Nadkarni Sacasa Research Laboratory

Mumbai, India

Nadkarni Sacasa Research Laboratory

Mumbai, India
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Havaldar F.H.,Nadkarni Sacasa Research Laboratory | Dabholkar B.V.,Nadkarni Sacasa Research Laboratory | Mule G.B.,Nadkarni Sacasa Research Laboratory
Synthetic Communications | Year: 2013

In this study, a series of 4-(4-methyl-phenyl)-substituted phthalazin-1-one derivatives have been synthesized with the combination of rapid microwave synthesis and phasetransfer catalyst methodology, which is characterized by very short reaction times and easy workup procedures and which can be exploited to generate some novel phthalazinone heterocycles. Substituted phthalazin-1-one derivatives have been synthesized from phthalyl derivatives as starting material. The structures of these compounds were confirmed by NMR and mass spectral studies. © 2013 Copyright Taylor and Francis Group, LLC.


Havaldar F.H.,Nadkarni Sacasa Research Laboratory | Mule G.B.,Nadkarni Sacasa Research Laboratory | Dabholkar B.V.,Nadkarni Sacasa Research Laboratory
Journal of Heterocyclic Chemistry | Year: 2013

Homophthalic anhydride 1 reacts with different aromatic amines to produce N-substituted homophthalimides 2 under microwave irradiation. A rapid microwave-assisted chemical synthesis of condensed 4-substituted furo[2,3-c]isoquinoline-1,5(2H,4H)-diones 3 and 5-substituted-2,3-dihydro-1H- pyrano[2,3-c]isoquinoline-1,6(5H)-diones 4 involving the condensation of a variety of alkanoyl chlorides with 2-arylisoquinoline-1,3-diones 2 in the presence of base and aprotic solvent is described for the first time. By contrast, the facile ring opening reaction of furo[2,3-c]isoquinoline-1,5(2H,4H) -dione 3 with Vilsmeier-Haack reagent under microwave irradiation yielded the α-β unsaturated carboxyaldehyde 5. This novel and clean one-pot methodology, which is characterized by very short reaction time and easy workup procedure, can be exploited to generate some novel condensed isoquinoline derivatives. © 2013 HeteroCorporation.


Ghugare P.,Nadkarni Sacasa Research Laboratory | Ghugare P.,Industrial Research Ltd. | Ghugare P.,University of Mumbai | Dongre V.,University of Mumbai | And 6 more authors.
Journal of Pharmaceutical and Biomedical Analysis | Year: 2010

Solid state investigation and polymorphic screening of indapamide, a diuretic drug generally used for the treatment of hypertension was carried out. Substantial differences were obtained in the solid state properties of crystals confirming the existence of a polymorphic and three pseudopolymorphic forms of indapamide. Detailed methods of preparation of the polymorphs and pseudopolymorphs are described. X-ray powder diffraction (XRPD), diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were employed for the characterization of different crystalline forms of indapamide. The stoichiometric ratio of solvents associated with the drug molecules in the pseudopolymorphic forms were calculated using TGA, nuclear magnetic resonance (NMR) spectroscopy and headspace gas chromatographic (HS-GC) analysis. © 2009 Elsevier B.V. All rights reserved.


PubMed | Nadkarni Sacasa Research Laboratory
Type: Journal Article | Journal: Journal of labelled compounds & radiopharmaceuticals | Year: 2015

A d4 -labeled isotopomer of deferasirox was synthesized as internal standard for use in a LC/mass spectroscopy (MS)/MS method developed for the simultaneous quantitative determination of deferasirox in human serum. d4 -deferasirox was synthesized from d8 -toluene.

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