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Rajesh N.,CSIR - Central Electrochemical Research Institute | Sarma R.,Nalbari College Nalbari | Prajapati D.,CSIR - Central Electrochemical Research Institute
Synlett | Year: 2014

A one-pot, three-component method for the synthesis of benzo-fused quinolines has been developed by tandem reaction between phenylacetylenes and naphthylamines. The first step of the reaction is hydroamination of the alkyne followed by a hydroarylation reaction to form the quinolines. Indium(III) trifluoromethanesulfonate was shown to be an efficient catalyst for the transformations, and the reaction proceeded in the absence of any other co-catalyst or additive to give the corresponding quinolines in good to excellent yields. © Georg Thieme Verlag Stuttgart . New York.

PubMed | Nalbari College Nalbari and Institute of Advanced Study in Science and Technology Guwahati
Type: | Journal: Frontiers in pharmacology | Year: 2016

Fatty foods, the most common diet today are the crux of many metabolic disorders which need urgent attention. Garcinia pedunculata Roxb. (GP, Clusiaceae) is a plant found available in Northeast (NE) region of India, is considered to have versatile therapeutic properties. The people of this region has been using dried pulp of GP fruit for the treatment of different stomach related diseases traditionally. This study aimed at evaluating the potential therapeutic action of the polyphenol-rich methanolic extract of the fruit in experimental induced obese rats. In vitro antioxidant and antidiabetic activity of GP extracts, i.e., fruit extract (GF) and seed extract (GS) were determined by using various methods viz., 1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2-Azinobis (3-ethyl benzthiazoline-6-sulphonic acid) (ABTS(+)), nitroblue tetrazolium (NBT) and -glucosidase inhibition assay for detection of antihyperglycemic activity. In vivo antilipidemic and antiobesity activities were evaluated by administrating oral dose of GF for 60 days on a high-fat diet (HFD) induced hyperlipidemia in the rat. GF showed higher antioxidant activity than GS by DPPH radical scavenging (IC50 = 4.01 g/ml), ABTS(+) (IC50 = 0.82 g/ml), NBT (IC50 = 0.07 g/ml) and also showed notable -glucosidase inhibitory activity (IC50 = 19.26 g/ml). Furthermore, GF treated rat revealed a reduction in the body weight (~60%), serum total cholesterol (33%), triglycerides (32%), low-density lipoprotein (38%) and liver biomarker enzymes after 60 days HFD fed animals. Simultaneously, GF supplementation significantly protected the HFD induced changes in hematological parameters. Histological observations clearly differentiate the structural changes in liver of HFD and GF treated group. This novel dietary lipid adsorbing agent of GF exhibited prevention of hyperlipidemia induced by HFD in the rat.

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