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Murshidābād, India

Bhattacharya S.M.,Science das Memorial and Research Center | Bhattacharya S.M.,KPC Medical College | Ghosh M.,Murshidabad Medical College
International Journal of Gynecology and Obstetrics

Objective: To assess the effects of tibolone on serum calcium and vitamin D3 levels, the effects on health-related quality of life (HRQOL), and the relationship between these variables.Methods: An open-label, prospective, parallel-arm study was conducted at S.C. Das Memorial Medical and Research Center, Kolkata, India, between July 2012, and June 2013.Women aged 34-55 years were eligible when they were experiencing surgicalmenopause and were symptomatic. Group A comprised patients who chose to receive tibolone (2.5 mg daily for 6 months) and group B comprised those who refused treatment. At baseline and 6 months, body mass index (BMI), serum calcium and vitamin D3 levels and HRQOL were assessed.Results: Of 79 participants, 53 were in group A and 26 in group B. After 6 months, BMI had increased significantly in both groups. The vitamin D3 level had increased significantly from baseline in group A (P = 0.02), and was higher than that in group B (P= 0.01).HRQOL had also improved significantly from baseline in group A (P= 0.001), and was significantly better than that in group B (P < 0.001). In group A, a significant correlation was found between HRQOL improvement and vitamin D3 levels (P < 0.001).Conclusion: Tibolone significantly increases the serum vitamin D3 level and improves HRQOL in menopausal women. © 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. Source

Dalui A.,Medical College and Hospital | Guha P.,Medical College and Hospital | De A.,Malda Medical College and Hospital | Chakraborty S.,Murshidabad Medical College | Chakraborty I.,Malda Medical College and Hospital
Indian Journal of Medical Research

Background & objectives: The family caregivers of patients with chronic diseases are known to undergo psychiatric stress leading to oxidative damage to glomerular membrane of kidney resulting in proteinuria. This study was aimed to compare current anxiety, depression levels and urinary albumin:creatinine ratio between primary caregivers of chronic mental patients and matched controls, and also whether the urinary albumin: creatinine ratio is correlated with stress factors (state and trait anxiety level, depression and caregiver burden) amongst caregivers. Methods: The present cross-sectional study included 131 subjects (93 primary caregivers of patients with major mental illness as cases and 38 normal controls). They completed the Burden Assessment Schedule of SCARF, State Trait Anxiety Inventory and Beck's Depression Inventory. A spot urine sample was tested for urinary albumin: creatinine ratio from all study subjects. Results: Mean values of current State and Trait anxiety, depression, urinary albumin:creatinine ratio were significantly higher in caregivers than controls (P<0.001). Urinary albumin: creatinine ratio was significantly correlated (P<0.001) with State and Trait anxiety level, depression as well as caregiver burden. Interpretation & conclusions: The study demonstrated depression, anxiety and albuminuria amongst primary caregivers of patients with mental illness. Increase in the caregivers' burden, depression and anxiety resulted in an increase in the urinary albumin: creatinine ratio. This indicates that psychological stress is one of the determinants of albumin excretion rate in otherwise healthy subjects. Source

Bose M.,Murshidabad Medical College | Ghosh R.,Nilratan Sircar Medical College | Mukherjee K.,Nilratan Sircar Medical College | Ghoshal L.,West Dermatology
Journal of Clinical and Diagnostic Research

Actinomycosis is a subacute or chronic suppurative bacterial infection caused by filamentous gram positive, anaerobic to microaerophilic non acid fast bacilli primarily of the genus Actinomyces that normally colonize the mouth, colon and vagina. Primary cutaneous actinomycosis is a rare entity and is generally associated with trauma. We report a case of primary cutaneous actinomycosis of the back and left axilla in a 32-year-old female patient with no suggestive history of trauma.The diagnosis was suggested by the characteristic lesions with multiple discharging sinuses draining sero-sanguinous fluid scattered all over the lesions. Gram positive bacilli with plenty of pus cells were demonstrated in the direct examination of the discharging pus. Diagnosis was confirmed by isolation of the organisms by anaerobic culture giving typical molar tooth colonies. Final confirmation was done by histopathological examination. Source

Chattopadhyay S.,Murshidabad Medical College | Shee B.,Medical College Kolkata | Sukul B.,Medical College Kolkata
Egyptian Journal of Forensic Sciences

Medico legal autopsies are conducted in all cases of unnatural deaths and unidentified bodies. The case load of unidentified bodies in autopsy at Calcutta is quite alarming. The profile of such cases has rarely been studied in India. The present study attempts to find out the circumstances and fate of the unidentified bodies on whom medico legal autopsies were conducted. One fourth (614) of all the cases brought for autopsy were unidentified at the time of postmortem examination. Subsequently, 109 cases were identified and the rest remained unidentified. The peak age group of the deceased was 31-45. years and the majority of them were males. Identity of the victims was possible only within the first week after autopsy. The family members were the ones to identify the deceased and the male members of the family were the commonest one to identify the victims. Natural death (48.3%) due to disease and pathological condition was the leading cause of death whereas among the unnatural causes, drowning (28.4%) was the commonest cause. The present study revealed that the homeless street dwellers of the city formed a substantial portion of the unfortunate victims. © 2013 . Source

Ghosh P.,NEON Laboratory | Saha K.,Murshidabad Medical College
Archives of Iranian Medicine

Multilocular cystic renal cell carcinoma (MCRCC) is a rare tumor with an excellent prognosis. We report a case of MCRCC in a 33-year-old male who presented with vague discomfort in the right flank for the last 1.5 years. Computed tomography (CT) scan revealed a multiseptate cystic mass in the upper pole of the right kidney. Surgically resected well-circumscribed cystic mass was formed entirely by thin-walled non-communicating cysts of variable size separated from surrounding renal parenchyma by a distinct fibrous wall. On histopathological examination, clear cells with prominent cytoplasmic border and low nucleocytoplasmic ratio were present in the lining epithelium as well as in the intervening septa. No solid area was appreciated in the cystic mass. Finally, after corroboration with the imprint cytology findings, the tumor was diagnosed as MCRCC with TNM staging and Fuhrman nuclear grading of T1bN0M0 and grade 1, respectively. Source

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