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Putikam J.K.,Nalanda Institute of Pharmaceutical science
Research Journal of Pharmacy and Technology | Year: 2012

The aim of the present study was to develop an extended release formulation of Metoprolol Succinate to maintain constant therapeutic levels of the drug for over 24 hrs. An efficient extended release formulation of Metoprolol Succninate could be designed as extended release Matrix tablet. The optimized formulation (B-8) was developed by using HPMC [Benecel K35M] and HEC [Natrosol 250HHX] Regulated drug release in first order manner was attained by using these polymers. This extended release formulation (B-8) was found similar and comparable to the innovator product. The developed extended release formulation was quite stable with regard to physical properties and dissolution rate in the accelerated stability studies. © RJPT All right reserved. Source


Narisi Reddy P.,Nalanda Institute of Pharmaceutical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Intestinal fast dissolving Esomeprazole tablets were formulated to get resistance from gastric juice in the presence of stomach because of Esomeprazole is degraded immediately in stomach/gastric juice. The tablets were prepared by direct compression technique using the super disintegrating agents like Crospovidone, Croscarmellose Sodium, Pre-gelatinized Starch, sodium bicarbonate and excipients are Mannitol in different ratios. These super disintegrates and excipients are used for the intestinal fast releasing of dose and the enteric coating solution was prepared by Acryl-EZE, Eudragit-L100-55. Pre-post compression parameters were conducted for prepared intestinal fast dissolving tablets. Source


Desireddy R.B.,Nalanda Institute of Pharmaceutical science | Desireddy R.B.,Narasaraopeta Institute of Pharmaceutical science | Bandhavi P.,Nalanda Institute of Pharmaceutical science | Bandhavi P.,Narasaraopeta Institute of Pharmaceutical science | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2013

The objective of the present study was to formulate mouth dissolving tablets of Ondansetron hydrochloride by using sublimation technique using camphor as subliming agent and using different concentrations of superdisintegrants like crospovidone, sodium starch glycolate, croscarmellose sodium by direct compression method. The results showed that Ondansetron with croscarmellose sodium and camphor fulfilled all the official requirements of Fast dissolving tablets. ©RJPT All right reserved. Source


Chandra Dinda S.,Berhampur University | Desireddy R.B.,Nalanda Institute of Pharmaceutical science | Jitendra Kumar P.,Nalanda Institute of Pharmaceutical science | Sai Chand A.,Nalanda Institute of Pharmaceutical science | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2013

A Validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Amlodipine besylate in pure and pharmaceutical formulations. Method was carried on Zodiac C18 column (250mm×4.6mm×5μ particle size) using Methanol: Acetonitrile: 0.01M Phosphoric acid (75:23:2) as mobile phase. Detection was carried out by U.V at 236nm. The proposed method obeyed linearity in the range of 10-100μg/ml and met all specifications as per ICH guidelines. Statistical analysis revealed that this method can be used in routine quality control studies of Amlodipine besylate in pure and its formulations. © RJPT All right reserved. Source


Lavanya Latha Reddy K.,Nalanda Institute of Pharmaceutical science | Sowjanya T.,Nalanda Institute of Pharmaceutical science | Bandhavi P.,Nalanda Institute of Pharmaceutical science | Raveendranath T.,Narasaraopet Institute of Pharmaceutical science | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2012

A new Ultra-violet Spectroscopic method was developed and validated for the determination of amlodipine besylate in tablet dosage form. The sample was analysed using methanol buffer. The λmax values for amlodipine besylate in the solvent medium was found to be 281 nm. The system obey Beer's law and shows linearity in the range of 5- 30μg/ml.% Recovery studies, Intra-day and interday precision were found to be 98.8%,99.98% and 99.99%. No interference was observed from common tablet adjuvants. The changes in the λmax values (Physical parameter) for amlodipine besylate was evaluated as for stability study. The method was successfully applied to the assay of amlodipine besylate in tablet formulation. The proposed method is fast, accurate and precise for the determination of amlodipine besylate for routine quality control of tablets. © RJPT All right reserved. Source

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