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Havaldar F.H.,Nadkarny Sacasa Research Laboratory | Vairal D.L.,Nadkarny Sacasa Research Laboratory
E-Journal of Chemistry | Year: 2010

A simple, specific, accurate and economical gradient reversed phase liquid chromatographic (RP-HPLC) method was developed and subsequently validated for the determination of glimipiride, rosiglitazone and pioglitazone hydrochloride. Separation was achieved with a nucleodur C-18 column having 250×4.6 mm i.d. with 5 μm particle size and water HPLC grade adjusted to pH 3.0 using diluted orthophosphoric acid and acetonitrile (80:20 v/v) with gradient program as eluent at a constant flow rate of 0.8 ml per min. UV detection was performed at 215 nm. The retention time of glimipiride, rosiglitazone and pioglitazone hydrochloride were about 17.9 min, 6.31 min and 8.24 min respectively. This method is simple, rapid and selective and can be used for routine analysis of antidiabetic drugs in pharmaceutical preparation. The proposed method was validated and successfully used for estimation of glimipiride, rosiglitazone and pioglitazone hydrochloride in the pharmaceutical dosage form.


Havaldar F.H.,Nadkarny Sacasa Research Laboratory | Vairal D.L.,Nadkarny Sacasa Research Laboratory
E-Journal of Chemistry | Year: 2010

A simple, specific, accurate and economical isocratic reversed phase liquid chromatographic (RP-HPLC) method was developed and subsequently validated for the determination of paracetamol, acetyl salicylic acid, mefenamic acid and cetirizine dihydrochloride. Separation was achieved with a Nucleodur 100 C-18 column having 250 x 4.6 mm i.d. with 5 μm particle size and disodium hydrogen phosphate buffer adjusted to pH 6.5 using diluted orthophosphoric acid and acetonitrile (60:40 v/v) as eluent at a constant flow rate of 1.0 mL per min. UV detection was performed at 220 nm. The retention time of acetyl salicylic acid, paracetamol, mefenamic acid and cetirizine dihydrochloride were 2.01 min, 2.92 min, 4.91 min and 10.2 min respectively. This method is simple, rapid and selective and can be used for routine analysis of analgesic and antipyretic drugs in pharmaceutical formulations. The proposed method was validated and successfully used for estimation of paracetamol, acetyl salicylic acid, mefenamic acid and cetirizine dihydrochloride in the pharmaceutical dosage form.


Havaldar F.H.,Nadkarny Sacasa Research Laboratory | Sharma A.K.S.,Nadkarny Sacasa Research Laboratory
Asian Journal of Chemistry | Year: 2011

4-Acetamido-2-methoxybenzoyl hydrazine (1) on condensation with different aromatic aldehydes yielded the substituted benzal-(4'- acetamido-2'- methoxybenzoyl)hydrazines (2a-f) which on cyclization with thioglycolic acid in presence of anhydrous aluminium chloride as catalyst afforded 2-(substituted phenyl)-3-(4'-acetamido-2'-methoxy benzamido)-5-H-thiazolidin-4-ones (3a-f). The structures of the newly synthesized compounds have been established by analytical and spectral methods. These compounds have also been screened for their biological activity.


Havaldar F.H.,Nadkarny Sacasa Research Laboratory | Mule G.,Nadkarny Sacasa Research Laboratory | Dabholkar B.,Nadkarny Sacasa Research Laboratory
Synthetic Communications | Year: 2011

Various 2-substituted benzimidazoles were prepared in one pot by condensation of o-phenylenediamine with an appropriate aldehyde in good to excellent yields using a mixture of Ti(IV) isopropoxide and cumene hydroperoxide. Copyright © 2011 Taylor & Francis Group, LLC.


Dabholkar V.V.,Organic Research Laboratory | Hawaldar F.,Nadkarny Sacasa Research Laboratory
Indian Journal of Heterocyclic Chemistry | Year: 2010

Ethyl-2-[diazo (substituted benzene)] acetoacetates II were treated with thiosemicarbazide to furnish 4-(substituted phenyl) azo-5-methyl-2-thioamido-3- pyrazolones III. Compounds II on treatment with one molar quantity of thiocarbohydrazide (TCH) yielded 4-(substituted phenyl) azo-5-methyl-2- thiocarboxyhydrazino-3-pyrazolones IV whereas bis-2-[4-(substituted phenyl) azo-5-methyl-3-pyrazolone] thioketones V were obtained by treating II with two molar quantity of TCH. All the final desired compounds have been synthesized by microwave irradiation technique as well as classical thermal method. The structures of the newly synthesized compounds have been established by analytical and spectral methods.


Havaldar F.H.,Nadkarny Sacasa Research Laboratory | Vasaikar P.K.,Nadkarny Sacasa Research Laboratory
Asian Journal of Chemistry | Year: 2010

2-Naphthoxyacetic acid hydrazide (1) was condensed with indole- 2,3-dione in ethanol to yield 3-(2′-naphthoxyacetylhydrazono)indolin- 2-one (2) which on aminomethylation with formaldehyde and different amines furnished 1-(substituted aminomethyl)-3-(2′-naphthoxyacetyl hydrazono)indolin-2- ones. The structures of the newly synthesized compounds have been established by analytical and spectral methods. These compounds have shown promising biological activity.

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