Nagoya, Japan
Nagoya, Japan

Nagoya University , abbreviated to Meidai , is a Japanese national university headquartered in Chikusa-ku, Nagoya. It is the last Imperial University in Japan and among the National Seven Universities. It is the 4th best ranked higher education institution in Japan.As of 2014, six faculty and alumni of the university have won the Nobel Prize in science. Wikipedia.


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Provided is an embedding medium for specimen preparation that, when preparing a curable base material nonpenetrating specimen, involves no thermal invasion of the tissue, minimizes wrinkling and tearing during thin slicing, and makes it possible to confirm the position of the tissue in the embedding medium, and also for preparing a curable base material penetrating specimen on the same plane as a curable base material nonpenetrating specimen. The problem can be solved by using an embedding medium for specimen preparation that includes gelatin that is in a liquid state at 15C-25C and assumes a solid state at 4C when made into an aqueous solution.


Patent
Nagoya University, Mitsubishi Group and Mitsubishi Materials Corporation | Date: 2017-04-26

A virtual plane obtained by a locus when a tangent line, which passes through a tool distal end edge, of a virtual circle formed when a tool distal end edge of a cutting edge is rotated in a tool circumferential direction is moved parallel to a tool axial line is a reference plane, an angle (ARt) at which a cross line of the reference plane and the cutting edge virtual plane, is inclined with respect to the tool axial line projected onto the reference plane, is in a range of -30 degrees to -60 degrees, an angle (RR) at which a cutting edge tangent line which passes through the tool distal end edge and extends outward in a tool radial direction, is inclined with respect to a predetermined tool radial direction, which passes through the tool distal end edge, is in a range of -30 degrees to -75 degrees.


Patent
Toagosei Co., Keio University and Nagoya University | Date: 2017-04-26

Provided are a synthetic peptide that induces the reprogramming of a differentiated cell, a reprogramming-inducing pharmaceutical composition that contains this synthetic peptide, and a method for producing an undifferentiated cell from a differentiated cell using this synthetic peptide. The peptide provided by the present invention is a synthetic peptide having a reprogramming-inducing peptide sequence formed of the amino acid sequence given by SEQ ID NO: 1 or a modified amino acid sequence thereof. The method for producing an undifferentiated cell provided by the present invention includes inducing the reprogramming of a target cell by culturing a cell culture which contains the target cell and to which the synthetic peptide has been supplied.


Patent
Nagoya University and Menicon Co. | Date: 2017-05-03

The present invention provides a bone formation promoter having high biological safety and capable of promoting bone formation. The bone formation promoter of the present invention includes a self-assembling peptide capable of forming a -sheet structure in an aqueous solution having a neutral pH; and a bone chip. A sum of charges of amino acid residues constituting the self-assembling peptide at pH 7.0 is unequal to 0.


Patent
Nagoya University and Nipro Corporation | Date: 2017-05-17

Provided is a locking plate system for treatment of a distal radius fracture, intended to improve cooperation between screw anchors made of metal and a plate made of resin as well as to enhance matching with respect to the radius. The radius locking plate (4) is a flat laminate of intermediate molding materials that each include carbon fibers as reinforcing material and thermoplastic resin as a matrix. The screw anchor (5) includes a shaft portion (10) which has a principal thread (13) achieving a self-tapping action formed thereon and an outer circumference of a head portion of the screw anchor (5) which has an auxiliary thread (13) achieving a self-tapping action tapped thereon. A diameter of a through-hole (6) in the radius locking plate (4), which allows the radius main body (3) and the fractured bone piece (2) to be threadably fixed to the radius locking plate (4), is oversized relative to the principal thread (11), and is undersized relative to the auxiliary thread (13).


Patent
Nagoya University and Asuka Medical Inc. | Date: 2017-06-07

A laser therapeutic device for a laser endoscope capable of relatively reducing the diameter of the endoscope while being capable of emitting a laser beam of a uniform intensity over a wide area is provided. An optical guide element (a square-shaped rod lens 15, a guide tube 2b) having a quadrangular cross section and guiding a therapeutic laser beam emitted from the tip of an optical fiber toward the tip side of a probe is used. On the tip side of a probe tube 2 being a barrel, using clearances C1 to C4 formed between the optical guide element and the inner circumferential surface of the probe tube, a camera unit 11 as imaging means and white-color LED units 12 and an ultraviolet LED unit 13 as illumination means are arranged.


The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.


Patent
Kyowa Hakko Bio Co. and Nagoya University | Date: 2017-03-09

The invention provides a method of increasing blood flow in a subject in need of increased blood flow by administering citrulline or a salt thereof and arginine or a salt thereof to the subject.


A three-dimensional image reconstruction method capable of analyzing a three-dimensional structure of membrane proteins present within a lipid membrane is offered. A three-dimensional image reconstruction method associated with the present invention comprises the steps of: obtaining a first transmission electron microscope image of a sample containing the membrane proteins present within a lipid membrane, the image having been taken by illuminating an electron beam on the sample from a direction tilted relative to a line normal to the membrane surface of the lipid membrane (step S10); obtaining a second transmission electron microscope image of the sample taken by illuminating the electron beam on the sample perpendicularly to the membrane surface of the lipid membrane (step S12); identifying orientations of the membrane proteins of the first transmission electron microscope image on a basis of the second transmission electron microscope image (step S14); and analyzing a three-dimensional structure of the membrane proteins from the first transmission electron microscope image on a basis of information about the identified orientations of the membrane proteins (step S18).


Yamamoto Y.,Nagoya University
Chemical Society Reviews | Year: 2014

Transition-metal (TM)-catalyzed hydroarylation reactions of alkynes have received much attention, because they enable the net insertion of alkyne C-C triple bonds into C-H bonds of aromatic precursors, resulting in regio- and stereo-selective formation of synthetically useful arylalkenes. Taking advantage of this feature, TM-catalyzed alkyne hydroarylations have been successfully used for the synthesis of heterocycles. TM-catalyzed alkyne hydroarylations can be classified into three major categories depending on the type of reaction and precursors involved: (1) palladium-catalyzed reductive Heck reactions of alkynes with aryl halides, (2) TM-catalyzed conjugate arylation reactions of activated alkynes with arylboronic acids, and (3) TM-catalyzed aromatic C-H alkenylations with alkynes. This review surveys heterocycle synthesis via TM-catalyzed hydroarylation of alkynes according to the above classification, with an emphasis on the scope and limitations, as well as the underlying mechanisms. © 2014 The Royal Society of Chemistry.

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