Punanov Y.A.,N N Petrov Research Institute For Oncology |
Gafton G.I.,N N Petrov Research Institute For Oncology |
Gudz Y.V.,kiforov Center For Emergency And Radiation Medicine |
Nabokov V.V.,Saint Petersburg State Pediatric Medical Academy |
And 8 more authors.
An analyzed cohort consists of 50 pediatric patients with osteo-sarcoma receiving combined therapy in N. N. Petrov Research Institute for Oncology (1999-2010). Thirty nine of them had localized disease, 11 patients had distant metastases. The treatment scheme included neoadjuvant therapy with cisplatin and doxorubicin, surgical treatment and adjuvant therapy depended on initial response and could include cisplatin, doxorubicin, high-dose methotrexate, ifosfamide, etoposide. Four-year over-all and relapse-free survival in children with localized disease was 74.3% and 69.2% accordingly. In 62% of patients were performed organ-preserving surgical interventions, in 22 patients was performed endoprosthetics, in 4 patients the defect was replaced by a bone autograft on a vascular bundle. The effectiveness of initial treatment and secondary endoprosthetics were analyzed. Six patients with lung metastases received normotermic lung chemoperfusion, 4 of them are alive and disease-free for 8 to 24 months. Source