N V Sklifosovskii Institute Of Emergency Medical Care

Moscow, Russia

N V Sklifosovskii Institute Of Emergency Medical Care

Moscow, Russia

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Kolokolchikova E.G.,N V Sklifosovskii Institute Of Emergency Medical Care | Zhirkova E.A.,N V Sklifosovskii Institute Of Emergency Medical Care | Golovatenko-Abramov P.K.,Russian Academy of Sciences | Platonov E.S.,Russian Academy of Sciences | And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2012

Morphofunctional evaluation of the effect of transplantation of allogeneic fibroblasts on skin regeneration after burn injury in albino outbred mice and mutant Hr hr/Hr hr (nude) mice was carried out using the radioautographic method. The pronounced stimulating effect of allogeneic fibroblasts on healing of burn wound observed in mice of both groups can be attributed to the action of bioactive substances released from destructed allogeneic fibroblasts and stimulating proliferation of stem/progenitor cells in the wound (epithelial cells in skin appendages and dermal cells in microvessel walls) at the early stages of healing. © 2012 Springer Science+Business Media, Inc.


Makarov M.S.,N V Sklifosovskii Institute Of Emergency Medical Care | Storozheva M.V.,N V Sklifosovskii Institute Of Emergency Medical Care | Konyushko O.I.,N V Sklifosovskii Institute Of Emergency Medical Care | Borovkova N.V.,N V Sklifosovskii Institute Of Emergency Medical Care | Khvatov V.B.,N V Sklifosovskii Institute Of Emergency Medical Care
Bulletin of Experimental Biology and Medicine | Year: 2013

Serum concentration of platelet-derived growth factor was measured in patients with trophic ulcers and proliferative activity of human fibroblasts was measured in wells with different content of added serum platelet-derived growth factor. In parallel, morphofunctional analysis of platelets from the whole blood of these patients was performed. A close correlation was found between morphofunctional parameters of blood platelets and serum concentration of plateletderived growth factor. Platelet-derived growth factor in concentrations below 150 pg per well stimulated fibroblast proliferation and preserved their viability. Platelet-derived growth factor in concentrations >200 pg per well suppressed fibroblast proliferation and impaired their viability. © 2013 Springer Science+Business Media New York.

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