Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center

Chennai, India

Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center

Chennai, India
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Palazhy S.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Viswanathan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Muruganathan A.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center
International Journal of Diabetes in Developing Countries | Year: 2017

Vitamin D levels have been documented to have significant inverse relationship with type 2 diabetes. However, data on the extent of vitamin D deficiency among type 2 diabetes subjects of India is lacking. The present study was undertaken among diabetic subjects of South India to address this lacuna. This retrospective study was conducted among patients attending a diabetes specialty hospital who had established type 2 diabetes mellitus. Demographic data and data on laboratory parameters such as vitamin D, HbA1c, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and serum calcium were obtained from the hospital information system. Vitamin D levels were classified as normal (≥30 ng/mL), insufficient (>20 to 29.9 ng/mL), and deficient (≤20 ng/mL). We included 4628 subjects with diabetes. Among them, 71.4 % were vitamin D deficient, 15 % were vitamin D insufficient, and 13.6 % were found to have normal vitamin D levels. On comparing the two genders, it was seen that the percentage of men and women with these conditions were similar. The proportion of subjects with these conditions across different age groups (30–50, 50–70, >70) were also similar. BMI, age, calcium levels, and HbA1c were found to be the major confounders for vitamin D status. Our study, done among type 2 diabetes people, show that vitamin D deficiency was highly prevalent among them. Considering such high prevalence, screening of diabetic patients for vitamin D deficiency would be beneficial in this population. © 2016, Research Society for Study of Diabetes in India.


Viswanathan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Kumpatla S.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Aravindalochanan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Rajan R.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | And 3 more authors.
PLoS ONE | Year: 2012

Background: Diabetes mellitus (DM) is recognised as an important risk factor to tuberculosis (TB). India has high TB burden, along with rising DM prevalence. There are inadequate data on prevalence of DM and pre-diabetes among TB cases in India. Aim was to determine diabetes prevalence among a cohort of TB cases registered under Revised National Tuberculosis Control Program in selected TB units in Tamil Nadu, India, and assess pattern of diabetes management amongst known cases. Methods: 827 among the eligible patients (n = 904) underwent HbA1c and anthropometric measurements. OGTT was done for patients without previous history of DM and diagnosis was based on WHO criteria. Details of current treatment regimen of TB and DM and DM complications, if any, were recorded. A pretested questionnaire was used to collect information on sociodemographics, habitual risk factors, and type of TB. Findings: DM prevalence was 25.3% (95% CI 22.6-28.5) and that of pre-diabetes 24.5% (95% CI 20.4-27.6). Risk factors associated with DM among TB patients were age (31-35, 36-40, 41-45, 46-50, >50 years vs <30 years) [OR (95% CI) 6.75 (2.36-19.3); 10.46 (3.95-27.7); 18.63 (6.58-52.7); 11.05 (4.31-28.4); 24.7 (9.73-62.7) (p<0.001)], positive family history of DM [3.08 (1.73-5.5) (p<0.001)], sedentary occupation [1.69 (1.10-2.59) (p = 0.016)], and BMI (18.5-22.9, 23-24.9 and ≥25 kg/m2 vs <18.5 kg/m2) [2.03 (1.32-3.12) (p = 0.001); 0.87 (0.31-2.43) (p = 0.78); 1.44 (0.54-3.8) (p = 0.47)]; for pre-diabetes, risk factors were age (36-40, 41-45, 46-50, >50 years vs <30 years) [2.24 (1.1-4.55) (p = 0.026); 6.96 (3.3-14.7); 3.44 (1.83-6.48); 4.3 (2.25-8.2) (p<0.001)], waist circumference [<90 vs. ≥90 cm (men), <80 vs. ≥80 cm (women)] [3.05 (1.35-6.9) (p = 0.007)], smoking [1.92 (1.12-3.28) (p = 0.017)] and monthly income (5000-10,000 INR vs <5000 INR) [0.59 (0.37-0.94) (p = 0.026)]. DM risk was higher among pulmonary TB [3.06 (1.69-5.52) (p<0.001)], especially sputum positive, than non-pulmonary TB. Interpretation: Nearly 50% of TB patients had either diabetes or pre-diabetes. © 2012 Viswanathan et al.


PubMed | Hopital Lapeyronie, University of Pennsylvania, Shanghai JiaoTong University, 306th Hospital of PLA and 10 more.
Type: Journal Article | Journal: The international journal of lower extremity wounds | Year: 2016

Innovations in technology are used in managing chronic wounds. Despite the wide range of technologies available, healing of chronic wounds remains variable. In this paper, the authors offer an evidence based approach to the use of technology for diagnosis and management based on the concept of standardised care.


Kumpatla S.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Soni A.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Viswanathan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center
Journal of Association of Physicians of India | Year: 2017

Objectives: To compare the bias, absolute bias, precision and accuracies between the equations, viz., CKD-EPI (Scr), CKD-EPI (Scys) and MDRD in Indian patients with type 2 diabetes. Methods: 198 patients who underwent 24 h urinary collection for assessing kidney function between November 2014-January 2015 were included. Cohen’s κ coefficient, Bland-Altman plot were calculated between estimated kidney function equations, and bias, precision, accuracies was calculated between the formulae. Results:The mean eGFR based on MDRD, CKD-EPI (Scr) and CKD-EPI (Scys) equations were 64.5±21.9, 70.2±25.1 and 74.7±31.0 ml/min/ 1.73m2 respectively. The overall mean absolute bias was smallest for MDRD vs CKD EPI (Scr). The precision was also least for MDRD vs CKD EPI (Scr) indicating that the agreement between these equations is consistent for the range of values. MDRD vs CKD EPI (Scr) had the highest accuracy in comparison to other compared formula. The performance between MDRD versus CKD EPI (Scys) was different. There was a good agreement between MDRD and CKD EPI (Scr).in both stage 3 and stage 4 CKD. The MDRD vs CKD EPI (Scr) classified 72.2% of the patients correctly. Conclusion: In conclusion, there was a good agreement between CKD-EPI (Scr) and MDRD equations. CKD-EPI equation based on creatinine estimation is widely accepted method and clinicians may use this equation in routine clinical practice to assess kidney function among patients with type 2 diabetes. © 2017, Journal of Association of Physicians of India. All rights reserved.


Kumpatla S.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Michael C.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Viswanathan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Viswanathan V.,Prof swanathan Diabetes Research Center
International Journal of Diabetes in Developing Countries | Year: 2015

This study was designed to evaluate the effect of yogasanas on glycaemic control, haemodynamic and lipid profile in newly diagnosed subjects with type 2 diabetes prescribed with oral hypoglycaemic agents (OHA). Three hundred and three (M:F 199:104) subjects were recruited in this prospective study and were divided into two groups. Group 1 (N = 149) were prescribed OHA alone, while group 2 subjects (N = 154) were prescribed OHA and received training individually once for regular yoga practice for 30 min daily. Baseline data on anthropometric, haemodynamic and biochemical details were collected, and subjects were asked to report for review after 3 months. All investigations were repeated after 3 months. A total of 241 subjects were available for follow-up. Diabetes treatment regimen was unchanged in both the groups during the study period. Both the groups were matched with respect to body mass index (BMI), glycaemic level, lipid profile and diet calorie consumption at baseline. BMI did not differ significantly at follow-up in both the groups. Glucose levels and HbA1c % showed greater reduction in group 2 practising yoga. Total and low-density lipoprotein (LDL) cholesterol alone improved in group 1, whereas improvement was seen in all lipid parameters in group 2. High-density lipoprotein (HDL) cholesterol was not statistically significant in both groups. Group 1 showed improvement in systolic blood pressure (P = 0.027), whereas group 2 subjects showed improvement in both systolic and diastolic blood pressures (P < 0.0001). In conclusion, regular practice of yoga along with conventional medicines could be beneficial for better control of diabetes. © 2015, Research Society for Study of Diabetes in India.


Aravindalochanan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Kumpatla S.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Rengarajan M.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Rajan R.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Viswanathan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center
Diabetes Technology and Therapeutics | Year: 2014

Background: Sedentarism in the workplace, which accelerates risk of diabetes, is least explored in the Indian population. The primary objective of this study was to assess whether prolonged sitting hours in work place predisposes individuals to risk of diabetes and also to estimate risk of diabetes in sedentary workers with a positive family history of diabetes (FHD). Subjects and Methods: Data of age-matched 514 subjects previously undiagnosed with diabetes from two different occupational groups (bank employees and schoolteachers) in Chennai, India from opportunistic screening were taken for analysis. The important explanatory variables were body mass index, waist circumference, duration of physical activity, positive FHD, and random capillary blood glucose (RCBG). Logistic regression analyses were done separately to identify determinants of diabetes in each group. Another logistic regression was performed after combining data to estimate risk associated with diabetes among sedentary subjects with positive FHD. Results: Factors associated with elevated RCBG among schoolteachers were systolic and diastolic blood pressure, whereas among bank employees, in addition to blood pressure, duration of sitting in work place and positive FHD were significantly associated with diabetes. Combined data analysis showed that subjects with duration of sitting of ≥180 min/day and a positive FHD are three times at risk of developing diabetes. Adjusting for total physical activity revealed that risk was higher among male subjects. Conclusions: Increased sitting duration for ≥180 min/day at the workplace was associated with elevated RCBG. There was a threefold higher risk for diabetes among these subjects with positive FHD. Encouraging physical activities in such groups, particularly in men, can be beneficial. © Copyright 2014, Mary Ann Liebert, Inc. 2014.


Viswanathan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Kumpatla S.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Narayan Rao V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center
Journal of Association of Physicians of India | Year: 2014

Objective: People with diabetic neuropathy are frequently prone to several bone and joint abnormalities. Simple radiographic findings have been proven to be quite useful in the detection of such abnormalities, which might be helpful not only for early diagnosis but also in following the course of diabetes through stages of reconstruction of the ulcerated foot. The present study was designed to identify the common foot abnormalities in south Indian diabetic subjects with and without neuropathy using radiographic imaging.Methods: About 150 (M:F 94:56) subjects with type 2 diabetes were categorised into three groups: Group I (50 diabetic patients), Group II (50 patients with neuropathy), and Group III (50 diabetic patients with both neuropathy and foot ulceration). Demographic details, duration of diabetes and HbA1c values were recorded. Vibration perception threshold was measured for assessment of neuropathy. Bone and joint abnormalities in the feet and legs of the study subjects were identified using standardised dorsi-plantar and lateral weight-bearing radiographs.Results: Radiographic findings of the study subjects revealed that those with both neuropathy and foot ulceration and a longer duration of diabetes had more number of bone and joint abnormalities. Subjects with neuropathy alone also showed presence of several abnormalities, including periosteal reaction, osteopenia, and Charcot changes.Conclusions: The present findings highlight the impact of neuropathy and duration of diabetes on the development of foot abnormalities in subjects with diabetes. Using radiographic imaging can help in early identification of abnormalities and better management of the diabetic foot. © 2014, Journal of Association of Physicians of India. All rights reserved.


Kumpatla S.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Soni A.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Narasingan S.N.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center | Viswanathan V.,Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center
Indian Heart Journal | Year: 2016

Elevated non-high density lipoprotein cholesterol (non-HDL-C) was the commonest lipid abnormality among T2DM patients with cardiovascular events (CV) events. Prevalence of elevated non-HDL-C was 21.6% among patients who were on statin therapy and with optimal low density lipoprotein-cholesterol (LDL-C) levels. Despite an optimal LDL-C level, 47% of the T2DM patients with CV events had elevated non-HDL-C. © 2015 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.


PubMed | University of Minnesota, Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center, Diabetologist and Endocrine and Metabolic Physician at Diabetes Care and Hormone Clinic and Madras Diabetes Research Foundation
Type: Journal Article | Journal: Acta diabetologica | Year: 2016

To evaluate the association of 87 genetic variants previously associated with type 2 diabetes mellitus (T2DM) in genome-wide association studies of populations of European ancestry in an Asian Indian population with early-onset type 2 diabetes mellitus (EOT2DM).The study groups comprised of 877 type 2 diabetes individuals, 436 individuals with EOT2DM (age at diagnosis below 35years), 441 individuals with older T2DM (diagnosis at 35years or greater) and controls with normal glucose tolerance (NGT) (n=400 younger than 35years; n=438 older than 35years). The participants were genotyped for 87 SNPs from 44 genes and 27 intergenic loci. Associations were tested using logistic regression.All the variants in TCF7L2 and CDKN2A/2B showed study-wide significance (p<1.410Some of the variants in TCF7L2 and CDKN2A/2B associated with T2DM are associated with EOT2DM as well. An intergenic SNP on chromosome 1p31 showed association only with early-onset T2DM in this Asian Indian population. The lack of association with many other SNPs of T2DM may be a reflection of the lack of power of the study, sample size, differences in the frequencies of genetic polymorphisms in different ethnic groups, effect sizes, as well as ancestral differences in pattern of LD between the genetic variants involved in early- and late-onset T2DM.


PubMed | Mv Hospital For Diabetes And Prof swanathan Diabetes Research Center
Type: Journal Article | Journal: Diabetes technology & therapeutics | Year: 2014

Sedentarism in the workplace, which accelerates risk of diabetes, is least explored in the Indian population. The primary objective of this study was to assess whether prolonged sitting hours in work place predisposes individuals to risk of diabetes and also to estimate risk of diabetes in sedentary workers with a positive family history of diabetes (FHD).Data of age-matched 514 subjects previously undiagnosed with diabetes from two different occupational groups (bank employees and schoolteachers) in Chennai, India from opportunistic screening were taken for analysis. The important explanatory variables were body mass index, waist circumference, duration of physical activity, positive FHD, and random capillary blood glucose (RCBG). Logistic regression analyses were done separately to identify determinants of diabetes in each group. Another logistic regression was performed after combining data to estimate risk associated with diabetes among sedentary subjects with positive FHD.Factors associated with elevated RCBG among schoolteachers were systolic and diastolic blood pressure, whereas among bank employees, in addition to blood pressure, duration of sitting in work place and positive FHD were significantly associated with diabetes. Combined data analysis showed that subjects with duration of sitting of 180min/day and a positive FHD are three times at risk of developing diabetes. Adjusting for total physical activity revealed that risk was higher among male subjects.Increased sitting duration for 180min/day at the workplace was associated with elevated RCBG. There was a threefold higher risk for diabetes among these subjects with positive FHD. Encouraging physical activities in such groups, particularly in men, can be beneficial.

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