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Ibaraki, Japan

Takahashi Y.,Teikyo University | Sugimoto K.,Nagaoka Perfumery Co. | Sugimoto K.,Osaka Prefecture University | Inui H.,Osaka Prefecture University | Fukusato T.,Teikyo University
World Journal of Gastroenterology | Year: 2015

Nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is considered to be a hepatic manifestation of metabolic syndrome, and its incidence is rapidly increasing worldwide. It is currently the most common chronic liver disease. NASH can progress to liver cirrhosis and hepatocellular carcinoma, and may result in liver-related death. Currently, the principal treatment for NAFLD/NASH is lifestyle modification by diet and exercise. However, pharmacological therapy is indispensable because obese patients with NAFLD often have difficulty maintaining improved lifestyles. The pathogenesis of NAFLD/NASH has not been completely elucidated. However, insulin resistance, inflammatory cytokines, and oxidative stress are thought to be important in the development and/or progression of the disease. Currently, insulin sensitizers (thiazolidinediones) and antioxidants (vitamin E) seem to be the most promising therapeutic agents for NAFLD/NASH, and lipid-lowering drugs, pentoxifylline, angiotensin receptor blockers, and n-3 polyunsaturated fatty acids also have promise. However, there is a lack of consensus regarding the most effective and appropriate pharmacotherapy for NAFLD/NASH. Animal experiments suggest that herbal medicines and natural products may be promising therapeutic agents for NAFLD/NASH, but their efficacy and safety are yet to be investigated in human studies. In this paper, we review the existing and potential pharmacological therapies for NAFLD/NASH. © 2015 Baishideng Publishing Group Inc. All rights reserved. Source


Patent
Nagaoka Perfumery Co. | Date: 2012-07-06

A fructose absorption inhibitor according to the present invention comprises a hydrolyzable tannin as an active ingredient. The hydrolyzable tannin preferably has a form composed of a gallic acid derivative and/or an ellagic acid derivative bound to a hydroxy group in glucose via an ester bond, and includes ellagitannin, gallotannin and so on.


Sugimoto K.,Osaka Prefecture University | Sugimoto K.,Nagaoka Perfumery Co. | Sakamoto S.,Osaka Prefecture University | Nakagawa K.,Nagaoka Perfumery Co. | And 6 more authors.
Food Chemistry | Year: 2011

Eucalyptus leaf extract (ELE) is rich in hydrolyzable tannins. We examined the effects of ELE and its constituents on lipopolysaccharide (LPS)-induced liver injury in mice. Mice fed a diet supplemented with 1% ELE were intraperitoneally administered LPS. Six hours later, the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly lower in the ELE-supplemented mice than in the controls; LPS-induced hepatic inducible nitric oxide synthase (iNOS) expression was also suppressed. ELE lowered LPS-stimulated iNOS expression in cultured RAW 264.7 macrophages. Furthermore, the aglycones of hydrolyzable tannins, gallic acid (GA) and ellagic acid (EA), inhibited iNOS induction to a greater extent than did ELE (15-fold higher). When mice were fed a 1% GA or EA diet, the increase in the serum ALT and AST activities and hepatic iNOS expression in response to the LPS challenge were significantly attenuated. Thus, hydrolyzable tannins in ELE ameliorate LPS-induced liver injury. © 2010 Elsevier Ltd. Source


Mitoshi M.,Kobe Gakuin University | Kuriyama I.,Kobe Gakuin University | Nakayama H.,Nagaoka Perfumery Co. | Miyazato H.,Nagaoka Perfumery Co. | And 6 more authors.
Journal of Agricultural and Food Chemistry | Year: 2012

In this study, the biological activity of 20 essential oils (EOs) from herbal plants and citrus fruits were investigated in terms of mammalian DNA polymerase (pol) inhibitory activity, cancer cell (human colon carcinoma, HCT116) growth inhibitory activity, antiallergic activity, as anti-β-hexosaminidase release activity in rat basophilic leukemia RBL-2H3 cells treated with calcium ionophore A23187, and antioxidant activity by a lipophilic-oxygen radical absorbance capacity method. These EOs showed patterns of inhibition of pol α, a DNA replicative pol, similar to their cancer cell growth inhibitory activity, and their inhibitory activity on pol λ, a DNA repair/recombination pol, by the EOs showed correlation with anti-β-hexosaminidase release activity. Among these EOs, chamomile (Matricaria chamomilla L.) was the strongest inhibitor of pols α and λ and showed significant effects on both cancer cell growth and mast cell degranulation. On the basis of these results, chamomile EO can be recommended as a potentially useful, bioactive candidate for therapeutic applications. © 2012 American Chemical Society. Source


Miyazato H.,Nagaoka Perfumery Co. | Hashimoto S.,Nagaoka Perfumery Co. | Hayashi S.,Nagaoka Perfumery Co.
European Food Research and Technology | Year: 2012

Yuzu (Citrus junos Sieb. ex Tanaka) is a variety of sour citrus fruit that is popular in Japan. In this study, we investigated its aroma, which many people, especially in Japan, find appealing. Aroma extract dilution analysis was used to screen the odour-active compounds in the yuzu volatile oil. An unknown odorant with an albedo-like odour and a high flavour-dilution factor was detected. To identify this odorant, it was separated via flash column chromatography on silica gel and then fractionated by preparative high-performance liquid chromatography on a reverse-phase column. The volatile fraction, which contained a significant amount of the target unknown compound, was analysed by gas chromatography-mass spectrometry and gas chromatography-olfactometry to determine its mass spectrum, retention index, and odour quality. By comparing the resultant data with that of a synthesised authentic reference compound, it was evident that the unknown odorant was trans-4,5-epoxy-(E,Z)-2,7-decadienal (3); this is the first time that it has been identified as an odour-active unsaturated aldehyde in yuzu volatile oil. From the results of a model formation experiment, we propose that trans-4,5-epoxy-(E,Z)-2,7-decadienal originates from α-linolenic acid via 13(S)-hydroperoxy-(Z,E,Z)-9,11,15-octadecatrienoic acid (13(S)-HPOT), which is a lipoxygenase-induced oxidation product of α-linolenic acid. © 2012 Springer-Verlag. Source

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