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Lebane D.,Mustapha University Hospital Center
Revue de Medecine Perinatale

The demographic transition which started in the eighties of the last century has lead to a new epidemiological transition, mainly expressed by the emergence of noncommunicable diseases although the communicable diseases still continue. The main factors that have contributed to the improvement of the Algerian population's health, and of the mother-infant couple in particular, result from the development of strategies that have started up in the beginning of the seventies. The observational studies for the last two decades [1] have concluded that the mortality rate has been observed to be high during the first weeks of life, and the causes of death also vary widely. After a hard struggle against the infant mortality and its exogenous causes, the perinatal health was finally accepted as a priority. The strategy obeys to the engagement of Algeria in following the directives of the millennium summit directed by the UN in 2000. The aim is to reach some points such as 2/3 decrease in the infant-juvenile mortality, 3/4 decrease in the maternal mortality for the period 1990-2015. If the political willing and the financial situation of the country answered to this important challenge, the lack in the organization and formation of health personnel still continue. The humanization of the cares, by enhancing the relation between the infant and mother (breastfeeding, skin-to-skin contact), may help the most vulnerable category of the infants. This is the strategy adopted by Algeria since 2006 throughout the setting of the national program of perinatality supported by promulgation of the decree of perinatality and normalization of neonatology from the official journal. © 2011 Springer. Source

Belguendouz H.,University of Science and Technology Houari Boumediene | Messaoudene D.,University of Science and Technology Houari Boumediene | Lahmar K.,University of Science and Technology Houari Boumediene | Ahmedi L.,University of Science and Technology Houari Boumediene | And 4 more authors.
Journal of Interferon and Cytokine Research

Uveitis is one of the major manifestations of Behçet Disease, a systemic inflammatory vasculitis. Our aim is to investigate in vivo and in vitro production of interferon (IFN)-γ and nitric oxide (NO) during Behçet uveitis (BU). Moreover, we evaluated the implication of IFN-γ and interleukin (IL)-10 in the regulation of NO production in vitro. Cytokines' concentrations were measured by ELISA, and NO levels were assessed by modified Griess's method. Our results showed that patients with active disease had significant elevation of IFN-γ and NO concentrations in both plasma and peripheral blood mononuclear cell culture supernatants compared with controls (P<0.01) or to patients with inactive disease (P<0.05). Further, IFN-γ induced significantly higher production of NO in cell culture supernatants, whereas IL-10 significantly reduced it (P<0.05). In conclusion, the elevated levels of IFN-γ in vivo and in vitro in patients with BU reflect the implication of this cytokine in the disease physiopathology. These results suggest that IFN-γ, through the induction of NO synthase 2 and the production of NO, is implicated in the genesis of the inflammatory process during active BU; whereas IL-10 seems to have protective properties. © Copyright 2011, Mary Ann Liebert, Inc. Source

An analysis at the Mustapha University Hospital Center of Algiers examined 78 hydatid samples collected between 2005 and 2012 to determine the fertility rate of metacestodes and the viability of protoscolices. The fertility rate of the hydatid cysts in humans was 88.4% and the protoscolex viability rate 74.5%. The fertility and viability rates found here are high, despite the use of scolicides. Source

Nouioua S.,Mustapha University Hospital Center | Cheillan D.,Hospices Civils de Lyon | Cheillan D.,INSA Lyon | Zaouidi S.,Mustapha University Hospital Center | And 6 more authors.
Neuromuscular Disorders

We report two sisters, aged 11 and 6. years, with AGAT deficiency syndrome (OMIM 612718) which is the least common creatine deficiency syndrome. They were born full-term to consanguineous parents and had moderate developmental delay. Examination showed an important language delay, a progressive proximal muscular weakness in the lower limbs with Gowers sign and myopathic electromyography. Investigations revealed undetectable guanidinoacetate and low level of creatine in plasma and urine, characteristic findings of AGAT deficiency syndrome. Brain magnetic resonance spectroscopy showed a markedly reduced level of creatine. Guanidinoacetate methyltransferase (GATM) gene sequencing revealed a homozygous missense mutation in exon 4:c.608A>C, (p.Tyr203Ser). Thirteen months after beginning the treatment with oral creatine monohydrate 200. mg/kg/day, then 400. mg/kg/day, there was a dramatic improvement in muscle strength with Gowers sign disappearance in both patients, and a mild improvement in language and cognitive functions. AGAT deficiency syndrome should be considered in all patients with language retardation and cognitive impairment associated to a myopathy of unknown etiology such that early diagnosis must lead to creatine supplementation to cure the myopathy and improve language and cognitive function. © 2013 Elsevier B.V. Source

Moreira C.,Unite dOncologie Pediatrique | Nachef M.N.,Unite Dhematologie et Doncologie Pediatrique | Ziamati S.,Service danatomopathologie | Ladjaj Y.,Mustapha University Hospital Center | And 3 more authors.
Pediatric Blood and Cancer

Background: The multidisciplinary management of nephroblastoma has been defined through multicentric prospective studies and an average 90% of patients cured expected. In Africa, such studies are uncommon and results are fragmentary or unknown in most of the countries. We report the results of the GFAOPNEPHRO 01 study using SIOP 2001 protocol approach. Procedure: From April 1, 2001 to March 31, 2004, 8 African Pilot Units were selected to participate in a nonrandomized prospective study. All patients referred with a clinical and radiological diagnosis of nephroblastoma were registered, those aged over 6 months and less than 18 years with a unilateral tumor not previously treated were included in this study and received preoperative chemotherapy. Patients with unfavorable histology or with a tumor other than Wilms tumor, and those with stage IV tumor and persistent disease after surgery were secondarily excluded. Results: Of the 229 patients initially registered, 166 were included and finally 133 retained in the study, after surgery. Tumor rupture occurred in 7.5% of the patients. Thirty-five percent were stage I, 22% stage II, 23% stage III, and 18% stage IV. Two-year disease-free survival and 5-year survival are, respectively: 77.9% and 76.7% for localized tumors, 72.7% and 71.6% for all study patients. Conclusions: It is possible to conduct African multicentric therapeutic studies within the framework of GFAOP. Results in terms of event-free survival and survival are satisfactory. Improvements with respect to procedure, data collection, and outcome are expected in a new study. © 2011 Wiley Periodicals, Inc. Source

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