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Severo C.B.,Mycology Laboratory | Guazzelli L.S.,Mycology Laboratory | Barra M.B.,Pathology Laboratory | Hochhegger B.,Radiology Service | Severo L.C.,Federal University of Rio Grande do Sul
Revista do Instituto de Medicina Tropical de Sao Paulo | Year: 2014

Nondiphtherial corynebacteria are ubiquitous in nature and commonly colonize the skin and mucous membranes of humans, however they rarely account for clinical infection. We present the first reported case of multiple pulmonary nodules caused by Corynebacterium striatum. The infection occurred in a 72-year-old immunocompetent female, and the diagnosis was obtained by Gram's stain and culture of lung biopsy. C. striatum should be recognized as a potential pathogen in both immunocompromised and normal hosts in the appropriate circumstances. Source


Welsh O.,Autonomous University of Nuevo Leon | Vera-Cabrera L.,Autonomous University of Nuevo Leon | Rendon A.,L.E.S.S. | Gonzalez G.,Autonomous University of Nuevo Leon | Bonifaz A.,Mycology Laboratory
Clinics in Dermatology | Year: 2012

Coccidioidomycosis is a systemic disease caused by Coccidioides immitis and C posadasii spp, which are predominant in arid zones of the American continent, mainly in the Southwestern United States and the northern states of Mexico, as well as other regions with different environmental conditions. Some countries of Central and South America are also endemic zones. Most infected patients are asymptomatic. Disseminated disease develops in less than 5% of clinically affected individuals. Culture, biopsy, and DNA probes are used for fungus identification. Prognosis is related to low antibody detection and a positive intradermic skin reaction to coccidioidin. Immunodepressed patients and pregnant women require special attention in diagnosis, therapy, and prognosis. Amphotericin B in its different forms, itraconazole, and fluconazole, are the most frequently used treatments. Posaconazole and voriconazole are prescribed in some unresponsive cases. © 2012 Elsevier Inc. Source


Kliemann D.A.,Federal University of Rio Grande do Sul | Antonello V.S.,Hospital Femina | Severo L.C.,Federal University of Rio Grande do Sul | Severo L.C.,Mycology Laboratory | And 2 more authors.
Journal of Infection in Developing Countries | Year: 2011

Saccharomyces species are emerging opportunistic fungal pathogens that can cause bloodstream infections in humans. These infections have often been associated with the ingestion of probiotics. Saccharomyces oesophagitis is a rare condition which has been described so far in only two publications. Here we report the case of a patient who was diagnosed with Saccharomyces oesophagitis. The clinical picture was indistinguishable from that of Candida oesophagitis. The Saccharomyces isolate was shown to be susceptible to fluconazole by both CLSI M27-A and disk diffusion methods. In contrast to cases of fungaemia, Saccharomyces oesophagitis does not seem to follow probiotic use. Due to the potential for antifungal resistance among emerging fungal pathogens, proper mycological identification at the species level is essential. © 2011 Kliemann et al. Source


da Silva Rodrigues G.,Federal University of Rio Grande do Sul | Severo C.B.,Federal University of Rio Grande do Sul | de Mattos Oliveira F.,Mycology Laboratory | da Silva Moreira J.,Pavilhao Pereira Filho | And 2 more authors.
Jornal Brasileiro de Pneumologia | Year: 2010

Objective: To analyze the association between paracoccidioidomycosis (Pcm) and cancer in a series of 25 cases and to review the literature on this topic. Methods: A retrospective review of 25 cases diagnosed with Pcm and cancer, retrieved from a series of 808 consecutive adult patients diagnosed with Pcm based on tests conducted in the Mycology Laboratory of the Santa Casa Complexo Hospitalar, in the city of Porto Alegre, Brazil, between 1972 and 2007. The diagnosis of Pcm was confirmed by means of direct microscopic examination, histopathological examination or immunodiffusion test. All cancer cases were confirmed by histopathological or cytopathological examination. Results: Respiratory symptoms were the principal complaints of the patients evaluated. Pulmonary involvement predominated, followed by skin and lymph node involvement. The most prevalent tumor was bronchial carcinoma, in 15 patients, followed by other types of carcinoma, and 1 patient had Hodgkin's lymphoma. In 16 patients (64%), the site of the Pcm was the same as that of the tumor. In most cases, Pcm treatment consisted of the isolated administration of sulfanilamide, sulfamethoxazole-trimethoprim, ketoconazole, itraconazole or amphotericin B. The most common treatment for cancer was surgery, followed by radiotherapy and chemotherapy. Of the 25 patients, 12 were cured of Pcm, and 4 died. In 9 patients, the final outcome was unknown. In the general population of the area under study, the prevalence of lung cancer was significantly higher in smokers with Pcm than in smokers without Pcm (p < 0.001). Conclusions: A diagnosis of Pcm appears to increase the risk of lung cancer. Source


Luangsa-Ard J.,National Center for Genetic Engineering and Biotechnology | Houbraken J.,Fungal Biodiversity Center | van Doorn T.,Fungal Biodiversity Center | Hong S.-B.,Korean Agricultural Culture Collection | And 3 more authors.
FEMS Microbiology Letters | Year: 2011

Paecilomyces lilacinus was described more than a century ago and is a commonly occurring fungus in soil. However, in the last decade this fungus has been increasingly found as the causal agent of infections in man and other vertebrates. Most cases of disease are described from patients with compromised immune systems or intraocular lens implants. In this study, we compared clinical isolates with strains isolated from soil, insects and nematodes using 18S rRNA gene, internal transcribed spacer (ITS) and partial translation elongation factor 1-α (TEF) sequences. Our data show that P. lilacinus is not related to Paecilomyces, represented by the well-known thermophilic and often pathogenic Paecilomyces variotii. The new genus name Purpureocillium is proposed for P. lilacinus and the new combination Purpureocillium lilacinum is made here. Furthermore, the examined Purpureocillium lilacinum isolated grouped in two clades based on ITS and partial TEF sequences. The ITS and TEF sequences of the Purpureocillium lilacinum isolates used for biocontrol of nematode pests are identical to those causing infections in (immunocompromised) humans. The use of high concentrations of Purpureocillium lilacinum spores for biocontrol poses a health risk in immunocompromised humans and more research is needed to determine the pathogenicity factors of Purpureocillium lilacinum. © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved. Source

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