Li S.,Yamanashi University |
Liang J.,Nagano College of Nursing |
Niimi M.,Yamanashi University |
Waqar A.B.,Yamanashi University |
And 5 more authors.
Journal of Atherosclerosis and Thrombosis | Year: 2014
Aim: Probucol is a lipid-lowering drug that is often prescribed for the treatment of familial hypercholesterolemia. However, it is not known whether probucol can change the lesion quality of atherosclerosis. Methods: We examined this possibility using WHHL rabbits, a model of human familial hypercholesterolemia. Three-month-old male WHHL rabbits were treated with either probucol (85 mg/kg/ day) or atorvastatin (6 mg/kg/day) for 16 weeks, and their plasma lipid levels and atherosclerotic lesions were compared with those of a control group. Results: We found that probucol treatment reduced the plasma cholesterol levels, but less remarkably than atorvastatin treatment. In spite of this, probucol treatment led to a prominent reduction of aortic en face lesions by 39% (P<0.01), whereas atorvastatin reduced these by 16% (P>0.05), compared with those in the control. Histological examinations revealed that the aortic lesions of probucol-treated rabbits were characterized by reduced macrophages and increased smooth muscle cells compared with those from both the control and atorvastatin groups. Furthermore, probucol treatment reduced the coronary artery stenosis and increased the plaque stability. Conclusions: These results suggest that probucol treatment may have beneficial effects on the plaque stability of hypercholesterolemic patients.
PubMed | Yamanashi University and Nagano College of Nursing
Type: Journal Article | Journal: Archives of psychiatric nursing | Year: 2015
This qualitative study explored experiences of recovery from severe mental illness based on semi-structured interviews with sixteen persons diagnosed with schizophrenia spectrum disorders using psychiatric rehabilitation facilities. The participants transcripts revealed two major themes: (1) ongoing efforts to live better and (2) inconsistent self-acceptance as a person living with a mental illness. The participants were aware of their responsibility to live with integrity. They all had hopes and goals, were able to respond to social cues, and considered what they could do independently. They wanted to be recognized as people who adapted successfully in society while inconsistently perceiving themselves as either sick or healthy. It is necessary to examine approaches that support the identities of persons who have been treated for schizophrenia and allow them to live comfortable within their communities.
PubMed | Yamanashi University and Nagano College of Nursing
Type: Journal Article | Journal: PloS one | Year: 2015
Hot spring or hot spa bathing (Onsen) is a traditional therapy for the treatment of certain ailments. There is a common belief that hot spring bathing has therapeutic effects for wound healing, yet the underlying molecular mechanisms remain unclear. To examine this hypothesis, we investigated the effects of Nagano hot spring water (rich in carbonate ion, 42C) on the healing process of the skin using a nude rat skin wound model. We found that hot spring bathing led to an enhanced healing speed compared to both the unbathed and hot-water (42C) control groups. Histologically, the hot spring water group showed increased vessel density and reduced inflammatory cells in the granulation tissue of the wound area. Real-time RT-PCR analysis along with zymography revealed that the wound area of the hot spring water group exhibited a higher expression of matrix metalloproteinases-2 and -9 compared to the two other control groups. Furthermore, we found that the enhanced wound healing process induced by the carbonate ion-enriched hot spring water was mediated by thermal insulation and moisture maintenance. Our results provide the evidence that carbonate ion-enriched hot spring water is beneficial for the treatment of skin wounds.
Miyoshi T.,Okayama University of Science |
Nakamura K.,Okayama University of Science |
Yoshida M.,Okayama University of Science |
Miura D.,Nagano College of Nursing |
And 7 more authors.
Cardiovascular Diabetology | Year: 2014
Background: Heart failure with left ventricular (LV) hypertrophy is often associated with insulin resistance and inflammation. Recent studies have shown that dipeptidyl peptidase 4 (DPP4) inhibitors improve glucose metabolism and inflammatory status. We therefore evaluated whether vildagliptin, a DPP4 inhibitor, prevents LV hypertrophy and improves diastolic function in isoproterenol-treated rats.Methods: Male Wistar rats received vehicle (n = 20), subcutaneous isoproterenol (2.4 mg/kg/day, n = 20) (ISO), subcutaneous isoproterenol (2.4 mg/kg/day + oral vildagliptin (30 mg/kg/day, n = 20) (ISO-VL), or vehicle + oral vildagliptin (30 mg/kg/day, n = 20) (vehicle-VL) for 7 days.Results: Blood pressure was similar among the four groups, whereas LV hypertrophy was significantly decreased in the ISO-VL group compared with the ISO group (heart weight/body weight, vehicle: 3.2 ± 0.40, ISO: 4.43 ± 0.39, ISO-VL: 4.14 ± 0.29, vehicle-VL: 3.16 ± 0.16, p < 0.05). Cardiac catheterization revealed that vildagliptin lowered the elevated LV end-diastolic pressure observed in the ISO group, but other parameters regarding LV diastolic function such as the decreased minimum dp/dt were not ameliorated in the ISO-VL group. Histological analysis showed that vildagliptin attenuated the increased cardiomyocyte hypertrophy and perivascular fibrosis, but it did not affect angiogenesis in cardiac tissue. In the ISO-VL group, quantitative PCR showed attenuation of increased mRNA expression of tumor necrosis factor-α, interleukin-6, insulin-like growth factor-l, and restoration of decreased mRNA expression of glucose transporter type 4.Conclusions: Vildagliptin may prevent LV hypertrophy caused by continuous exposure to isoproterenol in rats. © 2014 Miyoshi et al.; licensee BioMed Central Ltd.
Matsumoto J.,Nagano College of Nursing |
Tagaya A.,Nagano College of Nursing
INTERNOISE 2014 - 43rd International Congress on Noise Control Engineering: Improving the World Through Noise Control | Year: 2014
This study explored the effectiveness of background music for improving the sound environment in hospital wards. Participants were 21 female and 9 male Japanese college students. They were presented both noises in hospital wards and 10 kinds of music simultaneously and asked to evaluate the degree of annoyance and the degree of uncomfortableness of the sounds. Participants were also asked to rate both the degree of annoyance and the degree of uncomfortableness of noises when presented alone, and to rate them for each kind of music when presented without noises. It was found that participants were not particularly annoyed by the noises, but the noises made them feel uncomfortable. With respect to the music (for example, healing music and music with affective characteristics, such as elation, lightness, or affinity) presented with the noises, participants were not particularly annoyed by them and felt less uncomfortable than when the noises were presented alone. These results suggest that background music could be useful for improving the sound environment in hospital wards.
Hamauzu Y.,Shinshu University |
Nosaka T.,Nagano College of Nursing |
Ito F.,Shinshu University |
Suzuki T.,Shinshu University |
And 5 more authors.
Food Chemistry | Year: 2011
Rapidly dried onion (Allium cepa L. cv. Momiji No. 3) powder (OP) prepared from the outer layers (from second to fourth scale leaves from the surface) of onion bulbs was analysed for its quercetin and polyuronide contents, the effects of enzymatic treatment and the anti-atherogenic effect on rats fed a high-fat diet. Quercetin 4′-glucoside (50%), free quercetin (30%) and quercetin 3,4′-diglucoside (20%) were identified as quercetin derivatives, and boiling-water extraction was effective in extracting these compounds. OP contained 12.9% of polyuronides, the basic skeleton of pectin. Enzymatic degradation (cellulase and pectinase, 50 °C for 12 h, pH 6.0) of OP was effective in obtaining a slurry of smaller particle sizes. The free quercetin increased and the glucosides decreased with enzyme treatment. In Wistar rats fed an OP-added high-fat diet, the total cholesterol, HDL-cholesterol and triglyceride concentrations were not significantly different from the rats fed a high-fat diet without OP. However, the atherogenic index (AI) of Wistar rats fed an OP-added high-fat diet was lower (AI = 3.3) than rats fed the diet without OP (AI = 4.1). The incremental elastic modulus (IEM) of the aorta from rats fed the OP-added diet was also significantly lower than that of the rats fed the diet without OP. The AI and IEM values of the rats fed the OP-added diet were quite similar to the values of rats fed the diet without OP but were allowed spontaneous exercise. These results suggest that OP intake is effective for decreasing the risk of arteriosclerosis. © 2011 Elsevier Ltd. All rights reserved.
Matsumoto J.,Nagano College of Nursing |
Tagaya A.,Nagano College of Nursing
40th International Congress and Exposition on Noise Control Engineering 2011, INTER-NOISE 2011 | Year: 2011
The present study attempted to reveal the effects of natural sounds on cognition of noises that occur in hospital wards. Participants were 21 female and 9 male college students. They were presented both noises in hospital wards and natural sounds simultaneously and asked to evaluate the degree of annoyance and the degree of uncomfortableness of the sounds. Participants were also asked to rate both the degree of annoyance and the degree of uncomfortableness of noises when presented alone, and to rate them of each natural sound when presented without noises. It was found that participants were not particularly annoyed by the noises, but the noises made them feel somewhat uncomfortable. With respect to the natural sounds (for example, a great tit, a Japanese bush warbler, a cricket, an iron wind bell, and a water-filled bamboo tube striking a stone) presented with noises, participants were not particularly annoyed by them and felt less uncomfortable than when the noises were presented alone. These results suggest that natural sounds could be useful for improving the sound environment in hospital wards.
PubMed | Hiroshima City Asa Hospital, The Japanese Red Cross Hiroshima College of Nursing, Japanese Red Cross Toyota College of Nursing, Hiroshima University and 2 more.
Type: | Journal: Journal of investigative and clinical dentistry | Year: 2015
Oral microflora during pregnancy is critical to oral health care in the mother and her child. We examined the changes in the oral microbiota between pregnancy and nonpregnancy periods.The study was performed using 132 healthy pregnant women enrolled from Hiroshima City Asa Citizens Hospital and 51 healthy nonpregnant women as control. During pregnancy, 132 subjects were assessed for seven microbial species by the cultured method and polymerase chain reaction at the early (7-16weeks gestation), the middle (17-28weeks), and the late (29-39weeks) pregnancy periods. Pregnant women completed a series of questionnaires regarding oral and systemic health and lifestyle habits.The total cultivable microbial counts in the early pregnancy were significantly higher than that of the nonpregnant women (P<0.05). The incidences of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in gingival sulcus during the early and middle pregnancy were significantly higher than the nonpregnant group (P<0.05), while Prevotella intermedia and Fusobacterium nucleatum did not change. Candida species were more frequently detected during the middle and late pregnancy.The data suggest that pregnancy, especially in the early periods, promotes the proliferation of microorganisms in the oral cavity and facilitates a colonization of periodontal pathogens.
PubMed | Nagano College of Nursing
Type: Journal Article | Journal: Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology | Year: 2013
To elucidate the mechanism of insulin resistance due to insulin counterregulatory hormones (ICRHs) and evaluate ICRH secretion kinetics, ICRH concentrations were measured and correlated with blood glucose levels in 28 type 1 diabetic patients. Blood glucose was measured before bedtime. Early morning urine samples were collected the next morning before insulin injection and breakfast. Fasting blood glucose, cortisol, glucagon and HbA1c levels were measured. Growth hormone (GH), adrenaline, cortisol and C-peptide levels in morning urine samples were measured; SD scores were calculated for urine GH. The laboratory values (mean SD) were as follows; HbA1c of 8.1% 1.4%; pre-bedtime glucose of 203 105 mg/dl; fasting blood glucose of 145 87 mg/dl; serum cortisol of 21.6 5.5 g/dl; plasma glucagon of 98 41 pg/ml; urinary GH, 27.2 13.0 ng/gCr; urinary cortisol of 238 197 ng/gCr; and urinary Adrenaline of 22.9 21.0 ng/gCr. The mean urinary GH SD score was increased (+1.01 0.70; p=0.000); the mean plasma glucagon lebel (98 41 pg/ml) was not. Fasting blood glucose was positively correlated with plasma glucagon (R=0.378, p=0.0471) and negatively correlated with urinary cortisol (R=-0.476, p=0.010). Urinary adrenaline correlated positively with urinary GH (R=0.470, p=0.013) and urinary cortisol (R=0.522, p=0.004). In type 1 diabetes, GH, glucagon and cortisol hypersecretion may contribute to insulin resistance, but the mechanism remains unclear.
PubMed | Kochi University, The Japanese Red Cross Hiroshima College of Nursing, University of California at San Francisco and Nagano College of Nursing
Type: Journal Article | Journal: Nursing ethics | Year: 2015
Advocacy is an important role of psychiatric nurses because their patients are ethically, socially, and legally vulnerable. This study of Japanese expert psychiatric nurses judgments of interventions for patient advocacy will show effective strategies for ethical nursing practice and their relationship with Japanese culture.This article explores Japanese psychiatric nurses decision to intervene as a patient advocate and examine their ethical, cultural, and social implications.Using semi-structured interviews verbatim, themes of the problems that required interventions were inductively summarized by a qualitative analysis and their contexts and nursing judgments were examined.The participants were 21 nurses with 5 or more years of experience in psychiatric nursing.The research was approved by Institutional Review Board of research site and study facilities. The participants gave written informed consent.Analysis of 45 cases showed that nurses decided to intervene when (a) surrounding peoples opinions impeded patients safety, (b) healthcare professionals policies impeded patients decision-making, (c) own violent behaviors impeded treatment and welfare services for patients, (d) own or families low acceptance of illness impeded patients self-actualization, (e) inappropriate treatment or care impeded patients liberty, and (f) their families abused patients property.To solve conflicts between patients and their surrounding people, the nurses sought reconciliation between them, which is in accordance with Japanese cultural norms respecting harmony. When necessary, however, they protected patients rights against cultural norms. Therefore, their judgments cannot be explained by cultural norms alone.The findings indicate that the nurses judgments were based on respect for patients rights apart from cultural norms, and they first sought solutions fitting the cultural norms before other solutions. This seems to be an ethical, effective strategy if advocates know the culture in depth.