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Nagano-shi, Japan

Nagano College of Nursing is a public university in Komagane, Nagano, Japan. The school was established in 1995. Wikipedia.


Miyoshi T.,Okayama University of Science | Nakamura K.,Okayama University of Science | Yoshida M.,Okayama University of Science | Miura D.,Nagano College of Nursing | And 7 more authors.
Cardiovascular Diabetology | Year: 2014

Background: Heart failure with left ventricular (LV) hypertrophy is often associated with insulin resistance and inflammation. Recent studies have shown that dipeptidyl peptidase 4 (DPP4) inhibitors improve glucose metabolism and inflammatory status. We therefore evaluated whether vildagliptin, a DPP4 inhibitor, prevents LV hypertrophy and improves diastolic function in isoproterenol-treated rats.Methods: Male Wistar rats received vehicle (n = 20), subcutaneous isoproterenol (2.4 mg/kg/day, n = 20) (ISO), subcutaneous isoproterenol (2.4 mg/kg/day + oral vildagliptin (30 mg/kg/day, n = 20) (ISO-VL), or vehicle + oral vildagliptin (30 mg/kg/day, n = 20) (vehicle-VL) for 7 days.Results: Blood pressure was similar among the four groups, whereas LV hypertrophy was significantly decreased in the ISO-VL group compared with the ISO group (heart weight/body weight, vehicle: 3.2 ± 0.40, ISO: 4.43 ± 0.39, ISO-VL: 4.14 ± 0.29, vehicle-VL: 3.16 ± 0.16, p < 0.05). Cardiac catheterization revealed that vildagliptin lowered the elevated LV end-diastolic pressure observed in the ISO group, but other parameters regarding LV diastolic function such as the decreased minimum dp/dt were not ameliorated in the ISO-VL group. Histological analysis showed that vildagliptin attenuated the increased cardiomyocyte hypertrophy and perivascular fibrosis, but it did not affect angiogenesis in cardiac tissue. In the ISO-VL group, quantitative PCR showed attenuation of increased mRNA expression of tumor necrosis factor-α, interleukin-6, insulin-like growth factor-l, and restoration of decreased mRNA expression of glucose transporter type 4.Conclusions: Vildagliptin may prevent LV hypertrophy caused by continuous exposure to isoproterenol in rats. © 2014 Miyoshi et al.; licensee BioMed Central Ltd.


Hamauzu Y.,Shinshu University | Nosaka T.,Nagano College of Nursing | Ito F.,Shinshu University | Suzuki T.,Shinshu University | And 5 more authors.
Food Chemistry | Year: 2011

Rapidly dried onion (Allium cepa L. cv. Momiji No. 3) powder (OP) prepared from the outer layers (from second to fourth scale leaves from the surface) of onion bulbs was analysed for its quercetin and polyuronide contents, the effects of enzymatic treatment and the anti-atherogenic effect on rats fed a high-fat diet. Quercetin 4′-glucoside (50%), free quercetin (30%) and quercetin 3,4′-diglucoside (20%) were identified as quercetin derivatives, and boiling-water extraction was effective in extracting these compounds. OP contained 12.9% of polyuronides, the basic skeleton of pectin. Enzymatic degradation (cellulase and pectinase, 50 °C for 12 h, pH 6.0) of OP was effective in obtaining a slurry of smaller particle sizes. The free quercetin increased and the glucosides decreased with enzyme treatment. In Wistar rats fed an OP-added high-fat diet, the total cholesterol, HDL-cholesterol and triglyceride concentrations were not significantly different from the rats fed a high-fat diet without OP. However, the atherogenic index (AI) of Wistar rats fed an OP-added high-fat diet was lower (AI = 3.3) than rats fed the diet without OP (AI = 4.1). The incremental elastic modulus (IEM) of the aorta from rats fed the OP-added diet was also significantly lower than that of the rats fed the diet without OP. The AI and IEM values of the rats fed the OP-added diet were quite similar to the values of rats fed the diet without OP but were allowed spontaneous exercise. These results suggest that OP intake is effective for decreasing the risk of arteriosclerosis. © 2011 Elsevier Ltd. All rights reserved.


Li S.,Yamanashi University | Liang J.,Nagano College of Nursing | Niimi M.,Yamanashi University | Waqar A.B.,Yamanashi University | And 5 more authors.
Journal of Atherosclerosis and Thrombosis | Year: 2014

Aim: Probucol is a lipid-lowering drug that is often prescribed for the treatment of familial hypercholesterolemia. However, it is not known whether probucol can change the lesion quality of atherosclerosis. Methods: We examined this possibility using WHHL rabbits, a model of human familial hypercholesterolemia. Three-month-old male WHHL rabbits were treated with either probucol (85 mg/kg/ day) or atorvastatin (6 mg/kg/day) for 16 weeks, and their plasma lipid levels and atherosclerotic lesions were compared with those of a control group. Results: We found that probucol treatment reduced the plasma cholesterol levels, but less remarkably than atorvastatin treatment. In spite of this, probucol treatment led to a prominent reduction of aortic en face lesions by 39% (P<0.01), whereas atorvastatin reduced these by 16% (P>0.05), compared with those in the control. Histological examinations revealed that the aortic lesions of probucol-treated rabbits were characterized by reduced macrophages and increased smooth muscle cells compared with those from both the control and atorvastatin groups. Furthermore, probucol treatment reduced the coronary artery stenosis and increased the plaque stability. Conclusions: These results suggest that probucol treatment may have beneficial effects on the plaque stability of hypercholesterolemic patients.


Matsumoto J.,Nagano College of Nursing | Tagaya A.,Nagano College of Nursing
INTERNOISE 2014 - 43rd International Congress on Noise Control Engineering: Improving the World Through Noise Control | Year: 2014

This study explored the effectiveness of background music for improving the sound environment in hospital wards. Participants were 21 female and 9 male Japanese college students. They were presented both noises in hospital wards and 10 kinds of music simultaneously and asked to evaluate the degree of annoyance and the degree of uncomfortableness of the sounds. Participants were also asked to rate both the degree of annoyance and the degree of uncomfortableness of noises when presented alone, and to rate them for each kind of music when presented without noises. It was found that participants were not particularly annoyed by the noises, but the noises made them feel uncomfortable. With respect to the music (for example, healing music and music with affective characteristics, such as elation, lightness, or affinity) presented with the noises, participants were not particularly annoyed by them and felt less uncomfortable than when the noises were presented alone. These results suggest that background music could be useful for improving the sound environment in hospital wards.


Matsumoto J.,Nagano College of Nursing | Tagaya A.,Nagano College of Nursing
40th International Congress and Exposition on Noise Control Engineering 2011, INTER-NOISE 2011 | Year: 2011

The present study attempted to reveal the effects of natural sounds on cognition of noises that occur in hospital wards. Participants were 21 female and 9 male college students. They were presented both noises in hospital wards and natural sounds simultaneously and asked to evaluate the degree of annoyance and the degree of uncomfortableness of the sounds. Participants were also asked to rate both the degree of annoyance and the degree of uncomfortableness of noises when presented alone, and to rate them of each natural sound when presented without noises. It was found that participants were not particularly annoyed by the noises, but the noises made them feel somewhat uncomfortable. With respect to the natural sounds (for example, a great tit, a Japanese bush warbler, a cricket, an iron wind bell, and a water-filled bamboo tube striking a stone) presented with noises, participants were not particularly annoyed by them and felt less uncomfortable than when the noises were presented alone. These results suggest that natural sounds could be useful for improving the sound environment in hospital wards.

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