Mustapha University Hospital Center

Mustapha, Algeria

Mustapha University Hospital Center

Mustapha, Algeria

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Belguendouz H.,University of Science and Technology Houari Boumediene | Messaoudene D.,University of Science and Technology Houari Boumediene | Lahmar K.,University of Science and Technology Houari Boumediene | Ahmedi L.,University of Science and Technology Houari Boumediene | And 4 more authors.
Journal of Interferon and Cytokine Research | Year: 2011

Uveitis is one of the major manifestations of Behçet Disease, a systemic inflammatory vasculitis. Our aim is to investigate in vivo and in vitro production of interferon (IFN)-γ and nitric oxide (NO) during Behçet uveitis (BU). Moreover, we evaluated the implication of IFN-γ and interleukin (IL)-10 in the regulation of NO production in vitro. Cytokines' concentrations were measured by ELISA, and NO levels were assessed by modified Griess's method. Our results showed that patients with active disease had significant elevation of IFN-γ and NO concentrations in both plasma and peripheral blood mononuclear cell culture supernatants compared with controls (P<0.01) or to patients with inactive disease (P<0.05). Further, IFN-γ induced significantly higher production of NO in cell culture supernatants, whereas IL-10 significantly reduced it (P<0.05). In conclusion, the elevated levels of IFN-γ in vivo and in vitro in patients with BU reflect the implication of this cytokine in the disease physiopathology. These results suggest that IFN-γ, through the induction of NO synthase 2 and the production of NO, is implicated in the genesis of the inflammatory process during active BU; whereas IL-10 seems to have protective properties. © Copyright 2011, Mary Ann Liebert, Inc.


Nazef K.,Sudan University of Science and Technology | Khelil M.,Sudan University of Science and Technology | Chelouti H.,Sudan University of Science and Technology | Kacimi G.,Laboratoire Of Biochimie | And 5 more authors.
Archives of Medical Research | Year: 2014

Background and Aims: There is growing evidence that increased blood concentration of total homocysteine (tHcy) may be a risk factor for Alzheimer's disease (AD). The present study was conducted to evaluate the association of serum tHcy and other biochemical risk factors with AD. Methods: This is a case-control study including 41 individuals diagnosed with AD and 46nondemented controls. Serum levels of all studied biochemical parameters were performed. Results: Univariate logistic regression showed a significant increase of tHcy (p=0.008), urea (p=0.036) and a significant decrease of vitamin B12 (p=0.012) in AD group vs. controls. Using multivariate logistic regression, tHcy (p=0.007, OR=1.376) appeared as an independent risk factor predictor of AD. There was a significant positive correlation between tHcy and creatinine (p <0.0001). A negative correlation was found between tHcy and vitamin B12 (p <0.0001). Conclusions: Our findings support that hyperhomocysteinemia is a risk factor for AD in an Algerian population and is also associated with vitamin B12 deficiency. © 2014 IMSS.


Moreira C.,Unite doncologie Pediatrique | Nachef M.N.,Unite Dhematologie et Doncologie Pediatrique | Ziamati S.,Service Danatomopathologie | Ladjaj Y.,Mustapha University Hospital Center | And 3 more authors.
Pediatric Blood and Cancer | Year: 2012

Background: The multidisciplinary management of nephroblastoma has been defined through multicentric prospective studies and an average 90% of patients cured expected. In Africa, such studies are uncommon and results are fragmentary or unknown in most of the countries. We report the results of the GFAOPNEPHRO 01 study using SIOP 2001 protocol approach. Procedure: From April 1, 2001 to March 31, 2004, 8 African Pilot Units were selected to participate in a nonrandomized prospective study. All patients referred with a clinical and radiological diagnosis of nephroblastoma were registered, those aged over 6 months and less than 18 years with a unilateral tumor not previously treated were included in this study and received preoperative chemotherapy. Patients with unfavorable histology or with a tumor other than Wilms tumor, and those with stage IV tumor and persistent disease after surgery were secondarily excluded. Results: Of the 229 patients initially registered, 166 were included and finally 133 retained in the study, after surgery. Tumor rupture occurred in 7.5% of the patients. Thirty-five percent were stage I, 22% stage II, 23% stage III, and 18% stage IV. Two-year disease-free survival and 5-year survival are, respectively: 77.9% and 76.7% for localized tumors, 72.7% and 71.6% for all study patients. Conclusions: It is possible to conduct African multicentric therapeutic studies within the framework of GFAOP. Results in terms of event-free survival and survival are satisfactory. Improvements with respect to procedure, data collection, and outcome are expected in a new study. © 2011 Wiley Periodicals, Inc.


Nouioua S.,Mustapha University Hospital Center | Cheillan D.,Hospices Civils de Lyon | Cheillan D.,INSA Lyon | Zaouidi S.,Mustapha University Hospital Center | And 6 more authors.
Neuromuscular Disorders | Year: 2013

We report two sisters, aged 11 and 6. years, with AGAT deficiency syndrome (OMIM 612718) which is the least common creatine deficiency syndrome. They were born full-term to consanguineous parents and had moderate developmental delay. Examination showed an important language delay, a progressive proximal muscular weakness in the lower limbs with Gowers sign and myopathic electromyography. Investigations revealed undetectable guanidinoacetate and low level of creatine in plasma and urine, characteristic findings of AGAT deficiency syndrome. Brain magnetic resonance spectroscopy showed a markedly reduced level of creatine. Guanidinoacetate methyltransferase (GATM) gene sequencing revealed a homozygous missense mutation in exon 4:c.608A>C, (p.Tyr203Ser). Thirteen months after beginning the treatment with oral creatine monohydrate 200. mg/kg/day, then 400. mg/kg/day, there was a dramatic improvement in muscle strength with Gowers sign disappearance in both patients, and a mild improvement in language and cognitive functions. AGAT deficiency syndrome should be considered in all patients with language retardation and cognitive impairment associated to a myopathy of unknown etiology such that early diagnosis must lead to creatine supplementation to cure the myopathy and improve language and cognitive function. © 2013 Elsevier B.V.


Zait H.,Mustapha University Hospital Center | Ferhani Y.,Mustapha University Hospital Center | Achir I.,Mustapha University Hospital Center | Hamrioui B.,Mustapha University Hospital Center
Medecine et Maladies Infectieuses | Year: 2012

Objective: The authors retrospectively studied the epidemiological, clinical, diagnostic and therapeutic aspects of 71 cases of visceral leishmaniasis from 1998 to 2009. Population and methods: The diagnosis was made by finding Leishmania amastigotes in bone marrows smears and/or by serology. Results: Most cases occur in winter (35.2%) and in spring (36.6%). The source areas are endemic ones located in the north of Algeria (74.6%) and more rarely arid or semi-arid climate areas (8.4%). 88.7% of patients are children. The sex ratio is 1.53. The clinical characteristics are: fever (77.4%), paleness (43.6%); splenomegaly (83%), hepatomegaly (57.7%). The biological anomalies are: anemia (56.3%), thrombocytopenia (33.8%), and leucopenia (28.1%). N-methylglucamine (Glucantime ®) was most often prescribed (70.4%). Four deaths (5.6%) were recorded. Conclusion: Visceral leishmaniasis remains a pediatric affection but does not spare adults. © 2012 Elsevier Masson SAS.


Lebane D.,Mustapha University Hospital Center
Revue de Medecine Perinatale | Year: 2011

The demographic transition which started in the eighties of the last century has lead to a new epidemiological transition, mainly expressed by the emergence of noncommunicable diseases although the communicable diseases still continue. The main factors that have contributed to the improvement of the Algerian population's health, and of the mother-infant couple in particular, result from the development of strategies that have started up in the beginning of the seventies. The observational studies for the last two decades [1] have concluded that the mortality rate has been observed to be high during the first weeks of life, and the causes of death also vary widely. After a hard struggle against the infant mortality and its exogenous causes, the perinatal health was finally accepted as a priority. The strategy obeys to the engagement of Algeria in following the directives of the millennium summit directed by the UN in 2000. The aim is to reach some points such as 2/3 decrease in the infant-juvenile mortality, 3/4 decrease in the maternal mortality for the period 1990-2015. If the political willing and the financial situation of the country answered to this important challenge, the lack in the organization and formation of health personnel still continue. The humanization of the cares, by enhancing the relation between the infant and mother (breastfeeding, skin-to-skin contact), may help the most vulnerable category of the infants. This is the strategy adopted by Algeria since 2006 throughout the setting of the national program of perinatality supported by promulgation of the decree of perinatality and normalization of neonatology from the official journal. © 2011 Springer.


Tazir M.,Mustapha University Hospital Center | Tazir M.,University of Algiers 1 | Bellatache M.,Mustapha University Hospital Center | Bellatache M.,University of Algiers 1 | And 3 more authors.
Journal of the Peripheral Nervous System | Year: 2013

The prevalence of Charcot-Marie-Tooth (CMT) disease or hereditary motor and sensory neuropathy (HMSN) varies in different populations. While in some countries of Western Europe, the United States and Japan the dominant form of HMSN is the most frequent, in other countries such as those of the Mediterranean Basin, the autosomal recessive form (AR-CMT) is more common. Autosomal recessive CMT cases are generally characterized by earlier onset, usually before the age of 2 or 3 years, and rapid clinical progression that results in severe polyneuropathy and more marked distal limb deformities such as pes equino-varus, claw-like hands, and often major spinal deformities. Recent clinical, morphological and molecular investigations of CMT families with autosomal recessive inheritance allowed the identification of many genes such as GDAP1, MTMR2, SBF2, NDRG1, EGR2, SH3TC2, PRX, FGD4, and FIG4, implicated in demyelinating forms (ARCMT1 or CMT4), and LMNA, MED25, HINT1, GDAP1, LRSAM1, NEFL, HSPB1 and MFN2 in axonal forms (ARCMT2). However, many patients remain without genetic diagnosis to date, prompting investigations into ARCMT families in order to help discover new genes and common pathways. This review summarizes recent advances regarding the genotypes and corresponding phenotypes of AR-CMT. © 2013 Peripheral Nerve Society.


Messad S.,National Veterinary School of Algiers | Hamdi T.-M.,National Veterinary School of Algiers | Bouhamed R.,National Veterinary School of Algiers | Ramdani-Bouguessa N.,Mustapha University Hospital Center | Tazir M.,Mustapha University Hospital Center
Food Control | Year: 2014

Campylobacteriosis in humans is caused by thermotolerant Campylobacter spp, following consumption of contaminated poultry, most commonly broiler. The aim of this study was to assess the frequency of contamination by thermotolerant Campylobacter and to characterize antimicrobial resistance of the strains isolated from broilers in some farms and slaughterhouses in the region of Algiers.One hundred droppings samples, 100 contents of ceaca and 100 neck skins were taken from six poultry farms and five slaughterhouses, than analyzed according to NF. ISO 10272-1/1995 norm and the OIE recommendations. Susceptibility to antibiotics was determined according to the guidelines of the CA-SFM/2010 by disc diffusion method.Thermotolerant Campylobacter strains were isolated from 85%, 98%, and 80% of droppings, caecal content and neck skin, respectively. All the strains (100%) were resistant to nalidixic acid and sensitive to gentamicin and to chloramphenicol. 83.7% of them were resistant to tetracycline and to ciprofloxacin, 75.3% to ampicillin, 46.8% to amoxicillin/clavulanic acid and 21.7% were resistant to erythromycin. All the isolates showed a multi-drug resistance. Nineteen different profiles were identified with "AM, AMC, NA, CIP, TE" combination as the most common profile identified for 27% (n=74) of isolated strains. In addition, 15% of the strains were resistant to both erythromycin and ciprofloxacin, which are systematically used in treatment of human Campylobacter infections.Our results showed a high prevalence of thermotolerant Campylobacter with multidrug resistance profiles in poultry farms and slaughterhouses of Algiers. These results stress that the risk of human contamination throughout the food chain is very high, which may generate: i) a danger of food poisoning by ingestion of chicken meat and chicken meat products and, ii) a cross-resistance to antibiotics between human and avian strains. © 2013 Elsevier Ltd.


Zait H.,Mustapha University Hospital Center | Hamrioui B.,Mustapha University Hospital Center
Journal de Mycologie Medicale | Year: 2011

Pulmonary aspergilloma is intracavity development of the Aspergillus mycelia. It is an fungal complication that occurs, usually, at patients carrying a residual tuberculosis. It appears in a series of 39 cases of aspergilloma diagnosed by serology on ten years (of 1999 to 2009) at the laboratory of parasitology-mycology of the university hospital center of Mustapha of Algers, an incidence of 3.9 cases per year, a mean age of 49.5. years and a sex-ratio of 1.2. The clinic is dominated by the haemoptysis (71.7%). The development of the fungus ball frequently happened on residual tuberculosis (79.4%). The radiology found in favour images of aspergillosis: rounded mass sitting inside a cavity (12.8%) or an residual opacity (15.3%). At the laboratory, the precipitating antibodies against Aspergillus search by immuno-electrophoresis was found positive in 100% of the patients. © 2011 Elsevier Masson SAS.


An analysis at the Mustapha University Hospital Center of Algiers examined 78 hydatid samples collected between 2005 and 2012 to determine the fertility rate of metacestodes and the viability of protoscolices. The fertility rate of the hydatid cysts in humans was 88.4% and the protoscolex viability rate 74.5%. The fertility and viability rates found here are high, despite the use of scolicides.

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