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Nahāvand, Iran

Tammari E.,Persian Gulf University | Kazemi M.,Payame Noor University | Amani A.,Nahavand University
Journal of the Electrochemical Society | Year: 2014

Electrochemical oxidation of acetaminophen (1) in the presence of barbituric acid (2a), 1, 3-dimethyl barbituric acid (2b), 2- thiobarbituric acid (2c) and 1, 3-diethyl-2-thiobarbituric acid (2d) as nucleophiles in aqueous solution has been studied using cyclic voltammetry and controlled-potential coulometry. The results indicate that the p-quinone imine derived from electrooxidation of acetaminophen (1) participates in a Michael addition reaction with 2a-d to form the corresponding barbituric acid derivatives (7a-d). In addition, the homogeneous rate constants were estimated by comparing the experimental cyclic voltammetric responses with the digital simulated results. The electrochemical synthesis of 7a-d has been successfully performed in an undivided cell in good yields and purity at biological pH. © 2014 The Electrochemical Society. All rights reserved. Source

Nematollahi D.,Bu - Ali Sina University | Barnaji B.F.,Payame Noor University | Amani A.,Nahavand University
Iranian Journal of Pharmaceutical Research | Year: 2015

With the aim of obtaining information about drug-drug interaction (DDI) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and Controlled-potential coulometry. The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants. The cyclic voltammetric data were analyzed by digital simulation to measure the homogeneous parameters for the suggesting electrode mechanism. The calculated observed homogeneous rate constants (kobs) for the reaction of electrochemically generated N-acetyl-para benzoquinn-imine with antidepressant drugs was found to vary in the order kobs nortriptyline > kobs sertraline > kobs fluoxetine at biological pH. © 2015 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services. Source

Nematollahi D.,Bu - Ali Sina University | Feyzi Barnaji B.,Payame Noor University | Amani A.,Nahavand University
Journal of Sulfur Chemistry | Year: 2015

The electrochemical oxidation of N-Acetyl-p-Aminophenol (acetaminophen) (AC) has been studied in the presence of garlic and onion extracts using cyclic voltammetry, chronopotentiometry and chronocoulometry methods. The results revealed that the electrochemically generated toxic N-Acetyl-p-benzoquinone-imine participates in the Michael addition reaction with organosulfur compounds contained in garlic or onion extracts and is converted to its reduced none toxic form(s). Based on these results, garlic and onion extracts can be useful for the treatment of acetaminophen poisoning before starting clinical treatments. © 2014 © 2014 Taylor & Francis. Source

Beiginejad H.,University of Malayer | Amani A.,Nahavand University | Nematollahi D.,Bu - Ali Sina University | Khazalpour S.,Bu - Ali Sina University
Electrochimica Acta | Year: 2015

Electrochemical oxidation of some aminophenol derivatives (1-5) has been investigated both experimentally and theoretically. Experimental results were obtained using cyclic voltammetry and controlled potential coulometry. The theoretical results were calculated at DFT (B3LYP and BP86) levels of theory and 6-311 + G (p,d) basis sets. Using a general thermodynamic cycle, the calculated ΔGtot of the oxidation of the studied aminophenol derivatives indicates that thermodynamic is one of the important parameters on the potential oxidation. The obtained results show that electrochemical oxidation potential of 1-5 is directly dependent on the ΔGtot of electrochemical oxidation. In addition in this paper, mechanisms of the electrochemical oxidation of 4-(piperazin-1-yl) phenol (6) in the presence of various nucleophiles was studied in viewpoint of the thermodynamic. Mechanistic study of the electrochemical oxidation of 6 in the presence of different nucleophiles indicates that although the electrochemical oxidations of 6H+ in the presence of different nucleophiles have different mechanisms but proceed in the thermodynamically favored directions. © 2014 Elsevier Ltd. All rights reserved. Source

Zolfigol M.A.,Bu - Ali Sina University | Safaiee M.,Nahavand University | Bahrami-Nejad N.,Bu - Ali Sina University
New Journal of Chemistry | Year: 2016

A new and rational method for the synthesis of Fe3O4@SiO2@SiO2(CH)3Cl based magnetic nanoparticles with amino cobalt phthalocyanine tags (ACoPc-MNPs) was described and these were evaluated as a reusable catalyst for the one-pot synthesis of tetrahydrobenzo[b]pyran derivatives. The described reaction proceeded in high to excellent yield, with a short reaction time, and under mild and green solvent-free conditions at room temperature. The ACoPc-MNP catalyst was characterized via Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), X-ray fluorescence (XRF) analysis, energy-dispersive X-ray spectroscopy (EDX) and vibrating sample magnetometry (VSM). Moreover, the catalyst could be easily recovered by magnetic separation and recycled 4 times without significant loss of its catalytic activity. Moreover, by this synthetic method, some novel tetrahydrobenzo[b]pyran derivatives are prepared and characterized. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016. Source

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