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Patent
Mylan Laboratories Ltd. | Date: 2014-11-28

The present disclosure relates to a solid dispersion of amorphous cobicistat and methods of its preparation. Cobicistat may be complexed with a pharmaceutically acceptable carrier such as -cyclodextrin or hydroxy! propyl -cyclodextrin. The present disclosure also provides pharmaceutical formulations for administration to patients and methods of their use.


The present invention relates to novel and stable polymorphic forms of Perindopril (L)-Arginine designated as Form and amorphous form and processes for their preparation. The present invention also provides the novel polymorph Form with greater stability to heat and humidity and can be prepared on large scale by an efficient, economic and reproducible process.


Patent
Mylan Laboratories Ltd. | Date: 2014-12-29

An improved process for the preparation of empagliflozin is disclosed. Novel intermediates of formulas (13) and (14) for the preparation of empagliflozin are also disclosed, wherein R^(1 )and R^(2 )are independently hydrogen or hydroxyl protecting groups.


Patent
Mylan Laboratories Ltd. | Date: 2014-12-19

The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically acceptable salts. The present disclosure also provides intermediates useful in the synthesis of sofosbuvir.


The present invention provides an enzymatic process for the preparation of (S)-5-(4-Fluoro-phenyl)-5-hydroxy-Imorpholin-4-yl-pentan-1-one by the reduction of 1-(4-Fluoro-phenyl)-5-morpholin-4-yl-pentane-1,5-dione by using a suitable enzyme or by the resolution of (R, S)-5-(4-Fluoro-phenyl)-5-hydroxy-1 morpholin-4-yl-pentan-1-one by using an enzyme. The present invention also provides process for the preparation of Ezetimibe comprising the steps of a) protecting the componnd (S)-5-(4-Fluoro-phenyl)-5-hydroxy-1 morpholin-4-yl-pentan-1-one with hydroxy protecting group b) hydrolyzing the obtained componnd c) condensing with a chiral auxiliary d) reacting with an protected imine componnd e) converting to alkyl ester f) cyclizing and g) deprotecting to obtain Ezetimibe.


The present invention relates to novel and stable polymorphic forms of Perindopril (L)-Arginine designated as Form and amorphous form and processes for their preparation. The present invention also provides the novel polymorph Form with greater stability to heat and humidity and can be prepared on large scale by an efficient, economic and reproducible process.


Patent
Mylan Laboratories Inc | Date: 2014-12-03

The active ingredients of the pharmaceutical composition described consist of nebivolol, one or more ACE inhibitors and one or more ARB.


Patent
Mylan Laboratories Ltd. | Date: 2015-02-04

The present disclosure relates to novel crystalline dolutegravir sodium Form-M2, Form-M3, Form-M4 and process for the preparation thereof.


Patent
Mylan Laboratories Ltd. | Date: 2014-05-08

The present invention relates to an improved process for the preparation of Roflumilast. The present invention also relates to crystalline Form-I of Roflumilast.


Patent
Mylan Laboratories Inc. | Date: 2014-03-14

The presently disclosed subject matter is directed to a granule, wherein the granule has an active agent and a wax dispersed therein, and the granule exhibits excellent friability when compressed to form a pharmaceutical composition. The subject matter disclosed herein is also directed to methods of preparing the granules and the pharmaceutical compositions comprising the granules. The compositions and methods disclosed provide granules and pharmaceutical compositions for immediate release of the active agent and do not substantially prolong the release of the active agent from the granule.

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