N R Vekaria Institute Of Pharmacy

Gujarat, India

N R Vekaria Institute Of Pharmacy

Gujarat, India
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Khokhar Vishal G.,N R Vekaria Institute Of Pharmacy | Ashwin A.,N R Vekaria Institute Of Pharmacy
International Journal of PharmTech Research | Year: 2013

Three simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous analysis of Paracetamol (PCM) and Tapentadol (TAP) in combined pharmaceutical dosage form. Method A, Simultaneous Equation Method (Vierodt's method) applies measurement of absorptivities at two wavelengths, 257.00 nm (λmax of Paracetamol) and 289.00 nm, (λmax of Tapentadol) in zero order spectra. Method B, Absorbance Correction Method. It involves measurment at 309.00 nm (Corrected wavelenth) and 289.00 nm (λmax of Tapentadol) in zero order spectra. Method C, Dual Wavelength Method, involves measurement of difference in absorbance at 248.5 nm & 265.5 nm for estimation of Tapentadol and 282.00 nm & 296.5.00 nm for estimation of Paracetamol. Developed methods were validated according to ICH guidelines. The calibration graph follows Beer's law in the range of 6.0 to 30.0 μg/mL for both drug with R square value greater than 0.999. Accuracy of all methods was determined by recovery studies and showed % recovery between 98 to 102%. Intraday and inter day precision was checked for all methods and mean %RSD was found to be less than 2 for all the methods. The methods were successfully applied for estimation of Paracetamol and Tapentadol in marketed formulation.

The main purpose of this study was to prepare the losartan potassium controlled release floating tablets by using effervescent technique to extent the gastric residence time and enhance its bioavailability. The floating matrix tablets were prepared by using different proportion of polymers such as hydroxypropylmethylcellulose, karaya gum and sodium bicarbonate used as gas generating agent, by direct compression technique. Before compression the particulate matter of the series of formulations were evaluated for various micromeritic properties. The prepared floating tablets were evaluated for weight uniformity, drug content uniformity, friability, hardness, floating characteristics such as floating lag time, total floating time, water uptake studies, compatibility studies of drug with polymers and in vitro drug release. The mathematical models were also used to investigate the principle release mechanism of drug release. The results showed that all prepared floating tablet were have excellent swelling, floating capabilities with short floating lag time within 100 seconds and maintain controlled release up to 12 hours.

Kumar D.S.,N R Vekaria Institute Of Pharmacy | Monalisha D.,N R Vekaria Institute Of Pharmacy
Indian Journal of Natural Products and Resources | Year: 2012

Diabetes mellitus is a heterogeneous metabolic disease characterized by altered carbohydrate, lipid and protein metabolism. So many traditional herbs are being used by diabetic patients to control the disease. But very few studies have been performed to investigate the efficacy of these herbs clinically. In the present study, an attempt has been made to investigate the antidiabetic activity of roots of Cyperus kyllingia Endl. (Family-Cyperaceae) and also with alcoholic extract of its roots in diabetic mice. The crude roots at (570 mg/kg, orally) and the extract of the roots at (120 mg/kg, orally) showed significant antidiabetic activity. Histological study also showed significant result.

Sarkar S.,N R Vekaria Institute Of Pharmacy | Chauhan R.,Banasthali University | Dwivedi J.,Banasthali University
Turkish Journal of Pharmaceutical Sciences | Year: 2015

A novel series of azetidinone AZ1-6 been prepared from the building blocks 2, 3, 4 (trisubstituted benzaldehyde)-N-(6,7 substituted-1,3-benzothiazol-2-yl) semicarbazone [2.026a-o]. All of the synthesized compounds have been confirmed by elemental analyses, IR and 1H NMR spectral data. These newly synthesized compounds were screened for their antibacterial activity. Variable and modest activity was observed against the investigated strains of bacteria, however compounds AZ2, AZ3, AZ5 and AZ6 revealed significant antibacterial activity against Bacillus subtilis and Pseudomonas compared to the reference drug Procaine penicillin and Streptomycin. © 2015, Turkish Pharmacists Association. All rights reserved.

Baldaniya L.H.,N R Vekaria Institute Of Pharmacy | Saisivam S.,N R Vekaria Institute Of Pharmacy | Gohel M.C.,JKK Nataraja Dental College and Hospital
International Journal of Pharma and Bio Sciences | Year: 2012

The present study was carried out to formulate and evaluate sustained release floating microspheres of Carbamazepine using ethyl cellulose as the retardant material with high entrapment efficiency and extended release. A 23 factorial design was employed in formulating the GFDDS with Polymer-to-Drug ratio (X1), Acetone-to-Dichloromethane ratio (X2), and Stirring Speed (X3) as Independent Variables. Four dependent variables were considered: T50%, T80%, % Drug Entrapment Efficiency and Particle size. The main effect and interaction terms were quantitatively evaluated using a mathematical model. Microspheres were prepared by Oil-in-Water (O/W) Emulsion Solvent Evaporation method. A Mixed Solvent System (MSS) consisting of Acetone and Dichloromethane in a 2:1 ratio and water was chosen as aqueous phases, respectively. The prepared microspheres were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and drug loading. The In-Vitro release studies were performed using pH 1.2 SGF. The drug loaded microspheres showed 62-74% of entrapment and release was extended up to 10-12 h. SEM studies showed that the microspheres are spherical and porous in nature. The Infrared spectra and DSC thermograms showed stable character of Carbamazepine in the drug loaded microspheres and revealed the absence of drug-polymer interactions. The data obtained from In-vitro release were fitted to various kinetic models and had high degree of correlation was found in the Korsmeyer and Peppas model. The predicted values agreed well with the experimental values, and the results demonstrated the feasibility of the model in the development of GFDDS.

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