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Shani R.H.,University of Texas Health Science Center at Houston | Umpierez E.,Emory University | Nasert M.,Musculoskeletal Transplant Foundation | Hiza E.A.,Emory University | Xerogeanes J.,Emory University
Arthroscopy - Journal of Arthroscopic and Related Surgery

Purpose To quantify the structural and material properties of 10-mm central sections of the quadriceps and patellar tendons in the setting of anterior cruciate ligament reconstruction using cadaveric grafts and biomechanical analysis. Methods The structural and mechanical properties of 11 bone-patellar tendon-bone (BPTB) and 12 quadriceps tendon-bone (QT) allografts were evaluated. Ten-millimeter-wide tendon grafts from both patellar and quadriceps tendons were harvested and subjected to biomechanical testing using the MTS servohydraulic test machine (MTS Systems, Eden Prairie, MN). The cross-sectional area was also calculated and compared between the BPTB and QT grafts. Results The mean cross-sectional area was 91.2 ± 10 mm2 for the QT compared with 48.4 ± 8 mm2 for the BPTB (P =.005). The mean ultimate stress was 23.9 ± 7.4 MPa for the QT and 33.4 ± 9.0 MPa for the BPTB (P =.01). Ultimate strain was similar between the 2 tested groups, with a 10.7% change in the QT group and an 11.4% change in the BPTB group (P =.484). The Young modulus of elasticity was 255.3 ± 64.1 MPa for the QT and 337.8. ± 67.7 MPa for the BPTB (P =.006). The mean stiffness was 466.2 ± 133 N/mm for the QT and 278.0 ± 75 N/mm for the BPTB (P =.005). The mean ultimate load to failure was 2,185.9 ± 758.8 N for the QT compared with 1,580.6 ± 479.4 N for the BPTB (P =.045). Conclusions The cross-sectional area of the QT was nearly twice that of the BPTB. Ultimate load to failure and stiffness were also significantly higher for the QT graft. The variability in the cross-sectional area was similar in both tendon groups. Clinical Relevance On the basis of graft predictability and biomechanical properties, our study reaffirms that the QT graft is a biomechanically sound alternative for anterior cruciate ligament reconstruction. © 2016 Arthroscopy Association of North America. Source

Nasert M.A.,Musculoskeletal Transplant Foundation | Barber F.A.,Plano Orthopedic Sports Medicine and Spine Center
Arthroscopy - Journal of Arthroscopic and Related Surgery

Purpose: To assess the biomechanical performance of 2 different T-block modifications of bone-patella tendon-bone (BPTB) allografts. Methods: The matched knee pairs from 10 human cadavers (mean age 49 years) were fashioned into 30 BPTB allografts and divided into 3 groups (10 each): group 1, standard patella tendon-tibial attachment; group 2, T-block tibial attachment with 10 mm of unattached bone proximal to the patella tendon insertion with 15 mm of tendon attached; group 3, T-block tibial attachment with 15 mm of unattached bone proximal to the patella tendon insertion and 10 mm of tendon attached. A biocomposite interference screw secured each graft into a 10-mm tunnel in 15 pcf polyurethane foam. A 10-N preload was applied followed by 500 cycles of 10- to 150-N loading at 0.5 Hz. Grafts completing cyclic loading were destructively tested at 200 mm/min. Failure load, stiffness, elongation, and failure mode were recorded. Results: Failure loads and elongation for groups 1, 2, and 3 (790, 729, and 700 N; 0.15, 0.16, and 0.19 mm, respectively) were not statistically different (P > .1). Graft stiffness for groups 1 and 2 (214 and 186 N/mm) were not statistically different, but group 3 (170 N/mm) was different from group 1. All group 1 and 2 tests failed by graft pullout as did 8 of 10 from group 3. The other 2 failed by tendon tearing from bone. Conclusions: A T-block BPTB allograft harvested with 10 or 15 mm of unattached bone proximal to the tibial patella tendon insertion has no ultimate failure strength difference after cyclic loading compared with the standard BPTB allograft. The 15-mm T-block showed lower stiffness and more elongation at failure than the standard BPTB allograft whereas the 10-mm T-block exhibited comparable stiffness and elongation measurements to the standard BPTB allograft control specimens. Clinical Relevance: The T-block BPTB allograft construct should increase the availability of BPTB allografts for anterior cruciate ligament reconstruction and facilitate the use of grafts possessing longer tendon segments that are currently being discarded. © 2016 The Arthroscopy Association of North America. Source

Musculoskeletal Transplant Foundation | Date: 2013-10-31

The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or mixed polymers with allograft chondrocytes added in an amount ranging from 2.510

Musculoskeletal Transplant Foundation | Date: 2010-05-03

The present invention is a process for preparing soft tissue such as tendons, ligaments, cartilage, fascia, dermis, human valves and human veins for implant in a human and removes cellular components and forms an decellular matrix having as major components collagens and elastins while sterilizing the tissue. The process comprises the following steps: (1) isolating from a suitable donor a desired soft tissue sample of the biological material; (2) processing and decellularizing the soft tissue including inspection for visual defects, trimming and soaking the tissue in a detergent depending on whether the tissue is fascia or dermis and rinsing same with sterile water; (3) sterilizing the soft tissue in a vacuum and soaking the tissue in an antibiotic composition or peracetic acid depending on whether the soft tissue is fascia or dermis and rinsing same; (4) processing the tissue by cutting the tissue to size and perforating the tissue; and (5) dipping the tissue in 70% ethanol and packaging the tissue.

Musculoskeletal Transplant Foundation and DePuy | Date: 2013-10-09

The present invention is directed to an allograft intervertebral implant sized and configured for insertion between adjacent vertebral bodies in a spinal fusion surgery. The implant is preferably manufactured from two or more pieces of allograft bone joined together by a joint, more preferably a dovetail joint. The dovetail joint being sized and configured to substantially follow the exterior shape or surface of the intervertebral implant.

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