Time filter

Source Type

Narisi Reddy P.,Nalanda Institute of Pharmaceutical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Intestinal fast dissolving Esomeprazole tablets were formulated to get resistance from gastric juice in the presence of stomach because of Esomeprazole is degraded immediately in stomach/gastric juice. The tablets were prepared by direct compression technique using the super disintegrating agents like Crospovidone, Croscarmellose Sodium, Pre-gelatinized Starch, sodium bicarbonate and excipients are Mannitol in different ratios. These super disintegrates and excipients are used for the intestinal fast releasing of dose and the enteric coating solution was prepared by Acryl-EZE, Eudragit-L100-55. Pre-post compression parameters were conducted for prepared intestinal fast dissolving tablets.


Putikam J.K.,Nalanda Institute of Pharmaceutical science
Research Journal of Pharmacy and Technology | Year: 2012

The aim of the present study was to develop an extended release formulation of Metoprolol Succinate to maintain constant therapeutic levels of the drug for over 24 hrs. An efficient extended release formulation of Metoprolol Succninate could be designed as extended release Matrix tablet. The optimized formulation (B-8) was developed by using HPMC [Benecel K35M] and HEC [Natrosol 250HHX] Regulated drug release in first order manner was attained by using these polymers. This extended release formulation (B-8) was found similar and comparable to the innovator product. The developed extended release formulation was quite stable with regard to physical properties and dissolution rate in the accelerated stability studies. © RJPT All right reserved.


Desireddy R.B.,Nalanda Institute of Pharmaceutical science | Desireddy R.B.,Narasaraopeta Institute of Pharmaceutical science | Bandhavi P.,Nalanda Institute of Pharmaceutical science | Bandhavi P.,Narasaraopeta Institute of Pharmaceutical science | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2013

The objective of the present study was to formulate mouth dissolving tablets of Ondansetron hydrochloride by using sublimation technique using camphor as subliming agent and using different concentrations of superdisintegrants like crospovidone, sodium starch glycolate, croscarmellose sodium by direct compression method. The results showed that Ondansetron with croscarmellose sodium and camphor fulfilled all the official requirements of Fast dissolving tablets. ©RJPT All right reserved.


Chandra Dinda S.,Berhampur University | Desireddy R.B.,Nalanda Institute of Pharmaceutical science | Jitendra Kumar P.,Nalanda Institute of Pharmaceutical science | Sai Chand A.,Nalanda Institute of Pharmaceutical science | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2013

A Validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Amlodipine besylate in pure and pharmaceutical formulations. Method was carried on Zodiac C18 column (250mm×4.6mm×5μ particle size) using Methanol: Acetonitrile: 0.01M Phosphoric acid (75:23:2) as mobile phase. Detection was carried out by U.V at 236nm. The proposed method obeyed linearity in the range of 10-100μg/ml and met all specifications as per ICH guidelines. Statistical analysis revealed that this method can be used in routine quality control studies of Amlodipine besylate in pure and its formulations. © RJPT All right reserved.


Lavanya Latha Reddy K.,Nalanda Institute of Pharmaceutical science | Sowjanya T.,Nalanda Institute of Pharmaceutical science | Bandhavi P.,Nalanda Institute of Pharmaceutical science | Raveendranath T.,Narasaraopet Institute of Pharmaceutical science | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2012

A new Ultra-violet Spectroscopic method was developed and validated for the determination of amlodipine besylate in tablet dosage form. The sample was analysed using methanol buffer. The λmax values for amlodipine besylate in the solvent medium was found to be 281 nm. The system obey Beer's law and shows linearity in the range of 5- 30μg/ml.% Recovery studies, Intra-day and interday precision were found to be 98.8%,99.98% and 99.99%. No interference was observed from common tablet adjuvants. The changes in the λmax values (Physical parameter) for amlodipine besylate was evaluated as for stability study. The method was successfully applied to the assay of amlodipine besylate in tablet formulation. The proposed method is fast, accurate and precise for the determination of amlodipine besylate for routine quality control of tablets. © RJPT All right reserved.


Malleswari K.,Nalanda institute of Pharmaceutical science | Desi Reddy R.B.,Nalanda institute of Pharmaceutical science | Prasad G.,Nalanda institute of Pharmaceutical science | Hanura T.,Nalanda institute of Pharmaceutical science
International Journal of Pharmacy and Technology | Year: 2012

Paclitaxel is an anti cancer drug shows poor water-solubility; in order to improve solubility and dissolution rate; solid dispersions of Paclitaxel were prepared and evaluated. Solid dispersions of Paclitaxel were prepared using PEG 6000 and Poloxamer 407. Dissolution studies indicated significant enhancement in dissolution of Paclitaxel when dispersed in PEG 6000 and Poloxamer 407. Solid dispersions containing Paclitaxel / Poloxamer 407, 1: 8, showed a 14-fold increase in dissolution after 60 min (D60) and another dispersion containing Paclitaxel /PEG 6000, 1:10, showed an 8- fold increase in dissolution rate. Lyophilized solid dispersions also enhanced dissolution of Paclitaxel significantly. Xray diffraction and FT-IR were performed to determine the physicochemical properties of the solid dispersions in comparison with the pure drug. Lyophilized solid dispersions of Poloxamer 407 had the maximum effect on the rate and extent of dissolution of Paclitaxel.


Desi Reddy R.B.,Nalanda institute of Pharmaceutical science | Malleswari K.,Nalanda institute of Pharmaceutical science | Prasad G.,Nalanda institute of Pharmaceutical science | Prasanna D.,Nalanda institute of Pharmaceutical science
International Journal of Pharmaceutical and Clinical Research | Year: 2012

The objective of the study was to develop a oral controlled release drug delivery system of lamivudine using non effervescent approach with hydrocolloid gel forming agent HPMC (hydroxylpropyl methylcellulose) and sodium alginate. Alginate beads of lamivudine were prepared by ionotropic gelation method. The prepared alginate beads were subjected to evaluation for particle size, incorporation efficiency and in vitro drug release characteristics. Alginate beads were discrete spherical and free flowing with smooth surfaces and completely covered with polymer coat. The alginate beads produced were smooth and small in size with an average diameter of about 506.19±7.2μm to 537.31±8.6μm. The prepared floating alginate beads were exhibited prolonged drug release (~12 hrs) and remained buoyant for greater than 12hrs.The release kinetics showed that the release of drug from the beads followed zero order kinetics. Drug release was controlled by diffusion from the alginate beads that was slow and spreads over an extended period of time depending upon the drug polymer ratio.


Desi Reddy R.B.,Nalanda Institute of Pharmaceutical science | Naga Sowjanya G.,Nalanda Institute of Pharmaceutical science | Shanthi V.,Nalanda Institute of Pharmaceutical science | Rizpah P.,Nalanda Institute of Pharmaceutical science | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2012

Development of new analytical methods for the determination of drugs in pharmaceutical dosage forms is more important in pharmacokinetic, toxicological and biological studies. Ezetemibe is a hypo-lipidaemic agent. Two simple and sensitive spectrophotometric methods (Method A and Method B) were developed for the estimation of Ezetemibe in bulk and pharmaceutical preparations. The two methods are based on the formation of yellow chromophores with PDAB and Picric acid exhibiting maximum absorption at 420nm and 400nm respectively. These two methods obey Beer's law in the concentration range of 10-50μg/ml and 10-30μg/ml respectively. The methods were validated for use in routine quality control studies of Ezetemibe. Interference studies were conducted and it was found that the common excipients usually present in dosage forms do not interfere in the proposed methods. The optical characteristics, regression analysis data and precision of the methods were calculated. The accuracy of the methods was evaluated by estimating the amount of Ezetemibe in previously analyzed samples to which known amounts of Ezetemibe were spiked. The accuracy of the methods was also confirmed by comparison of the results obtained by proposed and reference methods. The methods were validated for use in routine quality control of Ezetemibe in bulk and pharmaceutical preparations. © RJPT All right reserved.

Loading Nalanda Institute of Pharmaceutical science collaborators
Loading Nalanda Institute of Pharmaceutical science collaborators