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Nagoya-shi, Japan

Ikeno F.,Stanford University | Suzuki Y.,Nagoya Heart Center | Yeung A.C.,Stanford University
Journal of Biomedicine and Biotechnology | Year: 2011

To improve human health, scientific discoveries must be translated into practical applications. Inherent in the development of these technologies is the role of preclinical testing using animal models. Although significant insight into the molecular and cellular basis has come from small animal models, significant differences exist with regard to cardiovascular characteristics between these models and humans. Therefore, large animal models are essential to develop the discoveries from murine models into clinical therapies and interventions. This paper will provide an overview of the more frequently used large animal models, especially porcine models for preclinical studies. © 2011 Yoriyasu Suzuki et al.

Komeda M.,Nagoya Heart Center
General Thoracic and Cardiovascular Surgery | Year: 2013

Finite element analysis method (FEM) provides suitable methodology to analyze a target with complex shape such as VSP patch. In this study, by employing the FEM, Ito and colleagues showed the importance of using a large patch to eliminate the dead space between the patch and LV endocardium. Intuitionally many surgeons believed the same way, but it now has been proven mathematically. Although the FEM model has some limitation in part due to too much simplified model, I believe that the study provides useful information to the patch mechanics for VSP closure and that it will help improving the outcome of surgical treatment of VSP. © 2013 The Japanese Association for Thoracic Surgery.

Yamane M.,Sayama Hospital | Muto M.,Cardiovascular and Respiratory Center | Matsubara T.,Nagoya Heart Center | Nakamura S.,Kyoto Katsura Hospital | And 6 more authors.
EuroIntervention | Year: 2013

Aims: The retrograde approach to CTO is promising, but questions remain with regard to its wider application and the potential risks. This study evaluated the feasibility and efficacy of retrograde recanalisation of chronic total occlusion (CTO) of the coronary arteries. Methods and results: A total of 378 consecutive patients (previously failed PCI 32.0%) who enrolled in 27 institutions in Japan underwent retrograde recanalisation for CTO. We analysed the data on lesion characteristics, procedural materials, technique used, complications and clinical outcomes. Successful retrograde recanalisation was achieved in 70.4% and the overall procedural success was 83.6%. Collateral crossing was achieved via a septal route in 68.9%, epicardial in 27.2% and bypass grafts in 2.6%, respectively. The retrograde approach was completed with implementation of reverse CART in 42.5%, direct wire crossing in 23.1%, bilateral wiring in 22.7%, and CART in 11.7%. Major and minor collateral injuries and coronary perforations were noted in 1.3%, 10.3% and 2.9% of cases, respectively. Stroke occurred in 0.3%, QWMI and emergency PCI in 0.3% of patients with successful recanalisation. Conclusions: Wider application of retrograde CTO PCI achieved a high rate of success in recanalisation with an acceptable rate of complications in Japan. © Europa Digital & Publishing 2013. All rights reserved.

Tokuyasu T.,Oita National College of Technology | Shuto T.,Oita National College of Technology | Yufu K.,Oita National College of Technology | Kanao S.,Kyoto University | And 2 more authors.
ICIC Express Letters | Year: 2010

Recently, computer-aided diagnosis (CAD) system has been used in diagnosing patients suffering from a variety of diseases. This study aims to propose a CAD system for cardiovascular field, in which patient's aneurysm and/or aortic vessel tissue can be diagnosed. Computed-tomography angiography (CTA) is commonly used in the diagnosis of a patient with aortic aneurysm, and CAD system constructs 3-D volume model of inner organs around aneurysm based on patient's CTA. Because the diagnosis with CTA relies on contrast agent, therefore the region of aneurysm and/or aortic vessel tissue resemble the neighboring organs in that the grayscale intensity is ill-defined in CTA image. In order to clearly detect the region of aneurysm and/or aortic vessel tissue from CTA, we apply the theory of Fuzzy inference to 3-D region growing method based on the theory of Fuzzy inference. Preliminaries and some experimental results will be described and discussed in this paper. ICIC International © 2010 ISSN.

Kohsaka S.,Keio University | Komeda M.,Nagoya Heart Center | Goto M.,Kyoto University | Sakata R.,Kyoto University | And 10 more authors.
Diabetes Care | Year: 2012

OBJECTIVE - Approximately 25% of patients who undergo percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) have diabetes, and the diagnosis of diabetes roughly doubles the mortality risk associated with coronary artery disease. However, the impact of diabetesmay differ according to ethnicity.Our objective was to examine the impact of diabetes on long-term survival among U.S. and Japanese patients who underwent PCI or CABG. RESEARCH DESIGN AND METHODS - For the current analysis, we included 8,871 patients from a Japanese multicenter registry (Coronary Revascularization Demonstrating Outcome database in Kyoto; median follow-up 3.5 years; interquartile range [IQR] 2.6-4.3) and 7,229 patients from a U.S. multipractice registry (Texas Heart Institute Research Database; median follow-up 5.2 years; IQR 3.8-6.5). RESULTS - Diabetes was more prevalent among Japanese than U.S. patients (39.2 vs. 31.0%; P<0.001). However, after revascularization, long-term all-cause mortality was lower in diabetic Japanese patients than in diabetic U.S. patients (85.4 vs. 82.2%; log-rank test P = 0.009), whereas it was similar in nondiabetic Japanese and U.S. patients (89.1 vs. 89.5%; P = 0.50). The national difference in crude mortality was also significant among insulin-using patients with diabetes (80.8 vs. 74.9%; P = 0.023). When long-term mortality was adjusted for known predictors, U.S. location was associated with greater long-term mortality risk than Japanese location among nondiabetic patients (hazard ratio 1.58 [95%CI 1.32-1.88]; P<0.001) and, especially, diabetic patients (1.88 [1.54-2.30]; P < 0.001). CONCLUSIONS - Although diabetes was less prevalent in U.S. patients than in Japanese patients, U.S. patients had higher overall long-term mortality risk. This difference was more pronounced in diabetic patients. © 2012 by the American Diabetes Association.

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