Nahāvand, Iran
Nahāvand, Iran

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PubMed | BIO IDEA Company, Nahavand University and Bu - Ali Sina University
Type: | Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy | Year: 2014

The reaction of K2[PdCl4] and PdCl2 with 5-methyl-5-(4-pyridyl)-2,4-imidazolidenedione (L) proceeded with the formation of two different Pd complexes, PdL2Cl2 (1) and PdL2Cl4 (2c), corresponded to a substitution reaction and a substitution reaction along with unanticipated oxidation, respectively. The nature of the oxidizing agent is unknown. These compounds have been studied by elemental analysis, IR, (1)H and (13)CNMR, molar conductivity, and cyclic voltammetry. In addition, structural optimization by DFT calculations and simulation of NMR spectra have been performed and compared with the experimental data. NBO analysis, HOMO and LUMO, have been used to elucidate the information regarding charge transfer within the molecules. Theoretical studies confirmed that in 1 and 2c the trans structures are about 41 and 33 kJ mol(-1) more stable than cis ones. Antibacterial activity and in vitro cytotoxicity of these compounds, as respectively assessed in six bacterial strains and two human tumor cell lines, have been investigated. Results showed the title complexes have the capacity of inhibiting the metabolic growth of bacteria and tumor cells to different extents.


Zolfigol M.A.,Bu - Ali Sina University | Safaiee M.,Nahavand University | Bahrami-Nejad N.,Bu - Ali Sina University
New Journal of Chemistry | Year: 2016

A new and rational method for the synthesis of Fe3O4@SiO2@SiO2(CH)3Cl based magnetic nanoparticles with amino cobalt phthalocyanine tags (ACoPc-MNPs) was described and these were evaluated as a reusable catalyst for the one-pot synthesis of tetrahydrobenzo[b]pyran derivatives. The described reaction proceeded in high to excellent yield, with a short reaction time, and under mild and green solvent-free conditions at room temperature. The ACoPc-MNP catalyst was characterized via Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), X-ray fluorescence (XRF) analysis, energy-dispersive X-ray spectroscopy (EDX) and vibrating sample magnetometry (VSM). Moreover, the catalyst could be easily recovered by magnetic separation and recycled 4 times without significant loss of its catalytic activity. Moreover, by this synthetic method, some novel tetrahydrobenzo[b]pyran derivatives are prepared and characterized. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2016.


Nematollahi D.,Bu - Ali Sina University | Barnaji B.F.,Payame Noor University | Amani A.,Nahavand University
Iranian Journal of Pharmaceutical Research | Year: 2015

With the aim of obtaining information about drug-drug interaction (DDI) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and Controlled-potential coulometry. The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen and antidepressant drugs (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants. The cyclic voltammetric data were analyzed by digital simulation to measure the homogeneous parameters for the suggesting electrode mechanism. The calculated observed homogeneous rate constants (kobs) for the reaction of electrochemically generated N-acetyl-para benzoquinn-imine with antidepressant drugs was found to vary in the order kobs nortriptyline > kobs sertraline > kobs fluoxetine at biological pH. © 2015 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.


Safaiee M.,Nahavand University | Zolfigol M.A.,Bu - Ali Sina University | Afsharnadery F.,Bu - Ali Sina University | Baghery S.,Bu - Ali Sina University
RSC Advances | Year: 2015

A new magnetically recoverable nanocatalyst was synthesized by covalent binding of an amino vanadium oxo phthalocyanine, on the surface of silica coated magnetite nano particles with 3-chloropropyl moieties. Full characterization of the prepared nano catalyst was performed with different physicochemical methods such as FT-IR spectra, X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscope (AFM), and thermal gravimetric analysis (TGA), energy-dispersive X-ray spectroscopy (EDX), and vibrating sample magnetometry (VSM), Brunauer-Emmett-Teller (BET), X-ray fluorescence (XRF) and inductively coupled plasma (ICP). Finally, catalytic activity of the prepared Fe3O4@SiO2@SiO2(CH2)3@AVOPc was examined in the synthesis of 3,4-dihydropyrano[c]chromenes derivatives. The nano catalysts provided excellent catalytic activities to yield the desired products in short reaction time, mild and green conditions under solvent-free at room temperature. The catalysts could be easily separated from the reaction mixture by a magnet, and recycled eight consecutive cycles without any losing significant activities. Moreover, by this synthetic method, some novel 3,4-dihydropyrano[c]chromenes derivatives are prepared and characterized. © 2015 The Royal Society of Chemistry.


Beiginejad H.,University of Malayer | Amani A.,Nahavand University | Nematollahi D.,Bu - Ali Sina University | Khazalpour S.,Bu - Ali Sina University
Electrochimica Acta | Year: 2015

Electrochemical oxidation of some aminophenol derivatives (1-5) has been investigated both experimentally and theoretically. Experimental results were obtained using cyclic voltammetry and controlled potential coulometry. The theoretical results were calculated at DFT (B3LYP and BP86) levels of theory and 6-311 + G (p,d) basis sets. Using a general thermodynamic cycle, the calculated ΔGtot of the oxidation of the studied aminophenol derivatives indicates that thermodynamic is one of the important parameters on the potential oxidation. The obtained results show that electrochemical oxidation potential of 1-5 is directly dependent on the ΔGtot of electrochemical oxidation. In addition in this paper, mechanisms of the electrochemical oxidation of 4-(piperazin-1-yl) phenol (6) in the presence of various nucleophiles was studied in viewpoint of the thermodynamic. Mechanistic study of the electrochemical oxidation of 6 in the presence of different nucleophiles indicates that although the electrochemical oxidations of 6H+ in the presence of different nucleophiles have different mechanisms but proceed in the thermodynamically favored directions. © 2014 Elsevier Ltd. All rights reserved.


Nematollahi D.,Bu - Ali Sina University | Feyzi Barnaji B.,Payame Noor University | Amani A.,Nahavand University
Journal of Sulfur Chemistry | Year: 2015

The electrochemical oxidation of N-Acetyl-p-Aminophenol (acetaminophen) (AC) has been studied in the presence of garlic and onion extracts using cyclic voltammetry, chronopotentiometry and chronocoulometry methods. The results revealed that the electrochemically generated toxic N-Acetyl-p-benzoquinone-imine participates in the Michael addition reaction with organosulfur compounds contained in garlic or onion extracts and is converted to its reduced none toxic form(s). Based on these results, garlic and onion extracts can be useful for the treatment of acetaminophen poisoning before starting clinical treatments. © 2014 © 2014 Taylor & Francis.


Safaiee M.,Nahavand University | Zolfigol M.A.,Bu - Ali Sina University | Tavasoli M.,Bu - Ali Sina University | Mokhlesi M.,Bu - Ali Sina University
Journal of the Iranian Chemical Society | Year: 2014

A simple method for the oxidative aromatization of Hantzsch 1,4-dihydropyridines to the corresponding pyridines is described using hydrogen peroxide as green oxidant and silica vanadic acid as catalyst in acetonitrile at room temperature. The catalyst can be easily recovered and reused for 15 reaction cycles without considerable loss of activity. © 2014 Iranian Chemical Society.


Amini M.,Bu - Ali Sina University | Deljou A.,Bu - Ali Sina University | Nabiabad H.S.,Nahavand University
Physiology and Molecular Biology of Plants | Year: 2016

Developmental deficiency of somatic embryos and regeneration to plantlets, especially in the case of transformation, are major problems of somatic embryo regeneration in alfalfa. One of the ways to overcome these problems is the use of natural plant regulators and nutrients in the culture medium of somatic embryos. For investigating the influence of Cuscuta campestris extract on the efficiency of plant regeneration and transformation, chimeric tissue type plasminogen activator was transferred to explants using Agrobacterium tumefaciens, and transgenic plants were recovered using medium supplemented with different concentration of the extract. Transgenic plants were analyzed by PCR and RT-PCR. Somatic embryos of Medicago sativa L. developed into plantlets at high frequency level (52 %) in the maturation medium supplemented with 50 mg 1−1C. campestris extract as compared to the medium without extract (26 %). Transformation efficiency was 29.3 and 15.2 % for medium supplemented with dodder extract and without the extract, respectively. HPLC and GC/MS analysis of the extract indicated high level of ABA and some compounds such as Phytol, which can affect the somatic embryo maturation. The antibacterial assay showed that the extract was effective against some strains of A. tumefaciens. These results have provided a scientific basis for using of C. campestris extract as a good natural source of antimicrobial agents and plant growth regulator as well, that can be used in tissue culture of transgenic plants. © 2016, Prof. H.S. Srivastava Foundation for Science and Society.


PubMed | Nahavand University and Bu - Ali Sina University
Type: Journal Article | Journal: Physiology and molecular biology of plants : an international journal of functional plant biology | Year: 2016

Developmental deficiency of somatic embryos and regeneration to plantlets, especially in the case of transformation, are major problems of somatic embryo regeneration in alfalfa. One of the ways to overcome these problems is the use of natural plant regulators and nutrients in the culture medium of somatic embryos. For investigating the influence of


Tammari E.,Persian Gulf University | Kazemi M.,Payame Noor University | Amani A.,Nahavand University
Journal of the Electrochemical Society | Year: 2014

Electrochemical oxidation of acetaminophen (1) in the presence of barbituric acid (2a), 1, 3-dimethyl barbituric acid (2b), 2- thiobarbituric acid (2c) and 1, 3-diethyl-2-thiobarbituric acid (2d) as nucleophiles in aqueous solution has been studied using cyclic voltammetry and controlled-potential coulometry. The results indicate that the p-quinone imine derived from electrooxidation of acetaminophen (1) participates in a Michael addition reaction with 2a-d to form the corresponding barbituric acid derivatives (7a-d). In addition, the homogeneous rate constants were estimated by comparing the experimental cyclic voltammetric responses with the digital simulated results. The electrochemical synthesis of 7a-d has been successfully performed in an undivided cell in good yields and purity at biological pH. © 2014 The Electrochemical Society. All rights reserved.

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