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PubMed | Naif Arab University for Security science and University of Pretoria
Type: Journal Article | Journal: Biomedical chromatography : BMC | Year: 2016

Cases of poisoning by p-phenylenediamine (PPD) are detected sporadically. Recently an article on the development and validation of an LC-MS/MS method for the detection of PPD and its metabolites, N-acetyl-p-phenylenediamine (MAPPD) and N,N-diacetyl-p-phenylenediamine (DAPPD) in blood was published. In the current study this method for detection of these compounds was validated and applied to urine samples. The analytes were extracted from urine samples with methylene chloride and ammonium hydroxide as alkaline medium. Detection was performed by LC-MS/MS using electrospray positive ionization under multiple reaction-monitoring mode. Calibration curves were linear in the range 5-2000ng/mL for all analytes. Intra- and inter-assay imprecisions were within 1.58-9.52 and 5.43-9.45%, respectively, for PPD, MAPPD and DAPPD. Inter-assay accuracies were within -7.43 and 7.36 for all compounds. The lower limit of quantification was 5ng/mL for all analytes. The method, which complies with the validation criteria, was successfully applied to the analysis of PPD, MAPPD and DAPPD in human urine samples collected from clinical and postmortem cases.


Abd-El-Nabey B.A.,P.O. Box 426 | Abdel-Gaber A.M.,P.O. Box 426 | El Said Ali M.,Naif Arab University for Security science | Khamis E.,P.O. Box 426 | El-Housseiny S.,P.O. Box 426
International Journal of Electrochemical Science | Year: 2012

The effect of extract of cannabis plant on the corrosion of nickel in aqueous 0.5M sulphuric acid was investigated by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization techniques. EIS measurements showed that the dissolution process of nickel occurs under activation control. Potentiodynamic polarization curves indicated that the plant extract behaves as mixed-type inhibitor. The corrosion rates of nickel and the inhibition efficiencies of the extracts were calculated. The results obtained show that the extract solution of the plant could serve as an effective inhibitor for the corrosion of nickel in sulphuric acid media. Inhibition was found to increase with increasing concentration of the plant extract Theoretical fitting of different adsorption isotherms, Langmuir, Flory-Huggins, and the kinetic-thermodynamic model, were tested to clarify the nature of adsorption. Effect of temperature on the inhibitive action of cannabis extract for the corrosion of nickel in 0.5M sulphuric acid was investigated and the activation parameters of the corrosion process in absence andpresence of cannabis extract were calculated. © 2012 by ESG.


Hussein A.S.,Naif Arab University for Security science | Hussein A.S.,Research Institute of Nuclear Power Plants
Radioprotection | Year: 2014

Radon (222Rn) is a radioactive gas that occurs naturally when uranium in soil and rock breaks down. Long-term exposure to 222Rn increases the risk of lung cancer. The principal objective of this work was to determine the 222Rn activity concentration in an indoor air environment at the El-Dabaa site proposed for a nuclear power plant project in Egypt using the track etch technique with LR115 detectors. The annual average indoor 222Rn activity concentration in apartment buildings varies from 24 to 77 Bq.m-3, with a mean value of 54 Bq.m-3. The annual effective dose received by residents of the studied area was estimated to be 0.41 mSv. The annual estimated effective dose is less than the recommended action level by ICRP (3-10 mSv.y-1). The results from this work provide a radiological assessment program and update the background of the natural radioactivity map at the El-Dabaa site. © EDP Sciences, 2014.


Al-Qahtani K.M.A.,Princess Nora Bint Abdulrahman University | Ahmed H.A.M.,Naif Arab University for Security science | Al-Otaibi M.B.,Naif Arab University for Security science
Oriental Journal of Chemistry | Year: 2016

Since the dawn of civilization cosmetics have constituted a part of routine body care not only by the upper strata of society but also by middle and low class people. Heavy metals contamination in cosmetic products is becoming an important health problem in both worldwide and locally at the level of the Kingdom of Saudi Arabia (KSA). The aim of this study was to study. Quantitatively estimated heavy metals "lead, cadmium, mercury and Arsenic" using graphite. Total of 21 popular brands used lipstick products sold in Riyadh market samples from 3 different types of lipsticks frequently used among females in Saudi Arabia was digested. The digested samples were analyzed for lead, cadmium, mercury and Arsenic using graphite furnace- atomic absorption spectrometry. The mercury concentration was high followed by arsenic and cadmium, finally lead. The results indicate that the toxic heavy metals in all the samples were below the US FDA and SFDA permissible limits for cosmetic products with the exception the mercury content in some lipstick samples was higher than SFDA. There was no significant difference among the lipsticks in price categories. Continuous use and possible unintended ingestion of these toxic heavy metals, though in low levels in the cosmetics, may pose potential health risk due to their bioaccumulation in body organs. © 2016, Oriental Scientific Publishing Company. All rights reserved.


Mohamed K.M.,Naif Arab University for Security science | Al-Hazmi A.H.,Naif Arab University for Security science | Alasiri A.M.,Naif Arab University for Security science | Ali M.E.-S.,Naif Arab University for Security science
Journal of Chromatographic Science | Year: 2016

The stimulating herbal drug khat (cathine, cathinone) and its analog methcathinone are common substances of abuse in most countries. A GC-MS method was developed and validated for the detection and quantification of cathine, cathinone, methcathinone and ephedrine in oral fluid specimens. The analytes and internal standard (amphetamine-d5) were extracted from 0.5 mL oral fluids by ethyl acetate, and then the dried extracts were derivatized with heptafluorobutyric anhydride at 70°C for 30 min. The MS was used in selected ion monitoring mode. Ions monitored were m/z 117, 240 and 330 for cathine, m/z 77, 105 and 240 for cathinone, m/z 105, 210 and 254 for methcathinone, m/z 210, 254 and 344 for ephedrine and m/z 244 and 336 for amphetamine-d5. The calibration curves were linear (r2> 0.98) in the concentration range 20-2,000 ng/mL for all analytes. The intra- and inter-assay imprecisions were within (1.6-12.5%) and (1.5-9.5%), respectively, for all analytes. Intra-assay accuracies were between -5.9 and 6.7% for all analytes. The method was successfully applied to detect and quantify the target analytes from oral fluid specimens collected from Khat and methcathinone users. © 2016 The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.


Elyamany H.F.,Naif Arab University for Security science | Elyamany H.F.,Suez Canal University | Alkhairi A.H.,Naif Arab University for Security science
2015 IEEE/ACIS 16th International Conference on Software Engineering, Artificial Intelligence, Networking and Parallel/Distributed Computing, SNPD 2015 - Proceedings | Year: 2015

The advent of a new era of smart objects and networks of things inspired us to present a unified proposal for a model of a smart academic forum. It's an IoT architectural model that spans almost all vital divisions of the academic forum. We present IoT-architecture showing how academic services as well as data records could be delivered in an automated way to make academic life easier. This work elucidates the process of deriving the system concrete architectural model from IoT-A an outcome of European IoT-A project. A context view along with its IoT model is also presented. Finally, a connectivity model is described to show the interactivity among the main suggested architecture components. © 2015 IEEE.


Refaat A.M.,Naif Arab University for Security science
Egyptian Journal of Medical Human Genetics | Year: 2016

Background: Azoospermia constitutes 20% of male infertility situations and affects 1% of the total male population (Jarvi et al., 2010). This condition is classified into three major types; pre-testicular, testicular and post-testicular Azoospermia (Sermondade et al., 2012). Genetic defects causing Azoospermia are due to chromosomal or non-chromosomal alterations on the Y-Chromosome (Lee et al., 2011). Initial diagnosis of Azoospermia is established when no spermatozoa are detected on microscopic examination of semen (World Health Organisation, 1999). Objective: To evaluate the correlation of Y-STR Profiling results and the prevalence of Azoospermia, to help for early prognosis of Azoospermia before puberty. Methods: Buccal swab samples were taken from two groups of individuals (50 fertile and 50 Azoospermic patients), then DNA was isolated using QIAamp DNA Micro kit. DNA quantification was done using a Real-time PCR utilizing Quantifiler Kit. PCR was done using PowerPlex® Y PCR Amplification Kit, then amplified products were typed using a 3130 Genetic Analyzer. Results: Five haplotypes in four different Y-STR loci were found to possess significantly higher occurrence percentages in Azoospermic than in fertile Saudi individuals, which can serve as a group of pre-diagnostic markers for early prognosis of Azoospermia in Saudi population. Conclusion: There was a significant correlation of Y-STR Profiling results and the prevalence of Azoospermia condition, which supports the idea of using Y-STR Profiling in early prognosis of Azoospermia. © 2015 The Author.


Abd-El-Nabey B.A.,Alexandria University | Abdel-Gaber A.H.,Alexandria University | Ali M.E.S.,Naif Arab University for Security science | Khamis E.,Alexandria University | El-Housseiny S.,Alexandria University
International Journal of Electrochemical Science | Year: 2013

The effect of extract of cannabis plant on the corrosion of copper in aqueous 0.5M sulphuric acid was investigated by electrochemical impedance spectroscopy (EIS), potentiodynamic polarization, weight loss and optical micrograph techniques. EIS and polarization measurements showed that the dissolution process of copper occurs under diffusion control. Potentiodynamic polarization curves indicated that the plant extract behaves as cathodic-type inhibitor. The corrosion rates of copper and the inhibition efficiencies of the extract were calculated. The results obtained show that the extract solution of the plant could serve as an effective inhibitor for the corrosion of copper in sulphuric acid media. Theoretical fitting of different isotherms, Langmuir, Flory-Huggins, and the kinetic-thermodynamic model, were tested to clarify the nature of adsorption. © 2013 by ESG.


Ahmed H.A.M.,Naif Arab University for Security science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2015

Benzopyran (chromene) is one of the privileged medicinal pharmacophore, which appears as an important structural component in natural compounds and generated great attention because of their interesting biological activity. The derivatives of benzopyran moiety can be capable of interacting with a variety of cellular targets which leads to their wide ranging biological activities such as antitumor, antihepatotoxic, antioxidant, antiinflammatory, diuretic, anticoagulant, antispasmolytic, estrogenic, antiviral, antifungal, antimicrobial, anti-helminthic, hypothermal, vasodilatory, anti-HIV, antitubercular, herbicidal, anticonvulsant and analgesic activity. In the present study the synthesis of substituted benzopyran derivatives have been reported as one-pot reaction by reaction of 2-chlororesorcinol with malononitrile in the presence and aldehydes or ketones. The produced products were led to react with formamide to produce pyrimidochromene. Aminochromene-2-carbonitrile was converted into the corresponding imidate, which in turn converted upon treatment withhydrazine or ammonia to the corresponding amidine. The produced amidines were cyclized into the pyrimidochromene derivatives. The synthesized compounds have been characterized by TLC, Elemental analysis, IR and 1H-NMR Spectroscopy. Some of the synthesized compounds in this work were chosen and screened in vitro for their antimicrobial and anti-fungal activity against some strains of bacteria and fungi. The antibacterial and anti-fungal activities of synthesized compounds were compared with antibacterial and anti-fungal activity of the standard antibiotics Chloramphenicol and Sertaconazol. The most of the tested compounds revealed antibacterial and antifungal properties. This review is summarized to know about the different pharmacological activities of chromene nucleus with the extended knowledge about its antimicrobial and antifungal activity. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


PubMed | Naif Arab University for Security science
Type: Journal Article | Journal: Journal of chromatographic science | Year: 2016

The stimulating herbal drug khat (cathine, cathinone) and its analog methcathinone are common substances of abuse in most countries. A GC-MS method was developed and validated for the detection and quantification of cathine, cathinone, methcathinone and ephedrine in oral fluid specimens. The analytes and internal standard (amphetamine-d5) were extracted from 0.5 mL oral fluids by ethyl acetate, and then the dried extracts were derivatized with heptafluorobutyric anhydride at 70C for 30 min. The MS was used in selected ion monitoring mode. Ions monitored were m/z 117, 240 and 330 for cathine, m/z 77, 105 and 240 for cathinone, m/z 105, 210 and 254 for methcathinone, m/z 210, 254 and 344 for ephedrine and m/z 244 and 336 for amphetamine-d5 The calibration curves were linear (r(2)> 0.98) in the concentration range 20-2,000 ng/mL for all analytes. The intra- and inter-assay imprecisions were within (1.6-12.5%) and (1.5-9.5%), respectively, for all analytes. Intra-assay accuracies were between -5.9 and 6.7% for all analytes. The method was successfully applied to detect and quantify the target analytes from oral fluid specimens collected from Khat and methcathinone users.

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