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SALT LAKE CITY, Feb. 17, 2017 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ:MYGN), a leader in molecular diagnostics and personalized medicine, today announced new findings from the OlympiAD study that show its BRACAnalysis CDx®  test successfully identified patients with HER2-negative metastatic breast cancer who have BRCA mutations and who had improved response with Lynparza (olaparib), AstraZeneca’s PARP inhibitor. The high level results – announced earlier today from AstraZeneca – are the first reported clinical data from the OlympiAD study (NCT02000622), which assessed the efficacy and safety of olaparib monotherapy versus physicians’ choice of chemotherapy (i.e., capecitabine, vinorelbine or eribulin) in the treatment of metastatic breast cancer.  Of the 302 patients in the study, 98 percent (297/302) tested positive for germline BRCA1/2 mutations as determined by Myriad’s FDA-approved BRACAnalysis CDx test.  The results demonstrated a statistically-significant improvement of progression-free survival (PFS) among BRCA-mutated patients treated with olaparib compared to those treated with physicians’ choice. “We believe the results of the OlympiAD trial support use of the BRACAnalysis CDx test to help inform treatment decisions in the metastatic breast cancer setting and will expand the patient population who can benefit from BRCA testing,” said Johnathan Lancaster, M.D., Ph.D., chief medical officer of Myriad Genetic Laboratories.  “This study underscores Myriad’s commitment to our pharmaceutical partners and to advancing the field of personalized medicine so that new effective treatment options are available to patients.” It is estimated there are approximately 60,000 patients with metastatic breast cancer, two thirds of whom are not currently eligible for BRCA testing based upon family and personal history alone or current testing criteria.  If approved as a new indication this would triple the number of patients with metastatic breast cancer who would benefit from BRCA testing. The ongoing collaboration between Myriad and AstraZeneca to develop a novel companion diagnostic test to identify candidates for treatment with olaparib began in 2007.  In Dec. 2014, Myriad received FDA approval for BRACAnalysis CDx to help identify patients with advanced ovarian cancer who are eligible for fourth-line treatment with olaparib.  BRACAnalysis CDx is Myriad’s first FDA-approved companion diagnostic and was the first-ever laboratory developed test reviewed and approved by the FDA. About BRACAnalysis CDx® BRACAnalysis CDx is an in vitro diagnostic device intended for the qualitative detection and classification of variants in the protein coding regions and intron/exon boundaries of the BRCA1 and BRCA2 genes using genomic DNA obtained from whole blood specimens collected in EDTA.  Single nucleotide variants and small insertions and deletions (indels) are identified by polymerase chain reaction (PCR) and Sanger sequencing.  Large deletions and duplications in BRCA1 and BRCA2 are detected using multiplex PCR.  Results of the test are used as an aid in identifying ovarian cancer patients with deleterious or suspected deleterious germline BRCA variants eligible for treatment with Lynparza™ (olaparib).  This assay is for professional use only and is to be performed only at Myriad Genetic Laboratories, a single laboratory site located at 320 Wakara Way, Salt Lake City, UT 84108. About Lynparza Lynparza (olaparib) is an innovative, first-in-class oral poly ADP-ribose polymerase (PARP) inhibitor that may exploit tumour DNA damage response (DDR) pathway deficiencies to preferentially kill cancer cells. Lynparza is the foundation of AstraZeneca’s industry-leading portfolio of compounds targeting DNA damage response (DDR) mechanisms in cancer cells. Lynparza is currently approved by regulatory health authorities in the EU for use as monotherapy for the maintenance treatment of adult patients with platinum-sensitive relapsed BRCA-mutated (germline and/or somatic) high grade serous epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy. It is also approved in the US as monotherapy in patients with deleterious or suspected deleterious germline BRCA-mutated (as detected by an FDA- test) advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy. Lynparza is currently being investigated in another separate non-metastatic breast cancer Phase III study called OLYMPIA. This study is still open and recruiting patients internationally. About Myriad Genetics Myriad Genetics Inc. is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, Vectra, Prolaris and GeneSight are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G             Safe Harbor Statement This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including statements related to the ability of the BRACAnalysis CDx test to successfully identify metastatic breast cancer patients with improved outcomes from olaparib;  the results of the study demonstrating a statistically-significant improvement of progression-free survival (PFS) among BRCA-mutated patients treated with olaparib compared to those treated with physicians’ choice; the Company’s belief that the results of the OlympiAD trial support use of the BRACAnalysis CDx test to help inform treatment decisions in the metastatic breast cancer setting and will expand the patient population who can benefit from BRCA testing; the importance of the BRACAnalysis CDx test for this patient population and the ability to identify patients likely to benefit from PARP inhibition therapy; the number of patients with metastatic breast cancer who would benefit from BRCA testing if approved as a new indication; the Company’s ongoing collaboration with AstraZeneca to develop a novel companion diagnostic test to identify candidates for treatment with olaparib; and the Company's strategic directives under the captions “About BRACAnalysis CDx,” and "About Myriad Genetics."  These "forward-looking statements" are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by forward-looking statements. These risks and uncertainties include, but are not limited to: the risk that sales and profit margins of our molecular diagnostic tests and pharmaceutical and clinical services may decline; risks related to our ability to transition from our existing product portfolio to our new tests, including unexpected costs and delays; risks related to decisions or changes in governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services and any future tests and services are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities and our healthcare clinic; risks related to public concern over genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire; risks related to our projections about our business, results of operations and financial condition; risks related to the potential market opportunity for our products and services; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents or other intellectual property; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; and other factors discussed under the heading "Risk Factors" contained in Item 1A of our most recent Annual Report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.  All information in this press release is as of the date of the release, and Myriad undertakes no duty to update this information unless required by law.


SALT LAKE CITY, Feb. 17, 2017 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ:MYGN), a global leader in personalized medicine, today announced new data demonstrating the utility of the Prolaris® test to more accurately classify mortality risk and guide the management of newly diagnosed men with prostate cancer. The data are being presented at the 2017 Genitourinary Cancers Symposium (ASCO GU) meeting in Orlando, Fla. “Myriad is pioneering personalized medicine for prostate cancer and is committed to helping men achieve their treatment goals,” said Michael Brawer, M.D., vice president of Medical Affairs, Myriad Genetic Laboratories.  “We are excited about the new data on prostate cancer reclassification being presented at ASCO GU, which adds to the growing body of evidence supporting the Prolaris test and will help urologists to match treatment options with patients’ risk profiles.” This study evaluated the prognostic information provided by the Prolaris test plus CAPRA (i.e., clinical features) to generate an estimate of prostate cancer mortality within 10 years of diagnosis versus NCCN risk category as determined by clinical features alone.  The analysis included data from 16,442 men who received the Prolaris test.  Based on clinical features alone, men were classified according to NCCN guidelines as low (n=8,695), favorable intermediate (n=3,347), intermediate (n=3,086) or high risk (n=1,224).  After recalculating the risk of prostate cancer mortality using the Prolaris test plus CAPRA, approximately one third of patients were reassigned to a different 10-year mortality risk category.  The specific reclassifications by NCCN category were as follows: “Clinical features alone are useful, but as this study illustrates, and was demonstrated by our numerous prior clinical validation studies, the Prolaris test is a powerful and independent predictor of clinical outcome that can substantially improve the risk classification of newly diagnosed men with prostate cancer,” said Brawer. Follow Myriad on Twitter via @MyriadGenetics and stay informed about symposium news and updates by using the hashtag #GU17. About Prolaris®  Prolaris is a novel 46-gene RNA-expression test that directly measures tumor cell growth characteristics for stratifying the risk of disease-specific mortality in patients with prostate cancer. Prolaris provides a quantitative measure of the RNA expression levels of genes involved in the progression of tumor growth.  Low gene expression is associated with a low risk of disease-specific mortality in men who may be candidates for active surveillance and high gene expression is associated with a higher risk of disease-specific mortality in patients who may benefit from additional therapy.  For more information visit: www.prolaris.com. About Myriad Genetics Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, EndoPredict, Vectra, GeneSight and Prolaris are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G. Safe Harbor Statement        This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to data being presented at the at the 2017 Genitourinary Cancers Symposium;  the ability of the Prolaris test to more accurately classify mortality risk and guide the management of newly diagnosed men with prostate cancer; the ability to help urologists to match treatment options with patients’ risk profiles; and the Company’s strategic directives under the caption “About Myriad Genetics.”  These “forward-looking statements” are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests; risks related to changes in the governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of Assurex, Sividon and the Clinic; risks related to our projections about the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; the risk that we may be unable to comply with financial operating covenants under our credit or lending agreements;  the risk that we will be unable to pay, when due, amounts due under our credit or lending agreements; and other factors discussed under the heading “Risk Factors” contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


News Article | December 9, 2016
Site: www.eurekalert.org

SALT LAKE CITY, Utah, Dec. 9, 2016 - Myriad Genetics, Inc. (NASDAQ: MYGN), a leader in molecular diagnostics and personalized medicine, today announced results of a large head-to-head study comparing the efficacy of six tests used to predict the recurrence of breast cancer. A key finding was that EndoPredict® (EPclin), a second-generation test, was superior to Oncotype Dx™ (RS), a first-generation test, in predicting the long-term recurrence of breast cancer. The results are being featured today in a podium presentation at the 2016 San Antonio Breast Cancer Symposium (SABCS) in San Antonio, Texas. "In this important study, EndoPredict more accurately predicted the risk of breast cancer recurrence than the first-generation Oncotype Dx test, particularly in years five to 10 following surgery when half of breast cancer recurrences will happen," said Johnathan Lancaster, M.D., Ph.D., chief medical officer, Myriad Genetic Laboratories. "Clinicians can consider using EndoPredict to identify patients who can forgo chemotherapy with confidence, knowing they have a low risk of recurrence over 10 years." Title: Comprehensive comparison of prognostic signatures for breast cancer in TransATAC. Presenter: Ivana Sestak, Ph.D. Date: Friday, Dec.9, 2016: 4:15 p.m. CT. Location: S6-05; General Session 6 - Hall 3. This study was led by scientists at the Institute of Cancer Research in London. The analysis included 818 women with ER+/HER2- breast cancer (591 node-negative; 227 node-positive) from the TransATAC study and compared the power of six predictive signatures, including: clinical treatment score, immunohistochemical markers, Oncotype Dx recurrence score (RS), breast cancer index (BCI), Prosigna™ and EndoPredict (EPClin). Distant recurrence of breast cancer was the primary endpoint and the median follow-up period was 10 years. Overall, each of the three second-generation tests evaluated (breast cancer index, Prosigna and EndoPredict) outperformed Oncotype Dx in this cohort in predicting the recurrence of breast cancer in both node-negative and node-positive patients across both zero to 10 and five to 10 years post-surgery. In a head-to-head comparison between EndoPredict and Oncotype Dx in this study: 1. EndoPredict offered more predictive power than Oncotype Dx across zero to 10 years. 2. EndoPredict had superior predictive power over Oncotype Dx between five to 10 years. 3. EndoPredict was superior in classifying node-positive patients as low-risk compared to Oncotype Dx. "Myriad is committed to research that improves care for patients with breast cancer. Patients at high risk of cancer recurrence are candidates for adjuvant chemotherapy after surgery, while those at low risk can be spared chemotherapy and the side effects," said Lancaster. "We believe EndoPredict will help clinicians and patients understand the risk of breast cancer recurrence and identify more patients who can safely forgo chemotherapy. Additionally, EndoPredict does not contain an intermediate risk category and each patient receives a clear test result, allowing oncologists to confidently develop their treatment plan." The TransATAC study, in part, was previously published in the Journal of the National Cancer Institute. The current presentation at SABCS expands on that article and provides a comprehensive comparison of prognostic signatures for breast cancer. Follow Myriad on Twitter via @MyriadGenetics and stay informed about symposium news and updates by using the hashtag #SABCS16. EndoPredict is a second-generation, multigene test designed to predict disease recurrence in patients diagnosed with breast cancer. The test provides physicians with information to devise personalized treatment plans for their patients. EndoPredict has been validated in approximately 4,000 patients with node-negative and node-positive cancer and has been used clinically in over 13,000 patients. In contrast to the first-generation multigene prognostic test (i.e., Oncotype Dx), EndoPredict detects the likelihood of late metastases (i.e., metastasis formation after more than five years) and, therefore, can guide treatment decisions regarding the need for chemotherapy, as well as extended anti-hormonal therapy. Accordingly, therapy decisions backed by EndoPredict confer a high level of diagnostic safety. For more information, please visit: http://www. . Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics. Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs. Myriad is focused on three strategic imperatives: transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets. For more information on how Myriad is making a difference, please visit the Company's website: https:/ . Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, Vectra, Prolaris, EndoPredict and GeneSight are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G Prosigna is a trademark of NanoString Technologies, Seattle, Wash. Oncotype Dx is a trademark of Genomic Health, Redwood City, Calif. This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including statements related to the EndoPredict test significantly outperforming the first-generation test in predicting the risk of node-negative and node-positive breast cancer recurrence; the EndoPredict test being superior to Oncotype Dx and more accurate in predicting the long-term recurrence of breast cancer; the three second-generation tests evaluated outperforming Oncotype Dx in predicting the recurrence of breast cancer in both node-negative and node-positive patients across both zero to 10 and five to 10 years post-surgery; EndoPredict testing offering more predictive power than Oncotype Dx across zero to 10 years; EndoPredict testing having superior predictive power over Oncotype Dx between five to 10 years; EndoPredict testing being superior in classifying node-positive patients as low-risk compared to Oncotype Dx; our belief that EndoPredict testing will help clinicians and patients understand the risk of breast cancer recurrence and identify more patients who can safely forgo chemotherapy; data being presented at the 2016 San Antonio Breast Cancer Symposium being held Dec. 6 - Dec. 10, 2016 in San Antonio, Texas; and the Company's strategic directives under the captions "About EndoPredict" and "About Myriad Genetics." These "forward-looking statements" are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests; risks related to changes in the governmental or private insurers' reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of Assurex, Sividon and the Clinic; risks related to our projections about the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; the risk that we may be unable to comply with financial operating covenants under our credit or lending agreements; the risk that we will be unable to pay, when due, amounts due under our credit or lending agreements; and other factors discussed under the heading "Risk Factors" contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


SALT LAKE CITY, Dec. 09, 2016 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ:MYGN), a leader in molecular diagnostics and personalized medicine, today announced results of a large head-to-head study comparing the efficacy of six tests used to predict the recurrence of breast cancer.  A key finding was that EndoPredict® (EPclin), a second-generation test, was superior to Oncotype Dx™ (RS), a first-generation test, in predicting the long-term recurrence of breast cancer.  The results are being featured today in a podium presentation at the 2016 San Antonio Breast Cancer Symposium (SABCS) in San Antonio, Texas.  “In this important study, EndoPredict more accurately predicted the risk of breast cancer recurrence than the first-generation Oncotype Dx test, particularly in years five to 10  following surgery when half of breast cancer recurrences will happen,” said Johnathan Lancaster, M.D., Ph.D., chief medical officer, Myriad Genetic Laboratories. “Clinicians can consider using EndoPredict to identify patients who can forgo chemotherapy with confidence, knowing they have a low risk of recurrence over 10 years.” Podium Presentation Title: Comprehensive comparison of prognostic signatures for breast cancer in TransATAC. Presenter: Ivana Sestak, Ph.D. Date: Friday, Dec.9, 2016: 4:15 p.m. CT. Location: S6-05; General Session 6 - Hall 3. This study was led by scientists at the Institute of Cancer Research in London.  The analysis included 818 women with ER+/HER2- breast cancer (591 node-negative; 227 node-positive) from the TransATAC study and compared the power of six predictive signatures, including: clinical treatment score, immunohistochemical markers, Oncotype Dx recurrence score (RS), breast cancer index (BCI), Prosigna™ and EndoPredict (EPClin).  Distant recurrence of breast cancer was the primary endpoint and the median follow-up period was 10 years. Overall, each of the three second-generation tests evaluated (breast cancer index, Prosigna and EndoPredict) outperformed Oncotype Dx in this cohort in predicting the recurrence of breast cancer in both node-negative and node-positive patients across both zero to 10 and five to 10 years post-surgery.  In a head-to-head comparison between EndoPredict and Oncotype Dx in this study: "Myriad is committed to research that improves care for patients with breast cancer.  Patients at high risk of cancer recurrence are candidates for adjuvant chemotherapy after surgery, while those at low risk can be spared chemotherapy and the side effects," said Lancaster.  "We believe EndoPredict will help clinicians and patients understand the risk of breast cancer recurrence and identify more patients who can safely forgo chemotherapy.  Additionally, EndoPredict does not contain an intermediate risk category and each patient receives a clear test result, allowing oncologists to confidently develop their treatment plan.” The TransATAC study, in part, was previously published in the Journal of the National Cancer Institute (http://jnci.oxfordjournals.org/content/108/11/djw149.abstract).  The current presentation at SABCS expands on that article and provides a comprehensive comparison of prognostic signatures for breast cancer.  Follow Myriad on Twitter via @MyriadGenetics and stay informed about symposium news and updates by using the hashtag #SABCS16. About EndoPredict EndoPredict is a second-generation, multigene test designed to predict disease recurrence in patients diagnosed with breast cancer.  The test provides physicians with information to devise personalized treatment plans for their patients.  EndoPredict has been validated in approximately 4,000 patients with node-negative and node-positive cancer and has been used clinically in over 13,000 patients.  In contrast to the first-generation multigene prognostic test (i.e., Oncotype Dx), EndoPredict detects the likelihood of late metastases (i.e., metastasis formation after more than five years) and, therefore, can guide treatment decisions regarding the need for chemotherapy, as well as extended anti-hormonal therapy. Accordingly, therapy decisions backed by EndoPredict confer a high level of diagnostic safety. For more information, please visit: www.endopredictusa.com. About Myriad Genetics Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: https://www.myriad.com/. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, Vectra, Prolaris, EndoPredict and GeneSight are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G Note to Editors Prosigna is a trademark of NanoString Technologies, Seattle, Wash.  Oncotype Dx is a trademark of Genomic Health, Redwood City, Calif.             Safe Harbor Statement This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including statements related to the EndoPredict test significantly outperforming the first-generation test in predicting the risk of node-negative and node-positive breast cancer recurrence; the EndoPredict test being superior  to Oncotype Dx and more accurate in predicting the long-term recurrence of breast cancer; the three second-generation tests evaluated outperforming Oncotype Dx in predicting the recurrence of breast cancer in both node-negative and node-positive patients across both zero to 10  and five to 10 years post-surgery; EndoPredict testing offering more predictive power than Oncotype Dx across zero to 10 years; EndoPredict testing having superior predictive power over Oncotype Dx between five to 10 years; EndoPredict testing being superior in classifying node-positive patients as low-risk compared to Oncotype Dx; our belief that EndoPredict testing will help clinicians and patients understand the risk of breast cancer recurrence and identify more patients who can safely forgo chemotherapy; data being presented at the 2016 San Antonio Breast Cancer Symposium being held Dec. 6 – Dec. 10, 2016 in San Antonio, Texas; and the Company's strategic directives under the captions “About EndoPredict” and "About Myriad Genetics."  These “forward-looking statements” are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests; risks related to changes in the governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of Assurex, Sividon and the Clinic; risks related to our projections about the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; the risk that we may be unable to comply with financial operating covenants under our credit or lending agreements;  the risk that we will be unable to pay, when due, amounts due under our credit or lending agreements; and other factors discussed under the heading “Risk Factors” contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


Globally the market for pharmacogenomics is increasing rapidly mainly due to increasing safety in drug. The factors that influence the growth of Pharmacogenomics market; rising utilization in medication revelation processes, increasing interest for customized drugs, expanding security in treatment, Improve evidence of guideline for adequacy trials. • Myriad Genetics, Inc (U.S) • Transgenomic, Inc(U.S) • 23andMe (U.S) • Pathway Genomics (CA) • Genetech (CA) • GeneDX (U.S) • Teva Pharmaceutical Industries Ltd.(Israel) • Illumina, Inc.(U.s) • Assurex Health, Inc.(U.s) The report for Pharmacogenomics of Market Research Future comprises of extensive primary research along with the detailed analysis of qualitative as well as quantitative aspects by various industry experts, key opinion leaders to gain the deeper insight of the market and industry performance. The market for pharmacogenomics is segmented into mainly three; by application, by therapeutic application, by end user and its various sub-segments. By application include drug safety, Tailor treatments, drug discovery and others. Whereas by therapeutic application include cancer, oncology, cardiovascular and others. Furthermore by methods include haplotype analysis, multivariate techniques, quantitative trait analysis and others. Taste the market data and market information presented through more than 50 market data tables and figures spread in 120 numbers of pages of the project report. Avail the in-depth table of content TOC & market synopsis on “Global Pharmacogenomics Market Research Report - Forecast to 2027” • To provide detailed analysis of the market structure along with forecast for the next 10 years of the various segments and sub-segments of the global pharmacogenomics market • To provide insights about factors affecting the market growth • To Analyze the Pharmacogenomics Market based on various factors- price analysis, supply chain analysis, porters five force analysis etc. • To provide historical and forecast revenue of the market segments and sub-segments with respect to four main geographies and their countries- Americas, Europe, Asia, and Middle East & Africa. • To provide country level analysis of the market with respect to the current market size and future prospective • To provide country level analysis of the market for segment by application, by therapeutic application, by methods and its sub-segments. • To provide strategic profiling of key players in the market, comprehensively analyzing their core competencies, and drawing a competitive landscape for the market • To track and analyze competitive developments such as joint ventures, strategic alliances, mergers and acquisitions, new product developments, and research and developments in the global pharmacogenomics market. Americas • North America • US • Canada • Latin America Europe • Western Europe • Germany • France • Italy • Spain • UK • Rest of Western Europe • Eastern Europe Asia– Pacific Asia • China • India • Japan • South Korea • Rest of Asia Pacific The Middle East& Africa The report gives the clear picture of current market scenario which includes historical and projected market size in terms of value and volume, technological advancement, macro economical and governing factors in the market. The report provides details information and strategies of the top key players in the industry. The report also gives a broad study of the different market segments and regions. Global Infusion Systems market, by Product Type (Ambulatory Pumps, I.V. Disposables, Syringe Pump Systems, Volumetric Pump Sets and others), by applications (chemotherapy, cardiovascular diseases, Diabetes, Pediatrics and others) by end users (Hospitals, Clinics, Research Laboratories and others) - Forecast to 2027 https://www.marketresearchfuture.com/reports/infusion-systems-market At Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), Raw Research Reports (3R), Continuous-Feed Research (CFR), and Market Research & Consulting Services. MRFR team have supreme objective to provide the optimum quality market research and intelligence services to our clients. Our market research studies by products, services, technologies, applications, end users, and market players for global, regional, and country level market segments, enable our clients to see more, know more, and do more, which help to answer all their most important questions. For more information, please visit https://www.marketresearchfuture.com/reports/pharmacogenomics-market


SALT LAKE CITY, Feb. 23, 2017 (GLOBE NEWSWIRE) -- Assurex Health, a wholly-owned subsidiary of Myriad Genetics, Inc. (NASDAQ:MYGN), today announced that new data on the use of the GeneSight® Psychotropic test to deliver medication cost savings for mental health disorders was published in the journal Clinical Therapeutics.[1]  GeneSight Psychotropic is a precision medicine genetic test that helps guide medication selection in patients with major depressive disorder (MDD) and is the foundation of the Company’s industry-leading portfolio of tests for neuroscience disorders. The study, entitled: "Economic utility: Combinatorial Pharmacogenomics and Medication Cost Savings for Mental Healthcare in a Primary Care Setting" is a subanalysis from a previous prospective study analyzing cost savings for patients receiving combinatorial pharmacogenomic testing.[2]  The current study compared savings among various types of health care providers (HCPs) and analysed the cost of treatment decisions that were congruent with GeneSight test results (i.e., medication decisions in concordance with the patients’ test results) with those that were incongruent.  Using pharmacy claims data from 2,168 patients with MDD, the new analysis compared medication costs six months prior to GeneSight testing and for one year post-testing. The analysis measured both treatment congruence and cost savings per patient based on the type of healthcare provider administering care.  The findings showed that primary care providers (PCPs) treat the majority of mental health patients receiving psychotropic medication prescriptions, including treatment resistant patients.  In fact, patients treated by PCPs had tried a median of five medications, similar to psychiatrists whose patients had tried six medications. The data also demonstrated that PCPs who treated patients congruently with the GeneSight test saved payers and patients an average of $3,998 compared to incongruent decisions (p<0.001).  Additionally, psychiatrists who treated patients congruently with the GeneSight test saved an average of $1,308. [1] Brown L., Lorenz R., Li J., et al, Economic utility:  Combinatorial pharmacogenomics and medication cost savings for mental healthcare in a primary care setting.  Clin Ther. 2017; Accessed online at: http://dx.doi.org/10.1016/j.clinthera.2017.01.022. [2] J.G. Winner, J.M. Carhart, C.A. Altar, et al. Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1 year prospective evaluation. Curr Med Res Opin, 31 (2015), pp. 1633–1643. "In the treatment of major depression, clinicians and payers are looking for sensible options to improve patient care, while lowering overall costs to healthcare systems," said Bryan M. Dechairo, Ph.D., chief medical and science officer, Assurex Health. "Prior studies demonstrated that the GeneSight test can be used to guide patient treatment decisions. Now, we know that GeneSight can lower costs across healthcare provider types, but was especially effective in generating cost savings among primary care physicians, which is important because they treat the majority of patients with mental illness.” Follow Myriad on Twitter via @MyriadGenetics to stay informed about news and updates from the Company. About The GeneSight® Test The GeneSight test helps healthcare providers make better treatment decisions based on a person’s genetic makeup. GeneSight testing is based on advanced CPGx® technology, a patented approach that analyzes variations and combinations of a person’s genes along with FDA-approved medications for behavioral health conditions and chronic pain.  Numerous peer-reviewed, published studies have proven its clinical benefits and substantial healthcare cost savings. More than 18,000 healthcare professionals have used GeneSight to improve healthcare for more than 450,000 patients. Learn more at www.GeneSight.com. About Assurex Health Assurex Health, a wholly-owned subsidiary of Myriad Genetics, Inc., is an informatics-based, personalized medicine company providing treatment decision support to healthcare providers for behavioral health and chronic pain conditions. Assurex Health is the only company in the category with multiple peer-reviewed, published studies that demonstrate the clinical validity and clinical utility of the GeneSight test, including its substantial healthcare cost savings benefit. The Company has grown every quarter and has expanded internationally through a partnership with Canada’s Centre for Addiction and Mental Health (CAMH). For more on how Assurex Health is helping people gain mental wellness, visit www.AssurexHealth.com. About Myriad Genetics Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, EndoPredict, Vectra, GeneSight and Prolaris are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G. Safe Harbor Statement This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the ability of the GeneSight Psychotropic test to drive medication cost savings for mental health disorders; the ability of the GeneSight test to guide medication selection in patients with major depressive disorder (MDD); GeneSight test being the foundation of the Company’s industry-leading portfolio of tests for neuroscience disorders; and the Company’s strategic directives under the caption “About Myriad Genetics.”  These “forward-looking statements” are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests; risks related to changes in the governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of Assurex, Sividon and the Clinic; risks related to our projections about the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; the risk that we may be unable to comply with financial operating covenants under our credit or lending agreements;  the risk that we will be unable to pay, when due, amounts due under our credit or lending agreements; and other factors discussed under the heading “Risk Factors” contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


News Article | February 27, 2017
Site: marketersmedia.com

LONDON, UK / ACCESSWIRE / February 27, 2017 / Active Wall St. announces its post-earnings coverage on Myriad Genetics, Inc. (NASDAQ: MYGN). The Company released its second quarter fiscal 2017 (Q2 FY17) results on February 07, 2017. The Salt Lake City-based Company's total revenues reported a 2% y-o-y growth, outperforming market consensus estimates. Register with us now for your free membership at: One of Myriad Genetics' competitors within the Research Services space, INC Research Holdings, Inc. (NASDAQ: INCR), announced on February 06, 2017, that it will release its Q4 and full year 2016 financial results on Tuesday, February 28, 2017, prior to its quarterly earnings call at 8:00 a.m. ET. AWS will be initiating a research report on INC Research in the coming days. Today, AWS is promoting its earnings coverage on MYGN; touching on INCR. Get our free coverage by signing up to: In Q2 FY17, Myriad reported total revenues of $196.5 million, which came in above the $193.3 million reported in the year-ago same period. Total revenues numbers for the reported quarter beat market consensus estimates of $191 million. The year-over-year rise in the Company's top-line was primarily due to sequential growth in hereditary cancer revenues and strong GeneSight results. The molecular diagnostic Company posted GAAP net income of $5.9 million, or $0.09 per diluted share, in Q2 FY17 compared to $37.1 million, or $0.50 per diluted share, reported in Q2 FY16. The Company's Q2 FY17 non-GAAP net income stood at $17.5 million, or $0.26 per diluted share, compared to $33.5 million, or $0.45 per diluted share, in the previous year's comparable quarter. Wall Street had expected the Company to report non-GAAP net income of $0.24 per diluted share. During Q2 FY17, Myriad's gross profit came in at $152.1 million compared to $152.7 million in the prior year's same quarter. However, the Company's gross margin fell to 77.4% in Q2 FY17 from 79.0% in the year ago comparable quarter. The Company's operating expenses increased to $138.9 million in Q2 FY17 from $107.5 million in Q2 FY16. Moreover, the Company's operating income declined 71% during Q2 FY17 to $13.2 million from $45.2 million in Q2 FY16. The Company's operating margin also fell to 6.7% of total revenues in Q2 FY17 from 23.4% of total revenues in the previous year's corresponding quarter. In the reported quarter, non-GAAP operating income declined to $23.6 million, or 12.0% of total revenues, from $48.4 million, or 25.0% of total revenues, in the previous year's same quarter. During Q2 FY17, Molecular diagnostic tests reported total revenue of $183.9 million, up 1% from $182.6 million in Q2 FY16, primarily due to a 78% surged in EndoPredict testing revenues to $1.6 million and Prolaris testing revenues, which rose 63% to $3.1 million. However, in Q2 FY17, Hereditary cancer testing revenues fell 13% y-o-y to $143.9 million, Vectra DA testing revenues was down by 5% to $10.7 million, while other testing revenues remained flat at $2.9 million. Furthermore, the segment's GeneSight testing revenue during the reported quarter stood at $21.7 million. Additionally, Pharmaceutical and clinical service segment's revenues rose 18% y-o-y during Q2 FY17 to $12.6 million. During Q2 FY17, Myriad reported GAAP cash flow from operations of $31.4 million compared to $40.9 million in the prior year's comparable period. Furthermore, free cash flow during the reported quarter was $29.0 million versus $39.8 million in Q2 FY16. As on December 31, 2016, the Company had cash and cash equivalents balance of $108.1 million, compared to $68.5 million in as on June 30, 2016. Furthermore, the Company reported long-term debt balance of $204.0 million as on December 31, 2016. During Q2 FY17, the Company bought back approximately 600,000 shares of its common stock, for $10 million and ended the quarter with approximately $161 million remaining under its share repurchase program. In its guidance for Q3 FY17, Myriad's management expects revenues to be between $188 million and $190 million. For Q3 FY17, GAAP diluted EPS is projected to be in the range of $0.08 to $0.10, while adjusted EPS for the same period is forecasted to be in the range of $0.23 to $0.25. For full year FY17, the Company anticipates revenue range of $745 million to $755 million. Additionally, GAAP diluted EPS for FY17 is forecasted to be between $0.31 and $0.36; whereas full year adjusted EPS is estimated to be in the range of $1.00 to $1.05. Myriad Genetics At the closing bell, on Friday, February 24, 2017, MYGN's stock slightly slipped 0.37%, ending the trading session at $18.98. A total volume of 1.67 million shares were traded at the end of the day, which was higher than the 3-month average volume of 1.51 million shares. In the last month and previous three months, shares of the Company have surged 17.23% and 11.32%, respectively. Moreover, the stock rallied 13.86% since the start of the year. Shares of the company have a PE ratio of 19.08 and have a market capitalization of $1.30 billion. Active Wall Street (AWS) produces regular sponsored and non-sponsored reports, articles, stock market blogs, and popular investment newsletters covering equities listed on NYSE and NASDAQ and micro-cap stocks. AWS has two distinct and independent departments. One department produces non-sponsored analyst certified content generally in the form of press releases, articles and reports covering equities listed on NYSE and NASDAQ and the other produces sponsored content (in most cases not reviewed by a registered analyst), which typically consists of compensated investment newsletters, articles and reports covering listed stocks and micro-caps. Such sponsored content is outside the scope of procedures detailed below. AWS has not been compensated; directly or indirectly; for producing or publishing this document. The non-sponsored content contained herein has been prepared by a writer (the "Author") and is fact checked and reviewed by a third party research service company (the "Reviewer") represented by a credentialed financial analyst, for further information on analyst credentials, please email info@activewallst.com. Rohit Tuli, a CFA® charterholder (the "Sponsor"), provides necessary guidance in preparing the document templates. The Reviewer has reviewed and revised the content, as necessary, based on publicly available information which is believed to be reliable. Content is researched, written and reviewed on a reasonable-effort basis. The Reviewer has not performed any independent investigations or forensic audits to validate the information herein. The Reviewer has only independently reviewed the information provided by the Author according to the procedures outlined by AWS. AWS is not entitled to veto or interfere in the application of such procedures by the third-party research service company to the articles, documents or reports, as the case may be. Unless otherwise noted, any content outside of this document has no association with the Author or the Reviewer in any way. AWS, the Author, and the Reviewer are not responsible for any error which may be occasioned at the time of printing of this document or any error, mistake or shortcoming. No liability is accepted whatsoever for any direct, indirect or consequential loss arising from the use of this document. AWS, the Author, and the Reviewer expressly disclaim any fiduciary responsibility or liability for any consequences, financial or otherwise arising from any reliance placed on the information in this document. Additionally, AWS, the Author, and the Reviewer do not (1) guarantee the accuracy, timeliness, completeness or correct sequencing of the information, or (2) warrant any results from use of the information. The included information is subject to change without notice. This document is not intended as an offering, recommendation, or a solicitation of an offer to buy or sell the securities mentioned or discussed, and is to be used for informational purposes only. Please read all associated disclosures and disclaimers in full before investing. Neither AWS nor any party affiliated with us is a registered investment adviser or broker-dealer with any agency or in any jurisdiction whatsoever. To download our report(s), read our disclosures, or for more information, visit http://www.activewallst.com/disclaimer/. For any questions, inquiries, or comments reach out to us directly. If you're a company we are covering and wish to no longer feature on our coverage list contact us via email and/or phone between 09:30 EDT to 16:00 EDT from Monday to Friday at: CFA® and Chartered Financial Analyst® are registered trademarks owned by CFA Institute. LONDON, UK / ACCESSWIRE / February 27, 2017 / Active Wall St. announces its post-earnings coverage on Myriad Genetics, Inc. (NASDAQ: MYGN). The Company released its second quarter fiscal 2017 (Q2 FY17) results on February 07, 2017. The Salt Lake City-based Company's total revenues reported a 2% y-o-y growth, outperforming market consensus estimates. Register with us now for your free membership at: One of Myriad Genetics' competitors within the Research Services space, INC Research Holdings, Inc. (NASDAQ: INCR), announced on February 06, 2017, that it will release its Q4 and full year 2016 financial results on Tuesday, February 28, 2017, prior to its quarterly earnings call at 8:00 a.m. ET. AWS will be initiating a research report on INC Research in the coming days. Today, AWS is promoting its earnings coverage on MYGN; touching on INCR. Get our free coverage by signing up to: In Q2 FY17, Myriad reported total revenues of $196.5 million, which came in above the $193.3 million reported in the year-ago same period. Total revenues numbers for the reported quarter beat market consensus estimates of $191 million. The year-over-year rise in the Company's top-line was primarily due to sequential growth in hereditary cancer revenues and strong GeneSight results. The molecular diagnostic Company posted GAAP net income of $5.9 million, or $0.09 per diluted share, in Q2 FY17 compared to $37.1 million, or $0.50 per diluted share, reported in Q2 FY16. The Company's Q2 FY17 non-GAAP net income stood at $17.5 million, or $0.26 per diluted share, compared to $33.5 million, or $0.45 per diluted share, in the previous year's comparable quarter. Wall Street had expected the Company to report non-GAAP net income of $0.24 per diluted share. During Q2 FY17, Myriad's gross profit came in at $152.1 million compared to $152.7 million in the prior year's same quarter. However, the Company's gross margin fell to 77.4% in Q2 FY17 from 79.0% in the year ago comparable quarter. The Company's operating expenses increased to $138.9 million in Q2 FY17 from $107.5 million in Q2 FY16. Moreover, the Company's operating income declined 71% during Q2 FY17 to $13.2 million from $45.2 million in Q2 FY16. The Company's operating margin also fell to 6.7% of total revenues in Q2 FY17 from 23.4% of total revenues in the previous year's corresponding quarter. In the reported quarter, non-GAAP operating income declined to $23.6 million, or 12.0% of total revenues, from $48.4 million, or 25.0% of total revenues, in the previous year's same quarter. During Q2 FY17, Molecular diagnostic tests reported total revenue of $183.9 million, up 1% from $182.6 million in Q2 FY16, primarily due to a 78% surged in EndoPredict testing revenues to $1.6 million and Prolaris testing revenues, which rose 63% to $3.1 million. However, in Q2 FY17, Hereditary cancer testing revenues fell 13% y-o-y to $143.9 million, Vectra DA testing revenues was down by 5% to $10.7 million, while other testing revenues remained flat at $2.9 million. Furthermore, the segment's GeneSight testing revenue during the reported quarter stood at $21.7 million. Additionally, Pharmaceutical and clinical service segment's revenues rose 18% y-o-y during Q2 FY17 to $12.6 million. During Q2 FY17, Myriad reported GAAP cash flow from operations of $31.4 million compared to $40.9 million in the prior year's comparable period. Furthermore, free cash flow during the reported quarter was $29.0 million versus $39.8 million in Q2 FY16. As on December 31, 2016, the Company had cash and cash equivalents balance of $108.1 million, compared to $68.5 million in as on June 30, 2016. Furthermore, the Company reported long-term debt balance of $204.0 million as on December 31, 2016. During Q2 FY17, the Company bought back approximately 600,000 shares of its common stock, for $10 million and ended the quarter with approximately $161 million remaining under its share repurchase program. In its guidance for Q3 FY17, Myriad's management expects revenues to be between $188 million and $190 million. For Q3 FY17, GAAP diluted EPS is projected to be in the range of $0.08 to $0.10, while adjusted EPS for the same period is forecasted to be in the range of $0.23 to $0.25. For full year FY17, the Company anticipates revenue range of $745 million to $755 million. Additionally, GAAP diluted EPS for FY17 is forecasted to be between $0.31 and $0.36; whereas full year adjusted EPS is estimated to be in the range of $1.00 to $1.05. Myriad Genetics At the closing bell, on Friday, February 24, 2017, MYGN's stock slightly slipped 0.37%, ending the trading session at $18.98. A total volume of 1.67 million shares were traded at the end of the day, which was higher than the 3-month average volume of 1.51 million shares. In the last month and previous three months, shares of the Company have surged 17.23% and 11.32%, respectively. Moreover, the stock rallied 13.86% since the start of the year. Shares of the company have a PE ratio of 19.08 and have a market capitalization of $1.30 billion. Active Wall Street (AWS) produces regular sponsored and non-sponsored reports, articles, stock market blogs, and popular investment newsletters covering equities listed on NYSE and NASDAQ and micro-cap stocks. AWS has two distinct and independent departments. One department produces non-sponsored analyst certified content generally in the form of press releases, articles and reports covering equities listed on NYSE and NASDAQ and the other produces sponsored content (in most cases not reviewed by a registered analyst), which typically consists of compensated investment newsletters, articles and reports covering listed stocks and micro-caps. Such sponsored content is outside the scope of procedures detailed below. AWS has not been compensated; directly or indirectly; for producing or publishing this document. The non-sponsored content contained herein has been prepared by a writer (the "Author") and is fact checked and reviewed by a third party research service company (the "Reviewer") represented by a credentialed financial analyst, for further information on analyst credentials, please email info@activewallst.com. Rohit Tuli, a CFA® charterholder (the "Sponsor"), provides necessary guidance in preparing the document templates. The Reviewer has reviewed and revised the content, as necessary, based on publicly available information which is believed to be reliable. Content is researched, written and reviewed on a reasonable-effort basis. The Reviewer has not performed any independent investigations or forensic audits to validate the information herein. The Reviewer has only independently reviewed the information provided by the Author according to the procedures outlined by AWS. AWS is not entitled to veto or interfere in the application of such procedures by the third-party research service company to the articles, documents or reports, as the case may be. Unless otherwise noted, any content outside of this document has no association with the Author or the Reviewer in any way. AWS, the Author, and the Reviewer are not responsible for any error which may be occasioned at the time of printing of this document or any error, mistake or shortcoming. No liability is accepted whatsoever for any direct, indirect or consequential loss arising from the use of this document. AWS, the Author, and the Reviewer expressly disclaim any fiduciary responsibility or liability for any consequences, financial or otherwise arising from any reliance placed on the information in this document. Additionally, AWS, the Author, and the Reviewer do not (1) guarantee the accuracy, timeliness, completeness or correct sequencing of the information, or (2) warrant any results from use of the information. The included information is subject to change without notice. This document is not intended as an offering, recommendation, or a solicitation of an offer to buy or sell the securities mentioned or discussed, and is to be used for informational purposes only. Please read all associated disclosures and disclaimers in full before investing. Neither AWS nor any party affiliated with us is a registered investment adviser or broker-dealer with any agency or in any jurisdiction whatsoever. To download our report(s), read our disclosures, or for more information, visit http://www.activewallst.com/disclaimer/. For any questions, inquiries, or comments reach out to us directly. If you're a company we are covering and wish to no longer feature on our coverage list contact us via email and/or phone between 09:30 EDT to 16:00 EDT from Monday to Friday at: CFA® and Chartered Financial Analyst® are registered trademarks owned by CFA Institute.


News Article | February 27, 2017
Site: www.accesswire.com

LONDON, UK / ACCESSWIRE / February 27, 2017 / Active Wall St. announces its post-earnings coverage on Myriad Genetics, Inc. (NASDAQ: MYGN). The Company released its second quarter fiscal 2017 (Q2 FY17) results on February 07, 2017. The Salt Lake City-based Company's total revenues reported a 2% y-o-y growth, outperforming market consensus estimates. Register with us now for your free membership at: One of Myriad Genetics' competitors within the Research Services space, INC Research Holdings, Inc. (NASDAQ: INCR), announced on February 06, 2017, that it will release its Q4 and full year 2016 financial results on Tuesday, February 28, 2017, prior to its quarterly earnings call at 8:00 a.m. ET. AWS will be initiating a research report on INC Research in the coming days. Today, AWS is promoting its earnings coverage on MYGN; touching on INCR. Get our free coverage by signing up to: In Q2 FY17, Myriad reported total revenues of $196.5 million, which came in above the $193.3 million reported in the year-ago same period. Total revenues numbers for the reported quarter beat market consensus estimates of $191 million. The year-over-year rise in the Company's top-line was primarily due to sequential growth in hereditary cancer revenues and strong GeneSight results. The molecular diagnostic Company posted GAAP net income of $5.9 million, or $0.09 per diluted share, in Q2 FY17 compared to $37.1 million, or $0.50 per diluted share, reported in Q2 FY16. The Company's Q2 FY17 non-GAAP net income stood at $17.5 million, or $0.26 per diluted share, compared to $33.5 million, or $0.45 per diluted share, in the previous year's comparable quarter. Wall Street had expected the Company to report non-GAAP net income of $0.24 per diluted share. During Q2 FY17, Myriad's gross profit came in at $152.1 million compared to $152.7 million in the prior year's same quarter. However, the Company's gross margin fell to 77.4% in Q2 FY17 from 79.0% in the year ago comparable quarter. The Company's operating expenses increased to $138.9 million in Q2 FY17 from $107.5 million in Q2 FY16. Moreover, the Company's operating income declined 71% during Q2 FY17 to $13.2 million from $45.2 million in Q2 FY16. The Company's operating margin also fell to 6.7% of total revenues in Q2 FY17 from 23.4% of total revenues in the previous year's corresponding quarter. In the reported quarter, non-GAAP operating income declined to $23.6 million, or 12.0% of total revenues, from $48.4 million, or 25.0% of total revenues, in the previous year's same quarter. During Q2 FY17, Molecular diagnostic tests reported total revenue of $183.9 million, up 1% from $182.6 million in Q2 FY16, primarily due to a 78% surged in EndoPredict testing revenues to $1.6 million and Prolaris testing revenues, which rose 63% to $3.1 million. However, in Q2 FY17, Hereditary cancer testing revenues fell 13% y-o-y to $143.9 million, Vectra DA testing revenues was down by 5% to $10.7 million, while other testing revenues remained flat at $2.9 million. Furthermore, the segment's GeneSight testing revenue during the reported quarter stood at $21.7 million. Additionally, Pharmaceutical and clinical service segment's revenues rose 18% y-o-y during Q2 FY17 to $12.6 million. During Q2 FY17, Myriad reported GAAP cash flow from operations of $31.4 million compared to $40.9 million in the prior year's comparable period. Furthermore, free cash flow during the reported quarter was $29.0 million versus $39.8 million in Q2 FY16. As on December 31, 2016, the Company had cash and cash equivalents balance of $108.1 million, compared to $68.5 million in as on June 30, 2016. Furthermore, the Company reported long-term debt balance of $204.0 million as on December 31, 2016. During Q2 FY17, the Company bought back approximately 600,000 shares of its common stock, for $10 million and ended the quarter with approximately $161 million remaining under its share repurchase program. In its guidance for Q3 FY17, Myriad's management expects revenues to be between $188 million and $190 million. For Q3 FY17, GAAP diluted EPS is projected to be in the range of $0.08 to $0.10, while adjusted EPS for the same period is forecasted to be in the range of $0.23 to $0.25. For full year FY17, the Company anticipates revenue range of $745 million to $755 million. Additionally, GAAP diluted EPS for FY17 is forecasted to be between $0.31 and $0.36; whereas full year adjusted EPS is estimated to be in the range of $1.00 to $1.05. Myriad Genetics At the closing bell, on Friday, February 24, 2017, MYGN's stock slightly slipped 0.37%, ending the trading session at $18.98. A total volume of 1.67 million shares were traded at the end of the day, which was higher than the 3-month average volume of 1.51 million shares. In the last month and previous three months, shares of the Company have surged 17.23% and 11.32%, respectively. Moreover, the stock rallied 13.86% since the start of the year. Shares of the company have a PE ratio of 19.08 and have a market capitalization of $1.30 billion. Active Wall Street (AWS) produces regular sponsored and non-sponsored reports, articles, stock market blogs, and popular investment newsletters covering equities listed on NYSE and NASDAQ and micro-cap stocks. AWS has two distinct and independent departments. 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Scientists hail CRISPR/Cas9 as more accurate and efficient than other, now-traditional genetic engineering methods. As a result, CRISPR has generated worldwide debate about how it could accelerate the manipulation of plants, animals and even human beings at the molecular level. That some DNA modifications can be passed on to future generations raises particular concern. But the patent dispute, focusing on whether scientists at the Broad Institute of MIT and Harvard or those at University of California, Berkeley invented the technology, seems far from these ethical concerns. Each institution asserts that its scientists are the rightful inventors – and therefore the owners of the CRISPR/Cas9 patents. As proof, the scientists are submitting their published articles, laboratory notebooks and affidavits to the US Patent and Trademark Office, which will make a decision in the next few months. This decision will influence whose name will go down in the history books, and perhaps also who will receive a Nobel Prize. And it will determine which institution will make millions by licensing use of the patented invention to researchers at other universities and companies. But amid all the breathless anticipation, we've been ignoring two important lessons from the CRISPR/Cas9 patent dispute: patent systems no longer fit the realities of how science works, and patents give their owners significant control over the fate and shape of technologies. Do we need patents to stimulate innovation? The U.S. patent system was built on the idea that the promise of an exclusive right to commercialize a technology for a limited period of time provided an important innovation incentive. Even today, this argument is used to justify strong patent systems across the world. But as basic science and applied technology have become increasingly difficult to distinguish, and more university scientists are receiving patents on ground-breaking discoveries like CRISPR, the old rules no longer seem to make sense. The modern patent system was built with individual entrepreneurs and discrete machines in mind. But university-based science is usually incremental and collaborative, driven by the hopes of tenure, promotion, grant funding, respect among colleagues and, if extremely lucky, a major scientific discovery. Indeed, whichever emerging CRISPR history you read, you learn about a series of discoveries made by an international array of professors, postdoctoral fellows and students, driven by intellectual curiosities across multiple, seemingly disconnected topics. As they got involved, the Broad's Feng Zhang, Berkeley's Jennifer Doudna and the Max Planck Institute's Emmanuelle Charpentier, the scientists involved in the U.S. patent fight, were surely motivated by the excitement that they might get credit for a major biotechnology breakthrough. But to think that patents were a major motivator is a serious misunderstanding of how science works and what drives scientists. Most, if not all, of the patent revenues, after all, will go to their institutions and not to them personally. We have seen similar situations before in the world of biotechnology. When there are dozens of participants and multiple motivations, it's enormously difficult – if not simply incorrect – to identify one person or institution as deserving the credit. Furthermore, especially in cases where there is widespread scientific involvement, patents ultimately become more hindrance than help, forcing scientists already working in the field to apply for licenses in order simply to continue. For all these reasons, it's time to consider a more nuanced approach to patents in biotech, one that disentangles innovation and the public interest from profits. Power of patents, in absence of regulations The CRISPR dispute also highlights how patents influence the social and ethical consequences of a technology. We tend to focus on how patents assign credit, facilitate financial gain for their owners, and therefore shape the marketplace. But the control that patent offices award extends much further than that, particularly in the absence of regulations. As patent holders decide whether and how to license their technologies, they can determine the shape a particular field takes, the technologies that become available, who has access to them, and what kind of access they have. At present, despite CRISPR's potential to enable relatively simple human genetic engineering that could be passed down through generations and broad support for national and international laws to govern its development and use, there are no U.S. laws governing CRISPR research or technology. This lack of regulation means that whichever institution is eventually awarded the CRISPR patents will have enormous control over how the controversial technology develops. Its licensing decisions will essentially determine what kinds of research will take place in embryos, whether there will be limits on this research, and what kinds of human genetic engineering might become commercially available. Consider a similar situation, the now-famous case of biotechnology company Myriad Genetics' patents on the BRCA genes, which confer increased susceptibility for breast and ovarian cancer. In the mid-1990s, Myriad used its patents to establish a monopoly over BRCA gene testing in the United States. In the absence of regulations around genetic testing, the company's patents gave it control not only over who could offer BRCA gene testing but also how the technology was built and made available. This had important ethical and social implications. Myriad Genetics, which obviously had an interest in widespread use of its technology, essentially had the freedom to set standards about when and how BRCA gene testing would be made widely available, even in the face of significant uncertainties about the meaning of the test results and the treatment options available. And because it did not require that users seek testing through a genetics specialist, BRCA gene test users often had to wade through these complicated uncertainties on their own. (Years later, civil society groups launched an unprecedented court challenge that eventually led the U.S. Supreme Court to revoke these patents in 2013.) CRISPR's future use in one institution's hands Despite the enormous power the CRISPR patent holder will have in shaping the development and use of the new technology, we know little about how the Broad or Berkeley will handle it. Both institutions emphasize their commitments to the public interest, and particularly in licensing the technologies widely and cheaply to other nonprofit institutions. But neither has addressed these ethical questions. Will their licensing agreements include language that prevents the use of CRISPR for human gene editing, for instance? Or a requirement that licensees comply with National Institutes of Health guidelines that may emerge, even if those institutions do not use NIH funds? Both Doudna and Zhang have acknowledged the ethical challenges at stake and articulated their support for regulatory frameworks governing the use of CRISPR in people. But we don't know whether their institutions are thinking about how to develop systematic approaches to these issues in their licensing decisions. Particularly in the absence of a U.S. regulatory framework, the patent holder should address these ethical issues proactively and in a transparent manner. Consulting with ethicists, historians and social scientists who are experts in the topic can help developers understand who might stand to lose and win with CRISPR's development, how to avoid the eugenic mistakes of our past and how these ethical and social concerns are connected deeply to decisions about CRISPR patents and licenses. And in the future, we should seriously consider the importance of the patent system – almost by default – in shaping the moral dimensions of science and technology.


News Article | December 7, 2016
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SAN FRANCISCO--(BUSINESS WIRE)--Invitae Corporation (NYSE:NVTA), a genetic information company, today announced the expansion of its Breast Cancer STAT Panel with the addition of two important breast cancer predisposition genes – ATM and CHEK2 – and a faster turnaround time (TAT) with results available in as few as five days at no additional cost. The announcement was made at the San Antonio Breast Cancer Symposium (SABCS). “Recent research underscores the clinical utility of ATM and CHEK2 in making treatment decisions, and many of our provider clients have requested these genes be included,” said Robert Nussbaum, MD, chief medical officer of Invitae. “The addition of these genes to Invitae’s Breast Cancer STAT Panel provides clinicians with more comprehensive information without sacrificing time for results, ultimately supporting better patient care for patients and clinicians who need answers to help guide surgical decisions.” Invitae’s Breast Cancer STAT Panel includes seven well-established genes associated with a significantly increased risk of developing breast cancer: BRCA1, BRCA2, CDH1, PALB2, PTEN, STK11, and TP53. Invitae now offers the opportunity to add either or both ATM and CHEK2 based on research showing that each has important implications for understanding risk and guiding treatment decisions. The presence of a variant in any one of these nine genes, or a combination of them, may influence the patient and clinician choice between mastectomy and lumpectomy, whether to perform prophylactic salpingo-oophorectomy, and may inform choice of chemotherapy, including PARP inhibitors. Results for the expanded Breast Cancer STAT Panel are available in as few as five calendar days (average turnaround is seven). In order to provide clinicians with flexibility, Invitae will also provide testing for BRCA1 and BRCA2 only if desired with the same STAT turnaround time. Invitae also offers the ability to re-requisition additional cancer genes within 90 days at no additional charge. "When I ask most of my newly diagnosed breast cancer patients when they want surgery, their most frequent response is 'yesterday,'" said Barry Rosen, MD, breast cancer surgeon at Advocate Health in Barrington, Illinois. “Prior to Invitae's STAT testing, my patients were faced with the difficult choice to wait as long as a month for the testing to return before proceeding with surgery, or, more commonly, making a decision based on chance rather than science. Having a one week turnaround has dramatically improved my ability to care for my patients." Invitae’s Breast Cancer STAT Panel has the same high quality as Invitae’s current validated, hereditary cancer tests. Data published in the Journal of Molecular Diagnostics demonstrated the analytical accuracy (100%) and clinical concordance (99.8% compared to results from Myriad Genetics) of Invitae’s methods in a study of more than 1,000 patients in collaboration with Massachusetts General Hospital and the Stanford University School of Medicine. In addition, data showing the clinical utility of the Invitae hereditary breast and ovarian cancer (HBOC) panel test was published in a companion manuscript in JAMA Oncology. The additional genes are available at no additional charge and testing is available for both blood and saliva samples. The company recently announced agreements with the top five largest insurers in the United States, providing greater access for patients than ever before. Invitae’s transparent and affordable patient-pay option of $475 will continue to be available. As a matter of policy, Invitae does not hold samples or findings reports while managing insurance claims. “It is now so easy to just schedule my patients’ surgeries only one to two weeks into the future knowing full well that the Invitae STAT test will have returned results before the procedure to confirm which is the best surgical option,” said Paul Baron, MD, FACS, Breast and Melanoma Specialists of Charleston. “It has totally changed how I manage newly diagnosed patients.” Clinicians are able to access Invitae’s Clinical Consult Service through the entire testing process to select the right test, clarify results, and review individual patient cases at no additional charge. Invitae also makes telephone genetic counseling services available to patients before and after testing by clinician request. Invitae Corporation's (NYSE:NVTA) mission is to bring comprehensive genetic information into mainstream medical practice to improve the quality of healthcare for billions of people. Invitae’s goal is to aggregate most of the world’s genetic tests into a single service with higher quality, faster turnaround time, and lower price than many single-gene and panel tests today. The company currently provides a diagnostic service comprising hundreds of genes for a variety of genetic disorders associated with oncology, cardiology, neurology, pediatrics, and other rare disease areas. For more information, visit our website at invitae.com. This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to Invitae’s STAT panel influencing surgical decisions and treatment options and supporting better patient care. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially, and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: risks associated with the company’s ability to use rapidly changing genetic data to interpret test results accurately, consistently, and quickly; the company’s history of losses; the company’s need to scale its infrastructure in advance of demand for its tests and to increase demand for its tests; the company’s ability to develop and commercialize new tests and expand into new markets; the risk that the company may not obtain or maintain sufficient levels of reimbursement for its tests; laws and regulations applicable to the company’s business, including state licensing requirements and potential regulation by the Food and Drug Administration; and the other risks set forth in the company’s filings with the Securities and Exchange Commission, including the risks set forth in the company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2016. These forward-looking statements speak only as of the date hereof, and Invitae Corporation disclaims any obligation to update these forward-looking statements. NOTE: Invitae and the Invitae logo are trademarks of Invitae Corporation. All other trademarks and service marks are the property of their respective owners.

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