Nr Vekaria Institute Of Pharmacy
Nr Vekaria Institute Of Pharmacy
Saisivam S.,Nr Vekaria Institute Of Pharmacy |
Shakeel F.,King Saud University
Journal of Drug Delivery Science and Technology | Year: 2013
The aim of the present study was to develop floating matrix tablets of losartan potassium (LP). The floating matrix tablets of LP were prepared using different proportion of hydroxypropyl methyl cellulose (HPMC-K4M) and karaya gum. The prepared tablets were evaluated for various pre-compression & post-compression parameters, in vitro drug release and in vivo X-ray imaging in rabbits. All tablets showed excellent swelling and floating capabilities, short floating lag times and maintained controlled release for more than 16 h. The release of LP from optimized formulation F9 was found to be non-Fickian type. Gastric X-ray imaging of formulation F9 (containing LP/HPMC-K4M/karaya gum/microcrystalline cellulose/sodium bicarbonate/magnesium stearate/lactose) showed that the floating matrix tablet was continuously floating in the stomach region of the rabbit; hence, it could prolong the gastric retention time to more than 12 h. These results indicated that developed matrix tablets of LP could be successfully used for floating drug delivery system.
Bhimani J.G.,Nr Vekaria Institute Of Pharmacy |
Patel S.D.,Nr Vekaria Institute Of Pharmacy |
Srinivasm S.S.,Nr Vekaria Institute Of Pharmacy
International Journal of Pharmaceutical Sciences Review and Research | Year: 2014
Ropinirole is rapidly absorbed in humans; however it undergoes extensive first-pass metabolism and having only 50% bioavailability. Therefore, the sublingual delivery of Ropinirole hydrochloride would be major improvement in the clinical use of Ropinirole. The Sublingual tablets were prepared by direct compression procedure using different concentration of Crospovidone and Croscarmellose Sodium. Compatibility studies of drug and polymer were performed by FTIR spectroscopy. Preformulation property of API was evaluated. Post-compression parameters such disintegration time, wetting time, water absorption ratio in vitro drug release and ex vivo permeability study of optimized formulation were determined. FTIR spectroscopy study revealed that there was no possible interaction between drug and polymers. The pre-compression parameters were in acceptable range of pharmacopoeia specification. The disintegration time of optimized formulation (F5) was up to 40 sec. The in vitro release of Ropinirole hydrochloride was up to 9 minutes. The percentage relative permeability of Ropinirole hydrochloride from optimized sublingual tablets was found to be 90.51% after 30 minutes. Sublingual tablets Ropinirole hydrochloride of were successfully prepared with improved bioavailability. © 2014, Global Research Online. All rights reserved.
Chotaliya M.K.B.,Nr Vekaria Institute Of Pharmacy |
Chakraborty S.,Nr Vekaria Institute Of Pharmacy
International Journal of PharmTech Research | Year: 2012
The need for delivering drugs to patients efficiently with minimum side effects has prompted pharmaceutical industries to be engaged in development of new drug delivery systems. Pediatric and geriatric patients find it difficult to swallow solid dosage forms like tablets. Mouth dissolving tablet that dissolve or disintegrate rapidly in oral cavity result in solution, is an ultimate remedy for this problem. In addition they give pleasing mouth feeling. ODT has advantages such as patient compliance, quick onset of action, improved bioavailability, etc. Therefore, mouth dissolving tablets are attractive alternative to liquid and conventional tablet dosage forms. In recent past, several manufacturing technologies such as sublimation technique, spray drying technique. etc. are employed to overcome the limitations of conventional tablet dosage forms. Once the mouth dissolving tablets are prepared they are required to be evaluated for various parameters so as to have long term stability and better therapeutic efficacy.