the Weyl coupling parameter γ decreases. We also notice that when γ<0 there is an extra spike that appears inside the gap. © 2011 Elsevier B.V.


Li X.,Nanchang University | Hu Q.,Nanchang University | Yang Y.,Nanchang University | Wang Y.,Nanchang University | He F.,Tianjin University of Technology
Applied Catalysis A: General | Year: 2012

Wt.%BaTiO 3-Al 2O 3 (wt.%BaTiO 3 = 0-100%) composite supports were synthesized through varying the BaTiO 3 content by the "sol-(xero)gel" method. Ni/wt.%BaTiO 3-Al 2O 3 nickel-based catalysts prepared by incipient wetness method were evaluated for dry reforming of methane carried out between 690 °C and 800 °C. Characterizations using XRD, IR, N 2 adsorption-desorption, H 2-TPR, SEM, and XPS were conducted to investigate the structure or properties of the wt.%BaTiO 3-Al 2O 3 composite supports as well as the Ni/wt.%BaTiO 3-Al 2O 3 catalysts. The results demonstrate that BaTiO 3 particles are discontinuously dispersed on the surface of γ-Al 2O 3 in the form of individual isolated particles for the wt.%BaTiO 3-Al 2O 3 composite supports. Meanwhile, it is probably that the coexistence of BaAl 2O 4 spinel phase with the BaTiO 3 phase on the surface of γ-Al 2O 3 inhibits the Ni/wt.%BaTiO 3-Al 2O 3 catalysts from the formation of NiAl 2O 4 spinel phase, improving the catalytic performance of the catalysts. The Ni/BaTiO 3 catalyst showed poor stability and severe coke formation in the dry reforming of methane tested at 690 °C, which was thought to be mainly originated from the excessive strong electronic donor intensity of Ni/BaTiO 3 catalyst as well as the resulted CO disproportionation reaction. Compared with the Ni/BaTiO 3 catalyst, the Ni/wt.%BaTiO 3-Al 2O 3 catalysts with the addition of BaTiO 3 had a higher dispersion of active nickel and a weakened electronic donor intensity of the NiO x species. As a result, the synthesized Ni/32.4%BaTiO 3-Al 2O 3 catalyst exhibited a high catalytic activity, excellent stability as well as coking resistance for lower temperature dry reforming of methane. © 2011 Elsevier B.V.


Hu G.-J.,Nanchang University | Hu X.-X.,Jiangxi Agricultural University
International Journal of Theoretical Physics | Year: 2014

We investigate spin squeezing and the mean quantum Fisher information per particle χ 2 for mixed Hamiltonian model. By adopting frozen-spin approximation, we first derive a analytical expression of spin squeezing parameter ξ 2 and then numerically calculate ξ 2 and χ 2. It is shown that most of the time the spin squeezing appears alternatively in the x and y directions, but it cannot appear simultaneously in the two directions. It is also shown that the smaller external field strength induces better entanglement and larger period. © 2013 Springer Science+Business Media New York.


Deng J.-H.,Beijing Normal University | Zheng R.-T.,Beijing Normal University | Zhao Y.,Nanchang University | Cheng G.-A.,Beijing Normal University
ACS Nano | Year: 2012

The carbon nanotube (CNT) and graphene hybrid is an attractive candidate for field emission (FE) because of its unique properties, such as high conductivity, large aspect ratio of CNT, and numerous sharp edges of graphene. We report here a vapor-solid growth of few-layer graphene (FLG, less than 10 layers) on CNTs (FLG/CNT) and Si wafers using a radio frequency sputtering deposition system. Based on SEM, TEM, and Raman spectrum analyses, a defect nucleation mechanism of the FLG growth was proposed. The FE measurements indicate that the FLG/CNT hybrids have low turn-on (0.956 V/μm) and threshold fields (1.497 V/μm), large field enhancement factor (∼4398), and good stability. Excellent FE properties of the FLG/CNT hybrids make them attractive candidates as high-performance field emitters. © 2012 American Chemical Society.


Tang X.-S.,Wuhan University | Li D.-Q.,Wuhan University | Zhou C.-B.,Wuhan University | Zhou C.-B.,Nanchang University | Phoon K.-K.,National University of Singapore
Structural Safety | Year: 2015

Slope reliability under incomplete probability information is a challenging problem. In this study, three copula-based approaches are proposed to evaluate slope reliability under incomplete probability information. The Nataf distribution and copula models for characterizing the bivariate distribution of shear strength parameters are briefly introduced. Then, both global and local dispersion factors are defined to characterize the dispersion in probability of slope failure. Two illustrative examples are presented to demonstrate the validity of the proposed approaches. The results indicate that the probabilities of slope failure associated with different copulas differ considerably. The commonly used Nataf distribution or Gaussian copula produces only one of the various possible solutions of probability of slope failure. The probability of slope failure under incomplete probability information exhibits large dispersion. Both global and local dispersion factors increase with decreasing probability of slope failure, especially for small coefficients of variation and strongly negative correlations underlying shear strength parameters. The proposed three copula-based approaches can effectively reduce the dispersion in probability of slope failure and significantly improve the estimate of probability of slope failure. In comparison with the Nataf distribution, the copula-based approaches result in a more reasonable estimate of slope reliability. © 2014 Elsevier Ltd.


Ouyang G.,Yanshan University | Li J.,University of Sheffield | Li J.,Nanchang University | Liu X.,Peking University | And 2 more authors.
Epilepsy Research | Year: 2013

Understanding the transition of brain activities towards an absence seizure, called pre-epileptic seizure, is a challenge. In this study, multiscale permutation entropy (MPE) is proposed to describe dynamical characteristics of electroencephalograph (EEG) recordings on different absence seizure states. The classification ability of the MPE measures using linear discriminant analysis is evaluated by a series of experiments. Compared to a traditional multiscale entropy method with 86.1% as its classification accuracy, the classification rate of MPE is 90.6%. Experimental results demonstrate there is a reduction of permutation entropy of EEG from the seizure-free state to the seizure state. Moreover, it is indicated that the dynamical characteristics of EEG data with MPE can identify the differences among seizure-free, pre-seizure and seizure states. This also supports the view that EEG has a detectable change prior to an absence seizure. © 2012 Elsevier B.V.


Zhu T.,Beijing University of Posts and Telecommunications | Wang B.,Beijing University of Posts and Telecommunications | Wu B.,Beijing University of Posts and Telecommunications | Zhu C.,Nanchang University
Information Sciences | Year: 2014

Information flows in a network where individuals influence each other. In this paper, we study the influence maximization problem of finding a small subset of nodes in a social network that could maximize the spread of influence. We propose a novel information diffusion model CTMC-ICM, which introduces the theory of Continuous-Time Markov Chain (CTMC) into the Independent Cascade Model (ICM). Furthermore, we propose a new ranking metric named SpreadRank generalized by the new information propagation model CTMC-ICM. We experimentally demonstrate the new ranking method that can, in general, extract nontrivial nodes as an influential node set that maximizes the spread of information in a social network and is more efficient than a distance-based centrality. © 2014 Elsevier Inc. All rights reserved.


Kuang X.-M.,Nanchang University | Li W.-J.,Beijing Normal University | Ling Y.,Nanchang University
Classical and Quantum Gravity | Year: 2012

We construct a holographic p-wave superconductor model in the framework of quasi-topological gravity in the probe limit. The relation between the critical temperature and the coupling parameters of higher curvature terms is investigated. The numerical results for conductivity are presented as well. It turns out that our data fit the Drude model very well in the low-frequency limit, and the values of dc conductivity as well as the relaxation time are obtained numerically. © 2012 IOP Publishing Ltd.


Wu J.-P.,Beijing Normal University | Ling Y.,Nanchang University
Journal of Cosmology and Astroparticle Physics | Year: 2010

In this paper we investigate the scalar mode of first-order metric perturbations over spatially flat FRW spacetime when the holonomy correction is taken into account in the semi-classical framework of loop quantum cosmology. By means of the Hamiltonian derivation, the cosmological perturbation equations is obtained in longitudinal gauge. It turns out that in the presence of metric perturbation the holonomy effects influence both background and perturbations, and contribute the non-trivial terms Sh1 and Sh2 in the cosmological perturbation equations. © 2010 IOP Publishing Ltd and SISSA.


Deng J.-H.,Beijing Normal University | Zheng R.-T.,Beijing Normal University | Yang Y.-M.,Beijing Normal University | Zhao Y.,Nanchang University | Cheng G.-A.,Beijing Normal University
Carbon | Year: 2012

The growth of few-layer graphene (FLG) on carbon nanotubes (CNTs) was realized by using radio frequency hydrogen plasma sputtering deposition. A defect nucleation mechanism and a two dimensional growth model of the FLG were proposed, and field emission characteristics of these FLG-CNT hybrids were studied. They show excellent field emission properties, with a low turn-on electric field (0.98 V/μm) and threshold field (1.51 V/μm), large field enhancement factor (∼3980) and good stability behavior, which are much better than those of the as-grown CNT arrays. The sharp edges and the low work function of the hybrids are believed to be responsible for the improved field emission properties. © 2012 Elsevier Ltd. All rights reserved.


Hu C.-S.,Nanchang University | Wu Q.-H.,Nanchang University | Hu D.-Y.,Peking University
Journal of Thoracic Disease | Year: 2014

Objectives: To report and name firstly that there are cardiovascular disease (CVD), diabetes mellitus (DM) and cancers (CDC) strips; and disclose their mechanisms, classifications, and clinical significances. Study design: Narrative and systematic review study and interpretive analysis. Methods: Data sources and study selection: to collect and present related evidences on CDC strips from evidence-based, open-access, both Chinese- and English-language literatures in recent 10 years on clinical trials from PubMed according to keywords "CVD, DM and cancers" as well as authors' extensive clinical experience with the treatment of more than fifty thousands of patients with CVD, diabetes and cancers over the past decades, and analyze their related mechanisms and categories which based on authors' previous works. Data extraction: data were mainly extracted from 48 articles which are listed in the reference section of this review. Qualitative, quantitative and mixed data were included, narratively and systematically reviewed. Results: With several conceptual and technical breakthrough, authors present related evidences on CDC strips, these are, CVD and DM, DM and cancers, cancers and CVD linked, respectively; And "Bad SEED" +/- "bad soil" theory or doctrine may explain this phenomenon due to "internal environmental injure, abnormal or unbalance" in human body resulting from the role of risk factors (RFs) related multi-pathways and multitargets, which including organ & tissue (e.g., vascular-specific), cell and gene-based mechanisms. Their classifications include main strips/type B, and Branches/type A as showed by tables and figures in this article. Conclusions: There are CDC strips and related mechanisms and classifications. CDC strips may help us to understand, prevent, and control related common non-communicable diseases (NCDs) as well as these high risk strips. © Pioneer Bioscience Publishing Company.


Li C.-X.,Kunming University of Science and Technology | Li C.-X.,Chinese Academy of Geological Sciences | Duan Y.-H.,Kunming University of Science and Technology | Hu W.-C.,Nanchang University
Journal of Alloys and Compounds | Year: 2015

The density-functional theory with the generalized gradient approximation was performed to investigate the structural properties, phase stability, electronic structure, elastic properties, and optical properties of selected Ca5(PO3)4F (FA), Ca5(PO3)4Cl (ClA) and Ca5(PO3)4Br (BrA). Results of formation enthalpies show that FA is regarded as the most stable one in these apatites. The electronic structures including band structure, density of states and Mulliken analysis have been discussed. The predicted elastic moduli results indicate that the degree of elastic anisotropy is ordered as follows BrA > ClA > FA. By using the Clarke's model and Cahill's model, the thermal conductivities and the anisotropy in thermal conductivity have also been analyzed. Optic properties results indicate that the refractive indexes n for FA, ClA and BrA are 1.17, 1.19 and 1.21, respectively. © 2014 Elsevier B.V. All rights reserved.


Ling Y.,Nanchang University | Wu J.-P.,Beijing Normal University
Journal of Cosmology and Astroparticle Physics | Year: 2010

Recently Verlinde proposed that gravity is an entropie force caused by information changes when a material body moves away from the holographic screen. In this note we apply this argument to brane cosmology, and show that the cosmological equation can be derived from this holographic scenario. © 2010 IOP Publishing Ltd and SISSA.


Liu J.-T.,Nanchang University | Liu N.-H.,Nanchang University | Li J.,Xiamen University | Jing Li X.,Fujian Normal University | Huang J.-H.,Nanchang University
Applied Physics Letters | Year: 2012

The optical absorption of graphene layers prepared on top of a one-dimensional photonic crystal (1DPC) is investigated theoretically. The absorption of graphene with 1DPC is enhanced greatly over a broad spectral range due to photon localization. The absorption of graphene can also be tuned by varying either the incident angle or the distance between the graphene and the 1DPC. © 2012 American Institute of Physics.


Zhao S.-C.,Nanchang University | Liu Z.-D.,Nanchang University | Wu Q.-X.,Hainan University
Optics Communications | Year: 2010

This paper attempts a probe into negative refraction without absorption by means of an incoherent pump field and a strong coherent field coupling the dense four-level atomic system. With the application of the incoherent pump field to manipulate the populations in atomic levels and the variable strong coherent field to create quantum coherence, the constraint condition of two equal transition frequencies responding to the probe field in the atomic system isn't required. And these lead to the propagation transparency and strong magnetic response of the probe field, left-handedness with vanishing absorption in the atomic system. However, an excessive coherent field intensity would increase the absorption. © 2010 Elsevier B.V. All rights reserved.


Zhang C.,Shandong University of Science and Technology | Guo Z.,North China University of Water Conservancy and Electric Power | Liu Y.,Shandong University of Science and Technology | Cong X.,Shandong University of Science and Technology | Peng D.,Nanchang University
Renewable and Sustainable Energy Reviews | Year: 2014

With the attractive advantages of high efficiency and environmental friendliness, the ground-coupled heat pump system (GCHPs) has been widely applied in various buildings around the world in recent years, and the knowledge of underground thermal properties is a prerequisite for correct design of GCHPs. As an effective way to obtain thermal properties, thermal response test (TRT) has become a routine tool for the design of larger plants with ground heat exchangers (GHEs). This paper summarizes the specifications for in situ TRT, including test setup, minimum duration, heat input rate etc., analyzes the mathematical models currently available for GHE in TRT, and compares the parameter identification methods which are necessary to obtain reasonable properties according to in situ TRT data. In addition, this paper discusses and summarizes the shortages and imperfects of the current research on TRT and gives some recommendations for future work. © 2014 Published by Elsevier Ltd. All rights reserved.


Liu K.,Zhejiang University | Shen L.,Nanchang University | He S.,Zhejiang University | He S.,KTH Royal Institute of Technology
Optics Letters | Year: 2012

We demonstrate that one-way electromagnetic modes could be sustained by the edge of a gyromagnetic photonic crystal slab of triangular lattice under an external dc magnetic field. The applied magnetic field breaks the time-reversal symmetry of the three-dimensional system, and thus the original degeneracy point in k space, at which two dispersion surfaces intersect, is lifted, resulting in a photonic band gap below the light cone. At this band gap, the one-way mode is localized horizontally to the slab edge, while confined by the index contrast in the vertical direction. © 2012 Optical Society of America.


Zhu T.,Beijing University of Posts and Telecommunications | Wang B.,Beijing University of Posts and Telecommunications | Wu B.,Beijing University of Posts and Telecommunications | Zhu C.,Nanchang University
Expert Systems with Applications | Year: 2011

Understanding the individual behavior has shown to be of paramount importance to the triumph of the telecommunication operators to retain customers, enhance their purchasing capacity, and predict the churn rate. Different behavior patterns can be observed for different groups of users. Hence, there is an interesting problem posted in telecommunication network that how to define the users' role according to their behavior patterns. Traditionally, user behavior characterization methods generally based on their call detail record (CDR), which are user's individual features, are not appropriate to identify the role in network. In this paper, we develop a new methodology for identifying users' role based on their behaviors in telecommunication network using the social features instead of their individual features. Experiments have tested on synthetic data and large real datasets, and reveal good results on both of them. Finally, the methodology is not only limited to call graphs but also apply to other networks for role defining. © 2010 Elsevier Ltd. All rights reserved.


Hu W.-C.,Nanchang University | Liu Y.,Nanchang University | Li D.-J.,Shanghai JiaoTong University | Zeng X.-Q.,Shanghai JiaoTong University | Xu C.-S.,Nanchang University
Computational Materials Science | Year: 2014

Structural, mechanical and electronic properties of Laves phases Al 2Zr and Al2Hf with C14-type structure were investigated by performing the first-principle calculations. The calculated equilibrium structural parameters agree closely with available experimental values. Mechanical parameters, such as bulk modulus B, shear modulus G, Young's modulus E and the Poisson's ratio ν are determined within the framework of the Voigt-Reuss-Hill approximation. We show that both Al2Zr and Al 2Hf are mechanically stable and brittle with the estimation from the Poisson's ratio and the B/G relationship. The mechanical anisotropies of the two phases are discussed in detail using several different anisotropic indexes and factors, showing that the anisotropy degree of Al2Hf is slightly larger than that of Al2Zr. In addition, the Debye temperature and anisotropic sound velocity of the two phases are predicted. Finally, the electronic structures are determined to reveal the bonding characteristics of both phases. These results are helpful to deepen the understanding of the physical and chemical nature of C14-type Al2Zr and Al2Hf. © 2013 Elsevier Ltd. All rights reserved.


Wu J.J.,Chung Hua University | Hou D.J.,National Taiwan Normal University | Liu K.,Zhejiang University | Shen L.,Nanchang University | And 4 more authors.
Optics Express | Year: 2014

We apply the concept of spoof surface plasmon polaritons (SPPs) to the design of differential microstrip lines by introducing periodic subwavelength corrugations on their edges. The dispersion relation and field distribution of those lines are analyzed numerically. And then through designing practical coupling circuits, we found that compared with conventional differential microstrip lines, the electromagnetic field can be strongly confined inside the grooves of the corrugated microstrip lines, sothe crosstalk between the differential pair and the adjacent microstrip lines is greatly reduced, and the conversion from the differential signal to the common mode signal can also be effectively suppressed. The propagation length of those lines is also very long in a wide band. Moreover, the experimental results in time domain demonstrate those lines perform very well in high-speed circuit. Therefore, those novel kinds of spoof SPPs based differential microstrip lines can be widely utilized in high-density microwave circuits and guarantee signal integrity in high-speed systems. © 2014 Optical Society of America


Zhou N.,Nanchang University | Zhou N.,Beijing University of Posts and Telecommunications | Zhang A.,Nanchang University | Zheng F.,Nanchang University | And 2 more authors.
Optics and Laser Technology | Year: 2014

The existing ways to encrypt images based on compressive sensing usually treat the whole measurement matrix as the key, which renders the key too large to distribute and memorize or store. To solve this problem, a new image compression-encryption hybrid algorithm is proposed to realize compression and encryption simultaneously, where the key is easily distributed, stored or memorized. The input image is divided into 4 blocks to compress and encrypt, then the pixels of the two adjacent blocks are exchanged randomly by random matrices. The measurement matrices in compressive sensing are constructed by utilizing the circulant matrices and controlling the original row vectors of the circulant matrices with logistic map. And the random matrices used in random pixel exchanging are bound with the measurement matrices. Simulation results verify the effectiveness, security of the proposed algorithm and the acceptable compression performance. © 2014 Elsevier Ltd.


Liu Y.,Nanchang University | Hu W.-C.,Nanchang University | Li D.-J.,Shanghai JiaoTong University | Zeng X.-Q.,Shanghai JiaoTong University | And 2 more authors.
Intermetallics | Year: 2012

The effects of pressure on the structural, electronic properties and ionic configuration of MgCu 2 Laves phase were investigated by means of the first-principles method based on the density functional theory with generalized gradient approximation. The results for the equilibrium lattice constants are in good agreement with the previous experimental and other theoretical results. The elastic properties including the isotropic bulk modulus B, shear modulus G, Young modulus E and Poisson's ratio ν of the cubic C15-type structure MgCu 2 were determined by using the Voigt-Reuss-Hill averaging scheme. The results show that the MgCu 2 Laves phase is ductile according to the analysis of G/B and Cauchy pressure. The Debye temperatures obtained from the elastic stiffness constants increase with increasing pressure. Finally, the pressure-dependent behavior of density of states and ionic configuration are successfully calculated and discussed. © 2012 Elsevier Ltd. All rights reserved.


Huang X.,Nanchang University | Aguilar Z.P.,Zystein LLC | Li H.,Nanchang University | Lai W.,Nanchang University | And 3 more authors.
Analytical Chemistry | Year: 2013

A Ru(phen)3 2+-doped silica fluorescent nanoparticle (FN)-based immunochromatographic test strip (ICTS) sensor was developed for rapid, high sensitivity, easy to use, and low cost quantitative detection of enrofloxacin (ENR) residues in chicken meat. The fluorescence signal intensity of the FNs at the test line (FIT) and control line (FIC) was determined with a prototype of a portable fluorescent strip reader. Unique properties of Ru(phen)3 2+ doped silica nanoparticles (e.g., large Stokes shift, high emission quantum yield, and long fluorescence lifetime) were combined with the advantages of ICTS and an easy to make portable fluorescent strip reader. The signal was based on FIT/FIC ratio to effectively eliminate strip to strip variation and matrix effects. Various parameters that influenced the strip were investigated and optimized. Quantitative ENR detection with the FNs ICTS sensor using 80 μL sample took only 20 min, which is faster than the commercial ELISA kit (that took 90 min). The linear range of detection in chicken extract was established at 0.025-3.500 ng/mL with a half maximal inhibitory concentration at 0.22 ± 0.02 ng/mL. Using the optimized parameters, the limit of detection (LOD) for ENR using the FNs ICTS sensor was recorded at 0.02 ng/mL in chicken extract. This corresponds to 0.12 μg/kg chicken meat which is two (2) orders of magnitude better that the maximum residue limits (MRLs) imposed in Japan (10 μg/kg) and three (3) orders of magnitude better than those imposed in China. The intra- and inter-assay coefficient of variations (CVs) were 6.04% and 12.96% at 0.5 ng/mL, 6.92% and 12.61% at 1.0 ng/mL, and 6.66% and 11.88% at 2.0 ng/mL in chicken extract, respectively. The recoveries using the new FNs ICTS sensor from fifty (50) ENR-spiked chicken samples showed a highly significant correlation (R 2 = 0.9693) with the commercial enzyme-linked immunosorbent assay (ELISA) kit. The new FNs ICTS sensor is a simple, rapid, sensitive, accurate, and inexpensive quantitative detection of ENR residues in chicken meat and extracts. © 2013 American Chemical Society.


Wu J.,Nanchang University | Luo X.,Nanchang University | Zhou N.,Nanchang University | Zhou N.,Beijing University of Posts and Telecommunications
Optics and Laser Technology | Year: 2013

With the help of spectrum truncation, an encryption and decryption method for four images is proposed based on chaos and the multiple-order discrete fractional Fourier transform (MODFrFT). The spectra of four images gotten by the discrete cosine transform (DCT) are truncated and combined into a single array sequentially encrypted by the MODFrFT. The resulting performance is better than other similar algorithms in literature where the spectrum truncation is done in discrete Fourier transform(DFT) domain. Furthermore, the complex mode is introduced to reduce the data loss. The combined spectrum array is encoded with the MODFrFT twice and chaos is introduced to scramble the phases of complex matrix before each MODFrFT. The technology of rate-distortion control is introduced to balance the qualities of the decrypted images. Numerical simulations demonstrate the effectiveness and the security of the proposed four-image encryption algorithm. © 2012 Elsevier Ltd.


Zhou Z.,Shanghai JiaoTong University | Ji Z.,Shanghai JiaoTong University | Wang Y.,Shanghai JiaoTong University | Li J.,Nanchang University | And 3 more authors.
Gastroenterology | Year: 2014

Background & Aims Little is known about factors that promote gastric carcinogenesis. We analyzed multiple microarray data sets for messenger RNAs (mRNAs) that were increased significantly in human gastric tumor samples, compared with the adjacent normal gastric tissue. We found expression of tripartite motif 59 (TRIM59), which encodes a putative ubiquitin ligase, to be increased, and investigated its effects in gastric cancer cell lines.Methods We analyzed microarray data sets from the Oncomine database. We used quantitative polymerase chain reaction and immunoblotting to measure levels of TRIM59 mRNA and protein in 50 human gastric cancer and paired normal tissues, obtained from Renji Hospital and the First Affiliated Hospital of Nanchang University, in China. We also measured protein levels in the gastric epithelial cell line GES-1; the cancer cell lines MKN45, AGS, SGC7901, BGC823, Snu5, N87, and Snu1; and in tissue arrays of 108 human gastric tumors. TRIM59 was knocked down and overexpressed in gastric cancer cell lines, and the effects on proliferation, clone formation, migration, and growth of xenograft tumors in nude mice were assessed. TRIM59-related signaling pathways were examined by immunoblotting and quantitative polymerase chain reaction. We analyzed interactions among TRIM59, P53, and ubiquitin in immunoprecipitation studies.Results Levels of TRIM59 mRNA and protein were increased significantly in gastric tumors compared with nontumor tissues; increased levels were associated with advanced tumor stage and shorter patient survival times. TRIM59 knockdown reduced proliferation, clone formation, and migration of gastric cancer cell lines, as well as growth of xenograft tumors in nude mice; overexpression of TRIM59 had the opposite effects. TRIM59 interacted physically with P53, increasing its ubiquitination and degradation. Increased levels of TRIM59 in human gastric tumors correlated with reduced expression of P53 target genes.Conclusions The putative ubiquitin ligase TRIM59 is up-regulated in human gastric tumors compared with nontumor tissues. Levels of TRIM59 correlate with tumor progression and patient survival times. TRIM59 interacts with P53, promoting its ubiquitination and degradation, and TRIM59 might promote gastric carcinogenesis via this mechanism. © 2014 by the AGA Institute.


Wang W.,Nanchang University | Hao H.,Chongqing University of Posts and Telecommunications
Chinese Optics Letters | Year: 2010

Antireflection coatings are very important for high-efficiency solar cells. An ideal antireflection structure should lead to zero reflection loss on solar-cell surfaces over an extended solar spectral range for all angles of incidence. Based on the optical thin-film theory, two multilayer structures are adopted as initial stacks in two conditions, respectively. With the aid of a conjugate graduate optimized method, the incident angles of antireflection coating are 0°-60°, the working wavelength range is 400-1200 nm, and two broadband and wide-angle antireflections are designed. The results show that they can all evidently reduce residual reflection. © 2010 Chinese Optics Letters.


Yang L.,Nanchang University | Kuang H.,Nanchang University | Zhang W.,Nanchang University | Aguilar Z.P.,Zystein LLC. | And 4 more authors.
Nanoscale | Year: 2015

In spite of the immense benefits from iron oxide magnetic nanoparticles (IOMNs), there is scanty information regarding their metabolic activities and toxicity in vivo. In this study, we investigated the size dependent in vivo biodistribution, toxicokinetics, and toxicity and gene expression changes of various sizes of carboxyl coated IOMNs (diameters of 10, 20, 30, and 40 nm). Our findings demonstrated that the various sizes of IOMNs accumulated primarily in the liver and spleen on the first day post-injection. Interestingly, size dependent biodistribution and transport were observed: the smallest IOMNs (10 nm) showed the highest uptake by the liver, whereas the largest IOMNs (40 nm) showed the highest uptake by the spleen. Moreover, the IOMNs with the smallest size (10 nm) were cleared faster from the liver and kidneys, but more readily entered the brain and the uterus. IOMNs with the largest size (40 nm) accumulated more readily but were easily eliminated in the spleen. However, the level of iron in the heart decreased in all IOMN exposed groups. In addition, blood biochemistry, hematological analyses and histological examination demonstrated that there was no apparent acute toxicity caused by IOMNs in mice. However, smaller IOMNs (10 nm and 20 nm) more effectively changed the expression level of sensitive genes related to oxidant stress, iron transport, metabolic process, apoptosis, and others. This journal is © The Royal Society of Chemistry.


Chen H.,Nanchang University | Li L.,General Hospital of Jinan Military Command | Wang S.,Affiliated Hospital of Academy of Military Medical science | Lei Y.,Nanchang University | And 5 more authors.
Oncotarget | Year: 2014

miR-126 is an endothelial-specific microRNA essential for governing vascular integrity and angiogenesis. Its role in tumor angiogenesis of gastric cancer (GC) is unclear. This study aimed at determining the role of miR-126 in GC angiogenesis. Down-regulation of miR-126 was found to inversely correlate with an increased microvessel density (MVD) and vascular endothelial growth factor A (VEGF-A) expression in gastric cancer tissues. Bioinformatics analysis and luciferase reporter assay revealed that miR-126 directly targeted the 3'-untranslated region (3'-UTR) of VEGF-A mRNA. In addition, the restoration of miR-126 expression by lentivirusmiR- 126 (Lenti-miR-126) transfection obviously reduced the expression of VEGF-A and the activition of its downstream genes, Akt, mTOR and Erk1/2 in gastric cancer cell lines SGC-7901, MKN-28 and MKN-45. In contrast, the down-regulation of miR-126 expression by lentivirus-anti-miR-126 (Lenti-anti-miR-126) transfection obviously up-regulated the expression of VEGF-A and its downstream signaling pathways. In vivo xenograft mice model experiments clarified the down-regulation of VEGF-A and MVD as well as inhibition of tumor growth by up-regulation of miR-126. Overall, the results from our study suggested that miR-126 could suppress tumor growth and tumor angiogenesis of GC through VEGF-A signaling, and it is a novel potential therapeutic target for GC.


Song X.,Linyi Normal University | Xu S.,Linyi Normal University | Chen L.,CAS Yantai Institute of Coastal Zone Research | Wei Y.,China Pharmaceutical University | Xiong H.,Nanchang University
Journal of Applied Polymer Science | Year: 2014

Food security as a world issue has received increasing concern, and therefore, effective analytical methods and technologies have been continuously developed. However, the matrix complexity of food samples and the trace/ultratrace presence of targeted analytes require highly efficient cleanup and enrichment materials and procedures. Molecularly imprinted polymers (MIPs) with specific recognition abilities as versatile materials are being increasingly developed for diverse species in various fields, especially in food analysis. In this review, we mainly summarize the recent advances in MIPs used for food matrices over the last 5 years. We focus on toxic and harmful substances, such as pesticide/drug residues, heavy metals, microbial toxins, and additives. Some relatively new preparation methods involving surface imprinting, composites, and stimuli responsiveness are reviewed. Different MIPs as solid-phase adsorbents in solid-phase extraction, solid-phase microextraction, matrix solid-phase dispersion, stirring bar sorptive extraction, and magnetic material extraction and as stationary phases in chromatographic separation for foodstuff have been comprehensively summarized. MIP-based biomimetic sensing and enzymelike catalysis receive special attention. Moreover, some limitations and comparisons related to MIPs performances are also discussed. Finally, some significant attempts to further promote MIP properties and applications to ensure food safety are discussed. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40766. © 2014 Wiley Periodicals, Inc.


Liu Y.,Nanchang University | Xie Y.,Eastern Michigan University
Energy Economics | Year: 2013

This paper provides a comprehensive nonlinear analysis of asymmetric adjustment of the dynamic relationship between energy intensity and urbanization using the time series data of 1978-2010 in China at both the national and the macro regional levels. Two sets of unit root tests are applied first to check whether the variables of energy intensity and urbanization are heterogeneous with and without structural breaks, respectively. Cointegration tests are then applied to determine whether long-term relationships are present when structural breaks are or aren't accounted for. The asymmetric adjustment analyses are finally applied to examine how the variables in time-series respond to the deviations from the equilibrium through an integration of threshold vector error correction model (TVECM), and to examine how they respond to the co-existence of TVECM and the threshold. The findings of the systematic tests and analyses confirm the existence of non-linear causal relationships between the energy intensity and urbanization in China. Energy intensity has an asymmetric adjusting effect to urbanization in the whole country and the Central belt. An asymmetric adjustment running from the energy intensity to urbanization is also identified when structural breaks are accounted for, which occurred in 1988, 1993, 2000 and 2006. Furthermore, the two-regime threshold vector error correction model shows that the adjustment process of the energy intensity toward equilibrium is highly persistent when a threshold is reached. There exists a mean-reverting behavior, indicating that the energy intensity grows faster than the urbanization in China when the threshold is reached. © 2012 Elsevier B.V..


Peng D.,Nanchang University | Zhang X.,Nanjing Southeast University
Applied Energy | Year: 2011

Solar collector/regenerator (C/R) using liquid desiccant combines solar photothermic transformation and regeneration of liquid desiccant together, effectively achieving the regeneration for solar energy-driven liquid desiccant cooling systems. In this paper a group of dimensionless heat and mass transfer equations describing the heat and mass transfer process in the solar C/R were obtained by introducing total temperature difference (ΔT0) and dimensionless heat loss coefficient (hz). For the sake of predicting the heat loss of air stream and simplifying calculation, the models of dimensionless air temperature (θa) and equilibrium humidity ratio (YeL) along with the height of solar C/R were put forward. An analytical solution was formed by two differential equations on the dimensionless heat and mass transfer driving potentials and the heat and mass conservation equations. Compared with the numerical simulation results, the analytical results on the outlet parameters of solar C/R have great precision with different Lewis factor Le, total temperature difference ΔT0 and air-to salt mass flow rate ratio ASMR. Simultaneously, the effects of above variables on the regeneration performance were analyzed. Lastly, by comparing with the experimental data, the analytical calculation results can agree well with the experimental results validating the analytical model is an ideal way for predicting the performance of the solar C/R. © 2011 Elsevier Ltd.


Peng D.,Nanchang University | Zhang X.,Nanjing Southeast University
Energy | Year: 2011

Solar liquid collector/regenerator combines solar photothermic transformation and liquid regeneration together for solar energy-driven liquid desiccant cooling systems. A group of dimensionless heat and mass transfer equations describing the heat and mass transfer process in the solar C/R(Collector/Regenerator) were obtained by introducing total temperature difference (ΔT0) and dimensionless heat loss coefficient (hz). The increment of solution concentration ΔC was increased 2.9-3.5%/°C and 5.3%/°C for increasing unit inlet temperature of air stream and solution respectively and increased about 6.2%/(g/kg) and 0.9%/(g/kg) for decreasing unit inlet humidity ratio of air and solution concentration. Besides, the increasing number of heat transfer units (NTU), air-to-salt mass flow rate ratio (ASMR) and total temperature difference (ΔT0) can increase the performance of solution regeneration significantly. Compared to parallel flow regeneration, the performance of counterflow regeneration was increased about 10%. © 2011 Elsevier Ltd.


Cao Q.-Y.,Nanchang University | Li M.,Nanchang University | Zhou L.,Nanchang University | Wang Z.-W.,Shandong University of Science and Technology
RSC Advances | Year: 2014

Two new 2,2′:6′,2′′-terpyridine receptors bearing phenol groups, 1 and 2, have been prepared by coupling 4′-(4-aminophenyl)- 2,2′:6′,2′′-terpyridine with salicylaldehyde or 4-hydroxybenzaldehyde. Both receptors show colorimetric and fluorescent response to F- over other anions in organic solvent. In addition, a strong intramolecular N⋯H-O hydrogen bond was found in 1, which is attributed to its weaker binding ability to F- than that of 2, and an Excited-State Intramolecular Proton Transfer (ESIPT) emission quenching process. © 2013 The Royal Society of Chemistry.


Tang Q.,Linköping University | Tang Q.,Nanchang University | Solin N.,Linköping University | Lu J.,Linköping University | Inganas O.,Linköping University
Chemical Communications | Year: 2010

Herein we report a method to functionalize in vitro grown insulin amyloid fibrils with various inorganic materials. The counterion of the positively charged amyloid fibril is exchanged with anions from various salts; subsequent addition of appropriate cations results in functionalization of the amyloid fibril. We demonstrate the formation of apatite and platinum complex structures ordered by the amyloid template. © 2010 The Royal Society of Chemistry.


Deng X.-H.,Nanchang University | Deng X.-H.,Nanjing Southeast University | Liu J.-T.,Nanchang University | Yuan J.,Nanchang University | And 2 more authors.
Optics Express | Year: 2014

We investigate THz absorption properties of graphene-based heterostructures by using characteristics matrix method based on conductivity. We demonstrate that the proposed structure can lead to perfect THz absorption because of strong photon localization in the defect layer of the heterostructure. The THz absorption may be tuned continuously from 0 to 100% by controlling the chemical potential through a gate voltage. By adjusting the incident angle or the period number of the two PCs with respect to the graphene layer, one can tailor the maximum THz absorption value. The position of the THz absorption peaks can be tuned by changing either the center wavelength or the thicknesses ratio of the layers constituting the heterostructure. Our proposal may have potentially important applications in optoelectronic devices. © 2014 Optical Society of America.


Peng H.,Nanchang University | Yang A.,Nanchang University | Xiong J.,Jiangxi Province Agro Environmental Monitoring Station
Carbohydrate Polymers | Year: 2013

A green, straightforward, microwave-assisted method of synthesizing silver nanoparticles in an aqueous medium was developed using bamboo hemicelluloses as stabilizer and glucose as reducer. The effects of irradiation time as well as initial concentrations of hemicelluloses, glucose, and AgNO3 on the silver nanoparticle formation were studied. The silver nanoparticles were characterized by UV-vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The results indicated the formation of spherical, nanometer-sized particles. The reaction parameters significantly affected the formation rate, size and distribution of the silver nanoparticles. The average particle size was 8.3-14.8 nm based on TEM analysis. XRD analysis revealed that the particles calcined at 300 °C were face-centered cubic. XPS characterization showed that silver Ag(0) coexisted with silver Ag(I). The synthesis process of silver nanoparticles was rapid and eco-friendly. © 2012 Elsevier Ltd.


Zhang C.,Shandong University of Science and Technology | Chen P.,Shandong University of Science and Technology | Liu Y.,Shandong University of Science and Technology | Sun S.,Shandong University of Science and Technology | Peng D.,Nanchang University
Renewable Energy | Year: 2015

Thermal performance of vertical U-pipe borehole heat exchanger (BHE) is an important research subject for the design and application of ground-coupled heat pump system (GCHPs). This paper presents an improved evaluation method for thermal performance of BHE based on analytical solution model, which is validated by comparing with duct storage system (DST) model and field experiment. Using the evaluation method, impacts of inlet fluid temperature, fluid flow rate and borehole depth on thermal performance of two types of U-pipe BHEs are studied. The study provides a good alternative of the experimental method for thermal performance test (TPT) and a useful thermal performance evaluation tool for BHEs in GCHPs. © 2014 Elsevier Ltd.


Zhao B.,Tsinghua University | Wang Q.,Tsinghua University | Wang Q.,CAS Institute of Zoology | Du J.,Tsinghua University | And 3 more authors.
Cell Research | Year: 2012

Protein that interacts with C kinase 1 (PICK1) is a critical mediator of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking in neural synapses. However, its ubiquitous expression suggests that it may have other non-neural functions. Here we show that PICK1 antagonizes transforming growth factor beta (TGF-β) signaling by targeting TGF-β type I receptor (TβRI) for degradation. Biochemical analyses reveal that PICK1 directly interacts with the C-terminus of TβRI via its PDZ domain and acts as a scaffold protein to enhance the interaction between TβRI and caveolin-1, leading to enhanced lipid raft/caveolae localization. Therefore, PICK1 increases caveolin-mediated endocytosis, ubiquitination and degradation of TβRI. Moreover, a negative correlation between PICK1 expression and TβRI or phospho-Smad2 levels is observed in human breast tumors, indicating that PICK1 may participate in breast cancer development through inhibition of TGF-β signaling. Our findings reveal a non-neural function of PICK1 as an important negative regulator of TGF-β signaling. © 2012 IBCB, SIBS, CAS All rights reserved.


Niu Q.,Xi'an Jiaotong - Liverpool University | Wang X.,Nanchang University | Lu L.-Z.,Guizhou Normal University | Lu L.-Z.,Xiamen University
Asian Journal of Control | Year: 2011

By introducing a relaxation parameter, we derive a relaxed gradient based iterative algorithm for solving Sylvester equations. Theoretical analysis shows that the new method converges under certain assumptions. Comparisons are performed with the original algorithm, and results show that the new method exhibits fast convergence behavior with a wide range of relaxation parameters. © 2010 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society.


Liu Z.,Tsinghua University | Liu Z.,Nanchang University | Yang J.,Tsinghua University | Grey F.,Tsinghua University | And 7 more authors.
Physical Review Letters | Year: 2012

Upon shearing a microscale lithographically defined graphite mesa, the sheared section retracts spontaneously to minimize interface energy. Here, we demonstrate a sixfold symmetry of the self-retraction and provide a first experimental estimate of the frictional force involved, as direct evidence that the self-retraction is due to superlubricity, where ultralow friction occurs between incommensurate surfaces. The effect is remarkable because it occurs reproducibly under ambient conditions and over a contact area of up to 10×10μm2, more than 7 orders of magnitude larger than previous scanning-probe-based studies of superlubricity in graphite. By analyzing the sheared interface, we show how the grain structure of highly oriented pyrolitic graphite determines the probability of self-retraction. Our results demonstrate that such self-retraction provides a novel probe of superlubricity, and the robustness of the phenomenon opens the way for practical applications of superlubricity in micromechanical systems. © 2012 American Physical Society.


Peng D.,Nanchang University | Zhang X.,Nanjing Southeast University
Energy | Year: 2016

A regenerator is one of the main components of a solar liquid desiccant cooling system. The regenerator used in this application is a forced counter flow type solar collector/regenerator(C/R). Experimental results of the tests indicate that there occurs a maximum value for regeneration efficiency at some air flow-rate. The regeneration efficiency of solution at ambient temperature decreases with the increase in solution flow-rate, instead of increasing at moderate temperature. The inlet temperature of solution has great influence on the regeneration efficiency and a higher concentration of solution is accompanied by a lower efficiency of regeneration. Compared with the regeneration efficiency at Ya,in = 20 g/kg, the regeneration efficiency was increased by about 40% at Ya,in = 10 g/kg. Higher solar radiation intensity will better regeneration performance of the C/R. Air flow-rate has far more effect on heat and mass coefficients between air and solution than solution flow-rate. The solution inlet temperature and salt concentration have contrary effects on heat and mass transfer coefficients with increase in their values. By Simpson numerical integration, two correlations on heat and mass transfer characteristics were given. Finally, it was concluded that the proposed solar collector/regenerator performs satisfactorily in humid climates of the Southern China. © 2016 Elsevier Ltd


Luo X.G.,Nanjing Southeast University | Liu N.,Anhui Science and Technology University | He J.Z.,Nanchang University
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2013

A Brownian refrigerator with the cold and hot reservoirs alternating along a space coordinate is established. The heat flux couples with the movement of the Brownian particles due to an external force in the spatially asymmetric but periodic potential. After using the Arrhenius factor to describe the behaviors of the forward and backward jumps of the particles, the expressions for coefficient of performance (COP) and cooling rate are derived analytically. Then, through maximizing the product of conversion efficiency and heat flux flowing out, a new upper bound only depending on the temperature ratio of the cold and hot reservoirs is found numerically in the reversible situation, and it is a little larger than the so-called Curzon and Ahlborn COP ÉCA=(1/√1-τ)-1. After considering the irreversible factor owing to the kinetic energy change of the moving particles, we find the optimized COP is smaller than É CA and the external force even does negative work on the Brownian particles when they jump from a cold to hot reservoir. © 2013 American Physical Society.


Zou W.,Nanchang University | He Q.,Nanchang University | He Q.,University Paris Est Creteil | Huang M.,Nanchang University | And 3 more authors.
Journal of the Mechanics and Physics of Solids | Year: 2010

The Eshelby problem consists in determining the strain field of an infinite linearly elastic homogeneous medium due to a uniform eigenstrain prescribed over a subdomain, called inclusion, of the medium. The salient feature of Eshelby's solution for an ellipsoidal inclusion is that the strain tensor field inside the latter is uniform. This uniformity has the important consequence that the solution to the fundamental problem of determination of the strain field in an infinite linearly elastic homogeneous medium containing an embedded ellipsoidal inhomogeneity and subjected to remote uniform loading can be readily deduced from Eshelby's solution for an ellipsoidal inclusion upon imposing appropriate uniform eigenstrains. Based on this result, most of the existing micromechanics schemes dedicated to estimating the effective properties of inhomogeneous materials have been nevertheless applied to a number of materials of practical interest where inhomogeneities are in reality non-ellipsoidal. Aiming to examine the validity of the ellipsoidal approximation of inhomogeneities underlying various micromechanics schemes, we first derive a new boundary integral expression for calculating Eshelby's tensor field (ETF) in the context of two-dimensional isotropic elasticity. The simple and compact structure of the new boundary integral expression leads us to obtain the explicit expressions of ETF and its average for a wide variety of non-elliptical inclusions including arbitrary polygonal ones and those characterized by the finite Laurent series. In light of these new analytical results, we show that: (i) the elliptical approximation to the average of ETF is valid for a convex non-elliptical inclusion but becomes inacceptable for a non-convex non-elliptical inclusion; (ii) in general, the Eshelby tensor field inside a non-elliptical inclusion is quite non-uniform and cannot be replaced by its average; (iii) the substitution of the generalized Eshelby tensor involved in various micromechanics schemes by the average Eshelby tensor for non-elliptical inhomogeneities is in general inadmissible. © 2009 Elsevier Ltd. All rights reserved.


Li D.-Q.,Wuhan University | Jiang S.-H.,Wuhan University | Jiang S.-H.,Nanchang University | Cao Z.-J.,Wuhan University | And 3 more authors.
Engineering Geology | Year: 2015

This paper proposes a multiple response-surface method for slope reliability analysis considering spatially variable soil properties. The scales of fluctuation of soil shear strength parameters are summarized. The effect of theoretical autocorrelation functions (ACFs) on slope reliability is highlighted since the theoretical ACFs are often used to characterize the spatial variability of soil properties due to a limited number of site observation data available. The differences in five theoretical ACFs, namely single exponential, squared exponential, second-order Markov, cosine exponential and binary noise ACFs, are examined. A homogeneous c- ϕ slope and a heterogeneous slope consisting of three soil layers (including a weak layer) are studied to demonstrate the validity of the proposed method and explore the effect of ACFs on the slope reliability. The results indicate that the proposed method provides a practical tool for evaluating the reliability of slopes in spatially variable soils. It can greatly improve the computational efficiency in relatively low-probability analysis and parametric sensitivity analysis. The extended Cholesky decomposition technique can effectively discretize the cross-correlated non-Gaussian random fields of spatially variable soil properties. Among the five selected ACFs, the squared exponential and second-order Markov ACFs might characterize the spatial correlation of soil properties more realistically. The probability of failure associated with the commonly-used single exponential ACF may be underestimated. In general, the difference in the probabilities of failure associated with the five ACFs is minimal. © 2014 Elsevier B.V.


Schaper A.K.,University of Marburg | Hou H.,Nanchang University | Wang M.,Japan National Institute of Materials Science | Bando Y.,Japan National Institute of Materials Science | Golberg D.,Japan National Institute of Materials Science
Carbon | Year: 2011

Carbon nanoscrolls, made of rolled up graphene, are expected to show unique electronic properties different from those of nested multi-wall tubes. Here we report in situ TEM observations and electrical measurements of the transport and breakdown behaviour of catalytically grown, multi-turn monochiral graphene scrolls, 30-65 nm in outer diameter. Generally, the low-bias IV region proved strictly linear Ohmic behaviour, non-linear increase in conductance occurred beyond an applied voltage of ∼0.4 V. Excellent maximum conductance values up to G ∼ 63 G0 and sustainable current-carrying capacities up to J = 8.5 × 108 A/cm2 were found in the most successful samples right before electric breakdown. Inferior values are ascribed to defect-rich or semiconducting scrolls. This study emphasizes the promising nature of carbon nanoscrolls for a number of electronic device applications. © 2011 Elsevier Ltd. All rights reserved.


Liu Y.,Nanchang University | Xie Y.,Eastern Michigan University
Annals of the Association of American Geographers | Year: 2013

China has witnessed rapid economic growth in recent decades, but it increasingly faces the challenges of water shortage and arable land depletion. This article develops a space-time panel filter model (STPFM) to measure the dragging effects of the arable land and available water resources on economic growth in China at both the national and regional levels. Unlike traditional panel models, the STPFM allows us to explicitly account for spatial cross-regional dependence in the data. This is particularly important for two interrelated reasons. First, the aggregated output and its resource factors as well as physical capital and human capital have been shown to be spatially correlated and cross-regionally dependent. Second, STPFM can potentially mitigate the bias of variable omissions by taking into account spatial dependence and diffusion. The results show that the aggregate drag of arable land and available water resources reduces annual economic growth rate by about 1.3 percentage points in China as a whole, and significant differences exist in both disaggregate and aggregate drags over the provinces and regions. Our experiment confirms that the STPFM is an effective technique to quantify joint spatial and temporal dragging effects of natural resources on economic growth. © 2013 Copyright Taylor and Francis Group, LLC.


Dong W.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Journal of Agricultural and Food Chemistry | Year: 2013

Near-infrared spectroscopy (NIRS) calibrations were developed for the discrimination of Chinese hawthorn (Crataegus pinnatifida Bge. var. major) fruit from three geographical regions as well as for the estimation of the total sugar, total acid, total phenolic content, and total antioxidant activity. Principal component analysis (PCA) was used for the discrimination of the fruit on the basis of their geographical origin. Three pattern recognition methods, linear discriminant analysis, partial least-squares-discriminant analysis, and back-propagation artificial neural networks, were applied to classify and compare these samples. Furthermore, three multivariate calibration models based on the first derivative NIR spectroscopy, partial least-squares regression, back-propagation artificial neural networks, and least-squares-support vector machines, were constructed for quantitative analysis of the four analytes, total sugar, total acid, total phenolic content, and total antioxidant activity, and validated by prediction data sets. © 2012 American Chemical Society.


Lin K.,Zhejiang University of Technology | Lin K.,University of Sao Paulo | Shu F.-W.,Nanchang University | Wang A.,Zhejiang University of Technology | And 2 more authors.
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

In this paper, we present all [(d+1)+1]-dimensional static diagonal vacuum solutions of the nonprojectable Hořava-Lifshitz gravity in the IR limit and show that they give rise to very rich Lifshitz-type structures, depending on the choice of the free parameters of the solutions. These include the Lifshitz space-times with or without hyperscaling violation, Lifshitz solitons, and black holes. Remarkably, even the theory breaks explicitly the Lorentz symmetry and allows generically instantaneous propagations, universal horizons still exist, which serve as one-way membranes for signals moving with any large velocities. In particular, particles even with infinitely large velocities would just move around on these boundaries and would not be able to escape to infinity. Another remarkable feature appearing in the Lifshitz-type space-times is that the dynamical exponent z can take its values only in the ranges 1≤z<2 for d≥3 and 1≤z<∞ for d=2, due to the stability and ghost-free conditions of the theory. © 2015 American Physical Society.


Ni Y.,Nanchang University | Li S.,Nanchang University | Kokot S.,Queensland University of Technology
Food Chemistry | Year: 2011

The new simple, cost effective and well performing differential pulse stripping voltammetry method for the simultaneous determination of antibiotics - oxytetracycline, tetracycline and chlorotetracycline was researched and developed. It depends on the reduction of these compounds at a hanging mercury drop electrode. The samples were extracted from (i) spiked animal feed, and (ii) fresh fish muscle dosed with the drugs. The voltammograms from the drug mixture produced complex, overlapping profiles, and chemometrics methods were applied for calibration modelling. The analytical linear ranges were within 0.02-0.18μgmL-1 and the corresponding LODs were 3-5μgL-1 for the three analytes. These values compare well with those from the HPLC and fluorescence methods in the literature. The % relative prediction errors from the verification trials were between 4% and 9% with % Recoveries being 103-107. Also, the % Recoveries of the antibiotics from animal feeds as measured by the new method were comparable with those from the HPLC analysis (85%), i.e. the method is highly competitive, especially as a screening approach. © 2010 Elsevier Ltd.


Zhang R.,Nanchang University | Chiang W.-C.,University of Tulsa | Wu C.,Tsinghua University
International Journal of Production Economics | Year: 2014

In this paper, we focus on the relationship between operations-based variables (specifically, production speed, scrap rate and maintenance speed) and the manufacturing cost. These variables usually produce opposite influences on the variable cost and the fixed cost. For example, setting the production speed at a high level is beneficial for reducing the variable cost. However, maintaining the high speed incurs considerable fixed costs at the same time. Therefore, an optimization approach is necessary to determine the optimal values of the operational variables for minimizing the average cost. First, a discrete-event simulation procedure is designed for describing the stochastic production environment and for evaluating the settings. Then, an optimization approach based on the ordinal optimization (OO) philosophy and particle swarm optimization (PSO) is used to search in the continuous space of the operational variables. In this process, the optimal computing budget allocation technique is applied so as to fully utilize the computational resource and potentially save the computational time. Finally, numeric computations are conducted for verifying the effectiveness of the proposed algorithm. Sensitivity analysis and discussions are also presented. © 2013 Elsevier B.V.


Ni Y.,Nanchang University | Song R.,Nanchang University | Kokot S.,Queensland University of Technology
Analytical Methods | Year: 2012

Chromatographic fingerprints of raw, wine-treated and braised rhubarb samples were obtained by liquid chromatography with a diode array detector (LC-DAD). Eight LC peaks were selected for fingerprint analysis, and six compounds were identified as gallic acid, emodin, chrysophanol, palmidin, rhein glucoside and desoxyrhaponticin. A data matrix of the chromatographic fingerprints from the three types of sample was submitted to principal component analysis (PCA) and this indicated that the three types of rhubarb were distinguished in the PC1 versus PC2 space. Training, verification and prediction data sets of the three types of HPLC fingerprint were processed successfully by chemometrics data classification methods, K-nearest neighbor (KNN), linear discriminant analysis (LDA) and least squares support vector machines (LS-SVM), and these types of rhubarb sample were classified satisfactorily. © 2012 The Royal Society of Chemistry.


Performance of a novel analytical method for complex samples, based on combined or fused high-performance liquid chromatography (HPLC) and Fourier transform infrared spectroscopy (FT-IR) data, was compared with that based on measurements from either of the techniques. The analytes were different varieties of Radix Paeoniae (Shaoyao), traditional Chinese medicines (TCM), from various regions. When the HPLC and FT-IR datasets (L and R) were separately submitted to either PCA or several supervised classification and prediction methods, the recognition rates were unsatisfactory. Thus, the potential of combined data of these two techniques was investigated, and two statistical methods for reducing the dimensions of the fused data were developed based on: (i) four PCs from the L and R matrices, and (ii) selection of optimum variables by the genetic algorithm-partial least squares (GA-PLS). PCA of these two fused sets indicated improved discrimination of the different sample clusters. Subsequent application of the supervised classification and prediction methods - linear discriminant analysis (LDA), least squares-support vector machine (LS-SVM), and radial basis function neural network (RBF-ANN) - indicated significantly higher recognition rates. Thus, the best discrimination of the complex Shaoyao TCM samples on the basis of their variety and geographical origin, was obtained with the use of non-linear RBF-ANN and LS-SVP models. © 2012 The Royal Society of Chemistry.


Ni Y.,Nanchang University | Su S.,Nanchang University | Kokot S.,Queensland University of Technology
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2010

The interaction between fluoroquinolones (FQs), ofloxacin and enrofloxacin, and bovine serum albumin (BSA) was investigated by fluorescence and UV-vis spectroscopy. It was demonstrated that the fluorescence quenching of BSA by FQ is a result of the formation of the FQ-BSA complex stabilized, in the main, by hydrogen bonds and van der Waals forces. The Stern-Volmer quenching constant, KSV, and the corresponding thermodynamic parameters, ΔH, ΔS and ΔG, were estimated. The distance, r, between the donor, BSA, and the acceptor, FQ, was estimated from fluorescence resonance energy transfer (FRET). The effect of FQ on the conformation of BSA was analyzed with the aid of UV-vis absorbance spectra and synchronous fluorescence spectroscopy. Spectral analysis showed that the two FQs affected the conformation of the BSA but in a different manner. Thus, with ofloxacin, the polarity around the tryptophan residues decreased and the hydrophobicity increased, while for enrofloxacin, the opposite effect was observed. © 2009 Elsevier B.V. All rights reserved.


Sun R.,Nanchang University | Wang Y.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Talanta | Year: 2014

A novel, highly selective resonance light scattering (RLS) method was researched and developed for the analysis of phenol in different types of industrial water. An important aspect of the method involved the use of graphene quantum dots (GQDs), which were initially obtained from the pyrolysis of citric acid dissolved in aqueous solutions. The GQDs in the presence of horseradish peroxidase (HRP) and H2O2 were found to react quantitatively with phenol such that the RLS spectral band (310 nm) was quantitatively enhanced as a consequence of the interaction between the GQDs and the quinone formed in the above reaction. It was demonstrated that the novel analytical method had better selectivity and sensitivity for the determination of phenol in water as compared to other analytical methods found in the literature. Thus, trace amounts of phenol were detected over the linear ranges of 6.00×10-8-2.16×10-6 M and 2.40×10-6-2.88×10-5 M with a detection limit of 2.20×10-8 M. In addition, three different spiked waste water samples and two untreated lake water samples were analysed for phenol. Satisfactory results were obtained with the use of the novel, sensitive and rapid RLS method. © 2014 Elsevier B.V.


Ni Y.,Nanchang University | Xia Z.,Nanchang University | Kokot S.,Queensland University of Technology
Journal of Hazardous Materials | Year: 2011

A novel kinetic spectrophotometric method was developed for determination of pyrocatechol, resorcin, hydroquinone and phenol based on their inhibitory effect on the oxidation of Rhodamine B (RhB) in acid medium at pH=3.0. A linear relationship was observed between the inhibitory effect and the concentrations of the compounds. The absorbance associated with the kinetic reactions was monitored at the maximum wavelength of 557nm. The effects of different parameters such as pH, concentration of RhB and KBrO3, and temperature of the reaction were investigated and optimum conditions were established. The linear ranges were 0.22-3.30, 0.108-0.828, 0.36-3.96 and 1.52-19.76μgmL-1 for pyrocatechol, resorcin, hydroquinone and phenol, respectively, and their corresponding detection limits were 0.15, 0.044, 0.16 and 0.60μgmL-1. The measured data were processed by several chemometrics methods, such as principal component regression (PCR), partial least squares (PLS) and artificial neural network (ANN), and a set of synthetic mixtures of these compounds was used to verify the established models. It was found that the prediction ability of PLS, PCR and RBF-ANN was similar, however, the RBF-ANN model did perform somewhat better than the other methods. The proposed method was also applied satisfactorily for the simultaneous determination of pyrocatechol, resorcin, hydroquinone and phenol in real water samples. © 2011 Elsevier B.V.


Zhang Q.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Journal of Agricultural and Food Chemistry | Year: 2013

The effect of ionic surfactants, sodium dodecyl sulfate (SDS) and N-cetyl-N,N,N-trimethylammonium bromide (CTAB), on the interaction between β-agonist salbutamol (SAL) and bovine serum albumin (BSA) was investigated with the use of fluorescence spectroscopy (FLS) and chemometrics methods [multivariate curve resolution-alternating least-squares (MCR-ALS) and parallel factor analysis algorithm (PARAFAC)]. It was found that the binding constant of SAL to BSA in the presence of CTAB was much larger than that without this ligand. The ligand/BSA stoichiometry was 4:1, that is, (CTAB)4-BSA, and was 2:1 with the ligand, that is, (SAL)2-BSA. These results were obtained from the concentration profiles extracted by MCR-ALS for all three reactants. Quantitative information on the complex CTAB-BSA-SAL species was obtained with the resolution of the excitation-emission fluorescence three-way data matrices by PARAFAC. This research has implications for the analysis of SAL in food and might be performed in laboratories associated with organizations such as the U.S. Food and Drug Administration (FDA) and the International Olympic Committee (IOC). © 2013 American Chemical Society.


Ni Y.,Nanchang University | Liu Y.,Nanchang University | Kokot S.,Queensland University of Technology
Analyst | Year: 2011

This work is concerned with the research and development of methodology for analysis of complex mixtures such as pharmaceutical or food samples, which contain many analytes. Variously treated samples (swill washed, fried and scorched) of the Rhizoma atractylodis macrocephalae (RAM) traditional Chinese medicine (TCM) as well as the common substitute, Rhizoma atractylodis (RA) TCM were chosen as examples for analysis. A combined data matrix of chromatographic 2-D HPLC-DAD-FLD (two-dimensional high performance liquid chromatography with diode array and fluorescence detectors) fingerprint profiles was constructed with the use of the HPLC-DAD and HPLC-FLD individual data matrices; the purpose was to collect maximum information and to interpret this complex data with the use of various chemometrics methods e.g. the rank-ordering multi-criteria decision making (MCDM) PROMETHEE and GAIA, K-nearest neighbours (KNN), partial least squares (PLS), back propagation-artificial neural networks (BP-ANN) methods. The chemometrics analysis demonstrated that the combined 2-D HPLC-DAD-FLD data matrix does indeed provide more information and facilitates better performing classification/prediction models for the analysis of such complex samples as the RAM and RA ones noted above. It is suggested that this fingerprint approach is suitable for analysis of other complex, multi-analyte substances. © 2011 The Royal Society of Chemistry.


Ni Y.,Nanchang University | Zhu R.,Nanchang University | Kokot S.,Queensland University of Technology
Analyst | Year: 2011

The interaction of aspirin and ibuprofen with bovine serum albumin (BSA) was studied by spectrofluorimetry under simulated physiological conditions. Both aspirin and ibuprofen quenched the intrinsic fluorescence of BSA and the binding ratios obtained were 2:1 for aspirin-BSA and 3:1 for ibuprofen-BSA interactions, respectively. The thermodynamic parameters (ΔH, ΔS and ΔG) obtained from the fluorescence spectroscopy data showed that the binding of aspirin to BSA involved van der Waals interactions and hydrogen bonds. Competitive experiments using warfarin and diazepam as site markers indicated that aspirin was mainly located in the hydrophobic pocket of site II of the protein as well as to a small extent in site I. Furthermore, the competitive interaction of the aspirin and ibuprofen with BSA, which was studied with the use of the three-way excitation-emission fluorescence spectra and a parallel factor analysis (PARAFAC) chemometrics method, showed that the competitive effect of ibuprofen was stronger than that of aspirin, i.e. the former molecule replaced the aspirin from the aspirin-BSA complex. © 2011 The Royal Society of Chemistry.


Yang J.,Tsinghua University | Liu Z.,Tsinghua University | Grey F.,Tsinghua University | Xu Z.,Tsinghua University | And 6 more authors.
Physical Review Letters | Year: 2013

A sheared microscopic graphite mesa retracts spontaneously to minimize interfacial energy. Using an optical knife-edge technique, we report first measurements of the speeds of such self-retracting motion (SRM) from the mm/s range at room temperature to 25 m/s at 235 C. This remarkably high speed is comparable with the upper theoretical limit found for sliding interfaces exhibiting structural superlubricity. We observe a strong temperature dependence of SRM speed which is consistent with a thermally activated mechanism of translational motion that involves successive pinning and depinning events at interfacial defects. The activation energy for depinning is estimated to be 0.1-1 eV. © 2013 American Physical Society.


Tang Y.,TU Dresden | Tang Y.,Sun Yat Sen University | Jacobi A.,TU Dresden | Vater C.,TU Dresden | And 3 more authors.
Stem Cells | Year: 2015

Reduced tissue levels of endothelial progenitor cells (EPCs) and functional impairment of endothelium are frequently observed in patients with diabetes and cardiovascular disease. The vascular endothelium is specifically sensitive to oxidative stress, and this is one of the mechanisms that causes widespread endothelial dysfunction in most cardiovascular diseases and disorders. Hence attention has increasingly been paid to enhance mobilization and differentiation of EPCs for therapeutic purposes. The aim of this study was to investigate whether Icariin, a natural bioactive component known from traditional Chinese Medicine, can induce angiogenic differentiation and inhibit oxidative stress-induced cell dysfunction in bone marrow-derived EPCs (BM-EPCs), and, if so, through what mechanisms. We observed that treatment of BM-EPCs with Icariin significantly promoted cell migration and capillary tube formation, substantially abrogated hydrogen peroxide (H2O2)-induced apoptotic and autophagic programmed cell death that was linked to the reduced intracellular reactive oxygen species levels and restored mitochondrial membrane potential. Icariin downregulated endothelial nitric oxide synthase 3, as well as nicotinamide-adenine dinucleotide phosphate-oxidase expression upon H2O2 induction. These antiapoptotic and antiautophagic effects of Icariin are possibly mediated by restoring the loss of mammalian target of rapamycin /p70S6K/4EBP1 phosphorylation as well as attenuation of ATF2 and ERK1/2 protein levels after H2O2 treatment. In summary, favorable modulation of the angiogenesis and redox states in BM-EPCs make Icariin a promising proangiogenic agent both enhancing vasculogenesis and protecting against endothelial dysfunction. © 2015 AlphaMed Press.


Ling Y.,CAS Institute of High Energy Physics | Ling Y.,Nanchang University | Ling Y.,CAS Institute of Theoretical Physics | Pan W.-J.,CAS Institute of High Energy Physics | Pan W.-J.,Nanchang University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

Intrigued by the holographic principle, Padmanabhan recently proposed a novel idea, saying that our cosmic space is emergent as cosmic time progresses. In particular, the expansion rate of the Universe is related to the difference between the surface degrees of freedom on the holographic horizon and the bulk degrees of freedom inside. In this note, we generalize this interesting paradigm to brane world, scalar-tensor gravity, and f(R) theory, respectively, and find that in the cosmological setting the Friedmann equations can be successfully derived. © 2013 American Physical Society.


Sun R.,Nanchang University | Wang Y.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Journal of Hazardous Materials | Year: 2014

Phenols are well known noxious compounds, which are often found in various water sources. A novel analytical method has been researched and developed based on the properties of hemin-graphene hybrid nanosheets (H-GNs). These nanosheets were synthesized using a wet-chemical method, and they have peroxidase-like activity. Also, in the presence of H2O2, the nanosheets are efficient catalysts for the oxidation of the substrate, 4-aminoantipine (4-AP), and the phenols. The products of such an oxidation reaction are the colored quinone-imines (benzodiazepines). Importantly, these products enabled the differentiation of the three common phenols - pyrocatechol, resorcin and hydroquinone, with the use of a novel, spectroscopic method, which was developed for the simultaneous determination of the above three analytes. This spectroscopic method produced linear calibrations for the pyrocatechol (0.4-4.0mgL-1), resorcin (0.2-2.0mgL-1) and hydroquinone (0.8-8.0mgL-1) analytes. In addition, kinetic and spectral data, obtained from the formation of the colored benzodiazepines, were used to establish multi-variate calibrations for the prediction of the three phenol analytes found in various kinds of water; partial least squares (PLS), principal component regression (PCR) and artificial neural network (ANN) models were used and the PLS model performed best. © 2013 Elsevier B.V.


Huang L.,Nanchang University | Liao L.-M.,Nanchang University | Liu A.-W.,Nanchang University | Wu J.-B.,Nanchang University | And 3 more authors.
Archives of Gynecology and Obstetrics | Year: 2014

Purpose: The long noncoding RNA HOTAIR has been reported to be a good biomarker for poor prognosis in a variety of human cancers. However, whether HOTAIR could serve as novel biomarker to predict prognosis in cervical cancer or not is unknown. The aim of the present study was to examine the expression of HOTAIR in cervical cancers and to investigate the relationship between this lncRNA expression levels and existing clinicopathological factors and patient survival.Methods: We examined the expression of HOTAIR in 218 cervical cancer tissues and matched 218 adjacent normal tissues using quantitative real-time RT-PCR and analyzed its correlation with the clinical parameters.Results: The results showed that HOTAIR expression in cervical cancer tissues was significantly upregulated compared with the matched nontumorous tissues (P < 0.0001). Increased HOTAIR expression was significantly correlated with FIGO stage (P < 0.0001), lymph node metastasis (P < 0.0001), depth of cervical invasion (P < 0.0001), tumor size (P = 0.006) and age (P = 0.020), but not other clinical characteristics. Moreover, cervical cancer patients with HOTAIR higher expression have shown significantly poorer overall survival (P < 0.0001) and disease-free survival (P < 0.0001) than those with lower HOTAIR expression. Univariate (P < 0.0001, HR = 4.566, 95 % CI 2.122–9.825) and multivariate (P = 0.012, HR = 2.863, 95 % CI 1.263–76.490). Cox regression analyses showed that HOTAIR expression served as an independent predictor for overall survival.Conclusions: our data indicate that high expression of HOTAIR is involved in cervical cancer progression and could be a potential target for diagnosis and gene therapy. © 2014, Springer-Verlag Berlin Heidelberg.


Zhang R.,Nanchang University | Chang P.-C.,Yuan Ze University | Wu C.,Tsinghua University
International Journal of Production Economics | Year: 2013

This paper studies a job shop scheduling problem with two new objective functions based on the setup and synergy costs besides the traditional total weighted tardiness criterion. The background is found in the real-world situation of a commercial vehicle producer, where the reduction of manufacturing costs has become a significant concern like in many heavy industry firms. The cost-related objective functions have been modeled in a quite general way so that they can also be applied to other similar types of production. To tackle this multi-objective scheduling problem, the paper presents a Pareto-based genetic algorithm incorporating a local search module, which utilizes the neighborhood properties specifically developed for each objective function. The computational experiments on both real-world and randomly generated scheduling instances verify the effectiveness of the proposed approach. The research presented in this paper could shed some light on the modeling and heuristic solving of practical production scheduling problems. © 2012 Elsevier B.V.


Zhong W.,Nanchang University | Zhong W.,Nanchang Hangkong University | Li F.,Nanchang University | Chen L.,Nanchang University | And 2 more authors.
Journal of Materials Chemistry | Year: 2012

Pristine and aligned electrospun fibers of poly[2-methoxy-5-(2′- ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) have been fabricated by electrospinning. The key to success was using a binary solvent system, in which a poor solvent was introduced to increase interchain interactions of MEH-PPV. At the same time, the poor solvent should have a low surface tension and high conductivity. The emission spectra of pristine MEH-PPV in electrospun fibers, spin coating film and dilute solution were acquired and analyzed. The emission anisotropy of aligned electrospun fibers was investigated by polarized emission measurement. For pristine MEH-PPV fibers, the emission anisotropy is 0.47 at emission peak, indicating alignment of MEH-PPV chains along the electrospun fiber axis. For MEH-PPV/poly (ε-caprolactone) (PCL) electrospun fibers, the interchain energy transfer in MEH-PPV was significantly depressed. As a result, MEH-PPV/PCL electrospun fibers exhibited a strong blue shift of emission maximum and increased emission anisotropy of 0.66 compared with pristine MEH-PPV electrospun fibers. The ease of electrospinning of pristine MEH-PPV provides new opportunities for its application in unique optoelectronic devices. © The Royal Society of Chemistry 2012.


Wang Y.,Nanchang University | Wang L.,Nanchang University | Yang T.,Tsinghua University | Li X.,Tsinghua University | And 5 more authors.
Advanced Functional Materials | Year: 2014

Sensing strain of soft materials in small scale has attracted increasing attention. In this work, graphene woven fabrics (GWFs) are explored for highly sensitive sensing. A flexible and wearable strain sensor is assembled by adhering the GWFs on polymer and medical tape composite film. The sensor exhibits the following features: ultra-light, relatively good sensitivity, high reversibility, superior physical robustness, easy fabrication, ease to follow human skin deformation, and so on. Some weak human motions are chosen to test the notable resistance change, including hand clenching, phonation, expression change, blink, breath, and pulse. Because of the distinctive features of high sensitivity and reversible extensibility, the GWFs based piezoresistive sensors have wide potential applications in fields of the displays, robotics, fatigue detection, body monitoring, and so forth. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Lin X.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Electrochimica Acta | Year: 2014

A simple one-step electrodeposition method was used to construct a glassy carbon electrode (GCE), which has been modified with Cu doped gold nanoparticles (GNPs), i.e. a Cu@AuNPs/GCE. This electrode was characterized with the use of scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. The eugenol was electrocatalytically oxidized at the Cu@AuNPs/GCE. At this electrode, in comparison with the behavior at the GCE alone, the corresponding oxidation peak current was enhanced and the shift of the oxidation potentials to lower values was observed. Electrochemical behavior of eugenol at the Cu@AuNPs/GCE was investigated with the use of the cyclic voltammetry (CV) technique, and additionally, in order to confirm the electrochemical reaction mechanism for o-methoxy phenols, CVs for catechol, guaiacol and vanillin were investigated consecutively. Based on this work, an electrochemical reaction mechanism for o-methoxy phenols was suggested, and in addition, the above Cu@AuNPs/GCE was successfully employed for the analysis of eugenol in food samples. © 2014 Elsevier Ltd.


Lin X.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Journal of Hazardous Materials | Year: 2013

A novel modified electrode was constructed by the electro-polymerization of 4,5-dihydroxy-3-[(2-hydroxy-5-sulfophenyl)azo]-2,7-naphthalenedisulfonic acid trisodium salt (acid chrome blue K (ACBK)) at a graphene oxide (GO)-nafion modified glassy carbon electrode (GCE). The characterization of an electrochemically synthesized poly-ACBK/GO-nafion film was investigated by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), atomic force microscopy (AFM) and scanning electron microscopy (SEM) techniques, and the results were interpreted and compared at each stage of the electrode construction. Electrochemical oxidation of eight β-agonists - clenbuterol, salbutamol, terbutaline, ractopamine, dopamine, dobutamine, adrenaline, and isoprenaline, was investigated by CV at the different electrodes. At the poly-ACBK/GO-nafion/GCE, the linear sweep voltammetry peak currents of the eight β-agonists increased linearly with their concentrations in the range of 1.0-36.0ngmL-1, respectively, and their corresponding limits of detection (LODs) were within the 0.58-1.46ngmL-1 range. This electrode showed satisfactory reproducibility and stability, and was used successfully for the quantitative analysis of clenbuterol in pork samples. © 2013 Elsevier B.V.


Li Z.,Nanchang University | Wang Y.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Sensors and Actuators, B: Chemical | Year: 2014

A novel, uncomplicated and rapid method of analysis for organophosphorus (OP) pesticides was researched and developed using the important, common OP, dipterex, as a typical example. The basis of the method involved the citrate-capped silver nanoparticles (citrate-capped AgNPs) and Acetylthiocholine (ATCh). The latter compound can be catalyzed by Acetylcholinesterase (AChE) to form thiocholine (TCh), which induces the aggregation of AgNPs. Correspondingly, the color of AgNPs in solution changes from bright yellow to pink, and the UV-vis characteristic absorption peak of AgNPs at about 400 nm decreases; simultaneously, a new absorption band appears at about 520 nm. Irreversible inhibition of AChE activity caused by dipterex, prevents the aggregation of AgNPs. Thus, a UV-vis spectrophotometric method was developed for the analysis of dipterex. The absorbance ratio A396 nm/A520 nm was found to be linearly related to the concentration of dipterex in the range of 0.25-37.5 ng mL-1 with a detection limit of 0.18 ng mL-1. This method was used successfully to analyse dipterex in spiked, different water samples. © 2013 Elsevier B.V.


Ni Y.,Nanchang University | Wang Y.,Nanchang University | Kokot S.,Queensland University of Technology
Sensors and Actuators, B: Chemical | Year: 2011

The interaction of 10-hydroxycamptothecine (HCPT) with DNA under pseudo-physiological conditions (Tris-HCl buffer of pH 7.4), using ethidium bromide (EB) dye as a probe, was investigated with the use of spectrofluorimetry, UV-vis spectrometry and viscosity measurement. The binding constant and binding number for HCPT with DNA were evaluated as (7.1 ± 0.5) × 104 M-1 and 1.1, respectively, by multivariate curve resolution-alternating least squares (MCR-ALS). Moreover, parallel factor analysis (PARAFAC) was applied to resolve the three-way fluorescence data obtained from the interaction system, and the concentration information for the three components of the system at equilibrium was simultaneously obtained. It was found that there was a cooperative interaction between the HCPT-DNA complex and EB, which produced a ternary complex of HCPT-DNA-EB. © 2011 Elsevier B.V.


Li Z.,Nanchang University | Wang Y.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2014

A rapid and effective sensor for the analysis of nitrophenol-based explosive substances, represented by trinitrophenol (TNP), has been developed with the use of the blue luminescent graphene quantum dots (GQDs); these GQDs are derived from citric acid by a pyrolysis procedure. They emit strong blue fluorescence at 450 nm after excitation at 365 nm, and TNP can quench this fluorescence because a fluorescence resonance energy transfer occurs. The quenching ratio (F0 - F)/F0 was related linearly to the concentration of TNP in the range of 0.1-15 μmol L-1 with a detection limit of 0.091 μmol L-1 (S/N = 3). The developed method exhibits high sensitivity, good linearity and reliable reproducibility for the quantitative analysis of TNP in water samples. The GQDs were used directly without any further treatment or complicated modification. © 2014 Elsevier B.V. All rights reserved.


Zhang R.,Nanchang University | Wu C.,Tsinghua University
Mathematical Problems in Engineering | Year: 2011

The job shop scheduling problem (JSSP) is a notoriously difficult problem in combinatorial optimization. In terms of the objective function, most existing research has been focused on the makespan criterion. However, in contemporary manufacturing systems, due-date-related performances are more important because they are essential for maintaining a high service reputation. Therefore, in this study we aim at minimizing the total weighted tardiness in JSSP. Considering the high complexity, a hybrid differential evolution (DE) algorithm is proposed for the problem. To enhance the overall search efficiency, a neighborhood property of the problem is discovered, and then a tree search procedure is designed and embedded into the DE framework. According to the extensive computational experiments, the proposed approach is efficient in solving the job shop scheduling problem with total weighted tardiness objective. Copyright © 2011 Rui Zhang and Cheng Wu.


Yinghui P.,Xiamen University | Yinghui P.,Nanchang University
Journal of Convergence Information Technology | Year: 2010

Watermark perceptibility and robustness must be ensured in order to enhance the practicality of digital watermarking. Taking human visual system characteristics into account fully, a particle swarm optimization method based on multi-wavelet digital watermarking is proposed. It utilizes Sa4 multi-wavelet to embed digital watermark, chooses intermediate frequency in embedding digital watermark adaptively according to the size of every energy mass, and uses multi-objective optimization method based on particle swarm optimization to optimize and adjust the embedded depth to obtain optimal effect. Experiments show the new proposed algorithm not only ensures the quality of watermarking-embed image and robustness against attacks, but also accelerate the operating speed relative to genetic algorithms.


Xia Z.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Food Chemistry | Year: 2013

A novel kinetic spectrophotometric method was developed for the simultaneous determination of caffeine, theobromine and theophylline in food samples. This method was based on the different kinetic characteristics between the reactions of analytes with cerium sulphate in sulphuric acid and the associated change in absorbance at 320 nm. Experimental conditions, the effects of sulphuric acid, cerium sulphate and temperature, were optimised. Linear ranges (0.4-8.4 μgmL-1) for all three analytes were established, and the limits of detection were: 0.30 μgmL-1 (caffeine), 0.33 μgmL-1 (theobromine) and 0.16 μgmL-1 (theophylline). The recorded data were processed by partial least squares and artificial neural network, and the developed mathematical models were then used for prediction. The proposed, novel method was applied to determine the analytes in commercial food samples, and there were no significant differences between the results from the proposed method and those obtained by high-performance liquid chromatography. © 2013 Elsevier Ltd. All rights reserved.


Zhang Q.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Talanta | Year: 2012

An analytical method was researched for the simultaneous determination of reactants and products during the binding of important small molecules such as levodopa (LD) with biopolymers such as bovine serum albumin (BSA). Voltammetry and fluorescence spectroscopy were used to obtain the analytical profiles from different reactant mixtures as a function of concentration. This enabled the extraction of the equilibrium constants (K SV) which are reported for the first time. Voltammetric results supported the formation of the LD-BSA complex but not that with dopamine. Further information of the LD-BSA system was unattainable because the measured composite profiles could not be extracted. New information was obtained when the extended data matrix was resolved by the MCR-ALS method. The previously unavailable extracted voltammogram profile of LD-BSA complex indicated that the complex was electroactive; this was unexpected if the LD-BSA system was in its folded state, and hence, it was suggested that the protein must be unfolded. The observation that the drug:BSA stoichiometry was 3:1, i.e. (levodopa) 3-BSA, supported this suggestion; these results were obtained from the MCR-ALS extracted concentration profiles for the three reaction components. © 2011 Elsevier B.V. All rights reserved.


Ni Y.,Nanchang University | Mei M.,Nanchang University | Kokot S.,Queensland University of Technology
Chemometrics and Intelligent Laboratory Systems | Year: 2011

An NIR spectroscopic method was researched and developed for the analysis of potato crisps (chips) chosen as an example of a common, cheap but complex product. Four similar types of the 'original flavour' potato chips from different manufacturers were analysed by NIR spectroscopy; as well, the quality parameters - fat, moisture, acid and peroxide values of the extracted oil were predicted. Principal component analysis (PCA) of the NIR data displayed the clustering of objects with respect to the type of chips.NIR spectra were rank-ordered with the use of the sparingly applied multiple criteria decision making (MCDM) ranking methods, PROMETHEE (Preference Ranking Organization METHod for Enrichment Evaluation) and GAIA (Geometrical Analysis for Interactive Aid), and a comprehensive quantitative description of the data was obtained.The four traditional parameters were predicted on the basis of the NIR spectra; the performance of the Partial Least Squares (PLS), and Kernel Partial Least Squares (KPLS) calibrations was compared with those from Least Squares-Support Vector Machines (LS-SVM) method. The LS-SVM calibrations, which model better data linearity and non-linearity, successfully predicted all four parameters.This work has demonstrated that NIR methodology with the use of chemometrics can describe comprehensively qualitative and quantitative properties of complex, processed substances as illustrated by the potato chips example, and indicated that this approach may be applied to other similar complex samples. © 2010 Elsevier B.V.


Lai Y.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Vibrational Spectroscopy | Year: 2011

Near-infrared spectroscopy (NIRS) was applied for direct and rapid collection of characteristic spectra from Rhizoma Corydalis, a common traditional Chinese medicine (TCM), with the aim of developing a method for the classification of such substances according to their geographical origin. The powdered form of the TCM was collected from two such different sources, and their NIR spectra were pretreated by the wavelet transform (WT) method. A training set of such Rhizoma Corydalis spectral objects was modeled with the use of the least-squares support vector machines (LS-SVM), radial basis function artificial neural networks (RBF-ANN), partial least-squares discriminant analysis (PLS-DA) and K-nearest neighbors (KNN) methods. All the four chemometrics models performed reasonably on the basis of spectral recognition and prediction criteria, and the LS-SVM method performed best with over 95% success on both criteria. Generally, there are no statistically significant differences in all these four methods. Thus, the NIR spectroscopic method supported by all the four chemometrics models, especially the LS-SVM, are recommended for application to classify TCM, Rhizoma Corydalis, samples according to their geographical origin. © 2011 Elsevier B.V. All Rights Reserved.


Lin X.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Journal of Hazardous Materials | Year: 2012

A new modified electrode was constructed by the electro-polymerization of 7-[(2,4-dihydroxy-5-carboxybenzene)azo]-8-hydroxyquinoline-5-sulfonic acid (DHCBAQS) at a graphene-nafion modified glassy carbon electrode (GCE). The construction process was performed stepwise and at each step the electrochemical characteristics were investigated particularly with respect to the oxidation of the three noxious analytes, 2-nitroaniline (2-NA), 3-nitroaniline (3-NA), 4-nitroaniline (4-NA); the electrode treated with the fluorescence reagent DHCBAQS performed best. At this electrode, the differential pulse voltammetry peak currents of the three isomers increased linearly with their concentrations in the range of 0.05-0.60μgmL-1, respectively, and their corresponding limits of detection (LODs) were all about 0.022μgmL-1. Furthermore, satisfactory results were obtained when this electrode was applied for the simultaneous quantitative analysis of the nitroaniline isomer mixtures by Principal component regression (PCR) and Partial least squares (PLS) as calibration methods (relative prediction error (PRET) - 9.04% and 9.23%) and average recoveries (101.0% and 101.7%), respectively. The above novel poly-DHCBAQS/graphene-nafion/GCE was successfully employed for the simultaneous analysis of the three noxious nitroaniline isomers in water and sewage samples. © 2012 Elsevier B.V.


Zhang R.,Nanchang University | Wu C.,Tsinghua University
Information Sciences | Year: 2012

Practical production scheduling problems usually involve some "bottleneck" machines, the scheduling policies for which could significantly affect the final solution quality. Therefore, it is beneficial to identify the bottleneck machines beforehand, so that we can intensify the optimization for these machines in the subsequent solving stage. To this end, a bottleneck machine identification algorithm is proposed in this paper for the job shop scheduling problem with the objective of minimizing total tardiness. In order to obtain the instance-specific information about bottleneck machine distribution, we first propose a new optimization model which relaxes some conventional constraints of the standard job shop problem. Then, a simulated annealing algorithm is applied to solve this newly defined problem. Based on the optimization result, the bottleneck characteristic value (which is a measure of bottleneck level) is calculated for each machine. To utilize the obtained bottleneck information for job shop scheduling, we design a genetic algorithm which allocates more computational resources to the identified bottleneck machines by using a hybrid encoding scheme. Computational results verify the effectiveness and the robustness of the proposed bottleneck identification procedure. It is shown that intensifying the local search effort for the bottleneck machines will generally result in higher solution quality within reasonably short computational time. © 2011 Elsevier Inc. All rights reserved.


Ni Y.,Nanchang University | Gu Y.,Nanchang University | Kokot S.,Queensland University of Technology
Chemometrics and Intelligent Laboratory Systems | Year: 2012

A spectrofluorimetric analytical method was researched and developed for the quantitative, simultaneous analysis of nitrofurazone and nitrofurantoin antibiotics. The method was based on the kinetic analysis of their hydrolysis reaction coupled with multivariate calibration methods. These consisted of several different multiway data models, and their prediction performance was compared on the basis of the above reaction. Nitrofurans do not fluoresce but their alkaline hydrolysis products show strong fluorescence at 245. nm/456. nm (excitation/emission wavelengths) and 240. nm/452. nm. Different multiway data matrices were acquired at various excitation and/or emission wavelengths, and/or reaction times and resolved by multiway calibration methods, i.e. the parallel factor analysis, unfolded principal component analysis-residual bilinearization and unfolded principal component analysis-residual trilinearization methods. All of these procedures facilitate the second-order advantage. The relationship between the concentration of the analytes and the fluorescence output was found to be nonlinear. Hence, the results from the calibration models were submitted to the radial basis function artificial neural networks for prediction. The best performing prediction model, unfolded principal component analysis-residual bilinearization-radial basis function artificial neural networks, was used to analyze the nitrofurans in fish samples and the results compared well with those obtained from the reference HPLC method. © 2012 Elsevier B.V.


Ni Y.,Nanchang University | Wang P.,Nanchang University | Kokot S.,Queensland University of Technology
Biosensors and Bioelectronics | Year: 2012

Electrochemical behavior of nitrofurazone (NFZ) was investigated with the use of cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. The pH-dependence of NFZ was studied at a glassy carbon electrode (GCE) in ethanol/Britton-Robinson buffer (30:70), and short-lived nitro-radicals were generated by the reduction of NFZ at high pHs (>7.0). In the presence of DNA, the DPV peak current of NFZ decreased and the peak potential shifted negatively, which indicated that there was an electrostatic interaction between NFZ and DNA. An electrochemical dsDNA/GCE biosensor was prepared to study the DNA damage produced in the presence NFZ; this process was followed with the use of the Co(phen)3 2+ electroactive probe. Also, the oxidation peaks of guanosine (750mV) and adenosine (980mV) indicated that DNA damage was related directly to the nitro-radicals. Experiments demonstrated that DNA damage occurred via two different steps while NFZ was metabolized and nitro-radicals were produced. Novel work with AFM on the NFZ/DNA interaction supported the suggestion that in vivo, the nitro-radicals were more cytotoxic than the NFZ molecules. A linear DPV calibration plot was obtained for NFZ analysis at a modified dsDNA/GCE (concentration range: 2.50×10-6-3.75×10-5molL-1; limit of detection: 8.0×10-7molL-1), and NFZ was determined successfully in pharmaceutical samples. © 2012 Elsevier B.V.


Ni Y.,Nanchang University | Wei M.,Nanchang University | Kokot S.,Queensland University of Technology
International Journal of Biological Macromolecules | Year: 2011

Interaction of isoprenaline (ISO) with calf-thymus DNA was studied by spectroscopic and electrochemical methods. The behavior of ISO was investigated at a glassy carbon electrode (GCE) by cyclic voltammetry (CV) and differential pulse stripping voltammetry (DPSV); ISO was oxidized and an irreversible oxidation peak was observed. The binding constant K and the stoichiometric coefficient m of ISO with DNA were evaluated. Also, with the addition of DNA, hyperchromicity of the UV-vis absorption spectra of ISO was noted, while the fluorescence intensity decreased significantly. Multivariate curve resolution-alternating least squares (MCR-ALS) chemometrics method was applied to resolve the combined spectroscopic data matrix, which was obtained by the UV-vis and fluorescence methods. Pure spectra of ISO, DNA and ISO-DNA complex, and their concentration profiles were then successfully obtained. The results indicated that the ISO molecule intercalated into the base-pairs of DNA, and the complex of ISO-DNA was formed. © 2011 Elsevier B.V.


Liu W.,Nanchang University | Wei J.,Nanchang University | Chen Y.,Nanchang University | Huo P.,Nanchang University | Wei Y.,Tsinghua University
ACS Applied Materials and Interfaces | Year: 2013

Photoluminescent fullerene nanoparticles/nanofibers have potential applications in bioimaging. A novel fluorescent nanofibrous material, consisting of fullerene nanoparticles and poly(L-lactide) (PLLA), was fabricated via a simple electrospinning method, and the composite nanofibers were characterized by various techniques such as scanning electron microscopy (SEM), laser scanning confocal microscopy (LSCM), and transmission electron microscopy (TEM). The nanofibers were uniform, and their surfaces were reasonably smooth, with the average diameters of fibers ranging from 300 to 600 nm. The fullerene nanoparticles were encapsulated within the composite nanofibers, forming a core-shell structure. The nanofiber scaffolds showed excellent hydrophilic surface due to the addition of water-soluble fullerene nanoparticles. The composite nanofibers used as substrates for bioimaging in vitro were evaluated with human liver carcinoma HepG2 cells, the fullerene nanoparticles signal almost displayed in every cell, implying the potential of fluorescent fullerene nanoparticles/PLLA nanofibers to be used as scaffolds for bioimaging application. © 2013 American Chemical Society.


Zuo W.,Tsinghua University | Huang F.,Tsinghua University | Chiang Y.J.,U.S. National Institutes of Health | Li M.,Chinese PLA General Hospital | And 11 more authors.
Molecular Cell | Year: 2013

Transforming growth factor β (TGF-β) is a potent antiproliferative factor in multiple types of cells. Deregulation of TGF-β signaling is associated with the development of many cancers, including leukemia, though the molecular mechanisms are largely unclear. Here, we show that Casitas B-lineage lymphoma (c-Cbl), a known proto-oncogene encoding an ubiquitin E3 ligase, promotes TGF-β signaling by neddylating and stabilizing the type II receptor (TβRII). Knockout of c-Cbl decreases the TβRII protein level and desensitizes hematopoietic stem or progenitor cells to TGF-β stimulation, while c-Cbl overexpression stabilizes TβRII and sensitizes leukemia cells to TGF-β. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TβRII at Lys556 and Lys567. Neddylation of TβRII promotes its endocytosis to EEA1-positive early endosomes while preventing its endocytosis to caveolin-positive compartments, therefore inhibiting TβRII ubiquitination and degradation. We have also identified a neddylation-activity-defective c-Cbl mutation from leukemia patients, implying a link between aberrant TβRII neddylation and leukemia development. © 2013 Elsevier Inc.


Ling Y.,CAS Institute of High Energy Physics | Ling Y.,Nanchang University | Ling Y.,CAS Institute of Theoretical Physics | Niu C.,CAS Institute of High Energy Physics | And 3 more authors.
Physical Review Letters | Year: 2014

We construct a gravity dual for charge density waves (CDWs) in which the translational symmetry along one spatial direction is spontaneously broken. Our linear perturbation calculation on the gravity side produces the frequency dependence of the optical conductivity, which exhibits the two familiar features of CDWs, namely, the pinned collective mode and gapped single-particle excitation. These two features indicate that our gravity dual also provides a new mechanism to implement the metal to insulator phase transition by CDWs, which is further confirmed by the fact that dc conductivity decreases with the decreased temperature below the critical temperature. © 2014 American Physical Society.


Zhang R.,Nanchang University | Song S.,Tsinghua University | Wu C.,Tsinghua University
Applied Soft Computing Journal | Year: 2013

In real-world manufacturing systems, the processing of jobs is frequently affected by various unpredictable events. However, compared with the extensive research for the deterministic model, study on the random factors in job shop scheduling has not received sufficient attention. In this paper, we propose a hybrid differential evolution (DE) algorithm for the job shop scheduling problem with random processing times under the objective of minimizing the expected total tardiness (a measure for service quality). First, we propose a performance estimate for roughly comparing the quality of candidate solutions. Then, a parameter perturbation algorithm is applied as a local search module for accelerating the convergence of DE. Finally, the K-armed bandit model is utilized for reducing the computational burden in the exact evaluation of solutions based on simulation. The computational results on different-scale test problems validate the effectiveness and efficiency of the proposed approach. © 2012 Elsevier B.V. All rights reserved.


Wang Y.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Analytical Biochemistry | Year: 2011

The interaction of salbutamol (Sal), an animal growth promoter, with DNA was investigated by differential pulse voltammetry (DPV), cyclic voltammetry (CV), and fluorescence spectroscopy. An irreversible reduction was observed from the cyclic voltammograms, and the reaction mechanism involved a one-electron change irreversible oxidation. In the presence of DNA, the DPV peak current decreased and the Sal peak shifted to higher potentials, indicating that Sal interacted with DNA to form an intercalation Sal-DNA complex. In addition, reaction binding parameters were extracted from the DPV data with the use of the multivariate curve resolution-alternating least squares (MCR-ALS) method; the binding constant and ratio were found to be (2.0 ± 0.5) × 10 5 M -1 and 1:1, respectively. Quantitative voltammetric analysis of Sal was performed in the concentration range of 3.02 × 10 -6 to 1.23 × 10 -4 mol L -1, and it was found that the detection limit was 5.11 × 10 -7 mol L -1 in the presence of 1.00 × 10 -6 mol L -1 DNA. The method was applied for the determination of Sal in spiked urine and human serum samples, and the calibration was successfully verified. © 2011 Elsevier Inc. All rights reserved.


Wang P.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Analyst | Year: 2013

A novel biosensor consisting of a glassy carbon electrode (GCE) modified by a polydiphenylamine-4-sulfonic acid (PDPASA, conjugated polymer) film and double-stranded DNA (dsDNA), i.e. dsDNA/PDPASA/GCE, was researched and developed for the analysis of catechol-a potentially toxic substance for humans and the environment. The surface properties of the PDPASA film, particularly after dsDNA was immobilized on it, were characterized with the use of atomic force microscopy (AFM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The surfaces of the novel DNA/PDPASA/GCE biosensor changed during the fabrication process and displayed high sensitivity for catechol. The oxidation potential of catechol decreased significantly and the corresponding current increased substantially as compared with the values obtained at the GCE alone and at the dsDNA/GCE. Also, with the addition of hydroquinone, two well discriminated CV peaks were obtained, and it was demonstrated that hydroquinone did not interfere with catechol. DPV analysis produced a linear catechol calibration (range: 0.750 to 8.25 × 10-6 mol L-1; detection limit: 6.48 × 10-7 mol L-1), and thus, various water samples were analysed successfully by this novel method. In addition, the DNA/PDPASA/GCE was used to study DNA damage in the presence of catechol with the use of the Co(phen)3 3+ electroactive probe. Results indicated that the potentially toxic catechol and its metabolites were all responsible for DNA damage. This journal is © 2013 The Royal Society of Chemistry.


Lin X.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Analytica Chimica Acta | Year: 2015

An electrochemical biosensor capable of indirect detection of DNA damage induced by any one of the three endocrine-disrupting compounds (EDCs) - bisphenol A (BPA), 4-nonylphenol (NP) and 4-t-octylphenol (OP), has been researched and developed. The methylene blue (MB) dye was used as the redox indicator. The glassy carbon electrode (GCE) was modified by the assembled dsDNA/graphene oxide-chitosan/gold nano-particles to produce a dsDNA/GO-CS/AuNPs/GCE sensor. It was characterized with the use of electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and scanning electron microscopy (SEM) techniques. The loading/release of the MB dye by the dsDNA/GO-CS/AuNPs film was investigated, and the results showed that the process was reversible. Based on this, the sensor was used to measure the difference between the loading capabilities of intact and damaged dsDNA in the films. The sensor was then successfully applied to detect DNA damage electrochemically. The differential pulse voltammetry (DPV) peak current ratio for MB, observed before and after DNA damage, increased linearly in the presence the BPA, NP or OP compounds; the treatment range was 10-60min, and the respective damage rates were 0.0069, 0.0044 and 0.0031min-1, respectively. These results were confirmed by the binding constants: 2.09×106M-1 (BPA-DNA), 1.28×106M-1 (NP-DNA) and 9.33×105M-1 (OP-DNA), all of which were obtained with the use of differential pulse stripping voltammetry (DPSV). © 2015 Elsevier B.V.


Song H.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Analytica Chimica Acta | Year: 2013

Hydrogen peroxide is an important analyte in biochemical, industrial and environmental systems. Therefore, development of novel rapid and sensitive analytical methods is useful. In this work, a hemin-graphene nano-sheets (H-GNs)/gold nano-particles (AuNPs) electrochemical biosensor for the detection of hydrogen peroxide (H2O2) was researched and developed; it was constructed by consecutive, selective modification of the GCE electrode. Performance of the H-GNs/AuNPs/GCE was investigated by chronoamperometry, and AFM measurements suggested that the graphene flakes thickness was ~1.3nm and that of H-GNs was ~1.8nm, which ultimately indicated that each hemin layer was ~0.25nm. This biosensor exhibited significantly better electrocatalytic activity for the reduction of hydrogen peroxide in comparison with the simpler AuNPs/GCE and H-GNs/GCE; it also displayed a linear response for the reduction of H2O2 in the range of 0.3μM to 1.8mM with a detection limit of 0.11μM (SN-1=3), high sensitivity of 2774.8μAmM-1cm-2, and a rapid response, which reached 95% of the steady state condition within 5s. In addition, the biosensor was unaffected by many interfering substances, and was stable over time. Thus, it was demonstrated that this biosensor was potentially suitable for H2O2 analysis in many types of sample. © 2013 Elsevier B.V.


Zhang X.,Nanchang University | Zhang X.,Tsinghua University | Yang B.,Tsinghua University | Liu M.,CAS Beijing National Laboratory for Molecular | And 3 more authors.
Polymer Chemistry | Year: 2013

Aggregation-induced emission (AIE) dye-based fluorescent organic nanoparticles (FONs) were prepared via Schiff base interactions between an AIE dye and a carbohydrate polymer (carboxymethyl chitosan). The obtained FONs with uniform size, high water dispersibility, strong fluorescence and high biocompatibility were explored for cell imaging applications. © 2013 The Royal Society of Chemistry.


Ni Y.,Nanchang University | Song R.,Nanchang University | Kokot S.,Queensland University of Technology
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

A novel method for the discrimination of the three kinds of Indigowoad Root sample, Radix Isatidis (RI), Rhizoma et Radix Baphicacanthis Cusia (RRBC) and simulated adulterated samples (AD) was researched and developed with the use of near infrared spectroscopy (NIR) and chemometrics. Principal component analysis (PCA) was applied to process the NIR data of 75 collected Indigowoad Root samples, and the three kinds of such sample were discriminated along the first principal component (PC1) axis. In addition, the data pretreatment methods - genetic algorithm-partial least squares (GA-PLS), successive projections algorithm (SPA), and wavelet transform (WT), were employed to select the key analytical wavelengths, and then, these were used as input variables for the three kinds of the pattern recognition method, such as K-nearest neighbor (KNN), radial basis function-artificial neural network (RBF-ANN), least squares-support vector machine (LS-SVM) and back propagation-artificial neural network (BP-ANN). The WT was the method of choice for data pretreatment, and three pretreatment-prediction method combinations performed well (basis: %recognition rate) - WT-KNN (98.2%) and BP-ANN (97.3%) as well as GA-PLS - LS-SVM (97.2). A BP-ANN calibration model was built for the quantitative discrimination of the three types of the complex Indigowoad Root samples, and it was successfully validated. © 2012 Elsevier B.V. All rights reserved.


Lin X.,Nanchang University | Ni Y.,Nanchang University | Li S.,Nanchang University | Kokot S.,Queensland University of Technology
Analyst | Year: 2012

An electrochemical method involving a gold nanoparticle modified glassy carbon electrode (AuNPs/GCE) was researched and developed for the simultaneous analysis of three β 2-agonists, ractopamine (RAC), salbutamol (SAL) and clenbuterol (CLB). The three analytes were electrocatalytically oxidized at the AuNP/GCE, which enhanced the oxidation peak current and influenced the shift of the oxidation potentials to lower values in comparison with the analysis involving only the GCE. The differential pulse stripping voltammetry (DPSV) voltammograms from the drug mixture produced complex, overlapping profiles, and chemometrics methods were applied for calibration modeling. The peak currents associated with RAC, SAL and CLB measurements were linear as a function of their concentrations (ranges within 0.005-0.150 μg mL -1); the detection limits for RAC, SAL and CLB were 2.4, 5.8 and 2.6 ng mL -1, respectively. It was shown that satisfactory quantitative results were obtained with the use of the MVC1 package of chemometrics methods e.g. the PLS1 calibration model produced a relative prediction error (RPE T) of 7.0% and an average recovery of 97.6%. The above AuNP/GCE was successfully employed for the simultaneous analysis of RAC, SAL and CLB in pork meat, liver and pig feed samples. © 2012 The Royal Society of Chemistry.


Ni Y.,Nanchang University | Zhang Q.,Nanchang University | Kokot S.,Queensland University of Technology
Analyst | Year: 2010

β-Agonists such as ractopamine (RAC) and clenbuterol (CLEN), have similar effects as anabolic steroids i.e. they promote growth of muscular tissue and reduce body fat. They have been used successfully with animals and humans but have also been banned in many countries principally, because of their serious side effects. However, their illegal use persists. Thus, their interaction with biomolecules such as bovine serum albumin (BSA) is of significance, especially the co-operative reaction of mixed ligands with the protein. Fluorescence and UV-vis spectra of complex mixtures of individual ligands, binary and ternary complexes with BSA resulted in significantly overlapping spectral profiles. Qualitative and quantitative information about the various complex ligand-protein species formed, was obtained with the resolution of the excitation-emission fluorescence three-way data matrices by chemometrics methods-MCR-ALS and PARAFAC. Individual spectra of the ligands, their binary complexes with BSA and their ternary complexes were extracted, and quantitative concentration profiles for each species in a particular interaction were constructed. Such analyses made it possible to interpret the role and behaviour of each reaction component. It was found that both ligands, RAC and CLEN, bound co-operatively in site I of the BSA. This was confirmed with the use of site markers such as warfarin (site I) and ibuprofen (site II). However, CLEN formed a 1:1 CLEN-BSA complex, while RAC formed a 2:1 RAC2-BSA binary species. Interestingly, when CLEN or RAC was added to RAC2-BSA or CLEN-BSA, respectively, ternary complexes were produced such as RAC 2-BSA-CLEN. Significantly, the presence of the second ligand in such an interaction in excess, appeared to increase the affinity of the added ligand for BSA. This may have consequences on the amount of steroid required to achieve a desired tissue growth effect. © 2010 The Royal Society of Chemistry.


Zou W.-N.,Nanchang University | He Q.-C.,Nanchang University | He Q.-C.,University Paris Est Creteil | Zheng Q.-S.,Nanchang University | Zheng Q.-S.,Tsinghua University
International Journal of Solids and Structures | Year: 2012

Within the framework of 2D or 3D linear elasticity, a general approach based on the superposition principle is proposed to study the problem of a finite elastic body with an arbitrarily shaped and located inclusion. The proposed approach consists in decomposing the initial inclusion problem into the problem of the inclusion embedded in the corresponding infinite body and the auxiliary problem of the finite body subjected to the appropriate boundary loading provided by solving the former problem. Thus, our approach renders it possible to circumvent the difficulty due to the unavailability of the relevant Green function, use various existing solutions for the problem of an inclusion inside an unbounded body and clearly makes appear the finite boundary effects. The general approach is applied and specified in the context of 2D isotropic elasticity. The complex potentials for the problem of an inclusion in an infinite body are given as two boundary integrals, and the boundary integral equation governing the complex potentials for the auxiliary problem is provided. In the important particular situation where a finite body with an arbitrarily shaped and located inclusion is circular, the exact explicit expressions for the complex potentials are derived, leading to those for the strain, stress and Eshelby's tensor fields inside and outside the inclusion. These results are analytically detailed and numerically illustrated for the cases of a square inclusion placed concentrically, and a circular inclusion located eccentrically, inside a circular body. © 2012 Elsevier Ltd. All rights reserved.


Wang X.,Nanchang University | Yin L.,CAS Shenyang Institute of Metal Research | Liu G.,CAS Shenyang Institute of Metal Research
Chemical Communications | Year: 2014

A light irradiation-assisted synthesis route was developed to prepare the heterostructured monolithic sheets of ZnO-CdS/reduced graphene oxide (RGO). These sheets show a 2.6 times higher photocatalytic hydrogen evolution rate than the reference ZnO-CdS/RGO prepared in the dark. © 2014 The Royal Society of Chemistry.


Zhang X.,Tsinghua University | Zhang X.,Nanchang University | Yang B.,Tsinghua University | Hui J.,Tsinghua University | And 2 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2014

An aggregation induced emission dye (RNH2) with two amino end-groups was facilely incorporated into stable cross-linked fluorescent organic nanoparticles via room temperature anhydride ring-opening polymerization and consecutive cross-linking with polyethylene polyamine. Thus obtained RO-OA-PEPA FONs were characterized by a series of techniques including 1H nuclear magnetic resonance, Fourier transform infrared spectroscopy, UV-vis absorption spectrum, fluorescent spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of RO-OA-PEPA FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high-water dispersibility, strong red fluorescence, stable uniform morphology (100-200nm) and excellent biocompatibility, making them promising for cell imaging application. © 2013 Elsevier B.V.


Zhang Q.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Journal of Pharmaceutical and Biomedical Analysis | Year: 2010

To investigate the interaction between Ractopamine (RAC), an animal growth promoter, and bovine serum albumin (BSA), three spectroscopic approaches (fluorescence, UV-vis and FT-IR) and three different experiments (two mole-ratio and a Job's methods) were used to monitor the biological kinetic interaction procedure. The Stern-Volmer quenching constants KSV, the binding constants Ka, and the number of binding sites n at 298, 301 and 304K were evaluated by molecular spectroscopic approaches. The values of enthalpy (-13.47kJmol-1) and entropy (78.39Jmol-1K-1) in the reaction indicated that RAC bound to BSA mainly by electrostatic and hydrophobic interaction. The site markers competitive experiments indicated that the binding of RAC to BSA primarily took place in site I. The spectra data matrix was further investigated with multivariate curve resolution-alternating least squares (MCR-ALS), and the concentration profiles and the pure spectra for three species (BSA, RAC and RAC-BSA) existed in the kinetic interaction procedure, as well as the apparent equilibrium constants, were obtained. © 2010 Elsevier B.V.


Zhang R.,Nanchang University | Wu C.,Tsinghua University
Computers and Operations Research | Year: 2011

In modern manufacturing systems, due date related performance is becoming increasingly important in maintaining a high service reputation. However, compared with the extensive research on makespan minimization, research on the total weighted tardiness objective is comparatively scarce, partly because this objective function is more difficult and complex to optimize. In this paper, we focus on the job shop scheduling problem with the objective of minimizing total weighted tardiness. First, we discuss the mathematical programming model and its duality when the processing orders for each machine are fixed. Then, a block-based neighborhood structure is defined and its important properties are shown. Finally, a simulated annealing algorithm is designed which directly utilizes the features of this neighborhood. According to the computational results, the new neighborhood considerably promotes the searching capability of simulated annealing and helps it converge to high-quality solutions. © 2010 Elsevier Ltd.


Wang Y.,CAS Shanghai Institute of Materia Medica | Wang Y.,Nanchang University | Li J.-X.,CAS Shanghai Institute of Materia Medica | Wang Y.-Q.,CAS Shanghai Institute of Materia Medica | Miao Z.-H.,CAS Shanghai Institute of Materia Medica
Oncotarget | Year: 2015

Tanshinone I (Tanshinone-1), a major active principle of Salvia miltiorrhiza (Danshen), has been shown to overcome tumor drug resistance and metastasis. Here we report that tanshinone-1 inhibits angiogenesis. Tanshinone-1 inhibited proliferation, migration and tube formation of vascular endothelial cells, rat aortic ring sprouting and the neovascularization of the chick chorioallantoic membrane in a concentration-dependent manner. In endothelial cells, tanshinone-1 almost completely inhibited phosphorylation of Stat3 at Tyr705 regardless of hypoxia or normoxia but only slightly decreased the hypoxia-induced HIF-1α accumulation. In tumor cells, contrastively, tanshinone-1 could not only make phosphorylation of Stat3 at Tyr705 disappear but also reduce the hypoxia-induced accumulation of HIF-1α to its baseline levels at normoxia. Consequently, VEGF secretion from tumor cells was reduced, which could potentiate the direct inhibition of tanshinone-1 on endothelial cells. Together with its overcoming tumor drug resistance and metastasis, our results reveal unique characteristics of tanshinone-1 and its improved derivatives as promising angiogenesis inhibitors.


Many complex natural or synthetic products are analysed either by the GC-MS (gas chromatography-mass spectrometry) or HPLC-DAD (high performance liquid chromatography-diode-array detector) technique, each of which produces a one-dimensional fingerprint for a given sample. This may be used for classification of different batches of a product. GC-MS and HPLC-DAD analyses of complex, similar substances represented by the three common types of the TCM (traditional Chinese medicine), Rhizoma Curcumae were analysed in the form of one- and two-dimensional matrices firstly with the use of PCA (Principal component analysis), which showed a reasonable separation of the samples for each technique. However, the separation patterns were rather different for each analytical method, and PCA of the combined data matrix showed improved discrimination of the three types of object; close associations between the GC-MS and HPLC-DAD variables were observed. LDA (linear discriminant analysis), BP-ANN (back propagation-artificial neural networks) and LS-SVM (least squares-support vector machine) chemometrics methods were then applied to classify the training and prediction sets. For one-dimensional matrices, all training models indicated that several samples would be misclassified; the same was observed for each prediction set. However, by comparison, in the analysis of the combined matrix, all models gave 100% classification with the training set, and the LS-SVM calibration also produced a 100% result for prediction, with the BP-ANN calibration closely behind. This has important implications for comparing complex substances such as the TCMs because clearly the one-dimensional data matrices alone produce inferior results for training and prediction as compared to the combined data matrix models. Thus, product samples may be misclassified with the use of the one-dimensional data because of insufficient information. © 2011 Elsevier B.V.


Yang Q.,Guangzhou University | Jie Z.,Nanchang University | Ye S.,Sun Yat Sen University | Li Z.,Nanchang University | And 4 more authors.
Oncogene | Year: 2014

MicroRNAs (miRNAs) are noncoding RNAs that function as post-transcriptional regulators of tumor oncogenes and suppressors. Single-nucleotide polymorphisms (SNPs) in miRNA genes are a novel class of genetic variations in the human genome that are currently being identified and investigated in human cancers. In this study, we aimed to investigate whether SNPs in the miR-27a gene affect miR-27a expression and alter susceptibility to gastric cancer. Therefore, we conducted a case-control population study and the allele and genotype frequencies for polymorphism rs11671784 in miR-27a gene were examined in the study population. As a result, we found that the G/A polymorphism in the miR-27a gene exhibited a significant effect on gastric cancer risk. Compared with GG homozygotes, subjects who were GA heterozygotes or AA homozygotes exhibited a decreased risk of gastric cancer. The G/A polymorphism impaired the processing of pre-miR-27a to mature miR-27a, resulting in significantly reduced expression of mature miR-27a and an increased level of its target HOXA10. Furthermore, we confirmed these findings in in vitro studies by overexpressing pre-miR-27a carrying G or A allele. It provided further evidence demonstrating that allelic difference of rs11671784 is linked to gastric tumorigenesis. In summary, our results indicate that the G/A polymorphism in miR-27a gene (rs11671784) decreases miR-27a expression, reduces gastric cancer risk and plays a role in gastric tumorigenesis. This is the first study to address the role and function of miR-27a polymorphism rs11671784 in gastric cancer. These results could be useful to assess individual susceptibility of gastric cancer and will improve our understanding of the potential contribution of miRNA SNPs to cancer pathogenesis. © 2014 Macmillan Publishers Limited.


Zheng J.,Capital Medical University | Yang M.,Capital Medical University | Shao J.,Nanchang University | Miao Y.,Capital Medical University | And 2 more authors.
Molecular Cancer | Year: 2013

Background: Macrophages, the key component of the tumor microenvironment, are differentiated mononuclear phagocyte lineage cells that are characterized by specific phenotypic characteristics that have been implicated in tumor growth, angiogenesis, and invasion. CX3CR1, the chemoattractant cytokine CX3CL1 receptor, plays an important role in modulating inflammatory responses, including monocyte homeostasis and macrophage phenotype and function. However, the role of CX3CR1 in the regulation of the tumor inflammatory microenvironment is not fully understood.Methods: Using in vivo hepatic metastasis model, human colon carcinoma specimens, immunohistochemical staining, TUNEL staining, flow cytometry analysis, Western blotting assay and co-culture in three-dimensional peptide gel, we determined the effects of CX3CR1 on angiogenic macrophage survival and tumor metastasis.Results: In this study, we found that CX3CR1 was expressed in human colon carcinomas in a histologic grade- and stage-dependent manner, and CX3CR1 upregulation in TAMs was correlated with poor prognosis. Furthermore, we showed that in a microenvironment lacking CX3CR1, the liver metastasis of colon cancer cells was significantly inhibited. The underlying mechanism is associated with decrease accumulation of angiogenic macrophages that can be partly attributed to increased apoptosis in the tumor microenvironment, thus leading to impaired tumor angiogenesis in the liver and suppressed tumor metastasis.Conclusions: Our results suggest a role of CX3CR1 in angiogenic macrophage survival in the tumor microenvironment contributing to tumor metastasis. © 2013 Zheng et al.; licensee BioMed Central Ltd.


Zhang R.,Nanchang University | Wu C.,Tsinghua University
International Journal of Production Research | Year: 2012

As the market competition becomes fiercer, contemporary make-to-order firms are confronted with both due date quotation and production scheduling problems at the same time. On the one hand, in order to attract customers, the firm needs to quote a short lead time; on the other hand, once a due date has been promised, the firm must spare no effort to deliver the goods no later than this date. If due date assignment and shop scheduling are processed separately by two systems, the overall performance is unlikely to be satisfactory because the two tasks are actually interrelated (e.g. a tighter due date setting will increase the chances of tardiness despite its appeal for the incoming customer). Therefore, we consider the problem by integrating due date assignment and shop scheduling into one optimisation model. A double-layered heuristic optimisation algorithm is presented for solving this problem. In the upper-layer genetic algorithm which performs coarse-granularity optimisation, Bayesian networks are used to learn the distribution of optimal due date values. As the second-layer algorithm, a parameter perturbation method is applied for a finer-granularity neighbourhood search. Computational experiments prove the efficacy and efficiency of the proposed algorithm. © 2012 Copyright Taylor and Francis Group, LLC.


Song H.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Biosensors and Bioelectronics | Year: 2014

The self-assembly of layered molybdenum disulfide-graphene (MoS2-Gr) and horseradish peroxidase (HRP) by electrostatic attraction into a novel hybrid nanomaterial (HRP-MoS2-Gr) is reported. The properties of the MoS2-Gr were characterized by X-ray diffraction (XRD), high-resolution transmission electron microscopy (TEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). UV-vis and Fourier transform infrared spectroscopy (FT-IR) indicate that the native structure of the HRP is maintained after the assembly, implying good biocompatibility of MoS2-Gr nanocomposite. Furthermore, the HRP-MoS2-Gr composite is utilized as a biosensor, which displays electrocatalytic activity to hydrogen peroxide (H2O2) with high sensitivity (679.7μAmM-1cm-2), wide linear range (0.2μM-1.103mM), low detection limit (0.049μM), and fast amperometric response. In addition, the biosensor also exhibits strong anti-interference ability, satisfactory stability and reproducibility. These desirable electrochemical properties are attributed to the good biocompatibility and electron transport efficiency of the MoS2-Gr composite, as well as the high loading of HRP. Therefore, this biosensor is potentially suitable for H2O2 analysis in environmental, pharmaceutical, food or industrial applications. © 2014 Elsevier B.V.


Zhang X.,Nanchang University | Zhang X.,Tsinghua University | Yang B.,Tsinghua University | Liu M.,CAS Beijing National Laboratory for Molecular | And 3 more authors.
Polymer Chemistry | Year: 2014

A polymerizable aggregation-induced emission (AIE) dye (named PhE) was facilely incorporated into polymer nanoparticles through reversible addition fragmentation chain transfer polymerization. The thus obtained fluorescent organic nanoparticles showed uniform size, high water dispersibility, strong fluorescence and excellent biocompatibility, and are expected to show great potential for cell imaging applications. © 2014 The Royal Society of Chemistry.


Zhang X.,Nanchang University | Zhang X.,Tsinghua University | Yang B.,Tsinghua University | Liu M.,CAS Beijing National Laboratory for Molecular | And 3 more authors.
Polymer Chemistry | Year: 2014

Aggregation induced emission (AIE) dye-based fluorescent organic nanoparticles (FONs) have recently emerged as novel fluorescent bioprobes due to their remarkable optical properties, water solubility and biocompatibility. In this work, a novel strategy for the fabrication of AIE-based FONs was developed via emulsion polymerization for the first time. During this procedure, a polymerizable AIE dye (named as PhE) with a double bond end functional group was facilely incorporated into the hydrophobic core of polymer nanoparticles. The obtained polymer nanoparticles (named as PhE-Pst NPs) exhibited strong fluorescence and high water dispersibility owing to the partial aggregation of PhE and the surface covered with a hydrophilic shell. More importantly, these FONs showed spherical morphology, uniform size (about 200 nm) and excellent biocompatibility, making them promising for bioimaging applications. © 2014 The Royal Society of Chemistry.


Zhang X.,Tsinghua University | Zhang X.,Nanchang University | Yang B.,Tsinghua University | Yang Y.,Tsinghua University | Wei Y.,Tsinghua University
Polymer Chemistry | Year: 2014

A renewable cross-linked fluorescent amphiphilic polymer was facilely fabricated from a new aggregation induced emission monomer and biobased itaconic acid via free radical polymerization. This amphiphilic polymer was prone to self-assemble into nanoparticles with high water dispersibility, low critical micelle concentration, bright red fluorescence, and excellent biocompatibility for cell imaging. This journal is © the Partner Organisations 2014.


Zhang R.,Nanchang University | Wu C.,Tsinghua University
Engineering Applications of Artificial Intelligence | Year: 2012

This paper aims at solving a real-world job shop scheduling problem with two characteristics, i.e.; the existence of pending due dates and job batches. Due date quotation is an important decision process for contemporary companies that adopt the MTO (make to order) strategy. Although the assignment of due dates is usually performed separately with production scheduling, there exist strong interactions between the two tasks. Therefore, we integrate these two decisions into one optimization model. Meanwhile, each order placed by the customer defines a batch of jobs, for which the same due date should be set. Thus, the completion times of these jobs should be close to one another in order to reduce waiting time and cost. For this purpose, we propose a dispatching rule to synchronize their manufacturing progresses. A two-stage local search algorithm based on the PMBGA (probabilistic model-building genetic algorithm) and parameter perturbation is proposed to solve the integrated scheduling problem and its superiority is revealed by the applications to a real-world mechanical factory. © 2011 Elsevier Ltd. All rights reserved.


Zhang X.,Nanchang University | Zhang X.,Tsinghua University | Yang B.,Tsinghua University | Hui J.,Tsinghua University | And 4 more authors.
Polymer Chemistry | Year: 2014

PEGylation of aggregation induced emission (AIE) based fluorescent organic nanoparticles (FONs) via one pot ring-opening polymerization and condensation reaction was developed for the first time. Thus PEGylated FONs exhibited high water dispersibility, strong fluorescence, uniform morphology and more important excellent biocompatibility, implying their high potential for various biomedical applications. This journal is © 2014 The Royal Society of Chemistry.


Dong W.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Applied Spectroscopy | Year: 2014

A novel near-infrared spectroscopy (NIRS) method has been researched and developed for the simultaneous analyses of the chemical components and associated properties of mint (Mentha haplocalyx Briq.) tea samples. The common analytes were: total polysaccharide content, total flavonoid content, total phenolic content, and total antioxidant activity. To resolve the NIRS data matrix for such analyses, least squares support vector machines was found to be the best chemometrics method for prediction, although it was closely followed by the radial basis function/partial least squares model. Interestingly, the commonly used partial least squares was unsatisfactory in this case. Additionally, principal component analysis and hierarchical cluster analysis were able to distinguish the mint samples according to their four geographical provinces of origin, and this was further facilitated with the use of the chemometrics classification methods-K-nearest neighbors, linear discriminant analysis, and partial least squares discriminant analysis. In general, given the potential savings with sampling and analysis time as well as with the costs of special analytical reagents required for the standard individual methods, NIRS offered a very attractive alternative for the simultaneous analysis of mint samples. © 2014 Society for Applied Spectroscopy.


Huang Y.,Tsinghua University | Chen Z.,Nanchang University
American Journal of Translational Research | Year: 2016

Inflammatory bowel disease (IBD) is a chronic nonspecific intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn’s disease (CD). Its pathogenesis remains not yet clear. Current researchers believe that after environmental factors act on individuals with genetic susceptibility, an abnormal intestinal immune response is launched under stimulation of intestinal flora. However, previous studies only focused on adaptive immunity in the pathogenesis of IBD. Currently, roles of innate immune response in the pathogenesis of intestinal inflammation have also drawn much attention. In this study, IBD related innate immunity and adaptive immunity were explained, especially the immune mechanisms in the pathogenesis of IBD. © 2016, E-Century Publishing Corporation. All Rights Reserved.


Zhang R.,Nanchang University | Wu C.,Tsinghua University
Entropy | Year: 2011

Due to the influence of unpredictable random events, the processing time of each operation should be treated as random variables if we aim at a robust production schedule. However, compared with the extensive research on the deterministic model, the stochastic job shop scheduling problem (SJSSP) has not received sufficient attention. In this paper, we propose an artificial bee colony (ABC) algorithm for SJSSP with the objective of minimizing the maximum lateness (which is an index of service quality). First, we propose a performance estimate for preliminary screening of the candidate solutions. Then, the K-armed bandit model is utilized for reducing the computational burden in the exact evaluation (through Monte Carlo simulation) process. Finally, the computational results on different-scale test problems validate the effectiveness and efficiency of the proposed approach. © 2011 by the authors.


Ashour-Abdalla M.,University of California at Los Angeles | El-Alaoui M.,University of California at Los Angeles | Goldstein M.L.,NASA | Zhou M.,Nanchang University | And 7 more authors.
Nature Physics | Year: 2011

Magnetic reconnection in magnetized plasmas represents a change in magnetic field topology and is associated with a concomitant energization of charged particles that results from a conversion of magnetic energy into particle energy. In Earth's magnetosphere this process is associated with the entry of the solar wind into the magnetosphere and with the initiation of auroral substorms. Using data from the THEMIS mission, together with global and test particle simulations, we demonstrate that electrons are energized in two distinct regions: a low-energy population (less than or equal to a few kiloelectronvolts) that arises in a diffusion region where particles are demagnetized and the magnetic topology changes, and a high-energy component (approaching 100keV) that results from betatron acceleration within dipolarization fronts that sweep towards the inner magnetosphere far from the diffusion region. Thus, the observed particle energization is associated with both magnetic reconnection and with betatron acceleration associated with macroscopic flows. © 2011 Macmillan Publishers Limited. All rights reserved.


Zhang X.,Nanchang University | Zhang X.,Tsinghua University | Wang K.,Tsinghua University | Liu M.,Nanchang University | And 3 more authors.
Nanoscale | Year: 2015

The development of polymeric luminescent nanomaterials for biomedical applications has recently attracted a large amount of attention due to the remarkable advantages of these materials compared with small organic dyes and fluorescent inorganic nanomaterials. Among these polymeric luminescent nanomaterials, polymeric luminescent nanomaterials based on dyes with aggregation-induced emission (AIE) properties should be of great research interest due to their unique AIE properties, the designability of polymers and their multifunctional potential. In this review, the recent advances in the design and biomedical applications of polymeric luminescent nanomaterials based on AIE dyes is summarized. Various design strategies for incorporation of these AIE dyes into polymeric systems are included. The potential biomedical applications such as biological imaging, and use in biological sensors and theranostic systems of these polymeric AIE-based nanomaterials have also been highlighted. We trust this review will attract significant interest from scientists from different research fields in chemistry, materials, biology and interdisciplinary areas. © The Royal Society of Chemistry 2015.


OuYang P.Y.,Sun Yat Sen University | Xie C.,Nanchang University | Mao Y.P.,Sun Yat Sen University | Zhang Y.,Sun Yat Sen University | And 4 more authors.
Annals of Oncology | Year: 2013

Background: We carried out this meta-analysis to demonstrate efficacies of neoadjuvant chemotherapy (NACT) and adjuvant chemotherapy (AC) for nasopharyngeal carcinoma (NPC) patients based on randomized, controlled trials (RCTs). Patients and methods: We comprehensively searched electronic databases and manuscripts for RCTs and extracted data from eligible studies for meta-analysis. Overall survival (OS) with hazard ratios (HRs), locoregional recurrence rate (LRR) and distant metastasis rate (DMR) with relative risks (RRs) were concerned using random and/or fixed-effects models. Subgroup and sensitivity analyses were also carried out. Results: Six trials in NACT group (n = 1418) and five in AC group (n = 1187) were eligible. HR of death for NACT was 0.82 [95% confidence interval (CI) 0.69-0.98, P = 0.03], corresponding to an absolute survival gain of 5.13% after 3 years. Significant reduction of DMR (P = 0.0002; RR 0.69, 95% CI 0.56-0.84) was also found from NACT. But no decrease in LRR (P = 0.49; RR 0.90, 95% CI 0.66-1.22) was observed. Patients receiving additional AC had lower LRR (P = 0.03; RR 0.71, 95% CI 0.53-0.96). But no benefit of OS and DMR were seen in AC. Conclusions: NACT can effectively enhance OS and reduce DMR, not LRR in NPC. And AC only helps to better control locoregional recurrence of NPC. © The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.


Zhang R.,Nanchang University | Song S.,Tsinghua University | Wu C.,Tsinghua University
International Journal of Production Economics | Year: 2013

The job shop scheduling problem (JSSP) has attracted much attention in the field of both information sciences and operations research. In terms of the objective function, most existing research has been focused on the makespan criterion (i.e.; minimizing the overall completion time). However, for contemporary manufacturing firms, the due date related performance is usually more important because it is crucial for maintaining a high service reputation. Therefore, in this study we aim at minimizing the total weighted tardiness in JSSP. Considering the high complexity, a novel artificial bee colony (ABC) algorithm is proposed for solving the problem. A neighborhood property of the problem is discovered, and then a tree search algorithm is devised to enhance the exploitation capability of ABC. According to extensive computational tests, the proposed approach is efficient in solving the job shop scheduling problem with total weighted tardiness criterion. © 2012 Elsevier B.V. All rights reserved.


Lin X.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Analytica Chimica Acta | Year: 2013

Electrochemical behavior of three antioxidants: butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and butylated hydroquinone (TBHQ), was investigated at a glassy carbon electrode modified with gold nanoparticles (AuNPs/GCE). This electrode was characterized by scanning electron microscopy (SEM). The experimental results indicated that the modified electrode was strongly electroactive during the redox reactions of BHA, BHT and TBHQ, and this was confirmed by the observed increased redox peak currents and shifted potentials; in addition, the oxidation products of BHA and TBHQ were found to be the same. The experimental conditions were optimized and the oxidation peaks of BHA and BHT were clearly separated. Based on this, an electrochemical method was researched and developed for the simultaneous determination of BHA, BHT and TBHQ in mixtures with the use of first derivative voltammetry; the linear concentration ranges were 0.10-1.50μgmL-1, 0.20-2.20μgmL-1 and 0.20-2.80μgmL-1, and detection limits were 0.039, 0.080 and 0.079μgmL-1, for BHA, BHT and TBHQ, respectively. The proposed method was successfully applied for the analysis of the three analytes in edible oil samples. © 2012 Elsevier B.V.


Ni Y.,Nanchang University | Wang Y.,Nanchang University | Kokot S.,Queensland University of Technology
Electroanalysis | Year: 2010

Interaction of a steroid drug, Ractopamine (RAC), and DNA was investigated by electroanalysis-differential pulse and cyclic voltammetry (DPV and CV), and UV-vis and fluorescence spectroscopy. DPV showed that RAC intercalated with DNA, and CV indicated that the reaction mechanism of RAC and dsDNA involved irreversible oxidation with the loss of two H+ and a transfer of two electrons. Reaction binding parameters were obtained. Pure spectra of RAC, DNA and the RAC-DNA complex, and their concentrations were extracted by multivariate curve resolution-alternating least squares method (MCR-ALS). Concentration profiles indicated quantitatively the course of the reaction. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Zhang R.,Nanchang University | Song S.,Tsinghua University | Wu C.,Tsinghua University
Knowledge-Based Systems | Year: 2012

Real-world manufacturing systems are influenced by various random factors, which must be taken into consideration in order to obtain an effective schedule. However, compared with the extensive research on the deterministic model, the stochastic job shop scheduling problem (SJSSP) has not been sufficiently studied. In this paper, we propose a two-stage particle swarm optimization (PSO) algorithm for SJSSP with the objective of minimizing the expected total weighted tardiness. In the first-stage PSO, a performance estimate is used for quick evaluation of the solutions, and a local search procedure is embedded for accelerating the convergence to promising regions in the solution space. The second-stage PSO continues the search process, but applies a more accurate solution evaluation policy, i.e. the Monte Carlo simulation. In order to reduce the computational burden, the optimal computing budget allocation (OCBA) method is used in this stage. Finally, the computational results on different-scale test problems validate the effectiveness of the proposed approach. © 2011 Elsevier B.V. All rights reserved.


Ni Y.,Nanchang University | Zhang F.,Nanchang University | Kokot S.,Queensland University of Technology
Analytica Chimica Acta | Year: 2013

The interaction of graphene oxide (GO), a medicinal drug (10-hydroxy camptothecin (HCPT)), and bovine serum albumin (BSA) was investigated with the aim of developing a method for the analysis of serum albumin proteins. It was demonstrated that HCPT could be readily loaded onto GO via the π-π stacking interaction, and the delivery of HCPT to BSA was improved in the presence of GO; this, in turn, facilitated the binding interaction of HCPT and BSA. Chemometrics methods, multivariate curve resolution-alternating least squares (MCR-ALS) and parallel factor analysis (PARAFAC), were applied to resolve spectral data, and this assisted in the elucidation of the above interaction. GO was found to enhance the fluorescence response of HCPT to BSA, and thus, a low cost fluorescence bio-sensing platform was developed for fluorescence-enhanced detection of BSA based on GO. The satisfactory analytical performance of this biosensor for BSA was attributed to the structure and electronic properties of GO. © 2013 Elsevier B.V.


Ling Y.,Nanchang University | Ling Y.,CAS Institute of Theoretical Physics | Wu Q.,Nanchang University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2010

The usual Einstein's equations is modified as a one parameter family of equations in the framework of rainbow gravity. In this Letter we derive the modified Friedmann-Robertson-Walker (FRW) equations when the cosmological evolution of radiation particles is taken into account. In particular, given some specific dispersion relations, the big bounce solutions to the modified FRW equations can be derived. Notably, to obtain a well defined rainbow metric at the moment of the big bounce, we find it seems necessary to introduce a cosmological constant which depends on the energy of probes as well, implying that a universe with a positive cosmological constant more likely undergoes a big bounce at least at this phenomenological level. © 2010 Elsevier B.V. All rights reserved.


Song H.,Nanchang University | Ni Y.,Nanchang University | Kokot S.,Queensland University of Technology
Microchimica Acta | Year: 2013

We report on a modified glassy carbon electrode (GCE) for sensing hydrogen peroxide (H2O2). It was constructed by consecutive electrochemical deposition of poly(anthranilic acid) and poly(diphenylamine sulfonate) on the GCE, followed by the deposition of copper oxide (CuO). The morphology and electrochemistry of the modified electrode was characterized by atomic force microscopy, X-ray diffraction, cyclic voltammetry, and electrochemical impedance spectroscopy. The catalytic performance of the sensor was studied with the use of differential pulse voltammetry under optimized conditions. This sensor displayed significantly better electrocatalytic activity for the reduction of H2O2 in comparison to a GCE without or with modification with CuO or polymer films alone. The response to H2O2 is linear in the range between 0.005 to ~11 mM, and the detection limit is 0.18 μM (at an S/N of 3). © 2013 Springer-Verlag Wien.


Ni Y.,Nanchang University | Wang P.,Nanchang University | Song H.,Nanchang University | Lin X.,Nanchang University | Kokot S.,Queensland University of Technology
Analytica Chimica Acta | Year: 2014

A novel electrochemical biosensor, DNA/hemin/nafion-graphene/GCE, was constructed for the analysis of the benzo(a)pyrene PAH, which can produce DNA damage induced by a benzo(a)pyrene (BaP) enzyme-catalytic product. This biosensor was assembled layer-by-layer, and was characterized with the use of cyclic voltammetry, electrochemical impedance spectroscopy (EIS) and atomic force microscopy. Ultimately, it was demonstrated that the hemin/nafion-graphene/GCE was a viable platform for the immobilization of DNA. This DNA biosensor was treated separately in benzo(a)pyrene, hydrogen peroxide (H2O2) and in their mixture, respectively, and differential pulse voltammetry (DPV) analysis showed that an oxidation peak was apparent after the electrode was immersed in H2O2. Such experiments indicated that in the presence of H2O2, hemin could mimic cytochrome P450 to metabolize benzo(a)pyrene, and a voltammogram of its metabolite was recorded. The DNA damage induced by this metabolite was also detected by electrochemical impedance and ultraviolet spectroscopy. Finally, a novel, indirect DPV analytical method for BaP in aqueous solution was developed based on the linear metabolite versus BaP concentration plot; this method provided a new, indirect, quantitative estimate of DNA damage. © 2014 Elsevier B.V.


Zhang B.-H.,Nanchang University | Wu F.-Y.,Nanchang University | Wu Y.-M.,University of Jinan | Zhan X.-S.,Nanchang University
Journal of Fluorescence | Year: 2010

Water-soluble Mn 2+-doped ZnS quantum dots (QDs) were prepared using mercaptoacetic acid as the stabilizer. The optical properties and structure features were characterized by X-Ray, absorption spectrum, IR spectrum and fluorescence spectrum. In pH 7.8 Tris-HCl buffer, the QDs emitted strong fluorescence peaked at 590 nm with excitation wavelength at 300 nm. The presence of sulfide anion resulted in the quenching of fluorescence and the intensity decrease was proportional to the S 2- concentration. The linear range was from 2.5×10 -6 to 3.8×10 -5mol L -1 with detection limit as 1.5×10 -7mol L -1. Most anions such as F -, Cl -, Br -, I -, CH 3CO 2 -, ClO 4 -, CO 3 2-, NO 2 -, NO 3 -, S 2O 3 2-, SO 3 2- and SO 4 2- did not interfere with the determination. Thus a highly selective assay was proposed and applied to the determination of S 2- in discharged water with the recovery of ca. 103%. © 2009 Springer Science+Business Media, LLC.


Ni Y.,Nanchang University | Wang S.,Nanchang University | Kokot S.,Queensland University of Technology
Analytica Chimica Acta | Year: 2010

The binding interaction of Alpinetin (APT) with bovine serum albumin (BSA) was studied by fluorescence, UV-visible and synchronous fluorescence spectroscopy (SFS) under simulated physiological conditions. The measured complex spectra were resolved by multivariate curve resolution-alternating least squares (MCR-ALS), yielding a host of data and information, which otherwise would have been impossible to obtain. The extracted profiles corresponded to the spectra of the single species in the APT/BSA mixture. In addition, the presence of the APT-BSA complex was demonstrated, and it was shown that the associated quenching of the fluorescence from the BSA protein resulted from the formation of APT-BSA complex via a static mechanism. The binding constant (Ka(ave)=2.34×106Lmol-1) and the number of sites (n=1) were obtained by fluorescence methods as were the thermodynamic parameters (ΔH0, ΔS0 and ΔG0). This work suggested that the principal binding between APT to BSA was facilitated by hydrophobic interactions. The thermodynamic parameters for APT were compared to those from the structurally similar Chrysin and Wogonin molecules. It appeared that the entropy parameters were relatively more affected by the small structural changes. SFS from the interaction of BSA and APT showed that the ligand affected the conformation of BSA. The competitive interaction of APT and site makers with BSA indicated site I as the binding area of APT in BSA. © 2010 Elsevier B.V.


Wang X.,Harbin Institute of Technology | Ni W.,Nanchang University
IEEE Transactions on Systems, Man, and Cybernetics, Part B: Cybernetics | Year: 2012

In this paper, the leader-following formation problem of multirobot systems with switching interconnection topologies is considered. The robots are required to move in a formation with formation constrains described in terms of relative distances of the robots and the formation (as whole entity) is required to track the trajectory generated by an exosystem. The exosystem of the considered multirobot systems provides driving forces or environmental disturbance, whose dynamics is different from the dynamics of the robots. A systematic distributed design approach for the leader-following formation problem is proposed via dynamic output feedback with the help of canonical internal model. © 2012 IEEE.


Liu J.,Anhui Medical University | Liu J.,U.S. Center for Disease Control and Prevention | Zhu L.-P.,U.S. Center for Disease Control and Prevention | Yang X.-L.,Nanchang University | And 2 more authors.
Bone | Year: 2013

Context: The association between 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) and bone mineral density (BMD) is controversial because of conflicting findings from previous studies. Objective and design: The purpose of the present study was to evaluate the effect of statins on BMD reported in randomized and non-randomized controlled trials. We searched PubMed and Embase, using text, medical subject headings (MeSH) and keywords "bone mineral density" and "statins" or "HMG-CoA reductase inhibitors". Our last PubMed and Embase queries were updated to August 2012. Data on participants, interventions, and outcomes from each study were abstracted independently by two authors. Results: Five case-control studies, six cohort studies and four randomized controlled trials (RCTs) met the inclusion criteria. Included studies involved 34,877 subjects (3824 in the intervention group and 31,053 in the control group) in 12 different countries with ages ranging from 44 to 66. years. Statins significantly increased BMD at lumbar spine [standardized mean difference (SMD) 0.15, 95% CI 0.09-0.22], total hip (SMD 0.22, 95% CI 0.17-0.27) and femoral neck (SMD 0.19, 95% CI 0.09-0.29). We carried out subgroup analyses on selected populations of the cohorts. Statistically significant increases were also observed in the lumbar spine (SMD 0.12, 95% CI 0.04-0.21), total hip (SMD 0.23, 95% CI 0.17-0.28) and femoral neck BMD (SMD 0.22, 95% CI 0.08-0.36). Conclusion: The results of this study suggest that statins may help improve and maintain BMD at the lumbar spine, hip and femoral neck, especially in Caucasians and Asians. It also provides justification for prospective RCTs to evaluate the possible role of statins in BMD in different ethnic populations, such as Latin American and Africans. © 2013 Elsevier Inc.


Nie W.,Jiangxi University of Traditional Chinese Medicine | Liao Q.,Harbin Institute of Technology | He J.,Nanchang University
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2010

We study a Feynman-like thermal Brownian motor, in which the asymmetric corrugated cylinder as the ratchet is coupled with a corrugated plate by the noncontact Casimir interaction between them. The source of driving of the system is the thermal fluctuations and its dynamic evolution is described by a set of Langevin equations. Further, the mean velocity and thermal efficiency of the motor in the overdamped limit are studied in detail as a function of the temperature of the baths, external load applied, magnitude of the Casimir interaction, and other relevant parameters by the numerical stimulation. The transport properties attained here and the essential roles of the Casimir interaction can be explicitly demonstrated by designing a Casimir Brownian motor with present nanotechnology. © 2010 The American Physical Society.


Liu G.-L.,Southern Medical University | Yang H.-J.,Nanchang University | Liu T.,Southern Medical University | Lin Y.-Z.,Wenzhou University
Asian Pacific Journal of Tropical Medicine | Year: 2014

Objective: To study the expression of E-cadherin, N-cadherin, TGF-β1 and Twist protein and investigate its significance in the occurrence and development of prostate cancer. Methods: The expression of E-cadherin, N-cadherin, TGF-β1 and Twist protein in 59 prostate cancer tissues and 21 adjacent tissues were detected by immunohistochemical SABC staining, and the correlation with clinicopathological features was analyzed. Results: Positive rates of E-cadherin, N-cadherin, TGF-β1 and Twist were 32.2%, 54.2%, 71.2% and 74.6%, respectively, in prostate cancer tissues and 85.7%, 9.52%, 19.0% and 9.52%, respectively, in cancer-adjacent tissues, with significant differences between the two groups (P<0.05). The reduced expression of E-cadherin was related to the differentiation of prostate cancer tissues and PSA level, but was not associated with clinical stage, lymph node metastasis, bony metastasis and age. The increased expression of N-cadherin, TGF-β1 and Twist was related to the differentiation of prostate cancer tissues, clinical stage, lymph node metastasis, bony metastasis, but not to age. The difference in positive expression of N-cadherin and TGF-β1 was significant between PSA≤20 μg/L group and PSA>20μg/L group, but the positive expression of Twist was not significant between groups. The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also highly negatively correlated with that of Twist. The expression of TGF-β1 was correlated with those of E-cadherin, N-cadherin and Twist. Conclusions: The reduced expression of E-cadherin, abnormal expression of N-cadherin, transformation form E-cadherin to N-cadherin and the increased expression of TGF-β1 and Twist play an important role in the occurrence and development of prostate cancer. © 2014 Hainan Medical College.


Shu W.,Beijing Jiaotong University | Qian W.,Nanchang University | Qian W.,Beijing Key Laboratory of Knowledge Engineering for Materials Science
Knowledge-Based Systems | Year: 2014

Attribute measures, used to evaluate the quality of candidate attributes, play an important role in the process of attribute reduction. They largely affect the computational efficiency of attribute reduction. Existing attribute measures are acted on the whole universe in complete decision systems. There are few studies on improving attribute reduction algorithms from the perspective of attribute measures in incomplete decision systems, which motivates the study in this paper. This paper proposes new attribute measures that act on a dwindling universe to quicken the attribute reduction process. In particular, the monotonicity guarantees the rationality of the proposed attribute measures to evaluate the significance of candidate attributes. On this basis, the corresponding attribute reduction algorithms are developed in incomplete decision systems based on indiscernibility relation and discernibility relation, respectively. Finally, a series of comparative experiments are conducted with different UCI data sets to evaluate the performance of our proposed algorithms. The experimental results indicate that the proposed algorithms are efficient and feasible. © 2014 Elsevier B.V. All rights reserved.


Zeng X.-H.,Nanchang University | Navarro B.,Howard Hughes Medical Institute | Navarro B.,Boston Childrens Hospital | Xia X.-M.,Washington University in St. Louis | And 4 more authors.
Journal of General Physiology | Year: 2013

During passage through the female reproductive tract, mammalian sperm undergo a maturation process termed capacitation that renders sperm competent to produce fertilization. Capacitation involves a sequence of changes in biochemical and electrical properties, the onset of a hyperactivated swimming behavior, and development of theability to undergo successful fusion and penetration with an egg. In mouse sperm, the development of hyperactivated motility is dependent on cytosolic alkalization that then results in an increase in cytosolic Ca2+.The elevation of Ca2+ is thought to be primarily driven by the concerted interplay of two alkalization-activated currents, a K+ current (KSPER) composed of pore-forming subunits encoded by the Kcnu1gene (also termed Slo3) and a Ca2+ current arising from a family of CATSPER subunits. After deletion of any of four CATSPER subunit genes (CATSPER1-4), the major remaining current in mouse sperm is alkalization-activated KSPER current. After genetic deletion of the Slo3 gene, KSPER current is abolished, but there remains a small voltage-activated K+current hypothesized to reflect monovalent flux through CATSPER. Here, we address two questions. First, does the residual outward K+current present in the Slo3-/-sperm arise from CATSPER? Second, can any additional membrane K+currents be detected in mouse sperm by patch-clamp methods other than CATSPER and KSPER? Here, using mice bred to lack both SLO3 and CATSPER1 subunits,we show conclusively that the voltage-activated outward current present in Slo3-/- sperm is abolished when CATSPER is also deleted. Any leak currents that may play a role in setting the resting membrane potentialinnoncapacitated sperm are likely smaller than the pipette leak current and thus cannot be resolved within the limitation of the patch-clamp technique. Together, KSPER and CATSPER appear to be the sole ion channels present in mouse sperm that regulate membrane potential and Ca2+ influx in response to alkalization. © 2013 Zeng et al.


Wang X.,Harbin Institute of Technology | Ni W.,Nanchang University | Yang J.,McMaster University
IET Control Theory and Applications | Year: 2013

In this study, we consider the distributed output regulation (DOR) problem of linear multi-agent systems subject to input saturation with switching topology. Owing to the input saturation elements, the considered systems is non-linear. It is natural to take the semiglobal frame for it which allows one to use distributed linear feedback controller. The basic problem is to design distributed feedback controller for the considered multi-agent systems in order to have all agents to track an active leader and/or distributed rejection with disturbance signals. Both the leader and the disturbance signal are modelled as the exogenous system with different dynamics and unmeasurable variables. A systematic distributed linear design approach based on the solvability condition is proposed for the considered DOR problem. © The Institution of Engineering and Technology 2013.


Nie W.,Jiangxi University of Traditional Chinese Medicine | Liao Q.,Harbin Institute of Technology | Zhang C.,Jiangxi University of Traditional Chinese Medicine | He J.,Nanchang University
Energy | Year: 2010

An irreversible cycle model of the micro-/nanoscaled Otto engine cycle with internal friction loss is established. The general expressions of the work output and efficiency of the cycle are calculated based on the finite system thermodynamic theory, in which the quantum boundary effect of gas particles as working substance and the mechanical Casimir effect of gas system are considered. It is found that, for a micro-/nanoscaled Otto cycle devices, the work output W and efficiency η of the cycle can be expressed as the functions of the temperature ratio τ of the two heat reservoirs, the volume ratio rV and the surface area ratio rA of the two isochoric processes, the dimensionless thermal wavelength λ and other parameters of cycle, while for a macroscaled Otto cycle devices, the work output W0 and efficiency η0 of the cycle are independent of the surface area ratio rA and the dimensionless thermal wavelength λ. Further, the influence of boundary of cycle on the performance characteristics of the micro-/nanoscaled Otto cycle are analyzed in detail by introducing the output ratio W/W0 and efficiency ratio η/η0. The results present the general performance characteristics of a micro-/nanoscaled Otto cycle and may serve as the basis for the design of a realistic Otto cycle device in micro-/nanoscale. © 2010 Elsevier Ltd.


Xiang F.,Nanchang University | Zhong J.,Harbin Institute of Technology | Gu N.,Nanchang University | Mukherjee R.,Rensselaer Polytechnic Institute | And 3 more authors.
Carbon | Year: 2014

We report a novel far-infrared (FIR) thermal reduction process to effectively reduce graphene oxide films for supercapacitor electrode applications. The binder-free graphene oxide films used in this study were produced by electro-spray deposition of a graphene oxide colloidal solution onto stainless steel current collectors. The reduction of graphene oxide was performed using a commercial FIR convection oven that is ubiquitous in homes for cooking and heating food. The reduction process incorporated a simple, one-step FIR irradiation carried out in ambient air. Further, the FIR irradiation process was completed in ∼3 min, wherein neither special atmosphere nor high temperature was employed, resulting in an economic, efficient and simplified processing technique. The as-produced FIR graphene electrode gave a specific capacitance of ∼320 F/g at a current density of ∼0.2 A/g with less than 94% loss in specific capacitance over 10,000 charge/discharge cycles. This is one of the best specific capacitances reported for all-carbon electrodes without any additives. Even at ultrafast charge/discharge rates (current densities as high as ∼100 A/g), the FIR graphene electrode still delivered specific capacitances in excess of 90 F/g. The measured energy and power densities of the FIR supercapacitors were found to be ∼3-6 times higher than commercial (activated carbon) supercapacitor devices. This excellent electrochemical performance of the FIR graphene coupled with its ease of production (in air at low temperatures) using a commercial home-use FIR convection oven indicates the significant potential of this concept for large-scale commercial electrochemical supercapacitor applications. © 2014 Elsevier Ltd. All rights reserved.


Ni W.,Nanchang University | Wang X.,Harbin Institute of Technology | Xiong C.,Nanchang University
Automatica | Year: 2013

This paper considers, for leader-following linear multi-agent systems (MAS) connected by switching graphs, the consensus controllability and observability, and extends the existing results which are valid only for fixed graph case. Unlike the general controllability and observability problems which require each state to be controllable and observable, we only examine the consensus state to be controllable and the tracking error states between the followers and the leader to be observable. As for the consensus controllability, the admissible control input for each follower agent can only obtain relative and local information from its neighbors, and the control objective is to render the MAS to achieve consensus, in the sense of convergence of each follower's state to that of a leader agent. As for the consensus observability, the output of the MAS is the information-flow in the multi-agent network, and the observation task is to reconstruct the tracking error states between the followers and the leader. It is demonstrated in this paper that the controllability and observability of each individual system and the jointly connected switching topology (including fixed topology as a special case) jointly imply the consensus controllability and observability of the MAS. The consensus controllability property is used in the robust leader-following consensus problem, and the consensus observability property is used in the robust observer-based leader-following consensus problem, both under switching topology. © 2013 Published by Elsevier Ltd.


Yang D.,University of Michigan | Yang D.,Nanchang University | Tan M.,University of Michigan | Wang G.,Nanchang University | Sun Y.,University of Michigan
PLoS ONE | Year: 2012

Radiotherapy is a treatment choice for local control of breast cancer. However, intrinsic radioresistance of cancer cells limits therapeutic efficacy. We have recently validated that SCF (SKP1, Cullins, and F-box protein) E3 ubiquitin ligase is an attractive radiosensitizing target. Here we tested our hypothesis that MLN4924, a newly discovered investigational small molecule inhibitor of NAE (NEDD8 Activating Enzyme) that inactivates SCF E3 ligase, could act as a novel radiosensitizing agent in breast cancer cells. Indeed, we found that MLN4924 effectively inhibited cullin neddylation, and sensitized breast cancer cells to radiation with a sensitivity enhancement ratio (SER) of 1.75 for SK-BR-3 cells and 1.32 for MCF7 cells, respectively. Mechanistically, MLN4924 significantly enhanced radiation-induced G2/M arrest in SK-BR-3 cells, but not in MCF7 cells at early time point, and enhanced radiation-induced apoptosis in both lines at later time point. However, blockage of apoptosis by Z-VAD failed to abrogate MLN4924 radiosensitization, suggesting that apoptosis was not causally related. We further showed that MLN4924 failed to enhance radiation-induced DNA damage response, but did cause minor delay in DNA damage repair. Among a number of tested SCF E3 substrates known to regulate growth arrest, apoptosis and DNA damage response, p21 was the only one showing an enhanced accumulation in MLN4924-radiation combination group, as compared to the single treatment groups. Importantly, p21 knockdown via siRNA partialy inhibited MLN4924-induced G2/M arrest and radiosensitization, indicating a causal role played by p21. Our study suggested that MLN4924 could be further developed as a novel class of radiosensitizer for the treatment of breast cancer. © 2012 Yang et al.


Xu W.,Nanchang University | Yang Z.,Nanchang University | Zhou S.-F.,University of South Florida | Lu N.,Nanchang University
Drug Design, Development and Therapy | Year: 2014

The incidence of cancer is increasing worldwide, but the biochemical mechanisms for the occurrence of cancer is not fully understood, and there is no cure for advanced tumors. Defects of posttranslational modifications of proteins are linked to a number of important diseases, such as cancer. This review will update our knowledge on the critical role of posttranscriptional regulation of phosphatase and tensin homolog (PTEN) and its activities and the functional impact on cancer behaviors. PTEN is a tumor suppressor gene that occupies a key position in regulating cell growth, proliferation, apoptosis, mobility, signal transduction, and other crucial cellular processes. The activity and function of PTEN are regulated by coordinated epigenetic, transcriptional, posttranscriptional, and posttranslational modifications. In particular, PTEN is subject to phosphorylation, ubiquitylation, somoylation, acetylation, and active site oxidation. Posttranslational modifications of PTEN can dynamically change its activity and function. Deficiency in the posttranslational regulation of PTEN leads to abnormal cell proliferation, apoptosis, migration, and adhesion, which are associated with cancer initiation, progression, and metastasis. With increasing information on how PTEN is regulated by multiple mechanisms and networked proteins, its exact role in cancer initiation, growth, and metastasis will be revealed. PTEN and its functionally related proteins may represent useful targets for the discovery of new anticancer drugs, and gene therapy and the therapeutic potentials should be fully explored. © 2014 Xu et al.


Zhang T.X.,Alabama A&M University | Zhang T.X.,Nanchang University
Astrophysical Journal Letters | Year: 2010

A new mechanism for supernova explosions called gravitational field shielding is proposed, in accord with a fivedimensional fully covariant Kaluza-Klein theory with a scalar field that unifies the four-dimensional Einsteinian general relativity and Maxwellian electromagnetic theory. It is shown that a dense compact collapsing core of a star will suddenly turn off or completely shield its gravitational field when the core collapses to a critical density, which is inversely proportional to the square of mass of the core. As the core suddenly turns off its gravity, the extremely large pressure immediately stops the core collapse and pushes the mantle material of supernova moving outward. The work done by the pressure in the expansion can be the order of energy released in a supernova explosion. The gravity will resume and stop the core from a further expansion when the core density becomes less than the critical density. Therefore, the gravitational field shielding leads a supernova to impulsively explode and form a compact object such as a neutron star as a remnant. It works such that a compressed spring will shoot the oscillator out when the compressed force is suddenly removed. © 2010. The American Astronomical Society. All rights reserved.


Xia Y.-H.,Nanchang University | Huang S.-G.,Nanchang University
Dianji yu Kongzhi Xuebao/Electric Machines and Control | Year: 2012

It needs to correctly handle the relationship between utilization of tooth harmonic magnetic field and armature winding voltage waveform distortion for not affecting the operation performance of the hybrid excitation permanent magnet synchronous generator utilizing tooth harmonic for excitation, which is key problem utilizing tooth harmonic to achieve hybrid excitation. The reason of the field current pulsation provided by the tooth harmonic excitation system and the characteristics of the harmonic electromotive force(EMF) in the armature winding induced by the additional magnetic field were analyzed qualitatively based on the electric machine theory. Employing the method of shunting capacitance in the tooth harmonic excitation system can reduce the pulsation of the field current and weaken the harmonic EMF in the armature winding. Calculation and test are performed for one hybrid excitation permanent magnet synchronous generator utilizing tooth harmonic for excitation, and the comparison of calculated and experimental results verifies the correctness of the theoretical analysis.


Shen X.,Nanchang University | Jia R.,Nanchang University
Dianli Xitong Zidonghua/Automation of Electric Power Systems | Year: 2012

In view of the existing problem arising in the power generation market after implementing the correlated regulatory policy, a countable evaluation index system is built to systematically transfer the abstract reform request and the regulatory goals into quantifiable examination index. Then a modeling and analyzing method of rate variable based in-tree in system dynamics is used to quantitatively study the effect of correlated regulatory policy implementation. The results show that: (1) the key factors influencing the implementing effect of the coupled coal-electricity policy include the lowest linkage coal price rises, the linkage ratio, the coal price increase, and the timeliness of the policy implementation; (2) the main factors influencing the implementing effect of other regulatory policies, such as benchmark price, approval system of enterprise investment project, and replacing small units with large ones, include the different profitability, the loss of survival ability of the old unit, and the reliability of the power demand forecast; (3) if such improved measures as controlling the coal price rises and power demand, and adjusting the lowest coal price rises and the linkage ratio are taken, it may take effect in relieving the coal and power price contradiction, improving the unit profitability, inspiring the investment, and promoting the balance between power supply and demand. © 2012 State Grid Electric Power Research Institute Press.


Xie X.,Baylor College of Medicine | Tang K.,Baylor College of Medicine | Tang K.,Nanchang University | Yu C.-T.,Baylor College of Medicine | And 2 more authors.
Seminars in Cell and Developmental Biology | Year: 2013

The formation of complex organisms is highly dependent on the differentiation of specialized mature cells from common stem/progenitor cells. The orphan nuclear receptors chicken ovalbumin upstream promoter transcription factors (COUP-TFs) are broadly, but not ubiquitously, expressed in multiple tissues throughout embryonic development and COUP-TFs are indispensible for proper organogenesis. Recently, growing evidence suggests a critical role of COUP-TFs in multiple aspects of stem/progenitor cell biology. In this review, we highlight the progress of COUP-TFs function and its underlying mechanism in driving stem/progenitor cell self-renewal, lineage specification, differentiation, maintenance, and cell identity in diverse tissue types. These studies provide novel insights into future clinical utilities of COUP-TFs in stem cell based therapies and in the management of diseases. © 2013 Elsevier Ltd.


Li Y.,Nanchang University | Xiang Y.,Nanchang University | Peng S.,Nanchang University | Wang X.,Nanchang University | Zhou L.,Nanchang University
Electrochimica Acta | Year: 2013

Zr-doped TiO2 nanotube arrays (Zr-TiO2-NT) and TiO2 nanotube arrays (TiO2-NT) were prepared via anodic oxidation of titanium foils in ethylene glycol solution and modified by heat treatment in the presence of urea pyrolysis products at 400 °C. Zr doping changes the morphology of Zr-TiO2-NT and its conduction band edge shifts negatively compared with that of TiO2-NT. For the modification of Zr-TiO2-NT in the presence of urea pyrolysis products, Zr doping can not only enhance the polymerization degree of the surface-modified carbon nitride polymers but also promote the N doping. The modified TiO2-NT and Zr-TiO2-NT films exhibit significant photocurrent responses upon visible light irradiation. Zr doping improves markedly the visible-light photoelectrochemical H2 production of the modified Zr-TiO 2-NT. © 2012 Elsevier Ltd.


Deng X.-F.,Nanchang University | Wen X.-Q.,Nanchang University | Xu J.-Y.,Nanchang University | Ding Y.-P.,Nanchang University | Huang T.,Nanchang University
Astrophysical Journal | Year: 2010

At a stellar mass of 3 × 1010 M Θ, we divide the volume-limited Main galaxy sample of the Sloan Digital Sky Survey Data Release 6 (SDSS DR6) into two distinct families and explore the environmental dependence of galaxy properties for High Stellar Mass (HSM) and Low Stellar Mass (LSM) galaxies. It is found that for HSM and LSM galaxies, the environmental dependence of some typical galaxy properties, such as color, morphologies, and star formation activities, is still very strong, which at least shows that the stellar mass is not fundamental in correlations between galaxy properties and the environment. We also note that the environmental dependence of the size for HSM and LSM galaxies is fairly weak, which is mainly due to the galaxy size being insensitive to environment. © 2010. The American Astronomical Society. All rights reserved.


Liu Y.,Nanchang University
Aquatic Ecosystem Health and Management | Year: 2014

Urban rivers and lakes play a significant role in providing ecosystem services, such as water supply, purification, nutrient retention, recreation, aesthetics, and more. However, there is no widely-accepted methodology for how to dynamically evaluate the ecosystem service values of urban rivers and lakes. Using data from survey and remote sensing of Nanchang City, China, this article constructs a conceptual framework based on the Millennium Ecosystem Assessment to propose an integrated approach to evaluate the ecosystem service values of urban rivers and lakes. Furthermore, the article employs a GIS-based Markov chain model to predict the future probable distribution pattern of land use in Nanchang City, while it uses an artificial neural network model to simulate the potential changing of ecosystem service values. The Millennium Ecosystem Assessment-based dynamic evaluation shows that in the first period of 1989-1999, provisioning services are dominant, followed by regulating services, supporting services and cultural services, while during the second period of 1999-2008, regulating services rank firstly in the total change of ecosystem service values, followed by supporting services, cultural services and provisioning services. The artificial neural network-based simulation indicates that the total will slightly increase in line with a small undulation in regulating service values, whilst the most changes brought by the provisioning services will be stable. This study is intended to serve as a tool to be used in decision making for proper and informed urban aquatic ecosystem management. © 2014 Copyright © 2014 AEHMS.


Xiao S.-B.,Nanchang University
Applied Mechanics and Materials | Year: 2014

With the continuous development of computer technology, the technology in designing and developing 3D games has been more and more mature. Compared to the traditional ones, 3D games present more real screen effects and stronger visual impact due to its adopting the concept of stereo space coordinates, increasing the arbitrariness of space operation and its own attraction. By applying media video technology to 3D table tennis games, players can hit the ball with the racket to implement the move of the ball in the game scene. To achieve the ball's real-time depiction, every frame in the game must be updated. An outstanding 3D game cannot be developed without an excellent 3D game engine. The complex graphic algorithm of the game is encapsulated in modules efficiently while simple and effective SDK interface, powerful editor and matching third-party plug-ins are provided externally. Meanwhile, it possesses the function in network, database and script, etc, making the development of 3D games easier and of high quality. Numerous UI (graphical interfaces) are offered in the whole game to help players understand and learn the game. The game is operated so easily that it can be well played only through click, which simplifies the fussy operation of regular ones and provides players with more enjoyment. © (2014) Trans Tech Publications, Switzerland.


Li Y.-H.,Nanchang University | Zhang L.,Nanchang University | Huang J.,Nanchang University | Liang R.-P.,Nanchang University | Qiu J.-D.,Nanchang University
Chemical Communications | Year: 2013

Using graphene quantum dots (GQDs) with a boronic acid-substituted bipyridinium salt (BBV), a label-free fluorescence assay for glucose detection is presented. © 2013 The Royal Society of Chemistry.


Xiao Q.,Fudan University | Xiao Q.,Nanchang University | Ye S.,Fudan University | Wu J.,Fudan University | Wu J.,CAS Shanghai Institute of Organic Chemistry
Organic Letters | Year: 2012

A silver(I)-catalyzed tandem reaction of 2-alkynylbenzaldoxime with alkylidenecyclopropane gives rise to benzo-7-azabicyclo[4.2.2]dec-7-en-4-ones in moderate to good yields. The complexity and diversity could be easily incorporated with the formation of three bonds during the process. © 2012 American Chemical Society.


Zheng X.-J.,Nanchang University | Qiu J.-D.,Nanchang University | Zhang L.,Nanchang University | Wang Z.-X.,Nanchang University | Liang R.-P.,Nanchang University
Chemical Communications | Year: 2013

Using unmodified Au nanorods with enzyme-linkage reaction, a label-free colorimetric method for simple and convenient assay of DNA methylation is presented. This journal is © 2013 The Royal Society of Chemistry.


Zhang H.,Nanchang University
Advanced Materials Research | Year: 2012

With the rapid development of the global economy, more and more enterprises emphasize on the coordination with the partners to improve the supply chain competitive capability. This paper focuses on the united scheduling of the three-layer supply chain and the coordination mechanisms of agile supply chain. The objective is to minimize the total transportation cost and improve the customer's service level, which is achieved by scheduling the jobs and delivering them to the next stage in batches. Based on the features of the optimal scheduling, a dynamic programming algorithm is proposed. © (2012) Trans Tech Publications, Switzerland.


Liu S.-Q.,Nanchang University | Chen X.-C.,Nanchang University
Physica A: Statistical Mechanics and its Applications | Year: 2011

The generalized dispersion equation for longitudinal oscillation in an unmagnetized, collisionless, isotropic and relativistic plasma is derived in the context of nonextensive q-distribution. The analytical expression for the dispersion relation is obtained in an ultra-relativistic regime, which is related to the q-parameter and temperature. In the limit q→1, the result based on the relativistic Maxwellian distribution is recovered. Using the numerical simulation method, we obtain the full dispersion curve which cannot be given by an analytic method. It is shown that the numerical solution is in good agreement with the analytical result in the long-wavelength, short-wavelength and near light wave region for ultra-relativistic plasmas. © 2011 Elsevier B.V. All rights reserved.


Chen J.,Nanchang University | Chen J.,Zhejiang University | Zhu L.,Zhejiang University
Journal of Hazardous Materials | Year: 2011

An enhanced method of hydroxyl-Fe-pillared bentonite (H-Fe-P-B) during the degradation of Orange II was studied to provide novel insight to interactions of degradation intermediates with heterogeneous catalyst in UV-Fenton system. Based on the degradation mechanism of Orange II, oxalate enhanced mechanism of H-Fe-P-B in heterogeneous UV-Fenton system was developed. The results showed that additional oxalate could increase the Fe leaching of H-Fe-P-B during heterogeneous UV-Fenton process, which led to higher mineralization efficiency of Orange II and lower energy consumption of treatment. When the concentrations of additional sodium oxalate increased up to 0.1mmolL-1, 0.2mmolL-1 and 0.4mmolL-1, the rate of Orange II degradation could increase 30%, 46% and 63%, respectively. The iron ions leached from catalyst could be adsorbed back to the catalyst again after the organic intermediates were mineralized completely. Then the catalyst of H-Fe-P-B could be reused and additional pollution caused by iron ions could be avoided. © 2010 Elsevier B.V.


Cheng B.,Nanchang University | Xu J.,Nanchang University | Ouyang Z.,Nanchang University | Xie C.,Nanchang University | And 3 more authors.
Optics Express | Year: 2013

ZnO nanowires have relatively high sensitivity as ultraviolet (UV) photodetectors, while the bandgap of 3.37 eV is an important limitation for their applications in solar-blind UV (SBUV), visible (VIS) and near infrared (NIR) range. Besides UV response, in this study, we demonstrate the promising applications of individual undoped ZnO NWs as high performance SBUV-VIS-NIR broad-spectral-response photodetectors, strongly depended on applied bias voltage and illumination intensity. The dominant mechanism is attributed to the existence of surface states in nanostructured ZnO. At a negative bias voltage electrons can be injected into surface states from electrode, and moreover, under light illumination photogenerated electron-hole pairs can be separated efficiently by surface built-in electric field, resulting into a decrease of potential barrier height and depletion region width, and simultaneously accompanying a filling of oxygen vacancy and a rise of ZnO Fermi level. © 2010 Optical Society of America.


Runzi L.,Nanchang University | Yinglan W.,Nanchang University | Shucheng D.,Nanchang University
Chaos | Year: 2011

In this paper, an active backstepping design is proposed to achieve combination synchronization between three different chaotic systems: Lorenz system, Chen's system, and Lü system. The proposed method is a systematic design approach and consists in a recursive procedure that interlaces the choice of a Lyapunov function with the design of active control. Numerical simulations are shown to verify the feasibility and effectiveness of the proposed control technique. © 2011 American Institute of Physics.


Xiao S.-B.,Nanchang University
Applied Mechanics and Materials | Year: 2014

In the paper the interactive multimedia network autonomous learning platform is analyzed, through which its use case diagram is presented. The autonomous learning platform consists of user register module, user login module, teacher profile module, discussion and Q/A module, online test module, learning video module, system introduction module, material download module and backstage administration module. Primarily, the design and development of the platform is meant to solve the problem of data exchange between database and pages. Data are updated or deleted when the data of pages are transmitted to backstage database. The implementation of the autonomous learning platform fulfills people's urgent demands of the online education, settles the drawback that education and being educated in traditional approach cannot be conducted at different time and in different places, and enhances the efficiency of teacher's teaching and students' learning enormously as well. © (2014) Trans Tech Publications, Switzerland.


Wang Y.,Nanchang University | Zhang G.,Nanchang University | Wang L.,Nanchang University
Pesticide Biochemistry and Physiology | Year: 2014

Prometryn possesses much potential hazard to environment because of its chemical stability and biological toxicity. Here, the binding properties of prometryn with human serum albumin (HSA) and the protein structural changes were determined under simulative physiological conditions (pH 7.4) by multispectroscopic methods including fluorescence, UV-vis absorption, Fourier transform infrared (FT-IR) and circular dichroism (CD) spectroscopy, coupled with molecular modeling technique. The result of fluorescence titration suggested that the fluorescence quenching of HSA by prometryn was considered as a static quenching procedure. The negative enthalpy change (δH○) and positive entropy change (δS○) values indicated that the binding process was governed mainly by hydrophobic interactions and hydrogen bonds. The site marker displacement experiments suggested the location of prometryn binding to HSA was Sudlow's site I in subdomain IIA. Furthermore, molecular docking studies revealed prometryn can bind in the large hydrophobic activity of subdomain IIA. Analysis of UV-vis absorption, synchronous fluorescence, CD and FT-IR spectra demonstrated that the addition of prometryn resulted in rearrangement and conformational alteration of HSA with reduction in α-helix and increases in β-sheet, β-turn and random coil structures. This work provided reasonable model helping us further understand the transportation, distribution and toxicity effect of prometryn when it spreads into human blood serum. © 2014 Elsevier Inc.


Hui X.,Nanchang University
Applied Mechanics and Materials | Year: 2014

Through in-depth research on branding and marketing microblogging theory, summarizes the advantages and methods based automotive marketing microblogging branding strategy, analyze the current situation of the car microblogging marketing, implementation and effectiveness of the monitoring of the development of automobile brand communication strategy will be comprehensive exposition, based on theoretical build car branding and marketing strategy microblogging system. © (2014) Trans Tech Publications, Switzerland.


Zhou C.,Nanchang University | Li M.,Nanchang Institute of Technology | Yuan K.,Nanchang University | Deng S.,Nanchang University | Peng W.,Nanchang University
Infection, Genetics and Evolution | Year: 2012

The aim of the present study is to detect the frequency and distribution of cross infection and hybridization of human and pig . Ascaris in China. Twenty high polymorphic microsatellite loci were selected to screen 258 . Ascaris worms from humans and pigs from six provinces in China. The software programs S. tructure, B. aps and N. ewhybrids were used to determine the case of cross infection and hybridization of human and pig . Ascaris. Results showed that cross infection was detected in all sampled locations and of the total 20 cross infection cases, 19 were indentified as human infections by pure-bred pig type . Ascaris in contrast to only one case of pig infection by pure-bred human type . Ascaris. Similar to the findings in cross infection, hybrid . Ascaris was also detected in all locations and both host species and most of hybrids (95%) were detected from human host. The distribution of cross infection and hybrids showed significant difference between the two host species and among three categories of genotype in terms of G1, G2 and G3, and also between the south and north regions (for hybrids only). The results strongly suggest pig . Ascaris as an important source of human ascariasis in endemic area where both human and pig . Ascaris exist. In consideration of current control measures for human ascariasis targeting only infected people, it is urgently needed to revise current control measures by adding a simultaneous treatment to infected pigs in the sympatric endemics. The knowledge on cross transmission and hybridization between human and pig . Ascaris is important not only for public health, but also for the understanding of genetic evolution, taxonomy and molecular epidemiology of . Ascaris. © 2012 Elsevier B.V..


Wang G.,China Research Institute of Daily Chemical Industry | Qu W.,Shanxi Datong University | Du Z.,China Research Institute of Daily Chemical Industry | Cao Q.,Nanchang University | Li Q.,China Research Institute of Daily Chemical Industry
Journal of Physical Chemistry B | Year: 2011

Three novel amphiphilic dicephalic (double-headed) surfactants containing oligo(ethylene-oxide)methyl-ether and a sugar moiety TGA-m (m = 1, 2, and 3) that incorporate a tetrasiloxane at the terminus of a hydrocarbon chain were designed and synthesized. Their surface activity and aggregation behavior in aqueous solution were systematically investigated by surface tension, dynamic light scattering (DLS), and transmission electron microscopy (TEM) techniques at 298 K. The surface tension measurements provided the critical aggregation concentration (CAC) and the surface tension at the CAC (γcac). In addition, with application of the Gibbs adsorption isotherm, the maximum surface excess concentration (τmax) and the minimum surface area/molecule (Amin) at the air-water interface were estimated. The effect of EO chain length on the surface activity and aggregation behavior was also investigated. It was found that both the γcac and the CAC were lower than those for reported traditional hydrocarbon surfactants. Aggregates of three surfactants, TGA-m (m = 1, 2, and 3), formed in aqueous solutions could be assigned as spherical vesicles as suggested by analysis using DLS and TEM. Moreover the formation of vesicles can be confirmed by the encapsulation of bromophenol blue. These results indicate that these three surfactants have excellent efficiencies of vesicle formation and surface tension reduction in the aqueous phase. © 2011 American Chemical Society.


The effectiveness of fixatives for fixing biological specimens has long been widely investigated. However, the lowest concentrations of fixatives needed to completely fix whole cells or various cellular structures remain unclear. Using real-time imaging and quantification, we determined the lowest concentrations of glutaraldehyde (0.001-0.005, ~0.005, 0.01-005, 0.01-005, and 0.01-0.1 %) and formaldehyde/paraformaldehyde (0.01-0.05, ~0.05, 0.5-1, 1-1.5, and 0.5-1 %) required to completely fix focal adhesions, cell-surface particles, stress fibers, the cell cortex, and the inner structures of human umbilical vein endothelial cells within 20 min. With prolonged fixation times (>20 min), the concentration of fixative required to completely fix these structures will shift to even lower values. These data may help us understand and optimize fixation protocols and understand the potential effects of the small quantities of endogenously generated aldehydes in human cells. We also determined the lowest concentration of glutaraldehyde (0.5 %) and formaldehyde/paraformaldehyde (2 %) required to induce cell blebbing. We found that the average number and size of the fixation-induced blebs per cell were dependent on both fixative concentration and cell spread area, but were independent of temperature. These data provide important information for understanding cell blebbing, and may help optimize the vesiculation-based technique used to isolate plasma membrane by suggesting ways of controlling the number or size of fixation-induced cell blebs.


In the green building concept, not only do the influences of the local climate, architectural form, usage mode, facilities condition, construction process, building materials and access management on the external environment as well as the comfortable and healthy internal environment are taken into account, but also the different interests of investors, users, design, installation, operation and maintenance personnel are integrated. In other words, the relationship among the lasting design, favorable environment and beneficiaries must be balanced and interactive, and hence the optimal greening effect can be accomplished. From this point of view, the green building can balance and coordinate the different needs and energy dependences between the internal and external environments and the users, and hence the buildings and the environments can be melted together naturally. In this paper, the author studies the whole process of integrating the "green building" into residence districts by the Yushan Huafu Home Community for example. © (2012) Trans Tech Publications, Switzerland.


Deng X.-F.,Nanchang University | Bei Y.,Nanchang University | He J.-Z.,Nanchang University | Tang X.-X.,Nanchang University
Astrophysical Journal | Year: 2010

Using two volume-limited Main galaxy samples of the Sloan Digital Sky Survey Data Release 6 above and below the value of M*, we have investigated the environmental dependence of other galaxy properties for the same star formation activities. Only in the luminous passive class, a strong environmental dependence of the g - r color is observed, but the environmental dependence of other properties in this class is very weak. In other classes, we can conclude that the local density dependence of luminosity, g - r color, concentration index ci, and morphologies for star-forming galaxies and passive ones is much weaker than that obtained in the volume-limited Main galaxy samples. This suggests that star formation activity is a galaxy property very predictive of the local environment. In addition, we also note that passive galaxies are more luminous, redder, highly concentrated, and preferentially "early type. © 2010. The American Astronomical Society.


Xu J.,Nanchang University | Wu X.,Nanchang University
Research in Astronomy and Astrophysics | Year: 2010

By adding force gradient operators to symmetric compositions, we build a set of explicit fourth-order force gradient symplectic algorithms, including those of Chin and coworkers, for a separable Hamiltonian system with quadratic kinetic energy T and potential energy V. They are extended to solve a gravitational n-body Hamiltonian system that can be split into a Keplerian part H 0 and a perturbation part H 1 in Jacobi coordinates. It is found that the accuracy of each gradient scheme is greatly superior to that of the standard fourth-order Forest-Ruth symplectic integrator in T + V-type Hamiltonian decomposition, but they are both almost equivalent in the mean longitude and the relative position for H 0 + H 1-type decomposition. At the same time, there are no typical differences between the numerical performances of these gradient algorithms, either in the splitting of T + V or in the splitting of H 0 + H 1. In particular, compared with the former decomposition, the latter can dramatically improve the numerical accuracy. Because this extension provides a fast and high-precision method to simulate various orbital motions of n-body problems, it is worth recommending for practical computation. © 2010 National Astronomical Observatories of Chinese Academy of Sciences and IOP Publishing Ltd.


Wu X.,Nanchang University
Research in Astronomy and Astrophysics | Year: 2010

A global relationship between cosmological time and Belinskii-Khalatnikov- Lifshitz (BKL) time during the entire evolution of the Mixmaster Bianchi IX universe is used to explain why all the Lyapunov exponents are zero at the BKL time. The actual reason is that the domain of the cosmological time is finite as the BKL time runs from minus infinity to infinity. © 2010 National Astronomical Observatories of Chinese Academy of Sciences and IOP Publishing Ltd.


From theMain galaxy sample of the Sloan Digital Sky Survey Data Release 7, I construct two volume-limited samples with luminosities -20.5 ≤ M r ≤ -18.5 and -22.5≤ Mr ≤-20.5, respectively, to explore the environmental dependence of the star formation rate (SFR) and the specific star formation rate (SSFR) at fixed morphology. It is found that in these two volume-limited samples, galaxies in the lowest density regime preferentially have higher SFR and SSFR than galaxies in the densest regime. I divide each volume-limited Main galaxy sample into two distinct populations, the early type and the late type, and observe that the environmental dependence of the SFR and SSFR of galaxies remains true at fixed morphology: the SFR and SSFR of galaxies in the densest regime is still preferentially lower than that of the ones in the lowest density regime with the same morphological type. I also note that the environmental dependence of the SFR and SSFR of late-type galaxies is stronger than that of early-type galaxies. © 2010. The American Astronomical Society. All rights reserved.


Fu Z.,Nanchang University | Li Z.,Nanchang University | Xiong Q.,Nanchang University | Cai H.,Nanchang University
European Journal of Organic Chemistry | Year: 2014

By using simple and readily available DMSO as a convenient and environmentally friendly source of sulfur, a practical approach for the Pd-catalyzed decarboxylative methylthiolation of 2-nitrobenzoic acids was developed. A range of substituents on the aryl group of the ortho-nitrobenzoic acid were compatible with this process. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Ju F.J.,Nanchang University
Environment, Energy and Applied Technology - Proceedings of the 2014 3rd International Conference on Frontier of Energy and Environment Engineering, ICFEEE 2014 | Year: 2015

With the development of society and economy, the radiation source as the key content of civilian non power nuclear technology has been widely applied in many fields of petroleum, chemical, paper making, cement, metallurgy, medical treatment, agriculture, in the meantime, also left a hidden danger to humans, the use of management is the problem of radiation source. Long term since, the monitoring work of radiation source has been in the artificial monitoring stage backward, radiation source is lost when the incident occurred; a colorless, tasteless and radioactive pollution are imperceptible; once the contaminated environment will be difficult to control and restore; radioactive source also has social sensitivity, the public has the abnormal fear of radiation, once the discovery of radioactivity pollution hazard, extremely easy to cause social unrest, effect of diazepam. So it has important significance and application value for monitoring social real-time reliable large amounts of radioactive source research on how the distribution of a wide range of different site environment. © 2015 Taylor & Francis Group, London.


Wu H.L.,Nanchang University
Environment, Energy and Applied Technology - Proceedings of the 2014 3rd International Conference on Frontier of Energy and Environment Engineering, ICFEEE 2014 | Year: 2015

This article analyzes the demand of the unmanned vehicle, made clear in the road traffic, and the basic requirements of the unmanned vehicle development present situation at home and abroad, and put forward the unmanned vehicle control and planning the overall scheme of the system control is divided into the underlying control, GPS navigation and laser radar environment perception of three parts. It also introduces the design principle of unmanned drone, analyzed the security of the intelligent unmanned and the design of the driverless cars running, analyzed the influence of the intelligent unmanned social benefit analysis, and the prospects of intelligent driverless cars in the future were discussed. © 2015 Taylor & Francis Group, London.


He Y.,Nanchang University | Chen N.,Nanchang University | Du G.,Nanchang University
Journal of the American Ceramic Society | Year: 2014

LaOF:Eu3+ nanoparticles were successfully prepared by annealing LaF3:Eu3+ nanocrytsals which were capped with SiO 2 shell. The SiO2 shell effectively prohibited the growth of LaF3:Eu3+ nanocrystals during the annealing process, and it was etched off after annealing to obtain the LaOF:Eu3+ nanoparticles. The LaOF:Eu3+ nanoparticles had a size comparable to the original LaF3:Eu3+ nanoparticles. Inorganic-organic hybrid nanoparticles of LaF3:Eu3+ and LaOF:Eu3+ nanoparticles with thenoyltrifluoroacetone (TTA) ligands were prepared. Strong luminescence as a result of the energy transfer from the TTA organic ligands to the LaF3:Eu3+ and LaOF:Eu3+ nanoparticles was observed. The LaOF:Eu3+-based hybrid nanoparticles exhibited stronger luminescence intensity and broader excitation spectral range than the LaF 3:Eu3+-based hybrid nanoparticles. Effect of the content of TTA ligands on the luminescence of the LaOF:Eu3+ nanoparticles was investigated in detail. © 2014 The American Ceramic Society.


Zhou L.,Nanchang University
2011 2nd International Conference on Mechanic Automation and Control Engineering, MACE 2011 - Proceedings | Year: 2011

The square truncated cone is processed by NC incremental forming in order to analyze the change law of metal texture. The experiment results show that a uniform thickness of the deformed region is maintained and in good accordance with that obtained by the sine law. The metal deformation law is searched by metallurgical analysis. The crystalline grain is stretched severely on the vertical section of the square truncated cone. The crystalline grain size is constant on the horizontal section of the square truncated cone. The metal shear deformation occurs in the square truncated cone. It is drawn that the NC incremental forming is a shear forming. The experiment is made to verify it. © 2011 IEEE.


Liu C.,Nanchang University
International Asia Conference on Industrial Engineering and Management Innovation: Core Areas of Industrial Engineering, IEMI 2012 - Proceedings | Year: 2013

This work researches on supply chain system of the process of Automobile Manufacture Enterprise's mass customization by using the method of QFD and reconstructs its HOQ, analyzes and compares the main factors deciding supply china system capability. At the basis of all of these, it put forward the improving measure and the method of optimizing supply chain system capability in order to advance service level and quality of supply chain system and further effectively satisfy the customer demand and enhance market shares. © Springer-Verlag Berlin Heidelberg 2013.


Huang G.,Nanchang University | Ni X.,Nanchang University | Wu X.,Nanchang University
European Physical Journal C | Year: 2014

We take into account the dynamics of a complete third post-Newtonian conservative Hamiltonian of two spinning black holes, where the orbital part arrives at the third post-Newtonian precision level and the spin–spin part with the spin–orbit part includes the leading-order and next-to-leading-order contributions. It is shown through numerical simulations that the next-to-leading-order spin–spin couplings play an important role in chaos. A dynamical sensitivity to the variation of single parameter is also investigated in some cases. In particular, there are a number of observable orbits whose initial radii are large enough and which are chaotic before coalescence. © 2014, The Author(s).


Yu J.,Nanchang University | Xia Y.,Nanchang University
Electrochimica Acta | Year: 2014

A facile one-step wet chemical method for preparing SnO2@OCNTs composite was described in this paper. The formation of composite is dried by the capillary force and electrostatic interaction. The results reveal that the Open-tips CNTs (OCNTs) are filled with ultrafine SnO2 nanoparticles (4-6 nm) and with a few SnO2 nanoparticles on the outside surface. The composite delivers a capacity of 848 mAh g-1 (based on the mass of composite) in the first cycle and keeps 83.5% of the original capacity after 300 cycles at the current density of 70 mA g-1. Furthermore, the composite still releases a capacity of 398 mAh g-1 at the current density of 3000 mA g-1. © 2014 Elsevier Ltd. All rights reserved.


Zou C.,Nanchang University | Hu H.,Nanchang University
Vascular Health and Risk Management | Year: 2013

Pioglitazone and other thiazolidinediones (TZDs) initially showed great promise as unique receptor-mediated oral therapy for type 2 diabetes, but a host of serious side effects, primarily cardiovascular, have limited their utility. It is crucial at this point to perform a risk-benefit analysis to determine what role pioglitazone should play in our current treatment of type 2 diabetes and where the future of this class of drugs is headed. This review provides a comprehensive overview of the present literature. Clinical data currently available indicate that pioglitazone is an effective and generally well-tolerated treatment option for use in patients with type 2 diabetes. Pioglitazone can still reduce adverse cardiovascular risk. © 2013 Zou and Hu.


Wang F.-H.,Nanchang University | Liu Y.,Nanchang University
Mocaxue Xuebao/Tribology | Year: 2012

Steel fiber reinforced ceramic-based friction material is prepared by nitrogen protection sintering method. The effects of steel fiber content on fade, recovery and wear performance of the ceramic-based friction material are studied and compared using XD-MSM constant speed friction tester. The worn surface morphology is observed by using scanning electron microscopy (SEM), and wear mechanism is discussed. The results show that the interface between steel fiber and ceramic matrix is good, the wear resistance of the friction material with a steel fiber content of 24% is improved. The fade ratio is as low as 5.8% and the recovery ratio is 107.8%, showing the excellent performances of heat fading resistance and recovery of the friction material. SEM analysis shows that steel fiber content has impact on the main wear mechanism of ceramic-based friction material. The main wear mechanisms of ceramic-based friction material with a low steel fiber content are brittle spalling and fatigue wear. By increasing steel fiber content, the main wear mechanism is abrasive wear. Further increasing steel fiber content, the wear mechanisms of ceramic-based friction material are brittle spalling and fatigue wear accompanying with adhesion wear.


Liang R.-P.,Nanchang University | Wang Z.-X.,Nanchang University | Zhang L.,Nanchang University | Qiu J.-D.,Nanchang University
Sensors and Actuators, B: Chemical | Year: 2012

In this contribution, we develop a novel type of multi-walled carbon nanotubes/silica nanoparticles array (MWCNTs/SiO 2) composite by the galvanostatic deposition technique. In this process, MWCNTs were mixed with ammonium fluorosilicate to form a doped precursory sol solution, the electrochemically generated hydroxyl ions at negative potentials promote the hydrolysis of ammonium fluorosilicate, and the simultaneously generated hydrogen bubbles assist the formation of three-dimensional porous silica matrix, further facilitating the construction of SiO 2 NPs array with uniform distribution, as confirmed by scanning electron microscopy. The formation of SiO 2 NPs array provides a higher surface area and biocompatible microenvironment for retaining the native activity of the immobilized biomolecules. Further incorporation of MWCNTs into SiO 2 NPs array improves the electronic conductivity and enhances the electroactive surface area of the film, making the fabricated three-dimensional porous MWCNTs/SiO 2 electrode an ideal platform for further immobilization of alpha-fetoprotein (AFP), as a model protein. This method achieves ultrasensitive detection of AFP antigen with ferricyanide as a probe. The obtained results provided a linear response range from 0.1 to 30.0 ng mL -1 AFP antigen with a lower detection limit of 0.018 ng mL -1. This work implies that the biocompatible and controllable three-dimensional porous SiO 2 NPs array possessed potential applications for biosensing. © 2012 Elsevier B.V. All rights reserved.


Zhang J.,Nanchang University | Zou W.,Nanchang University
Proceedings - 2nd IEEE International Conference on Advanced Computer Control, ICACC 2010 | Year: 2010

This paper presents an novel technique that employs both the color and edge direction features for Content-Based Image Retrieval (CBIR). In this method, a given image is first divided into sub-block which has the same size and then the color and edge direction features of each sub-block can be extracted. Next, it constructs a codebook of color feature using clustering algorithm and then each sub-block is mapped to the codebook. Finally, it uses the color index codes to image retrieval and uses the edge direction feature as the color feature's weight which belongs to the same color feature's sub-block. The effectiveness of this technique is demonstrated with the experiments. © 2010 IEEE.


Wang Q.,Chongqing University | Wang Q.,Nanchang University | Liu F.,Chongqing University | Li C.,Chongqing University
Journal of Cleaner Production | Year: 2013

Increasing pressures from energy price and environmental directive force the manufacturing enterprises to consider and initiate the implementation of energy assessment and energy quota practices to improve both their economic benefit and environmental performance. Against this background this paper presents an integrated method to evaluate energy efficiency in machining workshop. The integrated features of the assessing method are reflected in three aspects: (1) In this evaluation system, the energy profile of machining workshop is viewed from the machine tool layer, manufacturing unit layer, task layer and workshop layer to reveal the energy performance inside the workshop completely. (2) The assessing indexes for each layer include both effective energy indicator and Specific Energy Consumption (SEC) indicator. (3) An integrated calculation method of energy indexes is introduced, which combines off-line experiments with theoretical formulas. To verify its feasibility and validity, the assessment method is applied to a small machining workshop. The assessing results showed that the assessment method is helpful in providing support for machining scheme selection, energy saving discovery and energy quota allocation in plant, which has significance in practice. © 2013 Elsevier Ltd. All rights reserved.


Du J.,Nanchang University | Yang M.-N.,University of Manchester | Yang S.-F.,Hubei University
Applied Thermal Engineering | Year: 2016

In this paper, the study is focused on a double flow plate-fin heat exchanger (PFHE) which heat transfer element is staggered offset fin, and heat transfer model and the energy equations for the structure have been established, seven geometric parameters such as the fin height, fin length and fin wrinkling angle are taken as the decision variables for optimization. A genetic algorithm (GA) combined with orthogonal design is used to search for the optimal overall structure and the correlations about the fin heat transfer factor j and the friction factor f. The maximum total heat transfer rate and the minimum total pressure drop are taken as objective functions in the GA, respectively. Performance of the optimized structure is evaluated and correspondingly the heat transfer and hydrodynamic characteristics of the full-size PFHE are calculated by using a porous media approach. Numerical results show that the total heat transfer rate of the optimized structure is improved about 6.2% comparing with the original design, the total pressure drop decreases by about 40% and the volume can reduce about 2.7%. © 2016 Elsevier Ltd


Shang Y.,Nanchang University | Qi L.,Nanchang University | Wu F.,Nanchang University
Microchimica Acta | Year: 2012

We report on a simple strategy for the determination of zinc ion by using surface-modified quantum dots. The probe consists of manganese-doped quantum dots made from zinc sulfide and capped N-acetyl-L-cysteine. The particles exhibit bright yellow-orange emission with a peak at 598 nm which can be attributed to the 4T 1→ 6A 1 transition of Mn(II). This bright fluorescence is effectively quenched by modifying the sulfur anion which suppresses the radiative recombination process. The emission of the probe can then be restored by adding Zn(II) which causes the formation of a ZnS passivation layer around the QDs. The fluorescence enhancement caused is linear in the 1. 25 to 30 μM zinc concentration range, and the limit of detection is 0. 67 μM. © 2012 Springer-Verlag.


Ju F.J.,Nanchang University
Environment, Energy and Applied Technology - Proceedings of the 2014 3rd International Conference on Frontier of Energy and Environment Engineering, ICFEEE 2014 | Year: 2015

This study puts forward electric vehicle intelligent service platform based on cloud computing. With an Internet user access channels for electric cars, electric car core business to achieve the user’s query function, and charging reservation, route planning, policies and regulations show, online service and other auxiliary functions, and provide the user mobile phone client access. The emphasis is based on the cloud computing architecture theory, build a service platform, the core service layer, service management layer, user interface to access layer software architecture, analysis of the key technology of the operation service platform. Put forward the private and hybrid cloud deployment model based on coupling. © 2015 Taylor & Francis Group, London.


Zhang G.,Nanchang University | Fu P.,Nanchang University | Wang L.,Nanchang University | Hu M.,Nanchang University
Journal of Agricultural and Food Chemistry | Year: 2011

The interaction between farrerol and calf thymus DNA in a pH 7.4 Tris-HCl buffer was investigated with the use of neutral red (NR) dye as a spectral probe by UV-vis absorption, fluorescence, and circular dichroism (CD) spectroscopy, as well as viscosity measurements and DNA melting techniques. It was found that farrerol molecules could intercalate into the base pairs of DNA as evidenced by decreases in iodide quenching effect and single-stranded DNA (ssDNA) quenching effect, induced CD spectral changes, and significant increases in relative viscosity and denaturation temperature of DNA. Furthermore, the spectral data matrix of the competitive reaction between farrerol and NR with DNA was resolved with an alternative least-squares (ALS) algorithm, and the concentration profiles in the reaction and the corresponding pure spectra for three species (farrerol, NR, and DNA-NR complex) were obtained. This ALS analysis demonstrated the intercalation of farrerol to the DNA by substituting for NR in the DNA-NR complex. Moreover, the thermodynamic parameters enthalpy change (ΔH°) and entropy change (ΔS°) were calculated to be -16.49 ± 0.51 kJ mol -1 and 32.47 ± 1.02 J mol -1 K -1 via the van't Hoff equation, which suggested that the binding of farrerol to DNA was driven mainly by hydrophobic interactions and hydrogen bonds. © 2011 American Chemical Society.


One-dimensional chain copper (II) coordination polymer has been synthesized and characterized in the solvent mixture of water and alcohol with o-acetamidobenzoic acid, 4,4′bipyridine and copper Perchlorate. It is of tetragonal, space group P41212 with a = 1.57756 (10), b = 1.57756 (10), c = 2.1438 (3) nm, V= 5.3352 (8) nm3, Dc= 1.524 g/cm3, Z = 4, F(000) = 2536, R = 0.0479 and wR = 0.0979. The crystal structure shows two coordination modes. The copper (1) is coordinated with two nitrogen atoms of one 4,4′-bipyridine molecule and two oxygen atoms from two o-acetamidobenzoic acid molecules, forming a distorted tetrahedral coordination geometry; the copper(2) is coordinated with two nitrogen atoms of one 4,4′-bipyridine molecule, four oxygen atoms from two o-acetamidobenzoic acid molecules and two water molecules, generating a distorted octahedral coordination geometry. The result of TG analysis shows that the title complex is stable below 180.0 °C.


Zou W.-N.,Nanchang University | Tang C.-X.,Nanchang University | Pan E.,University of Akron
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2013

The third-order linear piezoelectricity tensor seems to be simpler than the fourth-order linear elasticity one, yet its total number of symmetry types is larger than the latter and the exact number is still inconclusive. In this paper, by means of the irreducible decomposition of the linear piezoelectricity tensor and the multipole representation of the corresponding four deviators, we conclude that there are 15 irreducible piezoelectric symmetry types, and thus further establish their characteristic web tree. By virtue of the notion of mirror symmetry and antisymmetry, we define three indicators with respect to two Euler angles and plot them on a unit disk in order to identify the symmetry type of a linear piezoelectricity tensor measured in an arbitrarily oriented coordinate system. Furthermore, an analytic procedure based on the solved axisdirection sets is also proposed to precisely determine the symmetry type of a linear piezoelectricity tensor and to trace the rotation transformation back to its natural coordinate system. © 2013 The Author(s) Published by the Royal Society.


Li J.,Nanchang University | Huang W.,Nanchang University | Shao L.,University of Sheffield | Allinson N.,University of Lincoln
Information Sciences | Year: 2014

Building recognition in urban environments aims to identify different buildings in a large-scale image dataset. This identification facilitates the annotation of any visual object to a building's façade and is an essential step in a variety of applications, such as automatic target detection in surveillance, real-time robot localization and visual navigation, architectural design, and 3D city reconstruction. Because of its importance, a significant number of building recognition systems have been proposed in recent years. Nevertheless, there is no systematic survey of building recognition in urban environments yet. To this end, we present a comprehensive review of the dominant building recognition systems by first grouping them into two categories: (i) effectiveness approaches that mainly focus on the improvement of recognition performance and (ii) efficiency methods that attempt to enhance the recognition speed. Effectiveness approaches are further categorized into two different groups: (i) feature representation-based algorithms and (ii) wide baseline matching-based methods. Efficiency methods are divided into: (i) dimensionality reduction-based methods and (ii) clustering-based algorithms. We provide analysis and discussions on each type of method and summarize their advantages and weaknesses in depth. Furthermore, we outline future research directions and associated challenges in this promising area. This survey can serve as a starting point for new researchers in building recognition to generate new ideas according to their specific requirements. © 2014 Elsevier Inc. All rights reserved.


Zhu Y.,Nanchang University
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi | Year: 2011

The present investigation was to construct lentiviral vector carrying the human gene NK4 and transfect the human bone mesenchymal stem cells (hBMSCs) and to determine the expression of NK4 gene in hBMSCs after transfection. The NK4 gene was obtained from HGF cDNA by polymerase chain reaction(PCR), and the pGC-FU-NK4 plasmid was constructed by double restriction enzyme digestion and gene recombinant. The titer of virus was tested by real-time quantitative PCR. After transfected by lentivirus, the green fluorescent protein (GFP) in hBMSCs was observed using fluorescence microscope, and the expression of NK4 in culture supernatant was detected by enzymelinked immunosorbent assay (ELISA). The sequence of the PCR product was consistent with the data of GeneBank by DNA sequencing. The virus titer was 2 X 10(8)TU/ml. Strong green fluorescence was observed in the cell membrane and cytoplasm of hBMSCs with fluorescent microscopy. The expression of NK4 in culture supernatant was increased with time extension. The hBMSCs can be transfected by NK4 gene expressing lentiviral vector safely and effectively, and the expressin and secretion of NK4 was persistent and stable.


Objective: To explore the effect of bone marrow mesenchymal stem cells (MSCs) engraftment on lung tissue at early stage of smoke inhalation injury in rabbits. Methods: MSCs were proliferated by the method of whole marrow culture and identified by flow cytometry. Forty-eight rabbits were randomly divided into smoke inhalation group (S group) and MSCs group (M group) after reproduction of rabbit smoke inhalation injury model. 10 ml of phosphate buffer saline (PBS) containing 1 × 10 7/ml MSCs was intravenously injected in M group, meanwhile 10 ml PBS was injected intravenously in S group. Eight rabbits were sacrificed at 2, 6 and 24 hours after intervention, and the lung tissue was harvested for morphological and pathological observation, and lung injury score was used to evaluate smoke inhalation injury. Results: Cultured cells were confirmed to be MSCs with flow cytometry. Lung injury in rabbits of M group was less serious in morphology and histopathology than that in S group. Though there was no significance in lung injury score between M group and S group at 2 hours after injury (4.0±0.7 vs. 4.5±0.6, P>0.05), the lung injury scores in M group at 6 hours and 24 hours after injury were significantly lower than those in S group (6 hours, 6.1±0.9 vs. 8.2±0.9, 24 hours, 4.6±0.9 vs. 10.4±0.8, both P<0.01). Conclusion: Intravenous engraftment of MSCs could ameliorate lung injury induced by smoke inhalation, and improve lung injury score significantly.


Wei C.,CAS Beijing Institute of Geographic Sciences and Nature Resources Research | Wen H.,CAS Beijing Institute of Geographic Sciences and Nature Resources Research | Wen H.,Nanchang University
Environmental Geochemistry and Health | Year: 2012

The aim of this study was to estimate the geochemical baseline concentrations of various heavy metals in the surface sediments of two large freshwater lakes in Taihu and Dianchi, China, and to assess the character and history of heavy metal contamination around the two lakes. Heavy metal concentrations in the sediments were obtained by field surveys and were supplemented with published data. The statistical methods of cumulative frequency and normalization were employed to obtain the baselines. The respective baseline concentrations for As, Sb, Hg, Co, Cr, Cu, Ni, Pb and Zn were 9. 92, 1. 67, 0. 14, 22. 62, 100. 56, 31. 63, 31. 97, 33. 05 and 97. 01 mg/kg, respectively, in Taihu, and 24. 60, 4. 29, 0. 25, 36. 78, 135. 68, 90. 05, 50. 76, 73. 56 and 208. 76 mg/kg, respectively, in Dianchi. The baseline concentrations of these heavy metals in Lake Taihu were equivalent to the pre-industrial concentrations determined from lakes in Sweden and Europe. Conversely, those in Lake Dianchi were much higher than the pre-industrial values. Li, Fe, Sc, Ti, V and Al were found to be the suitable reference elements for normalization, and one of these elements could be used to predict the baseline concentrations of heavy metals except Hg. Most of the heavy metals had one inflexion, and only Cu and Pb in Taihu, Sb, Pb and Zn in Dianchi, were found to have two inflexions in the cumulative curves, suggesting remarkable anthropogenic inputs of Cu and Pb in Taihu, Sb, Pb and Zn in Dianchi, which are generally consistent with the respective industrial structure around Taihu and Dianchi. © 2012 Springer Science+Business Media B.V.


Qi L.,Nanchang University | Shang Y.,Nanchang University | Wu F.,Nanchang University
Microchimica Acta | Year: 2012

We report on a colorimetric probe for the determination of Pb(II). It is based on the use of silver nanoparticles that have been functionalizd with iminodiacetic acid (IDA-Ag NPs). The absorption spectrum and solution color of IDA-Ag NPs undergo dramatic changes on exposure to Pb(II) with a new absorption peak appearing at 650 nm and a concomitant color change from yellow to green. This is assumed to result from the aggregation of IDA-Ag NPs induced by Pb(II). Under optimum conditions, there is a linear relationship between the ratio of the absorbances at 650 and 396 nm, respectively, and the concentration of Pb(II) in the 0. 4 to 8. 0 μM concentration range, with a detection limit of 13 nM. The method was applied to the determination of Pb(II) in tap water and urea samples, and recoveries ranged from 93. 7 % to 98. 6 %. © 2012 Springer-Verlag.


Xie Y.,Nanchang University
Proceedings of the 2016 IEEE 20th International Conference on Computer Supported Cooperative Work in Design, CSCWD 2016 | Year: 2016

The most commonly image retrieval method is based on the text at present. The big workload is one of the disadvantages of this approach, it also needs to add tags artificiality, which has a strong subjectivity. More and more people developed themselves into the research of content-based image retrieval technology, and so far there is not a universal retrieval method for any image. In this paper, a interactive retrieval method is realized, and the thought of the optimizing the feedback results by the human-computer interaction is put forward. Some methods for eigenvalue extraction such as the edge detection, the extraction of gray histogram and brightness histogram are studied. These algorithms are also used in the image retrieval system. Experimental results on the STANFORD VERSION LAB 101 Object Categories image library, show the efficiency of the proposed methods. The structure of the paper is as follows: chapter one is the introduction, chapter two is about the five feature extraction algorithms used in the system, chapter three is the idea of eigenvalue storage, chapter four is the experiment on this system, and chapter five is the conclusion. © 2016 IEEE.


Li J.-M.,Nanchang University | Nie S.-P.,Nanchang University
Food Hydrocolloids | Year: 2015

Hydrocolloids are among the most commonly used ingredients in the food industry. They function as thickeners, gelling agents, emulsifiers, stabilizers, fat replacers, clarifying agents, flocculating agents, clouding agents and whipping agents; additionally, they have applications in the areas of edible films, encapsulating flavors and crystallization inhibition. Besides, hydrocolloids are currently being found to have many increasing applications in the health realm: they provide low-calorie dietary fiber, among many other uses. This review focuses on the trends and progress in the exploration of hydrocolloids to fit the demands for different food products, gives an encyclopedic description of their applications in the food industry as ingredients, food additives and health promoters. Since the use of hydrocolloids is on the rise in many fields, this review that covers both functionality and nutrition of hydrocolloids in foods is both timely and of great interest. © 2015 Elsevier Ltd.


Xanthine oxidase (XO) catalyses hypoxanthine and xanthine to uric acid in human metabolism. Overproduction of uric acid will lead to hyperuricemia and finally cause gout and other diseases. Luteolin is one of the major components of celery and green peppers, its inhibitory activity on XO and their interaction mechanism were evaluated by multispectroscopic methods, coupled with molecular simulation. It was found that luteolin reversibly inhibited XO in a competitive manner with inhibition constant (Ki) value of (2.38±0.05)×10(-6) mol l(-1). Luteolin could bind to XO at a single binding site and the binding was driven mainly by hydrophobic interactions. Analysis of synchronous fluorescence and circular dichroism spectra demonstrated that the microenvironment and secondary structure of XO were altered upon interaction with luteolin. The molecular docking results revealed luteolin actually interacted with the primary amino acid residues located within the active site pocket of XO. Copyright © 2013 Elsevier Ltd. All rights reserved.


Wang F.,Xinyu University | Wang F.,Nanchang University | Liu Y.,Nanchang University
Materials and Design | Year: 2014

The purpose of the present work was to investigate and compare the mechanical and tribological behaviors of ceramic-matrix friction material (CMFM) with steel fiber (SF), mullite fiber (MF), and mixing SF and MF. The CMFM was prepared by hot-pressing sintering, and the tribological behaviors were determined using a constant speed friction tester. The worn surfaces and wear debris were observed by a scanning electron microscopy (SEM). Experiment results show that the combination of SF and MF can improve the mechanical properties that each single fiber does not have. The sever fade for the specimen reinforced by single MF during the whole friction testing can be attributed to the poor interface cohesive strength between MF and matrix. Mixing the SF and MF can improve the friction stability, and the friction coefficients for friction material with a mixture of the SF and MF increases with increasing MF content. For all specimens, increasing in the friction temperatures result in the increase of wear rates. © 2014 Elsevier Ltd.


Intemann J.J.,University of Washington | Yao K.,University of Washington | Yao K.,Nanchang University | Li Y.-X.,University of Washington | And 9 more authors.
Advanced Functional Materials | Year: 2014

A synergistic approach combining new material design and interfacial engineering of devices is adopted to produce high efficiency inverted solar cells. Two new polymers, based on an indacenodithieno[3,2-b]thiophene- difluorobenzothiadiazole (PIDTT-DFBT) donor-acceptor (D-A) polymer, are produced by incorporating either an alkyl thiophene (PIDTT-DFBT-T) or alkyl thieno[3,2-b]thiophene (PIDTT-DFBT-TT) π-bridge as spacer. Although the PIDTT-DFBT-TT polymer exhibits decreased absorption at longer wavelengths and increased absorption at higher energy wavelengths, it shows higher power conversion efficiencies in devices. In contrast, the thiophene bridged PIDTT-DFBT-T shows a similar change in its absorption spectrum, but its low molecular weight leads to reduced hole mobilities and performance in photovoltaic cells. Inverted solar cells based on PIDTT-DFBT-TT are explored by modifying the electron-transporting ZnO layer with a fullerene self-assembled monolayer and the MoO3 hole-transporting layer with graphene oxide. This leads to power conversion efficiencies as high as 7.3% in inverted cells. PIDTT-DFBT-TT's characteristic strong short wavelength absorption and high efficiency suggests it is a good candidate as a wide band gap material for tandem solar cells. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


A simple approach was demonstrated to manipulate dipole moment of interlayer in polymer solar cells (PSCs). The ionic liquid crystals (ILCs) 3-((2′-(4″-cyanobiphenyl-4-yloxy)ethyl)dimethylammonio) propanesulfonate (CbpNSO) with zwitterionic charges were blended with cationic conjugated polyelectrolyte (CPE) poly[3-(6-trimethylammoniumhexyl)thiophene] (PTNBr) to afford a novel CPE-ILC complex. The water/alcohol solubility of the CPE-ILC complex enables it to be green solvent processable. The spontaneous orientation of liquid crystal (LC) favors more ordered structural arrangement in CPE-ILC complexes. More importantly, LC-assistant assembly improves the orientation of dipole at cathode and significantly reduces the work function of ITO. The power conversion efficiency (PCE) of P3HT:PC60BM-based inverted PSCs with the layer of PTNBr-CbpNSO is increased by 37% with respect to that of the device with pure PTNBr. Incorporation of PTNBr-CbpNSO into the devices based on PBDTTT-C-T and PC71BM affords a notable PCE of 7.49%. It should be noted that mesogens reduce the activation energy of molecular reorganization and accelerate dipole orientation in CPE-ILC interlayer under external electric field, which enables the dipole of this interlayer can be readily manipulated. Because of the rapid orientation of the dipole, PTNBr-CbpNSO shows reversible dipole at the active layer/ITO interface during the reversible bias process. © 2014 American Chemical Society.


He Q.-H.,Nanchang University | Xu Y.,Nanchang University | Wang D.,Nanchang University | Kang M.,Nanchang University | And 2 more authors.
Food Chemistry | Year: 2012

The development of polyvinylidene fluoride (PVDF) membrane-based dot immunoassay for rapid and simultaneous detection of multi-mycotoxins in cereal samples is described. To facilitate the simultaneous identification of multiple mycotoxins in a single test, membrane reaction zones were constructed using PVDF membrane, rubber fences and scotch tape. The cut-off level for this method, assessed visually, were 20, 60, 1000, 20, and 250 μg kg -1 for Aflatoxin B 1, zearalenone, deoxynivalenol, ochratoxin A, and fumonisins B 1, respectively, and the final results can be obtained within 10 min. This simultaneous method was designed to be simple, with no time-consuming cleanup procedure, and good accuracy and reproducibility were obtained in recovery experiments. These results suggest that this method could be a useful on-site screening tool for the rapid detection of multiple mycotoxins in cereal samples without special instrumentation. © 2012 Elsevier Ltd. All rights reserved.


Yuan K.,Institute of Polymers | Chen L.,Institute of Polymers | Chen Y.,Institute of Polymers | Chen Y.,Nanchang University
Journal of Physical Chemistry B | Year: 2014

Novel PEIE-Ag composites by in situ growth of silver nanoparticles in poly(ethylenimine)-ethoxylated (PEIE) aqueous solution are explored as an efficient interfacial layer for improving inverted polymer solar cells (PSCs) performance. The hybrid PEIE-Ag interfacial material is simple to fabricate only via ultraviolet irradiation with good water-solubility and unique film formation. The generated Ag nanoparticles can anchor in the PEIE polymer chains to form a conductive continuous interpenetrating network structure. Combining of the advantages of PEIE and Ag nanoparticles, the PEIE-Ag shows enhanced charge transport, electron selective and collection, and improved light-harvesting, mainly due to the surface plasmon resonance effect, better energy alignment induced by the formation of ideal dipole layer, as well as the improved conductivity. These distinguished interfacial properties result in the power conversion efficiency of inverted PSCs based on poly[4,8-bis(2-ethyl-hexyl-thiophene-5-yl)-benzo[1,2-b:4,5-b]dithiophene-2,6-diyl]-alt-[2-(2-ethyl-hexanoyl)-thieno[3,4-b]thiophen-4,6-diyl] (PBDTTT-C-T) and [6,6]-phenyl C71-butyric acid methyl ester (PC71BM) photoactive layer substantially improved up to 7.66% from 6.11%. Moreover, the device performance is insensitively dependent on the thickness of the PEIE-Ag interfacial layer, broadening the thicknesses selection window for interfacial materials. These results demonstrate that PEIE-Ag is a potential interfacial material compatible with roll-to-roll techniques and suitable for printed electronic devices. © 2014 American Chemical Society.


Xing Y.,Nanchang University | Xing Y.,Nanchang Hangkong University | Chen Y.,Nanchang University | He X.,Nanchang University
Journal of Polymer Science, Part A: Polymer Chemistry | Year: 2011

Copolymerization of norbornene (NB) with methoxycarbonylnorbornene (NB-COOCH3) was carried out with catalytic system of Ni{CF 3C(O)CHC[N(naphthyl)]CH3}2 and B(C 6F5)3 in toluene. The catalytic system exhibited higher activity 2.69 × 105 (gpolymer/mol Ni h) for copolymerization of norbornene and methoxycarbonylnorbornene. The influence results of the comonomer feed content on the polymerization showed that the NB-COOCH3 has a very high insertion ratio in all copolymers, and the NB-COOCH3 content in copolymers can be controlled to be 7.9-77.6 mol % at content of 10-90 mol % of the NB-COOCH3 in the monomer feeds ratios. The reactivity ratios, rNB-COOCH3 = 0.578 and rNB = 0.859, were determined by the Kelen-TÜdÕs method. Copolymers were processed by solution casting method, dry/wet phase inversion technique, and electrospinning. The films prepared by solution casting method showed good transparency in the visible region. The membranes processed by dry/wet phase inversion technique were microporous structures. The fibers diameters fabricated by electrospinning were about 3 μm. © 2011 Wiley Periodicals, Inc.


Pu S.,Jiangxi Science and Technology Normal University | Zheng C.,Nanchang University | Sun Q.,Jiangxi Science and Technology Normal University | Liu G.,Jiangxi Science and Technology Normal University | Fan C.,Jiangxi Science and Technology Normal University
Chemical Communications | Year: 2013

The weak intramolecular F⋯N and S⋯N interactions in the novel pyridine-containing perfluorodiarylethenes achieved high cyclization quantum yields in solutions. While the F⋯N interactions stabilize the photoreactive conformation, the S⋯N contacts contribute from the energetic aspect. © 2013 The Royal Society of Chemistry.


The early determination of family for a newly found enzyme molecule becomes important because it is directly related to the detail information about which specific target it acts on, as well as to its catalytic process and biological function. Unfortunately, it is still a hard work to distinguish enzyme classes by experiments. With an enormous amount of protein sequences uncovered in the genome research, it is both challenging and indispensable to develop an automatic method for fast and reliably classifying the enzyme family. Using the concept of Chou's pseudo amino acid composition, we developed a new method that coupled discrete wavelet transform with support vector machine based on the amino acid hydrophobicity to predict enzyme family. The overall success rate obtained by the 10-cross-validation for the identification of the six enzyme families was 91.9%, indicating the current method could be an effective and promising high-throughput method in the enzyme research.


Chen X.,Nanchang University | Chen L.,Nanchang University | Chen Y.,Nanchang University
RSC Advances | Year: 2014

Efficient hybrid solar cells based on a blend of poly(3-hexylthiophene) (P3HT) and discotic liquid crystal ligands dithiol-functionalized triphenylene (TP-S) modified zinc oxide (ZnO) nanoparticles (TP-S@ZnO) were systematically investigated. The TP-S-modified ZnO nanoparticles possess a well-defined dispersibility, especially after annealing under the liquid-crystalline state (130 °C), originating from the help of the supramolecular self-assembly of the TP-S discs. Discotic liquid crystal ligands improve the compatibility between P3HT polymer and ZnO nanoparticles, which is beneficial for enhanced charge separation and transfer efficiency. On the other hand, the interfacial molecules TP-S can play a great role in the ordering and crystallinity of P3HT chains. X-ray diffraction (XRD) and wide-angle X-ray scattering (WAXS) studies indicate that the spontaneous self-assembly of the promotes P3HT chains to overall, the power conversion efficiency (PCE) of polymer/ZnO hybrid solar cells increased from 0.46% to 0.95% after ZnO was modified with TP-S under thermal annealing. As expected, DLC molecular interface modification can provide a viable and interesting method to promote the compatibility and a large interfacial area between polymers and nanocrystals, subsequently improving the performance of photovoltaic devices.


Zhang Y.,Nanchang University | Zhang G.,Nanchang University | Li Y.,Nanchang University | Hu Y.,Nanchang University
Journal of Agricultural and Food Chemistry | Year: 2013

The binding of permethrin (PE) with calf thymus DNA (ctDNA) in physiological buffer (pH 7.4) was investigated by ultraviolet-visible (UV-vis) absorption, fluorescence, circular dichroism (CD), and Fourier transform infrared (FT-IR) spectroscopy merging with multivariate curve resolution-alternating least-squares (MCR-ALS) chemometrics approach. The MCR-ALS was applied to resolve the combined spectroscopic data matrix, which was obtained by UV-vis and fluorescence methods. The concentration profiles of PE, ctDNA, and PE-ctDNA complex and their pure spectra were then successfully obtained. The PE molecular was found to be able to intercalate into the base pairs of ctDNA as evidenced by decreases in resonance light-scattering signal and iodide-quenching effect and increase in ctDNA viscosity. The results of FT-IR spectra indicated that PE was prone to bind to G-C base pairs of ctDNA, and the molecular docking studies were used to validate and clarify the specific binding. The observed changes in CD signals revealed that the DNA turned into a more highly wound form of B-conformation. The calculated thermodynamic parameters, enthalpy change (ΔH) and entropy change (ΔS), suggested that hydrogen bonds and van der Waals forces played a predominant role in the binding of PE to ctDNA. © 2013 American Chemical Society.


Yang Z.,Nanchang University
International Journal of Simulation: Systems, Science and Technology | Year: 2015

This paper builds the power transformer diagnosis model based on the improved particle swarm optimization— support vector machine (MPSO-SVM). Speed update and particle self-adaptation self-variation are introduced to optimize the standard particle swarm algorithm, thus overcoming the defect of the standard particle swarm optimization algorithm and increasing the power transformer fault diagnosis accuracy rate of SVM. Through the analysis of the relationship between the transformer fault and the dissolved gas, the volume content of the dissolved gas of the transformer is adopted as the fault feature index. Through the experiment numerical analysis, results suggest that: the test sample recognition accuracy of the model parameters acquired by MPSO-SVM is higher than that acquired by the standard PSO by 17.86%. © 2015, UK Simulation Society. All rights reserved.


Chen W.Y.,Nanchang University
Applied Mechanics and Materials | Year: 2014

CDIO has become in recent years, guiding the teaching reform of advanced education concept, especially in the engineering personnel training mode and widespread application in the engineering curriculum.At home and abroad well-known colleges and universities according to the CDIO mode to cultivate students welcome by society and enterprises.Introducing the concept of CDIO architectural design teaching, research and establish a practice, pay attention to team collaboration and innovation of new course teaching mode. © (2014) Trans Tech Publications, Switzerland.


He X.,Nanchang University | He J.,Nanchang University
Science China: Physics, Mechanics and Astronomy | Year: 2012

Based on a two-qubit isotropic Heisenberg XXX model with a constant external magnetic field, we construct a four-level entangled quantum heat engine (QHE). The expressions for several thermodynamic quantities such as the heat transferred, the work and efficiency are derived. Moreover, the influence of the entanglement on the thermodynamic quantities is investigated analytically and numerically. Several interesting features of the variation of the heat transferred, the work and the efficiency with the concurrences of the thermal entanglement of different thermal equilibrium states are obtained. © Science China Press and Springer-Verlag Berlin Heidelberg 2012.


Liu W.,Tongji University | Chen H.,Tongji University | Lai Z.,Nanchang University
Optics Letters | Year: 2012

We report that a narrow guided-mode resonance (GMR) filter with high-index substrate can be achieved by introducing an added layer on the substrate. For this type of GMR filter, the refractive index and thickness of the added layer are the critical parameters for the GMR effect to occur. We demonstrate that this filter has good fabrication tolerances for the grating thickness and fill factor. Our design may promote the application of GMR filters in practice. © 2012 Optical Society of America.


Xu X.-W.,Nanchang University | Liu N.-H.,Nanchang University
Optics Communications | Year: 2010

The absorption-dispersion spectra of a six-level atom embedded in double-band photonic crystals are investigated. It is shown that if there is no defect mode in the photonic band gap, there are three types of transparency windows appear in the absorption-dispersion spectra. If a defect mode is introduced into the photonic band gap, we found some additional transparency windows in the absorption-dispersion spectra. One type of them appears as long as the defect mode exists, but the others appear only when the quantum interference occurs. The transparency windows can be changed by varying the parameters of the defect mode. © 2009 Elsevier B.V. All rights reserved.


Tong Y.,Nanchang University | Tong Y.,Nanchang Hangkong University | Chen L.,Nanchang University | He X.,Nanchang University | Chen Y.,Nanchang University
Electrochimica Acta | Year: 2014

Solid composite polymer electrolytes based on polyethylene oxide (PEO)/LiClO4 with the star-shaped liquid-crystalline copolymer, 3-arm- poly {10-[(4-cyano-4′-biphenyl) oxy] decatyl methacrylate}-block- poly [methoxy -poly (ethylene glycol) methacrylate] (3PMALC-PPEGMA), and 4-cyano-4′-[(10-hydroxyalkyl) oxy] (10-BPCN) biphenyl are prepared. The star-shaped liquid-crystalline copolymer 3PMALC-PPEGMA is composed of a conductive block (PPEGMA block) and an orientation block (PMALC block). Incorporation of star-shaped liquid-crystalline copolymer into the system promotes the better miscibility of composites and suppresses the crystallinity of PEO to favor the chain mobility. At the same time, the strong assembly ability of star-shaped liquid-crystalline copolymer ensures the composite systems to develop an ordered morphology for efficient lithium transportation. It is worthy to note that such ordered assembly could be further strengthened by adding the appropriate amount of small molecular liquid crystals (10-BPCN) to repair the stacking defects of star copolymer. As a results, composite polymer electrolytes based on the ternary blend containing 70/25/5 (PEO/3PMALC-PPEGMA/ 10-BPCN) mass percent with lithium perchlorate (LiClO4) exhibit the best performance with the maximum value of 1.3 × 10-5 S/cm (25 C) after annealed from liquid crystal state, enhanced by more than two orders of magnitude than the pristine PEO/LiClO4 electrolytes. The high lithium ion transference number and wide electrochemical stability window also show the acceptable performance of this system. Therefore the better miscibility and reduced crystallinity as well as the efficient transport channel in the present system pave a potential way to develop solid state polymer electrolytes for Li-ion batteries. © 2013 Elsevier Ltd.


Zhang W.,University of Houston | Zhang W.,Nanchang University | Trachootham D.,University of Houston | Trachootham D.,Thammasat University | And 10 more authors.
Nature Cell Biology | Year: 2012

Tissue stromal cells interact with leukaemia cells and profoundly affect their viability and drug sensitivity. Here we show a biochemical mechanism by which bone marrow stromal cells modulate the redox status of chronic lymphocytic leukaemia (CLL) cells and promote cellular survival and drug resistance. Primary CLL cells from patients exhibit a limited ability to transport cystine for glutathione (GSH) synthesis owing to a low expression level of Xc-transporter. In contrast, bone marrow stromal cells effectively import cystine and convert it to cysteine, which is then released into the microenvironment for uptake by CLL cells to promote GSH synthesis. The elevated level of GSH enhances leukaemia cell survival and protects them from drug-induced cytotoxicity. Furthermore, disabling this protective mechanism significantly sensitizes CLL cells to drug treatment in the stromal environment. This stromal-leukaemia interaction is critical for CLL cell survival and represents a key biochemical pathway for effectively targeting leukaemia cells to overcome drug resistance in vivo. © 2012 Macmillan Publishers Limited. All rights reserved.


Zhang G.,Nanchang University | Hu X.,Nanchang University | Fu P.,Nanchang University
Journal of Photochemistry and Photobiology B: Biology | Year: 2012

The interaction between carbaryl and calf thymus DNA (ctDNA) was investigated under simulated physiological conditions (Tris-HCl buffer of pH 7.4) using ethidium bromide (EB) dye as a probe by UV-vis absorption, fluorescence and circular dichroism (CD) spectroscopy, as well as DNA melting studies and viscosity measurements. It can be concluded that carbaryl molecules could intercalate into the base pairs of DNA as evidenced by hyperchromic effect of absorption spectra, decreases in iodide fluorescence quenching effect, induced CD spectral changes, and significant increases in melting temperature and relative viscosity of DNA. The binding constants and thermodynamic parameters of carbaryl with DNA were obtained by the fluorescence quenching method. Furthermore, a chemometrics approach, parallel factor analysis (PARAFAC), was applied to resolve the measured three-way synchronous fluorescence spectral data matrix of the competitive interaction between carbaryl and EB with DNA, and the results provided simultaneously the concentration profiles and corresponding pure spectra for three reaction components (carbaryl, EB and DNA-EB complex) of the kinetic system at equilibrium. This PARAFAC analysis demonstrated the intercalation of carbaryl to the DNA helix by substituting for EB in the DNA-EB complex. © 2012 Elsevier B.V. All rights reserved.


Wu J.,Nanchang University | Zhang L.,Nanchang University | Zhou N.,Nanchang University
Optics Communications | Year: 2010

A novel scheme for image encryption based-on the multiple-order discrete fractional cosine transform (MODFrCT) is proposed. The DFrCT has a similar relationship with the discrete fractional Fourier transform (DFrFT). Not only has the DFrCT many useful properties similar to the conventional discrete cosine transform, but it also has another property, namely its fraction, or its transform order. The image to be encrypted is transformed with the multiple-order DFrCT using a random row cipher key vector and a random column key vector successively, and the corresponding cipher key vectors of decryption are also very sensitive. The transmission of the encrypted image with the algorithm of the multiple-order DFrCT is faster due to its reality. The digital simulation results proved the validity and safety of this algorithm. © 2009 Elsevier B.V. All rights reserved.


Zhang R.,Nanchang University
2013 IEEE Conference Anthology, ANTHOLOGY 2013 | Year: 2014

In this paper, we propose a meta-heuristic algorithm for the job shop scheduling problem (JSSP) with total weighted tardiness criterion. First, we focus on the mathematical programming model and discuss its duality when the processing sequences on each machine are fixed. Then, a reverse-based neighborhood structure is defined and its important properties are shown. Finally, a particle swarm optimization algorithm is presented, which utilizes the neighborhood properties to promote the optimization efficiency. According to the computational results, the new neighborhood considerably promotes the searching capability of particle swarm optimization and accelerates its convergence to high-quality solutions. © 2013 IEEE.


Wang Z.D.,Nanchang University | Lai Z.Q.,Nanchang University | Hu Z.G.,Nanchang University
Journal of Alloys and Compounds | Year: 2014

Pb(Zr0.52Ti0.48)O3 ferroelectric thin films were in situ deposited on FTO glass substrate by RF magnetron sputtering process at low substrate temperature of 260 C, through optimizing the process parameters of sputtering power, sputtering gas pressure, and substrate temperature. Ferroelectric properties, surface morphology, and optical transmittance of PZT thin films are investigated by standardized ferroelectric test system, atomic force microscope, and UV-Vis spectrometer, respectively. The results show that the sample deposited at 260 C exhibits ferroelectric properties with Pr and Ps of 3.86 μm/cm2 and 8.85 μm/cm2, respectively. The arithmetic average roughness PZT thin film is 95.9 nm. Interestingly, the mean transmittance of the sample is above 80% in the visible light range. © 2013 Elsevier Ltd. All rights reserved.


Tang L.,Nanchang University | Gui W.,Nanchang University | Ding K.,Nanchang University | Chen N.,Nanchang University | Du G.,Nanchang University
Journal of Alloys and Compounds | Year: 2014

In this work, undoped YVO4 nanocrystals (10-15 nm in size) were first synthesized by a solvothermal method, and they were ion exchanged for Eu3+ ions to form YVO4:Eu3+ nanocrystals, which were then used to prepare YVO4:Eu3+- thenoyltrifluoroacetone hybrid nanostructures. As expected, the ion exchanged YVO4:Eu3+ nanocrystals exhibited the characteristic V-O charge transfer excitation band. Much stronger luminescence has been observed in the YVO4:Eu3+-thenoyltrifluoroacetone hybrid nanostructures due to energy transfer from thenoyltrifluoroacetone ligands to Eu3+ ions. The dependence of luminescence of the YVO 4:Eu3+-thenoyltrifluoroacetone hybrid nanostructures on the Eu3+ concentration and amount of thenoyltrifluoroacetone ligands was investigated in detail, and optimal preparation conditions were determined. Their UV-Vis absorption spectra and BET specific surface area were measured. X-ray diffraction technique, transmission electron microscopy, and Fourier transform infrared spectroscopy were used to study their microstructural characteristics. © 2013 Elsevier B.V. All rights reserved.


Chen L.,Nanchang University | Peng S.,Nanchang University | Chen Y.,Nanchang University
ACS Applied Materials and Interfaces | Year: 2014

A facile approach to develop the stable and well-defined bulk heterojunction (BHJ) nanomorphology has been demonstrated. Novel pyrene (Py)-functionalized diblock copolymers poly(3-hexylthiophene)-block-poly[3-(10- (pyren-1-yloxy)decyloxy)thiophene] (P3HT-b-P3TPy), and pyrene-functionalized fullerene [6,6]-phenyl-C61-butyric acid 1-pyrene butyl ester (PCBPy), were successfully synthesized. The π-π interactions of Py mesogens interdigitated between the functionalized fullerene and P3TPy segment can allow for the cooperative assembly of P3HT-b-P3TPy and PCBPy. The orientation of the Py mesogens also can further enhance the molecular arrangement. Compared with the as-cast and thermal annealing, solvent annealing can promote cooperative assembly of P3HT-b-P3TPy:PCBPy undergoing the slow film growth. Note that the assembly microstructure strongly depends on the molar ratio of P3HT and P3TPy with Py mesogens. Low loading of P3TPy block in the copolymers blends keeps the same behavior to the P3HT, whereas relatively high loading of Py mesogens favors the better intermolecular π-π stacking interactions between P3HT-b-P3TPy and PCBPy. As a result, the P3HT-b-P3TPy(3/1) forms the orientated nanowires with PCBPy in bulk heterojunction, and the average domain size is estimated to be 10-20 nm, which is desirable for enlarge surface area for donor/acceptor interfaces and give a bicontinuous pathway for efficient electron transfer. Furthermore, the cooperative assembly between P3HT-b-P3TPy and PCBPy is found to effectively suppress the PCBPy macrophase separation, and stabilize the blend morphology. © 2014 American Chemical Society.


Bai A.,Nanchang University | Bai A.,Beth Israel Deaconess Medical Center | Robson S.,Beth Israel Deaconess Medical Center
Purinergic Signalling | Year: 2015

CD39/ENTPD1 is a prototypic member of the ectonucleoside triphosphate diphosphohydrolase (ENTPDase) family on cell surface. CD39 has been reported to be a marker of regulatory immune cells and catalyzes extracellular hydrolysis of nucleotides to generate AMP and, in tandem with CD73, adenosine. We have recently found in addition that co-expression of CD39 and CD161 by human CD4+ T cells may become a biomarker of human Th17 cells. CD39 and CD161 have direct interactions that are further linked with acid sphingomyelinase (ASM). Upon activation of CD39 and CD161, the molecular interactions boost ASM bio-activity, which generates cellular ceramide to further mediate downstream signals inclusive of STAT3 and mTOR. We suggest modulation of human Th17 responsiveness by CD39 and CD161 and describe novel molecular mechanisms integrating elements of both extracellular nucleotide and sphingolipid homeostasis that are pivotal in the control of human Th17 cells and which could have therapeutic potential. © 2015, Springer Science+Business Media Dordrecht.


Chen L.,Nanchang University | Xie C.,Nanchang University | Chen Y.,Nanchang University
Advanced Functional Materials | Year: 2014

The utilization of a conjugated polyelectrolyte-ionic liquid crystal (CPE-ILC) complex as electron transporting layer (ETL) to improve the compatibility between the ITO and hydrophobic active layer and to promote the dipole orientation at cathode interface is reported. Simultaneously, a hole transporting layer (HTL) of solution processed tungsten oxide together with poly(2,6-bis(trimethyltin)-4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4, 5-b']dithiophene-alt-4,6-Dibromo-thieno[3,4-b]thiophene-2-carboxylic acid 2-[2-(2-methoxy-ethoxy)-ethoxy]-ethyl ester) (PBDTT-TT-TEG) efficiently shifts the work function of Ag electrode in this device. The interfacial modification of these interlayers achieves energy alignment at both electrodes. The power conversion efficiency (PCE) of the PSC based on ITO/PFN-CbpSO/PBDTTT-C-T:PC 70BM/PBDTT-TT-TEG/WO3/Ag with solution processed interlayers reaches to 7.8%. It is worthy to note that except for the electrodes, all layers of device are fabricated by solution process at room temperature and without annealing. In the case of incorporating ZnO layer into this device, the device efficiency further increases to 8.5%, which is the best value reported from PBDTTT-C-T:PC70BM-based solar cells with solution processed interlayers at both electrodes so far. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Shi Y.,Nanchang University | Li F.,Nanchang University | Chen Y.,Nanchang University
New Journal of Chemistry | Year: 2013

The well-defined rod-coil diblock copolymer poly(3-hexylthiophene)-b- poly(ethylene oxide) (P3HT-b-PEO) was used as the interfacial compatibilizer for P3HT/ZnO (1:2 w/w) hybrid heterojunction solar cells. The power conversion efficiency of the device was enhanced from 0.5 to 0.98% in the presence of 0-10 wt% P3HT-b-PEO under illumination of AM 1.5G (100 mW cm-2), resulting from the morphology variation. In the P3HT/ZnO/P3HT-b-PEO ternary blends, the block copolymer does not influence the crystallinity of ZnO NPs, but does influence the crystallinity of P3HT and the dispersion of ZnO NPs. An enhanced crystalline and fiber-like P3HT and more uniform dispersion of ZnO NPs are observed with a small amount of P3HT-b-PEO (10 wt%) loading, leading to a smaller domain size, enhanced interfacial area for charge separation and a favored active layer morphology for improving the device performance. On the other hand, the incorporated P3HT-b-PEO could also suppress macrophase separation during long time thermal annealing and improve the device thermal stability. These results demonstrated that the promising effect of the rod-coil diblock copolymers interfacial compatibilizer for controlling the morphology and improving the performance of hybrid bulk heterojunction solar cells. This journal is © 2013 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.


Li F.,Nanchang University | Shi Y.,Nanchang University | Yuan K.,Nanchang University | Chen Y.,Nanchang University
New Journal of Chemistry | Year: 2013

The rod-coil conjugated diblock copolymers of poly(3-hexylthiophene)-b- poly(ethylene oxide) (P3HT-b-PEO), acting as an electron donor, were blended with ZnO nanoparticles to fabricate the hybrid bulk-heterojunction (BHJ) solar cells. According to the ultraviolet-visible (UV-vis) absorption spectroscopy, the intensity at 610 nm, derived from a strong inter-molecular interaction of π-π stacking and the high crystallizability of the P3HT main chains, was higher in P3HT-b-PEO/ZnO blend films than that in P3HT/ZnO blend films especially after thermal treatment, revealing that PEO segments could make P3HT form more densely stacked and orderly structured. Due to the nature of block copolymers and the interaction between the oxygen atoms of the PEO chains and the ZnO polar surface, the surface defects of ZnO were passivated and the fine dispersion and self-assembly of ZnO in the polymer matrix driven by the P3HT-b-PEO diblock copolymer was obtained, leading to the improvement of device power conversion efficiency and thermal stability. Overall, this work demonstrated that the application of conjugated block copolymers in hybrid BHJ solar cells was a promising approach to improve the device performance and thermal stability. This journal is © 2013 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.


Hong K.,Nanchang University | Xiong Q.,Nanchang University
Current Opinion in Cardiology | Year: 2014

PURPOSE OF REVIEW: Atrial fibrillation, the most common cardiac supraventricular arrhythmia, affects more than 5 million people worldwide. Increasing evidence has demonstrated that genetic factors play an important role in the pathogenesis of atrial fibrillation, and multiple genes responsible for atrial fibrillation have been identified. This review will focus on the recent findings in atrial fibrillation genetic studies and discuss the clinical implications of exploring the atrial fibrillation genetic basis. RECENT FINDINGS: The advent of the candidate gene approach and genome-wide association studies has facilitated the process of investigating the complex genetic background underlying the pathogenesis of atrial fibrillation. Recent genetic investigations have offered further insights into the predisposing genes encoding ion channels, connexin, atrial natriuretic peptide, RyR2, T-box transcription factor, nucleoporins and zinc-finger transcription factor. Common single-nucleotide polymorphisms are important factors in the development of lone atrial fibrillation, recurrent atrial fibrillation or atrial fibrillation complicated with cardiac disorders. SUMMARY: Analyses of candidate genes have revealed a growing number of atrial fibrillation-related genes. A better understanding of the genetic mechanism underlying atrial fibrillation would be expected to lead to more accurate risk stratification of atrial fibrillation and the discovery of optimal clinical treatment strategies that carry maximal efficacy and minimal risk in a manner that is consistent with the vision of pharmacogenomics. © 2014 Wolters Kluwer Health.